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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aldehyde oxidase 1

aldehyde oxidase
Top mentioned proteins: ACID, CAN, HAD, V1a, fibrillin-1
Papers on aldehyde oxidase
Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.
New
Obach et al., Sweden. In Drug Metab Dispos, Feb 2016
In this study, we investigated several compounds that are known to produce human-unique metabolites through CYP2C9, UGT1A4, aldehyde oxidase (AO), or N-acetyltransferase that were poorly covered or not detected at all in the selected preclinical species.
Increased abscisic acid levels in transgenic maize overexpressing AtLOS5 mediated root ion fluxes and leaf water status under salt stress.
New
Li et al., Beijing, China. In J Exp Bot, Feb 2016
AtLOS5 overexpression significantly up-regulated the expression of ZmVp14-2, ZmAO, and ZmMOCO, and increased aldehyde oxidase activities, which enhanced ABA accumulation in transgenic plants under salt stress.
Molybdenum cofactor deficiency.
Review
New
Scaglia et al., Houston, United States. In Mol Genet Metab, Jan 2016
MoCD results in deficiency of the molybdenum cofactor dependent enzymes sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase and mitochondrial amidoxime reducing component.
Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms.
New
Chen et al., Shanghai, China. In Chem Res Toxicol, Jan 2016
Moreover, aldehyde oxidase also participated in the reductive activation of NIM.
Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase.
New
Kawai et al., Toyama, Japan. In Xenobiotica, Jan 2016
Studies using specific inhibitors and human recombinant enzyme systems showed that M1 (main metabolite in humans) formation is mediated by aldehyde oxidase (AO).
Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study.
New
Khodarahmi et al., Kermānshāh, Iran. In Bioorg Chem, Jan 2016
UNASSIGNED: Aldehyde oxidase (AO), a cytosolic molybdenum-containing hydroxylase, is predominantly active in liver and other tissues of mammalian species and involved in the metabolism of extensive range of aldehydes and nitrogen-containing compounds.
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates airway epithelial barrier integrity.
New
Hashimoto et al., Tokyo, Japan. In Allergol Int, Sep 2015
Moreover, based on pathway analysis, aldehyde oxidase 1 (AOX1) was identified as a downstream enzyme of Nrf2.
Endothelial toxicity of unusual nucleotide metabolites.
Review
New
Slominska et al., Gdańsk, Poland. In Pharmacol Rep, Aug 2015
This nucleoside is most likely produced by oxidation of nicotinamide containing precursor by aldehyde oxidase.
Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases.
Review
New
Moura et al., Caparica, Portugal. In J Biol Inorg Chem, Mar 2015
The mammalian xanthine oxidase/xanthine dehydrogenase, aldehyde oxidase, mitochondrial amidoxime-reducing component, plant nitrate reductase and bacterial aldehyde oxidoreductase and nitrate reductases will be considered.
Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy.
Review
New
Ohta et al., Hiroshima, Japan. In Drug Metab Pharmacokinet, Feb 2015
Aldehyde oxidase contributes to drug metabolism and pharmacokinetics (PK), and a few clinical studies were discontinued because of aldehyde oxidase metabolism.
In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans.
Review
Sanoh, Hiroshima, Japan. In Yakugaku Zasshi, 2014
We found that drug metabolism and pharmacokinetics mediated by CYP and non-CYP enzymes, such as UDP-glucuronosyltransferase and aldehyde oxidase, in chimeric mice with humanized liver were similar to those in humans.
Overexpression of EsMcsu1 from the halophytic plant Eutrema salsugineum promotes abscisic acid biosynthesis and increases drought resistance in alfalfa (Medicago sativa L.).
Wang et al., Bengbu, China. In Genet Mol Res, 2014
Molybdenum cofactor sulfurases influence aldehyde oxidase activity and ABA biosynthesis.
Aldehyde oxidase 1 gene is regulated by Nrf2 pathway.
GeneRIF
Sakai et al., Sapporo, Japan. In Gene, 2012
It was shown that show that Nrf2 binds to and strongly activates the rat AOX1 gene.
Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation.
GeneRIF
Rashidi et al., Tabrīz, Iran. In Biol Trace Elem Res, 2012
Data show that aldehyde oxidase (AO) and xanthine oxidase (XO) activities increased significantly after induction of diabetes.
Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.
GeneRIF
Rashidi et al., Tabrīz, Iran. In Bioprocess Biosyst Eng, 2011
Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method.
Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite.
GeneRIF
Zweier et al., Columbus, United States. In J Biol Chem, 2010
AO-catalyzed nitrite reduction can be an important source of NO generation, and its NO production will be further increased by therapeutic administration of nitrite
Heredity mode of genetic polymorphism in aldehyde oxidase activity in Donryu strain rats.
GeneRIF
Tanaka et al., Sendai, Japan. In Xenobiotica, 2008
The results indicate that the genetic polymorphism of aldehyde oxidase in Donryu strain rats obeys Mendelian heredity
Metabolism and disposition kinetics of nicotine.
Review
Impact
Benowitz et al., San Francisco, United States. In Pharmacol Rev, 2005
Enzymes involved in nicotine metabolism including cytochrome P450 enzymes, aldehyde oxidase, flavin-containing monooxygenase 3, amine N-methyltransferase, and UDP-glucuronosyltransferases are represented, as well as factors affecting metabolism, such as genetic variations in metabolic enzymes, effects of diet, age, gender, pregnancy, liver and kidney diseases, and racial and ethnic differences.
Enzyme-catalyzed activation of anticancer prodrugs.
Review
Impact
Vermeulen et al., Amsterdam, Netherlands. In Pharmacol Rev, 2004
The following endogenous enzymes are discussed: aldehyde oxidase, amino acid oxidase, cytochrome P450 reductase, DT-diaphorase, cytochrome P450, tyrosinase, thymidylate synthase, thymidine phosphorylase, glutathione S-transferase, deoxycytidine kinase, carboxylesterase, alkaline phosphatase, beta-glucuronidase and cysteine conjugate beta-lyase.
Aldehyde oxidase compartmentalization in Drosophila melanogaster wing imaginal disks.
Impact
Cunningham et al., In Science, 1977
Distribution of the enzyme aldehyde oxidase in mature Drosophilia melanogaster wing disks may allow visualization of known developmental compartments comprising (i) presumptive dorsal and ventral wing surfaces, and (ii) the presumptive anterior wing and the presumptive posterior wing.
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