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Aldehyde dehydrogenase 3 family, member B2

ALDH8, ALDH3B2
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ALDH3B1, ACID, Aldehyde Dehydrogenase, ToF, HAD
Papers on ALDH8
Structural and kinetic characterization of recombinant 2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas putida G7.
New
Nagem et al., Belo Horizonte, Brazil. In Arch Biochem Biophys, Sep 2015
NahI is in family 8 (ALDH8) of the NAD(P)(+)-dependent aldehyde dehydrogenase superfamily.
Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.
New
Nishimura et al., Kōbe, Japan. In Int J Oncol, Mar 2015
While ALDH1A2, ALDH1L1 and ALDH3B2 expression was consistently induced in spheres and associated with the sphere and colony formation, only ALDH1A2 expression was significantly correlated with the poor prognosis of neuroblastoma patients.
Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.
Kihara et al., Sapporo, Japan. In Biochem J, 2015
Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes.
Genome-wide DNA methylation analysis in alcohol dependence.
Zhang et al., Xinxiang, China. In Addict Biol, 2013
Associations with canonical pathways previously shown to be involved in AD were also observed, such as dehydrogenases 1A (ADH1A), ADH7, aldehyde dehydrogenases 3B2 (ALDH3B2) and cytochrome P450 2A13.
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
Chang et al., Gainesville, United States. In Chem Biol Interact, 2012
Furthermore, our TLDA results revealed that ALDH1, ALDH7, ALDH3 and ALDH8 are expressed in K562 cells.
Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene.
Hempel et al., Brisbane, Australia. In Chem Biol Interact, 2011
Mammalian ALDH3 genes (ALDH3A1, ALDH3A2, ALDH3B1 and ALDH3B2) encode enzymes of peroxidic and fatty aldehyde metabolism.
Biochemical genetics of opossum aldehyde dehydrogenase 3: evidence for three ALDH3A-like genes and an ALDH3B-like gene.
Holmes, Brisbane, Australia. In Biochem Genet, 2010
BLAT analyses were undertaken of the opossum genome using rat ALDH3A1, ALDH3A2, ALDH3B1, and ALDH3B2 amino acid sequences.
ALDH1A2 (RALDH2) genetic variation in human congenital heart disease.
Xavier-Neto et al., São Paulo, Brazil. In Bmc Med Genet, 2008
Sequence conservation of observed mutations was evaluated through phylogenetic tree construction from ungapped alignments containing ALDH8 s, ALDH1Ls, ALDH1 s and ALDH2 s.
Human aldehyde dehydrogenase gene family.
Review
Chang et al., Duarte, United States. In Eur J Biochem, 1998
Separations of ALDH3/ALDH10 and that of ALDH7/ALDH8 had occurred during the period of appearance and radiation of mammalian species.
Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.
Yoshida et al., Duarte, United States. In Gene, 1997
The structure of two human aldehyde dehydrogenase genes, ALDH7 and ALDH8, have been determined.
Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family.
Chang et al., Duarte, United States. In Gene, 1996
In this report, we describe the cDNA sequence and the expression of a new member of this family, ALDH8.
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