Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
Dublin, Ireland. In Am J Physiol Endocrinol Metab, Feb 2016
In the liver of DJB rats, betaine-homocysteine S-methyltransferase levels were decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine beta-synthase, glutathione S-transferase, and aldehyde dehydrogenase levels were increased.
Aldehyde dehydrogenase 1A1 in stem cells and cancer.
Gifu, Japan. In Oncotarget, Feb 2016
ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection.
Mucin 1-mediated chemo-resistance in lung cancer cells.
Seoul, South Korea. In Oncogenesis, Dec 2015
The proportion of the cancer stem cell marker, aldehyde dehydrogenase-positive cells, and epithelial-mesenchymal transition signaling protein levels were also elevated in A549/PTX.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
In Physiol Rev, 2014
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated.
Tumor-initiating cells are rare in many human tumors.
Toronto, Canada. In Cell Stem Cell, 2010
Moreover, aldehyde dehydrogenase-positive (ALDH(+)) and CD44(+)CD24(+) cells, phenotypically distinct cells enriched in TICs, were equally tumorigenic in NOD/SCID and NSG mice.
Ethanol metabolism, toxicity and genetic polymorphism.
Sagamihara, Japan. In Addict Biol, 1998
The relationships between the individual (and racial) differences in alcohol metabolism and toxicity, and the genetic polymorphism of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and cytochrome P-4502E1(CYPIIE1) were reviewed.