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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Supplier
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Increased expression of Notch 1 in a rat liver transplantation model.
New
Huang et al., Fuzhou, China. In Mol Med Report, 02 Aug 2015
The concentration levels of serum alanine aminotransferase and total bilirubin were significantly higher 5 and 7 days following transplantation in the DA/Lewis group, as compared with the DA/DA group (P<0.001).
A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
New
Ni et al., Beijing, China. In J Hazard Mater, 09 Jul 2015
Toxicity was evaluated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) leakage, and liver enzyme secretion (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) assays.
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, 30 Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway.
New
Wang et al., Chongqing, China. In Exp Ther Med, 30 Jun 2015
Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-α, early growth response protein 1 (Egr-1) and IL-1β, and morphological damage.
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy.
Review
New
Cappell et al., Royal Oak, United States. In World J Hepatol, 08 Jun 2015
A variant, called PBC-autoimmune hepatitis (AIH) overlap, is characterized by the above findings of PBC together with findings of elevated serum alanine aminotransferase, elevated serum immunoglobulin G, and circulating anti-smooth muscle antibodies, with liver biopsy demonstrating periportal or periseptal, lymphocytic, piecemeal necrosis.
Systematic review with meta-analysis: HIF-1α attenuates liver ischemia-reperfusion injury.
Review
New
Li et al., Chengdu, China. In Transplant Rev (orlando), 07 Jun 2015
In vivo animal studies showed different HIF-1α expression and distribution patterns in the ischemia and reperfusion stage due to distinctive partial oxygen pressure gradient intra-liver, and 5 animal studies (n=66) showed that stabilized HIF-1α treatment was associated with lower alanine aminotransferase (ALT) (SMD=-1.58;
Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.
New
Impact
UNITY-1 Study Group et al., Melbourne, Australia. In Jama, 05 Jun 2015
There were 7 serious adverse events, all considered unrelated to study treatment, and 3 adverse events (<1%) leading to treatment discontinuation, including 2 grade 4 alanine aminotransferase elevations.
Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.
New
Impact
Yin et al., Sydney, Australia. In Jama, 05 Jun 2015
Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation.
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.
New
Impact
MITO 11 investigators et al., Napoli, Italy. In Lancet Oncol, May 2015
The most common grade 3-4 adverse events were neutropenia (11 [30%] in the pazopanib group vs one [3%] in the paclitaxel group), fatigue (four [11%] vs two [6%]), leucopenia (four [11%] vs one [3%]), hypertension (three [8%] vs none [0%]), raised aspartate aminotransferase or alanine aminotransferase (three [8%] vs none), and anaemia (two [5%] vs five [14%]).
Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest.
New
Cheng et al., Shanghai, China. In Exp Ther Med, May 2015
The efficacy of cidan was analyzed by monitoring associated symptoms and liver function tests, including measuring the levels of α-1-fetoprotein, α-L-fucosidase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transferase.
Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial.
New
Impact
Demetri et al., Lyon, France. In Lancet Oncol, May 2015
In the imatinib group, the most common grade 3-4 adverse events were hypophosphataemia (19 [6%]), anaemia (17 [5%]), abdominal pain (13; 4%), and elevated lipase level (15; 5%), and in the nilotinib group were anaemia (18; 6%), elevated lipase level (15; 5%), elevated alanine aminotransferase concentration (12; 4%), and abdominal pain (11; 3%).
Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients.
Review
New
Kaplowitz et al., Arezzo, Italy. In Eur J Cancer, May 2015
Twenty percent of patients developed elevated alanine aminotransferase (ALT) >3×ULN.
Acute acalculous cholecystitis in a patient with primary Epstein-Barr virus infection: a case report and literature review.
Review
New
Cs et al., Århus, Denmark. In Int J Infect Dis, May 2015
During admission, increasing liver function tests indicated cholestasis (alanine aminotransferase 61 U/l, alkaline phosphatase 429 U/l and bilirubin 42μmol/l).
The relationship between the parenteral dose of fish oil supplementation and the variation of liver function tests in hospitalized adult patients.
New
Llop-Talaveron et al., Barcelona, Spain. In Nutr J, Dec 2014
and a decrease in alanine aminotransferase (ALT) (B = -0.82;
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis.
Review
New
Guo et al., Shanghai, China. In Drug Des Devel Ther, Dec 2014
P=0.23), total bilirubin (MD: -0.05 mg/dL; 95% CI: -0.21 to 0.12; P=0.58), and alanine aminotransferase (MD: -3.31 IU/L; 95% CI: -14.60 to 7.97; P=0.56) did not differ significantly.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
GeneRIF
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
GeneRIF
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
GeneRIF
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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