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Aldolase C, fructose-bisphosphate

ALDOC, fructose-bisphosphate aldolase C, aldolase 3, brain-type aldolase
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, ACID, HAD, GAPDH
Papers on ALDOC
Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.
Wanner et al., Los Angeles, United States. In Glia, Jan 2016
STAT3-CKO astrocytes had reduced basal expression of GFAP, lactate dehydrogenase B (LDHB), aldolase C (ALDOC), and astrocytic phosphoprotein 15 (PEA15), and elevated levels of tropomyosin (TPM4) and α actinin 4 (ACTN4).
Suppression of fructose-bisphosphate aldolase C expression as a predictor of advanced oral squamous cell carcinoma.
Chang et al., Taipei, Taiwan. In Head Neck, Dec 2015
METHODS: Fructose-bisphosphate aldolase C (ALDOC) expression in OSCC patients and cell lines was detected using quantitative real-time polymerase chain reaction (PCR).
Differential protein expression in chicken spermatozoa before and after freezing-thawing treatment.
Huang et al., T'ai-chung-shih, Taiwan. In Anim Reprod Sci, 2015
The differentially expressed proteins before and after freezing-thawing treatment, including fructose-bisphosphate aldolase C, triosephosphate isomerase, aconitate hydratase, tubulin and outer dense-fiber protein, are associated with sperm energy metabolism and flagellum structure.
Protein carbonylation after traumatic brain injury: cell specificity, regional susceptibility, and gender differences.
Mueller et al., Bethesda, United States. In Free Radic Biol Med, 2015
Proteomic analyses were also conducted and determined that the proteins most affected by carbonylation in response to TBI include glial fibrillary acidic protein, dihydropyrimidase-related protein 2, fructose-bisphosphate aldolase C, and fructose-bisphosphate aldolase A. Many other proteins, however, were not carbonylated by CCI.
Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure.
Westerterp et al., Maastricht, Netherlands. In Nutr Metab (lond), 2014
Protein levels of fatty acid binding protein 4 (FABP4), fructose-bisphosphate aldolase C (AldoC) and short chain 3-hydroxyacyl-CoA dehydrogenase (HADHsc) (adipose tissue biopsy, western blot), TEE (doubly labeled water), REE (ventilated hood), and AEE were assessed before and after the 8-wk diet.
MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia.
Martins-de-Souza et al., Campinas, Brazil. In Front Cell Neurosci, 2014
In astrocytes, MK-801 affected only aldolase C (ALDOC) under both acute conditions and HK1 and ALDOC following long term treatment, and TPI was the only enzyme affected under long term conditions in the neuronal cells.
GeneChip expression profiling reveals the alterations of energy metabolism related genes in osteocytes under large gradient high magnetic fields.
Qian et al., Xi'an, China. In Plos One, 2014
12 energy metabolism related genes (PFKL, AK4, ALDOC, COX7A1, STC1, ADM, CA9, CA12, P4HA1, APLN, GPR35 and GPR84) were further confirmed by real-time PCR.
Targeted quantitative analysis of synaptic proteins in Alzheimer's disease brain.
Nouwens et al., Australia. In Neurochem Int, 2014
Significantly lower levels of peroxiredoxin-1 and the energy-related enzymes creatine kinase B and fructose-bisphosphate aldolase C were found in non-AD hippocampus.
Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion.
Yamashima et al., Japan. In Free Radic Res, 2014
We found carbonyl modification not only of Hsp70.1 but also of mitochondrial aconitase, dihydropyrimidinase-related protein 2, T-complex protein 1 subunit alpha, dihydrolipoyl dehydrogenase, fructose-bisphosphate aldolase C, glutamate dehydrogenase 1, and aspartate aminotransferase.
Differential S-nitrosylation of proteins in Alzheimer's disease.
Asif et al., Karāchi, Pakistan. In Neuroscience, 2014
Superoxide dismutase (SOD2) [Mn], fructose-bisphosphate aldolase C (ALDOC) and voltage-dependent anion-selective channel protein 2 (VDAC2) showed differential S-nitrosylation signal, not previously reported in AD regions.
Aldolase positively regulates of the canonical Wnt signaling pathway.
Rosin-Arbesfeld et al., Tel Aviv-Yafo, Israel. In Mol Cancer, 2013
One of the different genes that were identified as Wnt signaling activators was Aldolase C (ALDOC).
Detailed expression pattern of aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice.
Sugihara et al., Tokyo, Japan. In Plos One, 2013
Aldolase C (Aldoc, also known as "zebrin II"), a brain type isozyme of a glycolysis enzyme, is expressed heterogeneously in subpopulations of cerebellar Purkinje cells (PCs) that are arranged longitudinally in a complex striped pattern in the cerebellar cortex, a pattern which is closely related to the topography of input and output axonal projections.
The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment.
Wyneken et al., Santiago, Chile. In Brain Res, 2013
Among them, Fructose-bisphosphate aldolase C (AldoC), a glycolytic/gluconeogenic enzyme primarily expressed in forebrain astrocytes, was up-regulated 7.6-fold.
Physiological response of adipocytes to weight loss and maintenance.
Westerterp et al., Maastricht, Netherlands. In Plos One, 2012
A marker for glycolysis decreased (AldoC) during weight loss in association with adipocyte shrinking, and remained decreased during follow-up in association with weight maintenance.
Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum.
Sriram et al., College Park, United States. In Microb Cell Fact, 2012
Additionally, gene expression assays showed that known, native glucose transporters in Pt are largely insensitive to glucose or light, whereas the gene encoding cytosolic fructose bisphosphate aldolase 3, an important glycolytic enzyme, is overexpressed in light but insensitive to glucose.
Projection patterns of single mossy fiber axons originating from the dorsal column nuclei mapped on the aldolase C compartments in the rat cerebellar cortex.
Sugihara et al., Tokyo, Japan. In J Comp Neurol, 2011
Dorsal column nuclei (DCN)-cerebellar axons project to multiple compartments with terminals clustered mainly in the conventional spinocerebellar region with a coarse topography, which relates to the cortical compartments defined by aldolase C.
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in the anterior cingulate cortex in men patients with schizophrenia.
Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease.
Butterfield et al., Lexington, United States. In Antioxid Redox Signal, 2010
Results identified fructose bisphospate aldolase C that showed elevated levels of protein carbonyls in inferior parietal lobule (IPL) from subjects with early stage-Alzheimer's disease.
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.
Dias-Neto et al., São José dos Campos, Brazil. In J Psychiatr Res, 2009
This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.
Dias-Neto et al., São Paulo, Brazil. In Bmc Psychiatry, 2008
This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.
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