GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
V-akt murine thymoma viral oncogene homolog 1
Akt, Rac, PKB, protein kinase B
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] (from
NCBI)
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Papers using
Akt
antibodies
CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-κB signaling pathway
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In Journal of Neuroinflammation, 2011
... Anti-phospho-PDGFR, anti-phospho-c-Src, anti-phospho-p42/p44 MAPK, anti-phospho-p38 MAPK, anti-phospho-JNK1/2, and anti-phospho-Akt antibodies were from Cell Signaling (Danver, MA) ...
Mitigating endoplasmic reticulum stress with revaprazan ameliorates stress-related mucosal disease
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In Journal of Clinical Biochemistry and Nutrition, 2011
Slug is upregulated during wound healing and regulates cellular phenotypes in corneal epithelial cells.
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In PLoS ONE, 2011
CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion.
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In PLoS ONE, 2010
... Monoclonal antibody Phospho-Akt (Ser473) and Phospho-Akt (Thr308) were purchased from Cell Signaling (Danvers, MA) ...
Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma
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In Sarcoma, 2010
... -IR3, doxorubicin, z-VAD-fmk, z-DEVD-fmk, wortmannin, AKTi-1/2 (AKT inhibitor VIII; Merck Chemicals, Darmstadt, Germany), fumonisin ...
Papers on
Akt
Angiotensin-(1-7): beyond the cardio-renal actions.
Review
New
Belo Horizonte, Brazil. In Clin Sci (lond), 30 Apr 2013
The interaction Ang-(1-7)/Mas regulates different signalling pathways, such as PI3K (phosphoinositide 3-kinase)/AKT and ERK (extracellularsignal-regulated kinase) pathways and involves downstream effectors such as NO, FOXO1 (forkhead box O1) and COX-2 (cyclo-oxygenase-2).
Growth inhibition of pancreatic cancer cells by Histone Deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo.
New
Singapore, Singapore. In Mol Carcinog, 08 Apr 2013
Taken together, HDACi decreases growth, increases apoptosis, and is associated with blocking the AKT/mTOR pathway.
Glucagon-induced acetylation of foxa2 regulates hepatic lipid metabolism.
New
Impact
Zürich, Switzerland. In Cell Metab, 05 Apr 2013
The transcription factor Foxa2 activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-Akt signaling-mediated phosphorylation at Thr156 and nuclear exclusion.
Subcellular control of Rac-GTPase signalling by magnetogenetic manipulation inside living cells.
New
Impact
Paris, France. In Nat Nanotechnol, 31 Mar 2013
Many cell functions rely on the coordinated activity of signalling pathways at a subcellular scale.
Estrogen receptor signaling as a target for novel breast cancer therapeutics.
Review
New
Villejuif, France. In Biochem Pharmacol, 15 Mar 2013
In addition, BC proliferation is enhanced by insulin and EGF, which stimulate signaling through the MAPK and PI3K/AKT pathways by activation of the IGF-1R and EGFR axes, respectively.
Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer.
New
Seoul, South Korea. In Int J Cancer, 07 Mar 2013
CRC patients with KRAS or PIK3CA mutations show activation of AKT and MTOR, particularly when KRAS and PIK3CA mutations coexist.
Rab11 regulates cell-cell communication during collective cell movements.
New
Impact
Montréal, Canada. In Nat Cell Biol, 03 Mar 2013
The small GTPase Rac is a key regulator of actin dynamics and cell migration but the mechanisms that restrict Rac activation and localization in a group of collectively migrating cells are unknown.
Which drug, and when, for patients with BRAF-mutant melanoma?
New
Impact
Washington, D.C., United States. In Lancet Oncol, 28 Feb 2013
Multiple resistance mechanisms have been identified, including those that lead to reactivation of the MAPK pathway and other pathways, such as the PI3K-AKT-mTOR and VEGF pathways.
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.
New
Impact
Stanford, United States. In Cell, 17 Feb 2013
The SSB-ribosome cycle and substrate recognition is modulated by its ribosome-bound cochaperone, RAC.
Molecular basis of physiological heart growth: fundamental concepts and new players.
Review
New
Impact
Cincinnati, United States. In Nat Rev Mol Cell Biol, Jan 2013
Physiological hypertrophy is initiated by finite signals, which include growth hormones (such as thyroid hormone, insulin, insulin-like growth factor 1 and vascular endothelial growth factor) and mechanical forces that converge on a limited number of intracellular signalling pathways (such as PI3K, AKT, AMP-activated protein kinase and mTOR) to affect gene transcription, protein translation and metabolism.
