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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Aug 2015.

V-akt murine thymoma viral oncogene homolog 2

Akt2, Akt3, PKBbeta
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, Insulin, CAN, HAD
Papers using Akt2 antibodies
PHI-base update: additions to the pathogen host interaction database
Zhou Yan et al., In BMC Genomics, 2007
... AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin ...
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Hers Ingeborg et al., In The Journal of Biological Chemistry, 2006
... p38, and Akt2 (L79BZ) antibodies were from Cell Signaling Technologies (New England Biolabs, ...
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
Stöckli Jacqueline et al., In The Journal of Biological Chemistry, 1997
... The Akt1-specific and Akt2-specific inhibitors were previously described (20) and were obtained from Merck.
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
Mori Masatomo et al., In The Journal of Cell Biology, 1997
... purchased from Cell Signaling Technology, and Akt1- and Akt2-specific antibodies and siRNA for Akt1 and Akt2 were obtained from Upstate Cell Signaling Solutions ...
Papers on Akt2
Melatonin protects porcine oocyte in vitro maturation from heat stress.
Liu et al., Beijing, China. In J Pineal Res, 20 Sep 2015
The presence of melatonin (10(-7) M) during the oocyte maturation under the heat stress reduced ROS formation, enhanced GSH production, inhibited cell apoptosis, and increased the gene expressions of SIRT1, AKT2 and Polg2.
Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells.
Chuu et al., Taiwan. In Cancer Lett, 19 Sep 2015
Micro-Western Array and Western blotting analysis indicated that re-expression of AR increased APC, Akt2, Akt3, PI3K p85, phospho-PI3K p85 Tyr458, PI3K p85, and E-cadherin but decreased GSK-3β, phospho-GSK-3β Ser9, phospho-mTOR Ser2448, Skp2, NF-κB p50, Slug, N-cadherin, β-catenin, vimentin, MMP-9, and Snail.
"Tropomodulin3 as the link between insulin-activated AKT2 and cortical actin remodeling in preparation of GLUT4 exocytosis".
Han et al., Singapore, Singapore. In Bioarchitecture, 17 Sep 2015
In a recent study in Nature Communications, (1) Lim et al identify Tropomodulin3 (Tmod3) as a downstream target of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network.
Combination therapy of hydroxyurea and an AKT2 inhibitor has beneficial effects on acute vaso-occlusive events in sickle cell disease mice.
Cho et al., Chicago, United States. In Blood, 11 Sep 2015
Using real-time fluorescence intravital microscopy, we demonstrated that short-term co-administration of HU and Akti XII, an AKT2 inhibitor, efficiently reduced neutrophil adhesion and platelet-neutrophil aggregation in venules of TNF-α- or hypoxia/reoxygenation-challenged Berkeley (SCD) mice.
Akt isoforms in vascular disease.
Bennett et al., Cambridge, United Kingdom. In Vascul Pharmacol, 31 Aug 2015
The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3.
The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines.
Shen et al., Beijing, China. In Oncotarget, 14 Aug 2015
PI3K/AKT/mTOR pathway components, PIK3CA, PIK3CD, AKT3, ECM1, GPCR, mTOR and PRKCB were increased but that the Nur77 and PTEN were decreased in A-H/S-H cells, identified by RNA-Seq and consistently confirmed by RT-PCR and Western blot analyses.
Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma.
Flores-Sarnat et al., Calgary, Canada. In Brain Dev, Jun 2015
The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutant AKT3 or AKT1 gene as the aetiology of focal somatic mosaicism in the periventricular neuroepithelium.
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Rodeheffer et al., New Haven, United States. In Nat Cell Biol, Apr 2015
Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2.
mTOR signaling in epilepsy: insights from malformations of cortical development.
Crino, Philadelphia, United States. In Cold Spring Harb Perspect Med, Apr 2015
Mutations in mTOR regulatory genes (e.g., TSC1, TSC2, AKT3, DEPDC5) have been associated with several focal MCD highly associated with epilepsy such as tuberous sclerosis complex (TSC), hemimegalencephaly (HME; brain malformation associated with dramatic enlargement of one brain hemisphere), and cortical dysplasia.
Phenotypes of AKT3 deletion: a case report and literature review.
Yu et al., Melbourne, Australia. In Am J Med Genet A, Jan 2015
AKT3 (v-akt murine thymoma viral oncogene homolog 3) is located at chromosome 1q44 and encodes a 479 amino acid protein, a member of the protein kinase B (PKB) family.
Signalling specificity in the Akt pathway in breast cancer.
Toker et al., Boston, United States. In Biochem Soc Trans, Oct 2014
Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism.
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
Sheridan et al., Seattle, United States. In Nat Genet, May 2014
The PI3K-AKT pathway modulates GSK-3β activity, and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation.
Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER).
Bonnefoi et al., Villejuif, France. In Lancet Oncol, Mar 2014
117 (39%) of 297 patients with genomic tests available presented with rare genomic alterations (defined as occurring in less than 5% of the general population), including AKT1 mutations, and EGFR, MDM2, FGFR2, AKT2, IGF1R, and MET high-level amplifications.
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Terzi et al., Paris, France. In Nat Med, 2013
Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction.
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
Walsh et al., Boston, United States. In Cell, 2012
We then genotyped single cortical cells to characterize the mosaicism of a somatic AKT3 mutation identified in a child with hemimegalencephaly.
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
Du et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, 2012
Results demonstrate that integrin outside-in signaling and platelet spreading requires Src family kinase-dependent and ADP receptor-amplified activation of the PI3K-Akt-GSK-3beta pathway.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
Gleeson et al., San Diego, United States. In Nat Genet, 2012
Exome sequencing and mass spectrometry analysis in paired brain-blood samples from individuals with hemimegalencephaly (20 cases) identified de novo somatic mutations in 30% of affected individuals in the PIK3CA, AKT3 and MTOR genes.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified mutations in AKT3, PIK3R2 and PIK3CA in 11 unrelated families with megalencephaly-capillary malformation and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromes
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
Tsatsanis et al., Irákleion, Greece. In Proc Natl Acad Sci U S A, 2012
Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Podrez et al., Cleveland, United States. In Cell Metab, 2012
nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism.
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