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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aldehyde dehydrogenase family 1, subfamily A1

aldehyde dehydrogenase
Top mentioned proteins: CAN, Aldehyde Dehydrogenase, ACID, HAD, V1a
Papers on aldehyde dehydrogenase
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
New
Hwang et al., Dublin, Ireland. In Am J Physiol Endocrinol Metab, Feb 2016
In the liver of DJB rats, betaine-homocysteine S-methyltransferase levels were decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine beta-synthase, glutathione S-transferase, and aldehyde dehydrogenase levels were increased.
Aldehyde dehydrogenase 1A1 in stem cells and cancer.
Review
New
Hara et al., Gifu, Japan. In Oncotarget, Feb 2016
ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection.
Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.
New
Kajiyama et al., Tokyo, Japan. In Clin Res Hepatol Gastroenterol, Feb 2016
RESULTS: For this purpose, we investigated the expression of various cell surface markers and of aldehyde dehydrogenase (ALDH) activity.
Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: from bench to bedside.
Review
New
Ren et al., Laramie, United States. In Sheng Li Xue Bao, Jan 2016
Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme metabolizing acetaldehyde and toxic aldehydes.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
New
Kim et al., Seoul, South Korea. In J Breast Cancer, Dec 2015
PURPOSE: CD133 and aldehyde dehydrogenase 1 (ALDH1) expression are reliable poor-prognosis markers associated with the presence of adverse biomarkers and subtypes of breast cancer.
Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts.
Review
New
Multhoff et al., M√ľnchen, Germany. In Cancers (basel), Dec 2015
Further molecular alterations and prognostic markers like the DNA-repair protein O6-methylguanine-DNA methyltransferase (MGMT), anti-apoptotic molecular chaperones, and/or the activity of aldehyde dehydrogenase 1 (ALDH1) have also been identified to play a role in the sensitivity to cytostatic agents.
Mucin 1-mediated chemo-resistance in lung cancer cells.
New
Yoon et al., Seoul, South Korea. In Oncogenesis, Dec 2015
The proportion of the cancer stem cell marker, aldehyde dehydrogenase-positive cells, and epithelial-mesenchymal transition signaling protein levels were also elevated in A549/PTX.
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.
New
Impact
Ding et al., Palo Alto, United States. In Science, Nov 2015
Our experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).
A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.
Review
Impact
Mochly-Rosen et al., Stanford, United States. In Annu Rev Pharmacol Toxicol, 2014
A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2.
Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Review
Shu et al., Wuhan, China. In Plos One, 2014
OBJECTIVE: Many studies have indicated the prognostic and clinicopathological value of aldehyde dehydrogenase 1 (ALDH1) in colorectal cancer (CRC) patients still remains controversial.
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis.
Kui et al., Chengdu, China. In Genet Mol Res, 2014
We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association.
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Impact
Khokha et al., Toronto, Canada. In Nat Cell Biol, 2014
Exosomal ADAM10 increases aldehyde dehydrogenase expression in breast cancer cells through Notch receptor activation and enhances motility through the GTPase RhoA.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
Review
Impact
Mochly-Rosen et al., In Physiol Rev, 2014
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated.
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.
GeneRIF
Plutzky et al., Boston, United States. In Endocrinology, 2012
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.
Impact
GeneRIF
Plutzky et al., Boston, United States. In Nat Med, 2012
data establish Aldh1a1 and its substrate Rald as previously unrecognized determinants of adipocyte plasticity and adaptive thermogenesis, which may have potential therapeutic implications
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.
GeneRIF
Smith et al., Vancouver, Canada. In Exp Hematol, 2012
ALDH1A1 deficiency increases ALDH3A1 expression. Mice deficient in both ALDH3A1 & ALDH1A1 have fewer HSCs, aberrant cell-cycle distribution, increased reactive oxygen species, p38 MAP kinase activity & sensitivity to DNA damage.
Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease.
GeneRIF
Strong et al., San Antonio, United States. In Plos One, 2011
analysis of neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases
Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: implications for muscle regeneration and repair.
GeneRIF
Huard et al., Pittsburgh, United States. In Plos One, 2010
This result demonstrates the critical role of stress resistance in myogenic cell therapy as well as confirms the role of ALDH as a marker for rapid isolation of murine and human myogenic progenitors for cell therapy.
Tumor-initiating cells are rare in many human tumors.
Impact
Matsui et al., Toronto, Canada. In Cell Stem Cell, 2010
Moreover, aldehyde dehydrogenase-positive (ALDH(+)) and CD44(+)CD24(+) cells, phenotypically distinct cells enriched in TICs, were equally tumorigenic in NOD/SCID and NSG mice.
Ethanol metabolism, toxicity and genetic polymorphism.
Review
Suwaki et al., Sagamihara, Japan. In Addict Biol, 1998
The relationships between the individual (and racial) differences in alcohol metabolism and toxicity, and the genetic polymorphism of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and cytochrome P-4502E1(CYPIIE1) were reviewed.
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