Antioxidant Activity and Cardioprotective Effect of a Nonalcoholic Extract of Vaccinium meridionale Swartz during Ischemia-Reperfusion in Rats.
New
Medellín, Colombia. In Evid Based Complement Alternat Med, Dec 2012
In cardiac tissue thiobarbituric acid reactive substances (TBARS) concentration, reduced glutathione (GSH) content, endothelial NOS (eNOS), and Akt expression were also measured.
Vitexicarpin acts as a novel angiogenesis inhibitor and its target network.
New
Beijing, China. In Evid Based Complement Alternat Med, Dec 2012
Then, we tested some key molecules in the VEGF pathway targeted by VIT and verified the inhibition effects of VIT on AKT and SRC phosphorylation.
Induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells.
New
Taiwan. In Evid Based Complement Alternat Med, Dec 2012
This cytotoxicity was caused by the downregulation of Akt and resultant upregulation of apoptosis signal-regulating kinase-1 (Ask1), p38, and c-Jun N-terminal kinase (JNK) activities, probably via protein phosphatase 2A (PP2A) activation.
[Predictive biomarkers for anti-EGFR antibodies].
Review
New
Chiba, Japan. In Gan To Kagaku Ryoho, Nov 2012
These facts suggest that additional activating mutations in the RAS-RAF-MAPK or PI3K-AKT-mTOR pathways may also confer resistance to anti-EGFR antibody therapies.
Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison.
Review
New
Sassari, Italy. In Biochim Biophys Acta, Aug 2012
Mounting evidence emphasises the role of up-regulation of RAS/ERK, P13K/AKT, IKK/NF-kB, WNT, TGF-ß, NOTCH, Hedgehog, and Hippo signalling pathways as well as of aberrant proteasomal activity in hepatocarcinogenesis. Signalling deregulation often occurs in preneoplastic stages of rodent and human hepatocarcinogenesis and progressively increases in carcinomas, being most pronounced in more aggressive tumours.
Activation of AKT is associated with metastasis of nasopharyngeal carcinoma.
New
GeneRIF
Guangzhou, China. In Tumour Biol, Feb 2012
Radiotherapy can increase the levels of AKT in nasopharyngeal carcinoma (NPC) cells that are associated with NPC metastasis and increase in mortality.
Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
GeneRIF
Kwangju, South Korea. In J Immunol, 2012
the PI3K/Akt/GSK3beta/NFATc1 signaling axis plays an important role in RANKL-induced osteoclastogenesis.
Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids.
GeneRIF
London, Canada. In Carcinogenesis, 2012
spheroid dispersion was at least partly dependent upon AKT activity
Silencing p110β prevents rapid depletion of nuclear pAkt.
GeneRIF
Stockholm, Sweden. In Biochem Biophys Res Commun, 2012
data show that p110beta is essential for the ATP- and statin-induced effects and support a role of nuclear pAkt in cancer development.
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
More papers using
Akt
antibodies
Impact
GeneRIF
Kodaira, Japan. In Nat Cell Biol, 2011
The E3 ligase (ZNRF1)-AKT-glycogen synthase kinase-3beta (GSK3B)-CRMP2 pathway plays an important role in controlling Wallerian degeneration.
The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.
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In Environmental Health Perspectives, 2009
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
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In Mediators of Inflammation, 2009
Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
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In Oncogene, 2009
The role of caveolin-1 in prostate cancer: clinical implications
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In PLoS ONE, 2009
... Caveolin-1 and Rac-1 antibodies were from BD Biosciences.
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
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In Breast Cancer Research : BCR, 2009
Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination.
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In PLoS ONE, 2009
Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes.
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In PLoS ONE, 2009
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
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In Blood Cancer Journal, 2009
High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice
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In PLoS ONE, 2009
Molecular mechanisms of resistance to tumour anti-angiogenic strategies
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In Molecular Cancer, 2009
Sustained delivery of sphingosine-1phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice
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In Clinical Science (London, England : 1979), 2009
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
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In PLoS ONE, 2008
Systems biology of growth factor-induced receptor endocytosis
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In Molecular Systems Biology, 2008
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
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In Cell death and differentiation, 2008
FRET and mechanobiology.
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In PLoS ONE, 2008
... A specific inhibitor of Rac GTPase, N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride (NSC23766), from Tocris Bioscience (Ellisville, Missouri), was ...
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
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In PLoS ONE, 2008
Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.
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In PLoS ONE, 2008
Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing.
