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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Supplier
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial.
New
Impact
Colding-Jørgensen et al., Southampton, United Kingdom. In Lancet Neurol, 30 Nov 2014
The most common adverse events (occurring in >3% of patients) were increased γ-glutamyltransferase (14 [10%] patients in the idalopirdine group vs two [2%] in the placebo group), diarrhoea (six [4%] vs nine [7%]), urinary tract infection (three [2%] vs nine [7%]), fall (three [2%] vs eight [6%]), increased alanine aminotransferase (nine [6%] vs none), and benign prostatic hyperplasia (two [5%] vs none).
Octreotide attenuates liver fibrosis by inhibiting hepatic heme oxygenase-1 expression.
New
Sun et al., Dalian, China. In Mol Med Report, 22 Nov 2014
The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and carboxyhemoglobin (COHb) in arterial blood, and the mean arterial pressure and portal vein pressure were also measured.
FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
New
Xu et al., Zhenjiang, China. In World J Gastroenterol, 21 Nov 2014
Activation of FXR by GW4064 alleviated hepatic inflammation induced by endotoxin in a murine NAFLD model fed an HF diet as reflected by reduced serum levels of aspartate aminotransferase and alanine aminotransferase.
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Review
New
Setji et al., Durham, United States. In World J Gastroenterol, 21 Nov 2014
However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered.
Effect of intra-arterial infusion with triolein emulsion on rabbit liver.
New
Choi et al., Yangsan, South Korea. In World J Gastroenterol, 21 Nov 2014
The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured to evaluate liver function in each group just before the infusion, at 2 h, day 1, day 4, and day 7 following infusion.
Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
TOPIC Study Group et al., New York City, United States. In Lancet Neurol, 31 Oct 2014
Adverse events that occurred in at least 10% of patients in either teriflunomide group and with an incidence that was at least 2% higher than that with placebo were increased alanine aminotransferase (40 [19%] of 216 patients in the 14 mg group, 36 [17%] of 207 in the 7 mg group vs 27 [14%] of 191 in the placebo group), hair thinning (25 [12%] and 12 [6%] vs 15 [8%]), diarrhoea (23 [11%] and 28 [14%] vs 12 [6%]), paraesthesia (22 [10%] and 11 [5%] vs 10 [5%]), and upper respiratory tract infection (20 [9%] and 23 [11%] vs 14 [7%]).
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
New
Impact
SOLSTICE Investigators et al., Durham, United States. In Lancet, 27 Oct 2014
Safety outcomes were serious adverse events and alanine aminotransferase (ALT) concentrations over 12 weeks, and cardiac events (death, myocardial infarction, recurrent ischaemia, stroke, and heart failure) at 90 days.
Risk stratification of HBV infection in Asia-Pacific region.
Review
New
Kao, Taipei, Taiwan. In Clin Mol Hepatol, 30 Sep 2014
The community-based REVEAL-HBV study illustrated the strong association between HBV-DNA level at study entry and risk of HCC over time, and male gender, older age, high serum alanine aminotransferase (ALT) level, positive HBeAg, higher HBV-DNA level, HBV genotype C infection and core promoter mutation are independently associated with a higher hepatocellular carcinoma (HCC) risk.
Methylglyoxal induces mitochondrial dysfunction and cell death in liver.
New
Shin et al., Kwangju, South Korea. In Toxicol Res, 30 Sep 2014
Furthermore, acute treatment of mice with methylglyoxal increased the plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indicating liver toxicity.
Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course and management.
Review
New
Liaw et al., Taipei, Taiwan. In J Hepatol, 29 Sep 2014
UNLABELLED: Hepatitis B flare, defined as an event with abrupt rise of alanine aminotransferase (ALT) to > 5 times upper limit of normal during chronic hepatitis B virus (HBV) infection, is considered to be the results of human leukocyte antigen-I restricted, cytotoxic T lymphocyte mediated immune response against HBV and its downstream mechanisms.
Oral GS-5806 activity in a respiratory syncytial virus challenge study.
New
Impact
Chien et al., Memphis, United States. In N Engl J Med, 21 Sep 2014
The results were similar in cohorts 5, 6, and 7. Adverse events, including low neutrophil counts and increased levels of alanine aminotransferase, were more common among participants receiving GS-5806.
An approach to acanthosis nigricans.
Review
New
Phiske, Mumbai, India. In Indian Dermatol Online J, Jul 2014
Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN.
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial.
New
Impact
Lublin et al., Baltimore, United States. In Lancet Neurol, Jun 2014
Fingolimod 0·5 mg caused more of the following adverse events versus placebo: lymphopenia (27 [8%] patients vs 0 patients), increased alanine aminotransferase (29 [8%] vs six [2%]), herpes zoster infection (nine [3%] vs three [1%]), hypertension (32 [9%] vs 11 [3%]), first-dose bradycardia (five [1%] vs one [<0·5%]), and first-degree atrioventricular block (17 [5%] vs seven [2%]).
Leptin-to-adiponectin ratio in obese adolescents with nonalcoholic fatty liver disease.
New
Kuralay et al., İzmir, Turkey. In Turk J Pediatr, May 2014
Moreover, L/A ratio correlated more strongly with weight for height (r: 0.528, p<0.0001), alanine aminotransferase (ALT) (r: 0.499, p<0.0001), triglyceride (r: 0.591, p<0.0001), and HOMA-IR (r: 0.574, p<0.0001) than did either leptin and adiponectin alone.
Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials.
Review
New
Chen et al., Shanghai, China. In Biomed Res Int, Dec 2013
The effect on alanine aminotransferase (ALT) of oral silymarin is not different from that of placebo (P = 0.45).
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
GeneRIF
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
GeneRIF
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
GeneRIF
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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