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V-akt murine thymoma viral oncogene homolog 2

Akt2, Akt3, PKBbeta
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, Insulin, HAD, CAN
Papers using Akt2 antibodies
PHI-base update: additions to the pathogen host interaction database
Supplier
Zhou Yan et al., In BMC Genomics, 2007
... AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin ...
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Supplier
Hers Ingeborg et al., In The Journal of Biological Chemistry, 2006
... p38, and Akt2 (L79BZ) antibodies were from Cell Signaling Technologies (New England Biolabs, ...
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
Supplier
Stöckli Jacqueline et al., In The Journal of Biological Chemistry, 1997
... The Akt1-specific and Akt2-specific inhibitors were previously described (20) and were obtained from Merck.
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
Supplier
Mori Masatomo et al., In The Journal of Cell Biology, 1997
... purchased from Cell Signaling Technology, and Akt1- and Akt2-specific antibodies and siRNA for Akt1 and Akt2 were obtained from Upstate Cell Signaling Solutions ...
Papers on Akt2
miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3.
New
Ye et al., Wuhan, China. In Tumour Biol, 23 Jun 2015
Further studies showed that miR-582-5p regulated the progression of HCC through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1.
MORFAN Syndrome: An Infantile Hypoinsulinemic Hypoketotic Hypoglycemia Due to an AKT2 Mutation.
New
Tekin et al., Ankara, Turkey. In J Pediatr, 21 Jun 2015
Whole-exome sequencing revealed a de novo AKT2 mutation.
Akt isoforms in vascular disease.
Review
New
Bennett et al., Cambridge, United Kingdom. In Vascul Pharmacol, 27 May 2015
UNASSIGNED: The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3.
Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases.
New
Heymach et al., Houston, United States. In Lung Cancer, 22 May 2015
Comprehensive genomic profiling revealed fusion of KIF5B (the-kinesin-family-5B-gene) and RET, in addition to AKT2 gene amplification.
Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients.
New
Corrias et al., Genova, Italy. In Oncotarget, 20 May 2015
Among the ARE-containing genes, miR-659-3p mimic and inhibitor specifically modified the expression of AKT3, BCL2, CYR61 and THSB2, belonging to the focal adhesion pathway.
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
New
Impact
Rodeheffer et al., New Haven, United States. In Nat Cell Biol, 30 Apr 2015
Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2.
mTOR signaling in epilepsy: insights from malformations of cortical development.
Review
New
Crino, Philadelphia, United States. In Cold Spring Harb Perspect Med, 30 Apr 2015
Mutations in mTOR regulatory genes (e.g., TSC1, TSC2, AKT3, DEPDC5) have been associated with several focal MCD highly associated with epilepsy such as tuberous sclerosis complex (TSC), hemimegalencephaly (HME; brain malformation associated with dramatic enlargement of one brain hemisphere), and cortical dysplasia.
Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells.
New
Xu et al., Xinxiang, China. In Genet Mol Res, Dec 2014
Based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the RAS and STAT3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the STAT3 signaling pathway, and proliferation and apoptosis of pit cells through the AKT3 signaling pathway.
Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma.
Review
New
Flores-Sarnat et al., Calgary, Canada. In Brain Dev, Nov 2014
The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutant AKT3 or AKT1 gene as the aetiology of focal somatic mosaicism in the periventricular neuroepithelium.
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
New
Impact
Sheridan et al., Seattle, United States. In Nat Genet, May 2014
The PI3K-AKT pathway modulates GSK-3β activity, and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation.
Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness.
Review
New
Verrelle et al., Clermont-Ferrand, France. In J Neurooncol, Apr 2014
More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma.
Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER).
New
Impact
Bonnefoi et al., Villejuif, France. In Lancet Oncol, Mar 2014
117 (39%) of 297 patients with genomic tests available presented with rare genomic alterations (defined as occurring in less than 5% of the general population), including AKT1 mutations, and EGFR, MDM2, FGFR2, AKT2, IGF1R, and MET high-level amplifications.
Advances in small bowel neuroendocrine neoplasia.
Review
New
Beutler et al., Rochester, United States. In Curr Opin Gastroenterol, Mar 2014
Candidate therapeutically relevant alterations were found to affect SRC, SMAD genes, aurora kinase A, epidermal growth factor receptor, heat shock protein 90, and platelet-derived growth factor receptor as well as mutually exclusive amplification of RAC-alpha serine/threonine-protein kinase (AKT1) or AKT2 and other alterations of PI3K/Akt/mTOR signaling genes.
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Impact
Terzi et al., Paris, France. In Nat Med, 2013
Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction.
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
Impact
Walsh et al., Boston, United States. In Cell, 2012
We then genotyped single cortical cells to characterize the mosaicism of a somatic AKT3 mutation identified in a child with hemimegalencephaly.
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
GeneRIF
Du et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, 2012
Results demonstrate that integrin outside-in signaling and platelet spreading requires Src family kinase-dependent and ADP receptor-amplified activation of the PI3K-Akt-GSK-3beta pathway.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
Impact
GeneRIF
Gleeson et al., San Diego, United States. In Nat Genet, 2012
Exome sequencing and mass spectrometry analysis in paired brain-blood samples from individuals with hemimegalencephaly (20 cases) identified de novo somatic mutations in 30% of affected individuals in the PIK3CA, AKT3 and MTOR genes.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Impact
GeneRIF
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified mutations in AKT3, PIK3R2 and PIK3CA in 11 unrelated families with megalencephaly-capillary malformation and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromes
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
GeneRIF
Tsatsanis et al., Irákleion, Greece. In Proc Natl Acad Sci U S A, 2012
Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Impact
GeneRIF
Podrez et al., Cleveland, United States. In Cell Metab, 2012
nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism.
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