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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Aldo-keto reductase family 1, member B3

aldose reductase, Aldehyde Reductase
Top mentioned proteins: ACID, CAN, V1a, HAD, AGE
Papers on aldose reductase
Disruption of PHO13 improves ethanol production via the xylose isomerase pathway.
New
Kondo et al., Kōbe, Japan. In Amb Express, 31 Dec 2016
In this study, PHO13 was disrupted in a recombinant strain harboring multiple copies of the xylose isomerase (XI) gene derived from Orpinomyces sp., coupled with overexpression of the endogenous xylulokinase (XK) gene and disruption of GRE3, which encodes aldose reductase.
Mesoamerican Nephropathy or Global Warming Nephropathy?
New
Johnson et al., Aurora, United States. In Blood Purif, Feb 2016
Potential mechanisms include the development of hyperosmolarity with the activation of the aldose reductase-fructokinase pathway in the proximal tubule leading to local injury and inflammation, and the possibility that renal injury may be the consequence of repeated uricosuria and urate crystal formation as a consequence of both increased generation and urinary concentration, similar to a chronic tumor lysis syndrome.
Apigenin-7-O-β-d-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock.
New
Wang et al., Huaiyin, China. In Food Funct, Feb 2016
UNASSIGNED: Apigenin-7-O-β-d-glucuronide (AG), an active flavonoid derivative isolated from the agricultural residue of Juglans sigillata fruit husks, possesses multiple pharmacological activities, including anti-oxidant, anti-complement, and aldose reductase inhibitory activities.
A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages.
New
Rabilloud et al., Grenoble, France. In J Proteomics, Jan 2016
The zinc-specific responses are the most prominent ones and include mitochondrial proteins too, but also signaling molecules such as MyD88, proteins associated with methylglyoxal detoxification (glyoxalase 2, aldose reductase) and deoxyribonucleotide hydrolases.
In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase.
New
Xu et al., Zhuhai, China. In Food Sci Nutr, Nov 2015
The antidiabetic effects were evaluated by comparing the inhibitory properties of α-glycosidase, aldose reductase, and antioxidant activity.
Constituents and Pharmacological Activities of Myrcia (Myrtaceae): A Review of an Aromatic and Medicinal Group of Plants.
Review
Santos et al., Belém, Brazil. In Int J Mol Sci, 2014
Flavonoid glucosides and acetophenone derivatives showed aldose reductase and α-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes.
Constituents and Pharmacological Activities of Myrcia (Myrtaceae): A Review of an Aromatic and Medicinal Group of Plants.
Review
Santos et al., Belém, Brazil. In Int J Mol Sci, 2014
Flavonoid glucosides and acetophenone derivatives showed aldose reductase and α-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes.
Constituents and Pharmacological Activities of Myrcia (Myrtaceae): A Review of an Aromatic and Medicinal Group of Plants.
Review
da Silva Santos et al., Belém, Brazil. In Int J Mol Sci, 2014
Flavonoid glucosides and acetophenone derivatives showed aldose reductase and α-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes.
Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases.
Review
Sekhon et al., Sirsa, India. In Mini Rev Med Chem, 2014
Aldose reductase (AR) is an enzyme of aldoketo reductase super-family that catalyzes the conversion of glucose to sorbitol in the polyol pathway of glucose metabolism.
Update on genetics and diabetic retinopathy.
Review
Flynn et al., Miami, United States. In Clin Ophthalmol, 2014
Multiple smaller studies have investigated genotype-phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others.
Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F2α synthase, AKR1B3.
GeneRIF
Inoue et al., Suita, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A
Aldose reductase (AKR1B3) regulates the accumulation of advanced glycosylation end products (AGEs) and the expression of AGE receptor (RAGE).
GeneRIF
Bhatnagar et al., Louisville, United States. In Chem Biol Interact, 2011
the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products
Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice.
GeneRIF
Yang et al., Xiamen, China. In Diabetologia, 2011
Genetic deficiency of Ar significantly ameliorated development of key endpoints linked with early diabetic nephropathy in vivo.
Catalytic mechanism of the primary human prostaglandin F2α synthase, aldo-keto reductase 1B1--prostaglandin D2 synthase activity in the absence of NADP(H).
GeneRIF
Urade et al., Suita, Japan. In Febs J, 2011
a Y48F/H110F double mutant of AKR1B3 completely lost PGDS activity and showed only 2.9% of PGFS activity
Osmolarity and glucose differentially regulate aldose reductase activity in cultured mouse podocytes.
GeneRIF
Rybczyńska et al., Gdańsk, Poland. In Exp Diabetes Res, 2010
Activation of AR in podocytes may be implicated in diabetic podocytopathy.
Electric fields at the active site of an enzyme: direct comparison of experiment with theory.
Impact
Boxer et al., Stanford, United States. In Science, 2006
A nitrile-containing inhibitor is used to deliver a unique probe vibration to the active site of human aldose reductase, and the response of the nitrile stretch frequency is measured for a series of mutations in the enzyme active site.
The marriage of glucose and blood vessels: it isn't all that sweet.
Impact
Stern et al., Augusta, United States. In Cell Metab, 2005
Based on a recent paper by Vikramadithyan et al. (2005), this preview addresses the role of aldose reductase as a contributor to the pathogenesis of diabetic macrovascular disease.
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options.
Review
Impact
Bhatnagar et al., Galveston, United States. In Endocr Rev, 2005
Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme.
From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines.
Review
Impact
Flyvbjerg et al., Århus, Denmark. In Endocr Rev, 2004
This review focuses on the metabolic factors beyond blood glucose that are involved in the pathogenesis of diabetic kidney disease, i.e., advanced glycation end-products and the aldose reductase system.
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Impact
Brownlee et al., New York City, United States. In Nature, 2000
Three seemingly independent biochemical pathways are involved in the pathogenesis: glucose-induced activation of protein kinase C isoforms; increased formation of glucose-derived advanced glycation end-products; and increased glucose flux through the aldose reductase pathway.
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