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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Oct 2015.

V-akt murine thymoma viral oncogene homolog 2

Akt2, Akt3, PKBbeta
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, Insulin, HAD, CAN
Papers using Akt2 antibodies
PHI-base update: additions to the pathogen host interaction database
Zhou Yan et al., In BMC Genomics, 2007
... AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin ...
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Hers Ingeborg et al., In The Journal of Biological Chemistry, 2006
... p38, and Akt2 (L79BZ) antibodies were from Cell Signaling Technologies (New England Biolabs, ...
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
Stöckli Jacqueline et al., In The Journal of Biological Chemistry, 1997
... The Akt1-specific and Akt2-specific inhibitors were previously described (20) and were obtained from Merck.
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
Mori Masatomo et al., In The Journal of Cell Biology, 1997
... purchased from Cell Signaling Technology, and Akt1- and Akt2-specific antibodies and siRNA for Akt1 and Akt2 were obtained from Upstate Cell Signaling Solutions ...
Papers on Akt2
Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL.
Anderson et al., Oklahoma City, United States. In Adv Exp Med Biol, 31 Dec 2015
Our results suggest that PHLPP was more active than PHLPPL towards non-physiological substrates, whereas both PHLPP and PHLPP dephosphorylated the physiological substrates of Akt1 and Akt3 with similar efficiencies.
Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial-mesenchymal transition.
Khare et al., Columbia, United States. In Oncogene, 05 Nov 2015
Suppression of SPRY2 repressed AKT2 and EMT-inducing transcription factors and significantly increased E-cadherin expression.
Analysis of differentially expressed genes between endometrial carcinosarcomas and endometrioid endometrial carcinoma by bioinformatics.
Chen et al., Jinan, China. In Arch Gynecol Obstet, 15 Oct 2015
After network module analysis, PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1) and AKT2 (v-akt murine thymoma viral oncogene homolog 2) were selected as the co-expressed genes in the states of ECS while STAT3 (signal transducer and activator of transcription 3) and JAZF (JAZF zinc finger 1) were selected as the co-expressed genes in the states of EEC.
Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
Qiu et al., Shanghai, China. In Mol Med Report, 15 Oct 2015
Akt3, FGFR3, PSEN1, VEGFa and AR.
Akt isoforms in vascular disease.
Bennett et al., Cambridge, United Kingdom. In Vascul Pharmacol, Aug 2015
The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3.
Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma.
Flores-Sarnat et al., Calgary, Canada. In Brain Dev, Jun 2015
The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutant AKT3 or AKT1 gene as the aetiology of focal somatic mosaicism in the periventricular neuroepithelium.
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Rodeheffer et al., New Haven, United States. In Nat Cell Biol, Apr 2015
Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2.
mTOR signaling in epilepsy: insights from malformations of cortical development.
Crino, Philadelphia, United States. In Cold Spring Harb Perspect Med, Apr 2015
Mutations in mTOR regulatory genes (e.g., TSC1, TSC2, AKT3, DEPDC5) have been associated with several focal MCD highly associated with epilepsy such as tuberous sclerosis complex (TSC), hemimegalencephaly (HME; brain malformation associated with dramatic enlargement of one brain hemisphere), and cortical dysplasia.
Phenotypes of AKT3 deletion: a case report and literature review.
Yu et al., Melbourne, Australia. In Am J Med Genet A, Jan 2015
AKT3 (v-akt murine thymoma viral oncogene homolog 3) is located at chromosome 1q44 and encodes a 479 amino acid protein, a member of the protein kinase B (PKB) family.
Systematic Analysis of Endometrial Cancer-Associated Hub Proteins Based on Text Mining.
Zhang et al., Beijing, China. In Biomed Res Int, Dec 2014
These 17 proteins are EGFR, MET, PDGFRB, CCND1, JUN, FGFR2, MYC, PIK3CA, PIK3R1, PIK3R2, KRAS, MAPK3, CTNNB1, RELA, JAK2, AKT1, and AKT2.
Signalling specificity in the Akt pathway in breast cancer.
Toker et al., Boston, United States. In Biochem Soc Trans, Oct 2014
Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism.
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
Sheridan et al., Seattle, United States. In Nat Genet, May 2014
The PI3K-AKT pathway modulates GSK-3β activity, and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation.
Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER).
Bonnefoi et al., Villejuif, France. In Lancet Oncol, Mar 2014
117 (39%) of 297 patients with genomic tests available presented with rare genomic alterations (defined as occurring in less than 5% of the general population), including AKT1 mutations, and EGFR, MDM2, FGFR2, AKT2, IGF1R, and MET high-level amplifications.
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Terzi et al., Paris, France. In Nat Med, 2013
Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction.
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
Walsh et al., Boston, United States. In Cell, 2012
We then genotyped single cortical cells to characterize the mosaicism of a somatic AKT3 mutation identified in a child with hemimegalencephaly.
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
Du et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, 2012
Results demonstrate that integrin outside-in signaling and platelet spreading requires Src family kinase-dependent and ADP receptor-amplified activation of the PI3K-Akt-GSK-3beta pathway.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
Gleeson et al., San Diego, United States. In Nat Genet, 2012
Exome sequencing and mass spectrometry analysis in paired brain-blood samples from individuals with hemimegalencephaly (20 cases) identified de novo somatic mutations in 30% of affected individuals in the PIK3CA, AKT3 and MTOR genes.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified mutations in AKT3, PIK3R2 and PIK3CA in 11 unrelated families with megalencephaly-capillary malformation and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromes
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
Tsatsanis et al., Irákleion, Greece. In Proc Natl Acad Sci U S A, 2012
Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Podrez et al., Cleveland, United States. In Cell Metab, 2012
nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism.
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