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In PLoS ONE, 2008
... Anti-phospho-AKT (serine 473) antibody was from Cell Signaling Technology (Beverly, MA, USA) ...
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
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In PLoS ONE, 2008
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
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In PLoS ONE, 2008
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
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In PLoS ONE, 2008
Bone marrow microenvironment and the identification of new targets for myeloma therapy.
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In PLoS ONE, 2008
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
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In PLoS ONE, 2008
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells.
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In PLoS ONE, 2007
... -Akt antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells
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In Molecular Cancer, 2007
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
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In The Journal of Cell Biology, 2007
A novel calcium-binding protein is associated with tau proteins in tauopathy.
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In PLoS ONE, 2007
Enhanced recovery from contraction-induced damage in skeletal muscles of old mice following treatment with the heat shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin
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In Molecular Cancer, 2007
Unrestrictive identification of multiple post-translational modifications from tandem mass spectrometry using an error-tolerant algorithm based on an extended sequence tag approach
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In PLoS ONE, 2007
Inactivation of Adenosine A2A Receptor Attenuates Basal and Angiotensin II-induced ROS Production by Nox2 in Endothelial Cells*
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In The Journal of Biological Chemistry, 2007
Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells*
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In The Journal of Biological Chemistry, 2007
Membrane phosphatidylserine regulates surface charge and protein localization
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In The Journal of Cell Biology, 2007
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
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In Carcinogenesis, 2007
... p-IκBα, IKKα/β, p65, p50, p-ERK, p-p38, p-JNK, p-Akt, ERK, p38, c-Jun N-terminal kinase (JNK) and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion.
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In PLoS ONE, 2007
... Actin and Akt antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
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In PLoS ONE, 2007
Paraquat neurotoxicity is mediated by a Bak-dependent mechanism
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In Parkinson's Disease, 2007
The transgenic strain ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
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In PLoS Pathogens, 2007
Influence of tooth removal on mandibular bone response to mastication
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In Journal of Biomedicine and Biotechnology, 2007
The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes
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In The Journal of Cell Biology, 2006
Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.
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In PLoS ONE, 2006
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
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In Molecular Cancer, 2006
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
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In Biochimie, 2006
... of retinoblastoma gene (pRb) (Ser 795), phosphorylated glycogen synthase kinase-3β (GSK-3β) (Ser 9), pan-Akt (H-136), phospho-pan-Akt (Ser 473), anti-mouse, anti-rabbit, and anti-goat immunoglobulin G1 conjugated to horseradish peroxidase and Blotto (nonfat dry milk) were obtained from Santa Cruz Biotechnology, Inc ...
Genetic ablation of Rac1 in cartilage results in chondrodysplasia
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In BMC Developmental Biology, 2006
... (P-Akt (Ser 473) #4051; Akt #9272), Santa Cruz Biotechnology ...
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells
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In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... Antibodies against phospho-p38 (Thr180/Tyr182), p38, phospho-ERK1/2 (Thr42/Tyr44), ERK1/2, phospho-Akt (Ser473) and Akt were from Cell Signaling Technology (Beverly, MA, USA) ...
Cell polarity in development and cancer.
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In PLoS ONE, 2006
... The antibodies for detection of phospho-AKT (Ser473) and AKT were from Cell Signaling Technology (Danvers, MA) ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
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In PLoS ONE, 2006
Platelet-derived nitric oxide signaling and regulation
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In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... ) and anti-Akt mAbs were from Biovision (Mountain View, CA, USA) ...
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells
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In Journal of Neuroinflammation, 2005
IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop
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In The Journal of Cell Biology, 2005
... and Myogenin (M-225) were purchased from Santa Cruz Biotechnology, Inc., and antibodies to Akt and phospho-Akt (Ser473) were from Cell Signaling Technology ...
De novo emergence of insulin-stimulated glucose uptake in human aortic endothelial cells incubated with high glucose
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In Biochemical and Biophysical Research Communications, 2005
... alanine-rich protein kinase C substrate (MARCKS) (Ser152/156), anti-phospho-extracellular signal regulated kinase (ERK)1/2 (Thr202/Tyr204); anti-ERK1/2; anti-Akt and anti-phospho-Akt (Ser473) antibodies were from New England Biolabs UK (Hitchin, UK) ...
Cancer vaccines targeting carbohydrate antigens
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In Journal of Experimental & Clinical Cancer Research : CR, 2005
Intrahepatic cytokine expression is downregulated during HCV/HIV co-infection.
