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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Hepatotoxicity induced by trastuzumab used for breast cancer adjuvant therapy: a case report.
Tsuji et al., In J Med Case Reports, 10 Jan 2015
She began receiving epirubicin and cyclophosphamide therapy but developed hepatotoxicity (aspartate aminotransferase 43U/L, alanine aminotransferase 104U/L, alkaline phosphatase 634U/L, and gamma-glutamyl transpeptidase 383U/L).
Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of pea by-product.
El Senousy et al., Cairo, Egypt. In Nat Prod Res, 10 Jan 2015
These activities were assessed via measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein and albumin, malondialdehyde (MDA), reduced glutathione (GSH), protein thiols (PSH), nitrite/nitrate levels, glutathione-peroxidase (GSH-Px), glutathione-S-transferase (GST) activities, as well as, histopathological evaluation.
Differential protective effects of polyphenol extracts from apple peels and fleshes against acute CCl4-induced liver damage in mice.
Yang et al., Xi'an, China. In Food Funct, 10 Jan 2015
Administration of APP at 250 and 500 mg per kg bw to mice ahead of CCl4 injection was further shown to exhibit stronger in vivo protective effects than those of AFP and could observably antagonize the CCl4-induced increase in serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities and hepatic malondialdehyde levels, and prevent the CCl4-caused decrease in antioxidant superoxide dismutase and glutathione peroxidase activities, compared to CCl4-treated mice (p < 0.05).
Circulating pancreatic polypeptide concentrations predict visceral and liver fat content.
Murphy et al., London, United Kingdom. In J Clin Endocrinol Metab, 09 Jan 2015
Fasting PP concentrations independently predicted IHCL after controlling for age, gender, BMI, WHR, HOMA2-IR and serum concentrations of triglyceride (TG), total cholesterol (TC) and alanine aminotransferase (ALT).
CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes.
Schulze-Bergkamen et al., Baden-Baden, Germany. In World J Gastroenterol, 07 Jan 2015
After D-GalN/LPS treatment CYLD(-/-) mice exhibited significantly lower levels of alanine aminotransferase (ALT) (295 U/L vs 859 U/L, P < 0.05) and aspartate aminotransferase (AST) (560 U/L vs 1025 U/L, P < 0.01).
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.
Davidoff et al., Aş Şanamayn, Syria. In N Engl J Med, 20 Dec 2014
A transient increase in the mean alanine aminotransferase level to 86 IU per liter (range, 36 to 202) occurred between week 7 and week 10 in 4 of the 6 patients in the high-dose group but resolved over a median of 5 days (range, 2 to 35) after prednisolone treatment.
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.
for the NASH Clinical Research Network et al., Saint Louis, United States. In Lancet, 07 Dec 2014
A planned interim analysis of change in alanine aminotransferase at 24 weeks undertaken before end-of-treatment (72 weeks) biopsies supported the decision to continue the trial (relative change in alanine aminotransferase -24%, 95% CI -45 to -3).
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial.
Colding-Jørgensen et al., Southampton, United Kingdom. In Lancet Neurol, 30 Nov 2014
The most common adverse events (occurring in >3% of patients) were increased γ-glutamyltransferase (14 [10%] patients in the idalopirdine group vs two [2%] in the placebo group), diarrhoea (six [4%] vs nine [7%]), urinary tract infection (three [2%] vs nine [7%]), fall (three [2%] vs eight [6%]), increased alanine aminotransferase (nine [6%] vs none), and benign prostatic hyperplasia (two [5%] vs none).
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Setji et al., Durham, United States. In World J Gastroenterol, 21 Nov 2014
However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered.
Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial.
TOPIC Study Group et al., New York City, United States. In Lancet Neurol, Oct 2014
Adverse events that occurred in at least 10% of patients in either teriflunomide group and with an incidence that was at least 2% higher than that with placebo were increased alanine aminotransferase (40 [19%] of 216 patients in the 14 mg group, 36 [17%] of 207 in the 7 mg group vs 27 [14%] of 191 in the placebo group), hair thinning (25 [12%] and 12 [6%] vs 15 [8%]), diarrhoea (23 [11%] and 28 [14%] vs 12 [6%]), paraesthesia (22 [10%] and 11 [5%] vs 10 [5%]), and upper respiratory tract infection (20 [9%] and 23 [11%] vs 14 [7%]).
Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course and management.
Liaw et al., Taipei, Taiwan. In J Hepatol, Sep 2014
UNLABELLED: Hepatitis B flare, defined as an event with abrupt rise of alanine aminotransferase (ALT) to > 5 times upper limit of normal during chronic hepatitis B virus (HBV) infection, is considered to be the results of human leukocyte antigen-I restricted, cytotoxic T lymphocyte mediated immune response against HBV and its downstream mechanisms.
Oral GS-5806 activity in a respiratory syncytial virus challenge study.
Chien et al., Memphis, United States. In N Engl J Med, Sep 2014
The results were similar in cohorts 5, 6, and 7. Adverse events, including low neutrophil counts and increased levels of alanine aminotransferase, were more common among participants receiving GS-5806.
Toxicological in vitro and subchronic evaluation of LASSBio-596.
Tagliati et al., Monte Santo de Minas, Brazil. In Food Chem Toxicol, Sep 2014
However, subchronic toxicity study results revealed changes in the blood parameters of amylase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose and creatine kinase (CK) which is used for cardiotoxicity evaluation, although, did not identify any histopathological alterations.
An approach to acanthosis nigricans.
Phiske, Mumbai, India. In Indian Dermatol Online J, Jul 2014
Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
Consensus guidelines for the management of hepatitis C infection.
Consensus Guidelines Committee for the Management of Hepatitis C Infection, In Saudi Med J, 2003
Based on the SVR of the above mentioned clinical trial, the committee recommends treatment for patients with histologically proven CHC, with elevated serum alanine aminotransferase (ALT) and positive HCV ribonucleic acid (RNA).
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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