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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Nov 2014.

Glutamic-pyruvate transaminase

alanine aminotransferase, glutamic pyruvic transaminase
human homolog is a cytosolic alanine aminotransferase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, ACID, Serum albumin
Papers using alanine aminotransferase antibodies
Pregnane X receptor is a target of farnesoid X receptor.
Supplier
Pesce Maurizio, In PLoS ONE, 2005
... Serum content of total cholesterol, triglyceride, HDL, LDL, glucose and alanine aminotransferase were measured by enzymatic assays (Wako Chemicals; Osaka, Japan).
Papers on alanine aminotransferase
TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice.
New
Inchauspé et al., Lyon, France. In Gut, 26 Dec 2014
In addition, control of circulating levels of HBV DNA and HBsAg was observed while alanine aminotransferase levels remain in the normal range.
Shinzami Korean purple-fleshed sweet potato extract prevents ischemia-reperfusion-induced liver damage in rats.
New
Kwon et al., Seoul, South Korea. In J Sci Food Agric, 26 Dec 2014
RESULTS: Pretreatment with Shinzami extract decreased the aspirate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels in our hepatic I/R rat model.
Assessment of hepatic function, oxidant/antioxidant status, and histopathological changes in rats treated with atorvastatin: Effect of dose and acute intoxication with acetaminophen.
New
Youssef et al., Alexandria, Egypt. In Hum Exp Toxicol, 25 Dec 2014
ATV administration for 21 days resulted in a dose-dependent significant rise in serum activities of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase.
Hydroxychloroquine-induced toxic hepatitis in a patient with systemic lupus erythematosus: a case report.
New
Abdel Galil, Az Zaqāzīq, Egypt. In Lupus, 25 Dec 2014
Liver enzyme abnormality was defined as a 10-fold or greater increase in aspartate aminotransferase and alanine aminotransferase.
The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study.
New
Fraser et al., Glasgow, United Kingdom. In J Hypertens, 24 Dec 2014
METHODS:: Using cross-sectional data from a subsample (N = 1904) of a UK birth cohort, we assessed markers of NAFLD including ultrasound scan (USS) determined fatty liver, shear velocity (marker of liver fibrosis), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) at a mean age of 17.8 years.
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.
New
Impact
Davidoff et al., Aş Şanamayn, Syria. In N Engl J Med, 20 Dec 2014
A transient increase in the mean alanine aminotransferase level to 86 IU per liter (range, 36 to 202) occurred between week 7 and week 10 in 4 of the 6 patients in the high-dose group but resolved over a median of 5 days (range, 2 to 35) after prednisolone treatment.
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial.
New
Impact
Colding-Jørgensen et al., Southampton, United Kingdom. In Lancet Neurol, 30 Nov 2014
The most common adverse events (occurring in >3% of patients) were increased γ-glutamyltransferase (14 [10%] patients in the idalopirdine group vs two [2%] in the placebo group), diarrhoea (six [4%] vs nine [7%]), urinary tract infection (three [2%] vs nine [7%]), fall (three [2%] vs eight [6%]), increased alanine aminotransferase (nine [6%] vs none), and benign prostatic hyperplasia (two [5%] vs none).
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Review
New
Setji et al., Durham, United States. In World J Gastroenterol, 21 Nov 2014
However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered.
Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
TOPIC Study Group et al., New York City, United States. In Lancet Neurol, 31 Oct 2014
Adverse events that occurred in at least 10% of patients in either teriflunomide group and with an incidence that was at least 2% higher than that with placebo were increased alanine aminotransferase (40 [19%] of 216 patients in the 14 mg group, 36 [17%] of 207 in the 7 mg group vs 27 [14%] of 191 in the placebo group), hair thinning (25 [12%] and 12 [6%] vs 15 [8%]), diarrhoea (23 [11%] and 28 [14%] vs 12 [6%]), paraesthesia (22 [10%] and 11 [5%] vs 10 [5%]), and upper respiratory tract infection (20 [9%] and 23 [11%] vs 14 [7%]).
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
New
Impact
SOLSTICE Investigators et al., Durham, United States. In Lancet, 27 Oct 2014
Safety outcomes were serious adverse events and alanine aminotransferase (ALT) concentrations over 12 weeks, and cardiac events (death, myocardial infarction, recurrent ischaemia, stroke, and heart failure) at 90 days.
Risk stratification of HBV infection in Asia-Pacific region.
Review
New
Kao, Taipei, Taiwan. In Clin Mol Hepatol, Sep 2014
The community-based REVEAL-HBV study illustrated the strong association between HBV-DNA level at study entry and risk of HCC over time, and male gender, older age, high serum alanine aminotransferase (ALT) level, positive HBeAg, higher HBV-DNA level, HBV genotype C infection and core promoter mutation are independently associated with a higher hepatocellular carcinoma (HCC) risk.
Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course and management.
Review
New
Liaw et al., Taipei, Taiwan. In J Hepatol, Sep 2014
UNLABELLED: Hepatitis B flare, defined as an event with abrupt rise of alanine aminotransferase (ALT) to > 5 times upper limit of normal during chronic hepatitis B virus (HBV) infection, is considered to be the results of human leukocyte antigen-I restricted, cytotoxic T lymphocyte mediated immune response against HBV and its downstream mechanisms.
Oral GS-5806 activity in a respiratory syncytial virus challenge study.
New
Impact
Chien et al., Memphis, United States. In N Engl J Med, Sep 2014
The results were similar in cohorts 5, 6, and 7. Adverse events, including low neutrophil counts and increased levels of alanine aminotransferase, were more common among participants receiving GS-5806.
Toxicological in vitro and subchronic evaluation of LASSBio-596.
Review
New
Tagliati et al., Monte Santo de Minas, Brazil. In Food Chem Toxicol, Sep 2014
However, subchronic toxicity study results revealed changes in the blood parameters of amylase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose and creatine kinase (CK) which is used for cardiotoxicity evaluation, although, did not identify any histopathological alterations.
An approach to acanthosis nigricans.
Review
New
Phiske, Mumbai, India. In Indian Dermatol Online J, Jul 2014
Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN.
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
GeneRIF
Gong et al., Baltimore, United States. In Hepatology, 2009
Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
GeneRIF
Amacher et al., New London, United States. In Drug Chem Toxicol, 2007
Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
GeneRIF
Nozicka et al., Hradec Králové, Czech Republic. In Adv Clin Path, 2001
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
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