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In PLoS ONE, 2005
Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
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In Diabetes, 2005
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
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In PLoS ONE, 2005
... anti-phospho-mTOR (Ser2448), anti-phospho-HDM2 (Ser166), anti-phospho-FOXO1 (Ser319), anti-phospho-GSK3α/β (Ser21/9), immobilized AKT (1G1) antibodies (bead conjugated), immobilized phospho-AKT (Ser473) (D9E) antibodies (bead conjugated) and immobilized IgG mouse (bead conjugated) were from Cell Signaling Technology (New England Biolabs ...
Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei.
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In PLoS ONE, 2005
Tumor necrosis factor inhibitors for rheumatoid arthritis
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In Journal of Bone and Mineral Research, 2005
Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression.
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In PLoS ONE, 2005
Resveratrol inhibits insulin responses in a SirT1-independent pathway.
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In PLoS ONE, 2005
... Antibodies against Phospho Akt (ser473, CST) Akt (CST), Hsp72 (Abcam), P-Gsk3β (Abcam), Erk1/2 (Sigma), ...
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.
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In PLoS ONE, 2005
... The Akt kinase assay kit was acquired from Cell Signaling Technology (Boston, MA) ...
A death-promoting role for extracellular signal-regulated kinase
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In Molecular Systems Biology, 2005
Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall
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In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
Necrotic death as a cell fate.
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In PLoS ONE, 2005
... Antibodies against p-ERK, FOXO3a, p-FOXO3a (Thr32), p-FOXO3a (Ser253), Bad, PARP, NOXA and PUMA, and the AKT kinase assay kit were purchased from Cell Signaling Technology (Danvers, MA) ...
Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs.
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In PLoS ONE, 2005
uPAR induces epithelial–mesenchymal transition in hypoxic breast cancer cells
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In The Journal of Cell Biology, 2005
Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.
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In PLoS ONE, 2004
... Anti-Rac 1 monoclonal antibody was purchased from Becton Dickinson Biosciences (San Diego, CA), ...
Interferon-alpha promotes the anti-proliferative effect of gefitinib (ZD 1839) on human colon cancer cell lines.
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In PLoS ONE, 2004
... Rabbit anti-Cav1/2 antibody was purchased from Transduction Laboratories (Greenland, NH) and rabbit anti-pAkt and Akt from Cell Signaling (Danvers, MA) ...
Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis.
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In PLoS ONE, 2004
... subunit (clone JBS5), Akt and caspases were from Chemicon International, Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors
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In DARU Journal of Pharmaceutical Sciences, 2004
Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib
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In Journal of Cancer, 2004
... antibodies: mouse anti-EGFR (Ab-12; Lab Vision, Fremont, CA); mouse anti-p-Akt (Ser 473, #4051) and rabbit anti-Akt (#9272; both from Cell Signaling Technology, Beverly, MA); and ...
Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.
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In PLoS ONE, 2004
... PEBP2aA) antibody, anti-extracellular signal-regulated kinase (ERK), p-ERK, p-p38, p38, c-jun N-terminal kinase (JNK), p-JNK, Akt, p-Akt antibody, anti-mouse, and rabbit IgG peroxidase conjugate antibodies were purchased from Santa Cruz Biotechnology Inc (Waltham, MA, USA) ...
Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation.
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In PLoS ONE, 2004
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
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In The Journal of Cell Biology, 2004
Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C
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In European Journal of Nutrition, 2004
... The antibodies against AKT, phospho-(Ser473)-Akt, were from Santa Cruz Biotechnology (Heidelberg, Germany) ...
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
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In Molecular Cancer, 2004
In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells.
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In PLoS ONE, 2003
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
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In Journal of Experimental & Clinical Cancer Research : CR, 2003
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
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In British Journal of Cancer, 2003
Activation of Gαi3 triggers cell migration via regulation of GIV
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In The Journal of Cell Biology, 2003
... Rabbit IgG against phospho-Akt (serine 473) was purchased from Cell Signaling Technology, and mAb against ...
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
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In Molecular Cancer, 2003
Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells.
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In PLoS ONE, 2003
Chondroitin sulfate proteoglycans of bovine cornea: structural characterization and assessment for the adherence of Plasmodium falciparum-infected erythrocytes
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In BMC Biochemistry, 2003
... Rabbit polyclonal antibodies for phospho- and total- VEGFR-2, and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
Persistent activation of the Akt pathwayin head and neck squamous cell carcinoma: a potential target for UCN-01
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In Medicina Oral, Patología Oral y Cirugía Bucal, 2003
... (H-81 – Sc:15396; Santa Cruz Biotechnology, CA, USA), dilution 1:100, incubated at 4°C overnight, and anti-p-Akt 1 ⁄ 2 ⁄ 3 (Thr 308 – Sc:16646-R; Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Role of endoplasmic reticulum calcium content in prostate cancer cell growth regulation by IGF and TNFalpha
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In International Journal of Biological Sciences, 2003
... Anti-cyclin D1 and phosphorylated Akt substrate motif specific antibodies were purchased form Cell Signaling Technology, Danvers, MA ...
