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ALD5 Ald5p

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Aldehyde Dehydrogenase, CAN, ACID, HAD, Raldh3
Papers on ALD3
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Vasiliou et al., Denver, United States. In Pancreas, Jan 2016
METHODS: A tissue microarray of 61 pancreatic cancer patients were evaluated for protein expression of ALDH1B1 by immunohistochemistry.
Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.
Vanamala et al., United States. In J Nutr Biochem, Dec 2015
Thus, isolated colon CSCs (positive for CD44, CD133 and ALDH1b1 markers) with functioning p53 and shRNA-attenuated p53 were treated with PA at 5.0 μg/ml.
Short-term response of different Saccharomyces cerevisiae strains to hyperosmotic stress caused by inoculation in grape must: RT-qPCR study and metabolite analysis.
Garcia-Moruno et al., Asti, Italy. In Food Microbiol, Dec 2015
Among the ALD genes, only ALD6 was moderately induced in the hyperosmotic environment but not in all strains tested, while ALD3 and ALD4 were drastically glucose repressed.
Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).
Maloney et al., Rockville, United States. In J Med Chem, Sep 2015
This chemotype exhibits highly selective inhibition against ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as HPGD and HSD17β4.
ALDH1B1 links alcohol consumption and diabetes.
Vasiliou et al., Aurora, United States. In Biochem Biophys Res Commun, Sep 2015
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a mitochondrial enzyme sharing 65% and 72% sequence identity with ALDH1A1 and ALDH2 proteins, respectively.
Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
Hurley et al., Indianapolis, United States. In Chem Biol Interact, Jul 2015
Single concentration measurements at 10μM compound were performed using ALDH1A1, ALDH1A2, ALDH1A3, ALDH2, ALDH1B1, ALDH3A1, ALDH4A1, and/or ALDH5A1 to determine the selectivity of these 12 compounds toward ALDH2.
A genome-wide nanotoxicology screen of Saccharomyces cerevisiae mutants reveals the basis for cadmium sulphide quantum dot tolerance and sensitivity.
Marmiroli et al., Parma, Italy. In Nanotoxicology, Jun 2015
The transformation of sensitive mutants with centromeric plasmids harbouring DNA from a wild type strain restored the wild type growth phenotype when the complemented genes encoded either HSC82, DSK2 or ALD3.
[Increased expression of acetaldehyde dehydrogenase in cisplatin-resistant human lung adenocarcinoma A549/DDP cells].
Liu et al., Yinchuan, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, May 2015
Compared with A549 cells, the expressions of ALDH subtypes ALDH1A3 and ALDH1B1 mRNA significantly went up in A549/DDP cells.
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids.
Tsang et al., Bonn, Germany. In J Ovarian Res, 2014
RESULTS: A total of 573 gene transcripts, including CPA1, CDH1, INSL3, AMH, ALDH1B1, INHBA, CYP17A1, RBP4, GAS6, GAS7 and GATA4, were activated while 430 others including HSD17B7, HSD3B6, STAR, HMGCS1, HMGCR, CYP51, CYP11A1 and CYP19A1 were repressed in DHT-treated ovaries.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Xu et al., Shanghai, China. In Drug Des Devel Ther, 2014
High expression of ALDH1A2 and ALDH1B1 mRNA was found to be correlated to worser OS in all NSCLC patients, as well as in Ade, but not in SCC patients.
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
Vasiliou et al., Aurora, United States. In Adv Exp Med Biol, 2014
Acetaldehyde is metabolized by ALDH2, ALDH1B1, and ALDH1A1 to acetate.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.
Vasiliou et al., Aurora, United States. In Plos One, 2014
In the normal human colon, aldehyde dehydrogenase 1B1 (ALDH1B1) is expressed only at the crypt base, along with stem cells.
Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds.
Vanamala et al., Fort Collins, United States. In Nutrition, 2014
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a Wnt target gene, and aldehyde dehydrogenase 1 B1 (ALDH1B1) are good markers for normal and malignant human colon stem cells.
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.
Vasiliou et al., Aurora, United States. In Biochem Biophys Res Commun, 2011
ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer.
Structural modeling studies of aldehyde dehydrogenase X: insights into key interactions in the tetrameric assembly of the isoenzyme.
Azhar et al., Peshāwar, Pakistan. In Protein Pept Lett, 2011
An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Husemoen et al., Glostrup, Denmark. In Clin Exp Allergy, 2010
a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity.
Two sources of mitochondrial NADPH in the yeast Saccharomyces cerevisiae.
Murata et al., Uji, Japan. In J Biol Chem, 2009
there are two sources of mitochondrial NADPH in yeast: one is the mitochondrial Pos5p-NADH kinase reaction and the other is the mitochondrial Pos5p-NAD kinase reaction followed by the mitochondrial NADP(+)-dependent acetaldehyde dehydrogenase reaction.
The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors.
Linneberg et al., Glostrup, Denmark. In Alcohol Clin Exp Res, 2008
ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
Pappa et al., Denver, United States. In Pharmacology, 2000
Allelic variants of the ALDH1A1, ALDH1B1, ALDH3A1 and ALDH9A1 genes have also been observed but not yet characterized.
Molecular genetics of human aldehyde dehydrogenase.
Yoshida, Duarte, United States. In Pharmacogenetics, 1992
The ALDH5 gene, which is expressed in testes and liver, is highly polymorphic in both Caucasians and Orientals.
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