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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Jul 2015.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Supplier
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B.
New
Wang et al., Jinan, China. In World J Gastroenterol, 21 Aug 2015
P < 0.01), alanine aminotransferase (r = -0.461,
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, 30 Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Acute acalculous cholecystitis in a patient with primary Epstein-Barr virus infection: a case report and literature review.
Review
New
Larsen et al., Århus, Denmark. In Int J Infect Dis, 30 Jun 2015
During admission, increasing liver function tests indicated cholestasis (alanine aminotransferase 61 U/l, alkaline phosphatase 429 U/l and bilirubin 42μmol/l).
Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells.
New
Hou et al., T'ai-chung-shih, Taiwan. In Iran J Basic Med Sci, 30 Jun 2015
The GJ extract and GA significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats.
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy.
Review
New
Cappell et al., Royal Oak, United States. In World J Hepatol, 08 Jun 2015
A variant, called PBC-autoimmune hepatitis (AIH) overlap, is characterized by the above findings of PBC together with findings of elevated serum alanine aminotransferase, elevated serum immunoglobulin G, and circulating anti-smooth muscle antibodies, with liver biopsy demonstrating periportal or periseptal, lymphocytic, piecemeal necrosis.
Systematic review with meta-analysis: HIF-1α attenuates liver ischemia-reperfusion injury.
Review
New
Li et al., Chengdu, China. In Transplant Rev (orlando), 07 Jun 2015
In vivo animal studies showed different HIF-1α expression and distribution patterns in the ischemia and reperfusion stage due to distinctive partial oxygen pressure gradient intra-liver, and 5 animal studies (n=66) showed that stabilized HIF-1α treatment was associated with lower alanine aminotransferase (ALT) (SMD=-1.58;
Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.
New
Impact
UNITY-1 Study Group et al., Melbourne, Australia. In Jama, 05 Jun 2015
There were 7 serious adverse events, all considered unrelated to study treatment, and 3 adverse events (<1%) leading to treatment discontinuation, including 2 grade 4 alanine aminotransferase elevations.
Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.
New
Impact
Yin et al., Sydney, Australia. In Jama, 05 Jun 2015
Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation.
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.
New
Impact
MITO 11 investigators et al., Napoli, Italy. In Lancet Oncol, May 2015
The most common grade 3-4 adverse events were neutropenia (11 [30%] in the pazopanib group vs one [3%] in the paclitaxel group), fatigue (four [11%] vs two [6%]), leucopenia (four [11%] vs one [3%]), hypertension (three [8%] vs none [0%]), raised aspartate aminotransferase or alanine aminotransferase (three [8%] vs none), and anaemia (two [5%] vs five [14%]).
Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial.
New
Impact
Demetri et al., Lyon, France. In Lancet Oncol, May 2015
In the imatinib group, the most common grade 3-4 adverse events were hypophosphataemia (19 [6%]), anaemia (17 [5%]), abdominal pain (13; 4%), and elevated lipase level (15; 5%), and in the nilotinib group were anaemia (18; 6%), elevated lipase level (15; 5%), elevated alanine aminotransferase concentration (12; 4%), and abdominal pain (11; 3%).
Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients.
Review
New
Kaplowitz et al., Arezzo, Italy. In Eur J Cancer, May 2015
Twenty percent of patients developed elevated alanine aminotransferase (ALT) >3×ULN.
Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves' Orbitopathy.
New
Hiromatsu et al., Kurume, Japan. In Int J Endocrinol, Dec 2014
The results showed that seven patients developed severe liver dysfunction with elevated serum alanine aminotransferase (ALT > 300 U/L).
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis.
Review
New
Guo et al., Shanghai, China. In Drug Des Devel Ther, Dec 2014
P=0.23), total bilirubin (MD: -0.05 mg/dL; 95% CI: -0.21 to 0.12; P=0.58), and alanine aminotransferase (MD: -3.31 IU/L; 95% CI: -14.60 to 7.97; P=0.56) did not differ significantly.
Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats.
New
Hasan Chowdhury et al., Chittagong, Bangladesh. In Biomed Res Int, Dec 2014
Carbon tetrachloride induction increased the level of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and other biochemical parameters such as lipid profiles, total protein, and CK-MB.
Successful diagnosis of hyperpyrexia induced by isoniazid in a child with suspected extra-pulmonary tuberculosis.
New
Zhu et al., Guangzhou, China. In Int J Clin Exp Med, Dec 2014
After 4 days of treatment, the patient's body temperature increased (from 38.0°C to 40.1°C) and on the 11th day of treatment, serum chemistry results showed 400 U/L aspartate transaminase, 535 U/L alanine aminotransferase and 76.8 μmol/L total bile acid, which likely indicated drug-induced hepatic injury.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
GeneRIF
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
GeneRIF
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
GeneRIF
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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