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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jul 2015.

V-akt murine thymoma viral oncogene homolog 2

Akt2, Akt3, PKBbeta
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, Insulin, CAN, HAD
Papers using Akt2 antibodies
PHI-base update: additions to the pathogen host interaction database
Supplier
Zhou Yan et al., In BMC Genomics, 2007
... AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin ...
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Supplier
Hers Ingeborg et al., In The Journal of Biological Chemistry, 2006
... p38, and Akt2 (L79BZ) antibodies were from Cell Signaling Technologies (New England Biolabs, ...
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
Supplier
Stöckli Jacqueline et al., In The Journal of Biological Chemistry, 1997
... The Akt1-specific and Akt2-specific inhibitors were previously described (20) and were obtained from Merck.
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
Supplier
Mori Masatomo et al., In The Journal of Cell Biology, 1997
... purchased from Cell Signaling Technology, and Akt1- and Akt2-specific antibodies and siRNA for Akt1 and Akt2 were obtained from Upstate Cell Signaling Solutions ...
Papers on Akt2
Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis.
New
Fort et al., United States. In Am J Physiol Endocrinol Metab, 21 Aug 2015
Surprisingly, the glycolytic inhibitor 2-deoxyglucose (2-DG) markedly inhibited Akt1 and Akt3 activities, as well as protein synthesis.
Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma.
Review
New
Flores-Sarnat et al., Calgary, Canada. In Brain Dev, 30 Jun 2015
The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutant AKT3 or AKT1 gene as the aetiology of focal somatic mosaicism in the periventricular neuroepithelium.
Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival.
New
Khleif et al., Augusta, United States. In Oncoimmunology, May 2015
We found that Akt1 and Akt2, but not Akt3, drive the terminal differentiation of CD8 (+) T cells, and their inhibition enhances the therapeutically superior TCM phenotype.
Akt isoforms in vascular disease.
Review
New
Bennett et al., Cambridge, United Kingdom. In Vascul Pharmacol, May 2015
UNASSIGNED: The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3.
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
New
Impact
Rodeheffer et al., New Haven, United States. In Nat Cell Biol, Apr 2015
Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2.
mTOR signaling in epilepsy: insights from malformations of cortical development.
Review
New
Crino, Philadelphia, United States. In Cold Spring Harb Perspect Med, Apr 2015
Mutations in mTOR regulatory genes (e.g., TSC1, TSC2, AKT3, DEPDC5) have been associated with several focal MCD highly associated with epilepsy such as tuberous sclerosis complex (TSC), hemimegalencephaly (HME; brain malformation associated with dramatic enlargement of one brain hemisphere), and cortical dysplasia.
miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2.
New
Feng et al., Shanghai, China. In Cell Death Dis, Dec 2014
In this study, we found that miR-612 expression was significantly lower in CRC tissues or cells compared with peritumor tissues or normal cells, and lower in metastatic CRC specimens compared with non-metastatic specimens, whereas AKT2 exhibited opposite trend.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
New
Chen et al., Changsha, China. In Sci Rep, Dec 2014
Moreover, in 5-8F-shFlot-2 cells, which have inhibited Flot-2 expression, the NF-κB and PI3K/Akt3 pathways were inactivated.
AKT2-knockdown suppressed viability with enhanced apoptosis, and attenuated chemoresistance to temozolomide of human glioblastoma cells in vitro and in vivo.
New
Lu et al., Shanghai, China. In Onco Targets Ther, Dec 2014
The AKT2 kinase (protein kinase Bβ) is overexpressed in high-grade gliomas.
Expression, activation, and role of AKT isoforms in the uterus.
Review
New
Asselin et al., Trois-Rivières, Canada. In Reproduction, Nov 2014
The three isoforms of AKT: AKT1, AKT2, and AKT3, are crucial regulators of both normal and pathological cellular processes.
Signalling specificity in the Akt pathway in breast cancer.
Review
New
Toker et al., Boston, United States. In Biochem Soc Trans, Oct 2014
Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell survival, growth, proliferation and metabolism.
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
New
Impact
Sheridan et al., Seattle, United States. In Nat Genet, May 2014
The PI3K-AKT pathway modulates GSK-3β activity, and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation.
Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER).
New
Impact
Bonnefoi et al., Villejuif, France. In Lancet Oncol, Mar 2014
117 (39%) of 297 patients with genomic tests available presented with rare genomic alterations (defined as occurring in less than 5% of the general population), including AKT1 mutations, and EGFR, MDM2, FGFR2, AKT2, IGF1R, and MET high-level amplifications.
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Impact
Terzi et al., Paris, France. In Nat Med, 2013
Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction.
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
Impact
Walsh et al., Boston, United States. In Cell, 2012
We then genotyped single cortical cells to characterize the mosaicism of a somatic AKT3 mutation identified in a child with hemimegalencephaly.
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
GeneRIF
Du et al., Chicago, United States. In Arterioscler Thromb Vasc Biol, 2012
Results demonstrate that integrin outside-in signaling and platelet spreading requires Src family kinase-dependent and ADP receptor-amplified activation of the PI3K-Akt-GSK-3beta pathway.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
Impact
GeneRIF
Gleeson et al., San Diego, United States. In Nat Genet, 2012
Exome sequencing and mass spectrometry analysis in paired brain-blood samples from individuals with hemimegalencephaly (20 cases) identified de novo somatic mutations in 30% of affected individuals in the PIK3CA, AKT3 and MTOR genes.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Impact
GeneRIF
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified mutations in AKT3, PIK3R2 and PIK3CA in 11 unrelated families with megalencephaly-capillary malformation and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromes
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
GeneRIF
Tsatsanis et al., Irákleion, Greece. In Proc Natl Acad Sci U S A, 2012
Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Impact
GeneRIF
Podrez et al., Cleveland, United States. In Cell Metab, 2012
nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism.
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