gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Oct 2015.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
Low alanine aminotransferase levels and higher number of cardiovascular events in people with Type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.
Keech et al., Sydney, Australia. In Diabet Med, 03 Nov 2015
AIMS: To determine whether alanine aminotransferase or gamma-glutamyltransferase levels, as markers of liver health and non-alcoholic fatty liver disease, might predict cardiovascular events in people with Type 2 diabetes.
Epidemiology of hepatitis B and C infections and benefits of programs for hepatitis prevention in northeastern China: A cross-sectional study.
Wang et al., Changchun, China. In Clin Infect Dis, 03 Nov 2015
Among HBsAg-positive participants, 63.8% tested positive for HBV DNA, 20.2% had an abnormal alanine aminotransferase (ALT) level, and 10.7% had cirrhosis.
A phase 1 study evaluating the pharmacokinetics and preliminary efficacy of veliparib (ABT-888) in combination with carboplatin/paclitaxel in Japanese subjects with non-small cell lung cancer (NSCLC).
Tamura et al., Tokyo, Japan. In Cancer Chemother Pharmacol, 03 Nov 2015
Common treatment-emergent AEs, consistent with toxicities associated with carboplatin and paclitaxel, included leukopenia (100 %), neutropenia (100 %), anemia (83 %), thrombocytopenia (75 %), increased alanine aminotransferase (67 %), and increased aspartate aminotransferase (67 %).
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
Lee et al., Taejŏn, South Korea. In Mol Cells, 02 Nov 2015
However, mice treated with APAP alone developed massive centrilobular necrosis, and APAP increased their serum alanine aminotransferase and aspartate aminotransferase levels.
Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study.
O'Brien et al., Houston, United States. In Lancet Oncol, 29 Oct 2015
Grade 3 or more toxic effects included infections during induction (20 [54%] patients), increased aspartate aminotransferase and alanine aminotransferase concentration (14 [38%] patients), thrombotic events (three [8%]), myocardial infarction (three [8%]), hypertension (six [16%]), skin rash (eight [22%]), and pancreatitis (six [16%] patients).
A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency.
Quinn et al., Chicago, United States. In N Engl J Med, 10 Oct 2015
The primary end point was normalization of the alanine aminotransferase level.
The curative effect of adefovir dipivoxil treating HBeAg negative chronic hepatitis B and treating HBeAg positive chronic hepatitis B combining interferon α-2b.
Yu et al., Zhengzhou, China. In Pak J Pharm Sci, Jul 2015
We examined alanine aminotransferase (ALT) normalization and the Hepatitis B Virus (HBV)-DNA negative rate (undetectable rate), as well as, HBeAg / hepatitis B e antibody (HBeAb) sero-conversion rate to detect treatment effects.
Systematic review with meta-analysis: HIF-1α attenuates liver ischemia-reperfusion injury.
Li et al., Chengdu, China. In Transplant Rev (orlando), Jul 2015
In vivo animal studies showed different HIF-1α expression and distribution patterns in the ischemia and reperfusion stage due to distinctive partial oxygen pressure gradient intra-liver, and 5 animal studies (n=66) showed that stabilized HIF-1α treatment was associated with lower alanine aminotransferase (ALT) (SMD = -1.58;
Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients.
Kaplowitz et al., Arezzo, Italy. In Eur J Cancer, Jul 2015
Twenty percent of patients developed elevated alanine aminotransferase (ALT) >3×ULN.
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Acute acalculous cholecystitis in a patient with primary Epstein-Barr virus infection: a case report and literature review.
Larsen et al., Århus, Denmark. In Int J Infect Dis, Jun 2015
During admission, increasing liver function tests indicated cholestasis (alanine aminotransferase 61 U/l, alkaline phosphatase 429 U/l and bilirubin 42μmol/l).
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy.
Cappell et al., Royal Oak, United States. In World J Hepatol, Jun 2015
A variant, called PBC-autoimmune hepatitis (AIH) overlap, is characterized by the above findings of PBC together with findings of elevated serum alanine aminotransferase, elevated serum immunoglobulin G, and circulating anti-smooth muscle antibodies, with liver biopsy demonstrating periportal or periseptal, lymphocytic, piecemeal necrosis.
Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.
UNITY-1 Study Group et al., Melbourne, Australia. In Jama, Jun 2015
There were 7 serious adverse events, all considered unrelated to study treatment, and 3 adverse events (<1%) leading to treatment discontinuation, including 2 grade 4 alanine aminotransferase elevations.
Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.
Yin et al., Sydney, Australia. In Jama, Jun 2015
Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation.
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis.
Guo et al., Shanghai, China. In Drug Des Devel Ther, Dec 2014
P=0.23), total bilirubin (MD: -0.05 mg/dL; 95% CI: -0.21 to 0.12; P=0.58), and alanine aminotransferase (MD: -3.31 IU/L; 95% CI: -14.60 to 7.97; P=0.56) did not differ significantly.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
share on facebooktweetadd +1mail to friends