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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, ACID, CAN, fibrillin-1
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Title: Risk of elevated transaminases in non small cell lung cancer (NSCLC) patients treated with erlotinib, gefitinib and afatinib; a Meta analysis.
ElHalawani et al., Cairo, Egypt. In Expert Rev Respir Med, 11 Dec 2015
METHODOLOGY: Studies eligible for our analysis included randomized phase II and III trials of patients with NSCLC on the three agents which describe events of elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition.
Trichopoulos et al., Potsdam, Germany. In Am J Clin Nutr, 11 Dec 2015
A statistically significant attenuation of the association between coffee intake and HCC risk and thereby suspected mediation was confirmed for the inflammatory biomarker IL-6 and for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and total bilirubin, which-in combination-attenuated the regression coefficients by 72% (95% CI: 7%, 239%).
Liver Exposure Using Sterile Glove Pouch During Laparoscopic Right Liver Surgery in Hepatocellular Carcinoma Patients.
Sanyuan et al., Jinan, China. In World J Surg, 11 Dec 2015
The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased one day after LLR, and decreased to normal level on day 7 after LLR in both groups.
Association Between MC-2 Peptide and Hepatic Perfusion and Liver Injury Following Resuscitated Hemorrhagic Shock.
Garrison et al., Louisville, United States. In Jama Surg, 11 Dec 2015
MC-2 in HS also decreased levels of alanine aminotransferase, zonula occludens-1, and interleukin-1β compared with HS/CR alone.
Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study.
O'Brien et al., Houston, United States. In Lancet Oncol, 30 Nov 2015
Grade 3 or more toxic effects included infections during induction (20 [54%] patients), increased aspartate aminotransferase and alanine aminotransferase concentration (14 [38%] patients), thrombotic events (three [8%]), myocardial infarction (three [8%]), hypertension (six [16%]), skin rash (eight [22%]), and pancreatitis (six [16%] patients).
A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update.
Jacobson et al., Toronto, Canada. In Clin Gastroenterol Hepatol, 30 Nov 2015
CHB patients who have HBV DNA >2000 IU/mL, elevated alanine aminotransferase level, and any degree of fibrosis should receive antiviral therapy regardless of their hepatitis B e antigen status.
Management of Chronic Hepatitis B: An Overview of Practice Guidelines for Primary Care Providers.
Tran et al., Los Angeles, United States. In J Am Board Fam Med, 30 Nov 2015
In general, antiviral treatment should be initiated in patients with CHB who have a high risk of liver-related morbidity and who are likely to respond to treatment, that is, patients with persistently elevated serum HBV DNA and either increased serum alanine aminotransferase concentrations or advanced liver disease.
Clinical analysis of patients suffering from chronic hepatitis B superinfected with other hepadnaviruses.
Jia et al., Chongqing, China. In J Med Virol, 28 Nov 2015
The tested biochemical indices and markers of liver function included serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), prothrombin activity (PTA), serum albumin (Alb) and the serum levels of HBV DNA.
Teriflunomide: A Once-daily Oral Medication for the Treatment of Relapsing Forms of Multiple Sclerosis.
Miller, New York City, United States. In Clin Ther, 01 Nov 2015
In safety data pooled from the 4 studies, adverse events occurring in ≥2% of patients and ≥2% higher than in the placebo group were headache, alanine aminotransferase increase, diarrhea, alopecia (hair thinning), nausea, paresthesia, arthralgia, neutropenia, and hypertension.
A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency.
Quinn et al., Chicago, United States. In N Engl J Med, 10 Oct 2015
The primary end point was normalization of the alanine aminotransferase level.
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.
UNITY-1 Study Group et al., Melbourne, Australia. In Jama, Jun 2015
There were 7 serious adverse events, all considered unrelated to study treatment, and 3 adverse events (<1%) leading to treatment discontinuation, including 2 grade 4 alanine aminotransferase elevations.
Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.
Yin et al., Sydney, Australia. In Jama, Jun 2015
Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation.
Serum Gamma-Glutamyltransferase and Ferritin are Related to Insulin Resistance: A Population-Based Study.
Tian et al., In Clin Lab, Dec 2014
GGT was independently correlated with ferritin after adjustment for age, gender, place of residence, education, income, leisure-time physical activity, drinking, smoking, body mass index, systolic pressure, diastolic pressure, hepatitis B surface antigen, anti-hepatitis C virus, aspartate aminotransferase, alanine aminotransferase, total cholesterol, low density lipoprotein-cholesterol, triglyceride, high density lipoprotein-cholesterol, fasting plasma glucose, 2-hour postprandial plasma glucose, uric acid, and urinary albumin to creatinine ratio (p < 0.05).
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
Objective Diagnosis of Chronic Alcohol Abuse - Determination of Carbohydrate-Deficient Transferrin (CDT) with Capillary Electrophoresis.
Cittadini et al., Roma, Italy. In Forensic Sci Rev, 2000
The present paper reviews briefly in terms of diagnostic sensitivity and specificity the most important conventional markers of chronic alcohol abuse - e.g., γ-glutamyl transferase (GGT), erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) - as well as those more recently proposed, namely aldehyde dehydrogenase (ALDH), high density lipoprotein cholesterol, serum triglycerides, urate, fatty acid ethyl and methyl esters, phosphatidylethanol, dolichols, β-hexosaminidase and protein acetaldehyde adducts.
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