GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
V-akt murine thymoma viral oncogene homolog 2
Akt2, Akt3, PKBbeta
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
Akt2
antibodies
PHI-base update: additions to the pathogen host interaction database
Supplier
In BMC Genomics, 2007
... AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin ...
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Supplier
In The Journal of Biological Chemistry, 2006
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
Supplier
In The Journal of Biological Chemistry, 1997
... The Akt1-specific and Akt2-specific inhibitors were previously described (20) and were obtained from Merck.
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
Supplier
In The Journal of Cell Biology, 1997
Papers on
Akt2
Hemimegalencephaly, a paradigm for somatic postzygotic neurodevelopmental disorders.
New
Los Angeles, United States. In Curr Opin Neurol, 30 Apr 2013
The gene mutations involve components of the phosphatidylinositol 3-kinase (PI3K)-AKT (also known as protein kinase B)-mammalian target of rapamycin (mTOR) pathway and include PIK3CA, PIK3R2, AKT3, and MTOR.
MET and EGFR Mutations Identified in ALK-Rearranged Pulmonary Adenocarcinoma: Molecular Analysis of 25 ALK-Positive Cases.
New
Changchun, China. In J Thorac Oncol, 27 Mar 2013
METHODS:: Using the DNA extracted from formalin-fixed paraffin-embedded tumor samples, a MassArray-based Lung Cancer Mutations Screening Panel was performed to test for 179 individual mutations in 10 genes, including EGFR, KRAS, BRAF, ERBB2, JAK2, AKT1, AKT2, KIT, MET and PIK3CA, which have been implicated in lung carcinogenesis and/or considered as potential therapeutic targets.
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis.
New
Nagoya, Japan. In Plos One, Dec 2012
Amplification of the AKT2 gene, which is a downstream component of the Met/PI3K signaling pathway, was also observed in 5/21 samples by array-based CGH analysis.
Akt2 regulates metastatic potential in neuroblastoma.
New
Nashville, United States. In Plos One, Dec 2012
Here, we report a novel finding that of the three AKT isoforms, AKT2 specifically regulated N-myc expression in neuroblastoma cells.
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
New
Impact
Boston, United States. In Cell, Nov 2012
We then genotyped single cortical cells to characterize the mosaicism of a somatic AKT3 mutation identified in a child with hemimegalencephaly.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
New
Impact
San Diego, United States. In Nat Genet, Aug 2012
Exome sequencing and mass spectrometry analysis in paired brain-blood samples from individuals with HME (n = 20 cases) identified de novo somatic mutations in 30% of affected individuals in the PIK3CA, AKT3 and MTOR genes.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
New
Impact
Seattle, United States. In Nat Genet, Aug 2012
These include 2 mutations in AKT3, 1 recurrent mutation in PIK3R2 in 11 unrelated families with MPPH and 15 mostly postzygotic mutations in PIK3CA in 23 individuals with MCAP and 1 with MPPH.
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.
New
Impact
Bethesda, United States. In Nat Genet, Aug 2012
Correspondingly, loss of function of PTEN, a negative regulator of PI3K, or activating mutations in AKT1, AKT2 or AKT3 have been found in distinct disorders featuring overgrowth or hypoglycemia.
Sequence analysis of mutations and translocations across breast cancer subtypes.
New
Impact
Cambridge, United States. In Nature, Jul 2012
Furthermore, we have identified a recurrent MAGI3-AKT3 fusion enriched in triple-negative breast cancer lacking oestrogen and progesterone receptors and ERBB2 expression.
Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.
GeneRIF
Philadelphia, United States. In Am J Physiol Heart Circ Physiol, 2012
Flow cessation results in cell membrane depolarization, which is followed by PI3K/ Akt and PKC activation, which, in turn, causes NOX2 assembly and reactive oxygen species generation.
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms.
Review
Houston, United States. In Cell Res, 2012
Twist1 promotes EMT in part by directly repressing E-cadherin expression by recruiting the nucleosome remodeling and deacetylase complex for gene repression and by upregulating Bmi1, AKT2, YB-1, etc. Emerging evidence also suggests that Twist1 plays a role in expansion and chemotherapeutic resistance of cancer stem cells.
Short-chain fatty acid propionate alleviates Akt2 knockout-induced myocardial contractile dysfunction.
GeneRIF
Ürümqi, China. In Exp Diabetes Res, 2011
Akt2 knockout may elicit cardiomyocyte contractile and mitochondrial defects
Iris Nertschinskia Ethanol Extract Differentially Induces Cytotoxicity in Human Breast Cancer Cells Depending on AKT1/2 Activity.
Seoul, South Korea. In Asian Pac J Cancer Prev, 2011
Knockdown of endogenous AKT1 or AKT2 in breast cancer cells by RNA interference determined the sensitivity to I. nertschinskia ethanol extract compared to control cells.
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
GeneRIF
Philadelphia, United States. In Proc Natl Acad Sci U S A, 2011
analysis of resistance of Akt kinase and PP2A to dephosphorylation through ATP-dependent conformational plasticity
Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.
GeneRIF
Philadelphia, United States. In Am J Physiol Heart Circ Physiol, 2011
Suggest that in myocardial injury after ischemia-reperfusion injury increasing retention of Akt2-KO macrophages resulted in increasing cardiac Akt2-KO macrophage density in the myocardial space.
Clinical review#: Lipodystrophies: genetic and acquired body fat disorders.
Review
Dallas, United States. In J Clin Endocrinol Metab, 2011
Mutations in AGPAT2, BSCL2, CAV1, and PTRF have been reported in congenital generalized lipodystrophy and in LMNA, PPARG, AKT2, and PLIN1 in FPL.
An activating mutation of AKT2 and human hypoglycemia.
Impact
GeneRIF
London, United Kingdom. In Science, 2011
3 unrelated children with unexplained, recurrent and severe fasting hypoglycemia and asymmetrical growth were found to carry the same de novo mutation, p.Glu17Lys, in AKT2, in 2 cases as heterozygotes and in 1 case in mosaic form
Akt signalling in health and disease.
Review
Bristol, United Kingdom. In Cell Signal, 2011
Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1, Akt2 and Akt3 (or PKBα/β/γ respectively).
Promiscuous affairs of PKB/AKT isoforms in metabolism.
Review
Zürich, Switzerland. In Arch Physiol Biochem, 2011
The protein kinase B (PKB) family encompasses three isoforms; PKBα (AKT1), PKBβ (AKT2) and PKBγ (AKT3).
Contribution of PKB/AKT signaling to thyroid cancer.
Review
Catanzaro, Italy. In Front Biosci, 2010
In mammalian cells the Akt family comprises three highly homologous members -known as Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma- that regulate several processes including cell proliferation and survival, growth and response to nutrient availability, migration, tissue invasion and angiogenesis.
