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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Supplier
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection.
New
Kimura et al., Ōsaka, Japan. In Oncol Rep, 30 Nov 2014
Receiver operating characteristic (ROC) curve analysis was performed for calculating the area under the ROC (AUROC) for the FIB-4 index, aspartate aminotransferase (AST) to platelet ratio index, AST to alanine aminotransferase ratio, serum albumin, total bilirubin and platelet count for cirrhosis.
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial.
New
Impact
Colding-Jørgensen et al., Southampton, United Kingdom. In Lancet Neurol, 30 Nov 2014
The most common adverse events (occurring in >3% of patients) were increased γ-glutamyltransferase (14 [10%] patients in the idalopirdine group vs two [2%] in the placebo group), diarrhoea (six [4%] vs nine [7%]), urinary tract infection (three [2%] vs nine [7%]), fall (three [2%] vs eight [6%]), increased alanine aminotransferase (nine [6%] vs none), and benign prostatic hyperplasia (two [5%] vs none).
Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets.
New
Jung et al., Pusan, South Korea. In J Med Food, 30 Nov 2014
VN extract decreased HFD-induced body weight, liver weight, hepatic lipid accumulation, and plasma alanine aminotransferase, and suppressed oxidative stress and inflammation associated with hepatitis.
Usage of whey protein may cause liver damage via inflammatory and apoptotic responses.
New
Koçtürk et al., Manisa, Turkey. In Hum Exp Toxicol, 28 Nov 2014
Hepatotoxicity was evaluated by quanitation of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Gut-liver axis improves with meloxicam treatment after cirrhotic liver resection.
New
Tolba et al., Aachen, Germany. In World J Gastroenterol, 28 Nov 2014
Parameters measured included: microcirculation of the liver and small bowel; portal venous flow (PVF); gastrointestinal (GI) transit; alanine aminotransferase (ALT); malondialdehyde; interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-β1) and hypoxia-inducible factor 1 alpha (HIF-1α) levels; mRNA expression of cyclooxigenase-2 (COX-2), IL-6 and TGF-β1; liver and small bowel histology; immunohistochemical evaluation of hepatocyte and enterocyte proliferation with Ki-67 and COX-2 liver expression.
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Review
New
Setji et al., Durham, United States. In World J Gastroenterol, 21 Nov 2014
However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered.
Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
TOPIC Study Group et al., New York City, United States. In Lancet Neurol, 31 Oct 2014
Adverse events that occurred in at least 10% of patients in either teriflunomide group and with an incidence that was at least 2% higher than that with placebo were increased alanine aminotransferase (40 [19%] of 216 patients in the 14 mg group, 36 [17%] of 207 in the 7 mg group vs 27 [14%] of 191 in the placebo group), hair thinning (25 [12%] and 12 [6%] vs 15 [8%]), diarrhoea (23 [11%] and 28 [14%] vs 12 [6%]), paraesthesia (22 [10%] and 11 [5%] vs 10 [5%]), and upper respiratory tract infection (20 [9%] and 23 [11%] vs 14 [7%]).
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
New
Impact
SOLSTICE Investigators et al., Durham, United States. In Lancet, 27 Oct 2014
Safety outcomes were serious adverse events and alanine aminotransferase (ALT) concentrations over 12 weeks, and cardiac events (death, myocardial infarction, recurrent ischaemia, stroke, and heart failure) at 90 days.
Thioacetamide-induced liver injury: protective role of genistein.
New
Badawi et al., Cairo, Egypt. In Can J Physiol Pharmacol, 09 Oct 2014
Treatment of TAA-induced liver injury in rats with GEN decreased the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, and total and direct bilirubin, and increased the serum level of albumin.
Risk stratification of HBV infection in Asia-Pacific region.
Review
New
Kao, Taipei, Taiwan. In Clin Mol Hepatol, 30 Sep 2014
The community-based REVEAL-HBV study illustrated the strong association between HBV-DNA level at study entry and risk of HCC over time, and male gender, older age, high serum alanine aminotransferase (ALT) level, positive HBeAg, higher HBV-DNA level, HBV genotype C infection and core promoter mutation are independently associated with a higher hepatocellular carcinoma (HCC) risk.
Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course and management.
Review
New
Liaw et al., Taipei, Taiwan. In J Hepatol, 29 Sep 2014
UNLABELLED: Hepatitis B flare, defined as an event with abrupt rise of alanine aminotransferase (ALT) to > 5 times upper limit of normal during chronic hepatitis B virus (HBV) infection, is considered to be the results of human leukocyte antigen-I restricted, cytotoxic T lymphocyte mediated immune response against HBV and its downstream mechanisms.
Oral GS-5806 activity in a respiratory syncytial virus challenge study.
New
Impact
Chien et al., Memphis, United States. In N Engl J Med, 21 Sep 2014
The results were similar in cohorts 5, 6, and 7. Adverse events, including low neutrophil counts and increased levels of alanine aminotransferase, were more common among participants receiving GS-5806.
An approach to acanthosis nigricans.
Review
New
Phiske, Mumbai, India. In Indian Dermatol Online J, Jul 2014
Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN.
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial.
New
Impact
Lublin et al., Baltimore, United States. In Lancet Neurol, Jun 2014
Fingolimod 0·5 mg caused more of the following adverse events versus placebo: lymphopenia (27 [8%] patients vs 0 patients), increased alanine aminotransferase (29 [8%] vs six [2%]), herpes zoster infection (nine [3%] vs three [1%]), hypertension (32 [9%] vs 11 [3%]), first-dose bradycardia (five [1%] vs one [<0·5%]), and first-degree atrioventricular block (17 [5%] vs seven [2%]).
Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials.
Review
New
Chen et al., Shanghai, China. In Biomed Res Int, Dec 2013
The effect on alanine aminotransferase (ALT) of oral silymarin is not different from that of placebo (P = 0.45).
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
GeneRIF
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
GeneRIF
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
GeneRIF
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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