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.
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In Molecular Vision, 2003
Phase II study of Celecoxib and Trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab based treatments
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In Breast Cancer Research, 2003
The serine/threonine kinase Akt promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase
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In PLoS Pathogens, 2003
... Actin, phosphotyrosine, and Akt antibodies were from Santa Cruz Biotechnology (Santa Cruz, California, United ...
Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis
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In International Journal of Cell Biology, 2003
... Antibodies for immunodetection were from the following companies: caveolin-1 (Sigma, Mo, USA; C4490), Akt (Abcam (Cambridge, UK); ab28422), phospho-Akt ...
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
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In The Journal of Cell Biology, 2002
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
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In The Journal of Cell Biology, 2002
A random variance model for detection of differential gene expression in small microarray experiments
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In Breast Cancer Research : BCR, 2002
Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine
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In PLoS ONE, 2002
... Akt inhibitor III (SH-6) and LY294002 were purchased from Calbiochem; PI-103 was from BioVision and NU7441 from Tocris ...
Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells
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In Respiratory Research, 2002
Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines.
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In PLoS ONE, 2002
... Germany), anti-caspase-3 cleaved, anti-caspase-3, anti-caspase-9 cleaved, anti-caspase-9, anti-caspase-8 cleaved, anti-caspase-8, anti-PARP cleaved, anti-PARP, anti-FADD, anti-Akt-S473, anti-Akt (Cell Signaling, Frankfurt a.M., Germany), anti-β-actin ...
Adherence to a Mediterranean diet and survival in a Greek population
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In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.
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In PLoS ONE, 2002
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
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In Arthritis Research & Therapy, 2002
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells
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In Journal of Cellular Physiology, 2001
Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst
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In Journal of Biomedical Science, 2001
A role for the myoglobin redox cycle in the induction of endothelial cell apoptosis
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In Korean Journal of Anesthesiology, 2001
... Anti-p-Akt antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility
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In Oncogene, 2001
... Antibodies against p44/p42 ERK 1/2 (phosphospecific and total) and Akt (phosphospecific and total) were purchased from Cell Signaling (Beverly, MA) ...
Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells
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In The Journal of Experimental Medicine, 2001
... Rabbit anti-phospho-Akt (Ser472/473/474) was from BD Biosciences.
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
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In Oxidative Medicine and Cellular Longevity, 2001
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
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In The Journal of Cell Biology, 2001
Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
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In Breast Cancer Research : BCR, 2001
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
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In The Journal of Cell Biology, 2001
... antibody phosphospecific Akt (Thr308) antibody, phosphospecific Akt (Ser473) antibody, and Akt antibody were obtained from New England Biolabs, Inc ...
Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation
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In Journal of Cell Communication and Signaling, 2001
... The polyclonal antibodies against AKT and phosphorylated-AKT were purchased from Cell Signaling (Danvers, MA) ...
In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways
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In OncoTargets and therapy, 2001
... ), anti-Akt, anti-rabbit IgG, and anti-mouse IgG antibodies were provided by Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
ABC transporters as phenotypic markers and functional regulators of stem cells.
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In PLoS ONE, 2001
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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In PLoS ONE, 2000
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate
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In BMC Cancer, 2000
Electrostatics of nanosystems: Application to microtubules and the ribosome
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In PLoS Biology, 2000
Ten years of protein kinase B signalling: a hard Akt to follow
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In Purinergic Signalling, 2000
... origin, recommended for the detection of Ser 473 phosphorylated Akt 1 and corresponding phosphorylated Akt 2 and Akt 3 (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, ...
Covalently conjugated VEGF—fibrin matrices for endothelialization
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In The Journal of Cell Biology, 2000
Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell
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In The Journal of Cell Biology, 1999
The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2
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In The Journal of Experimental Medicine, 1999
... the phosphorylation state-specific antibodies phospho-p44/42 MAP kinase [T202/Y204] against ERK1 and 2 and phospho-Akt [Ser473] against PKB/Akt (New England Biolabs); anti-ERK2 (C-14) and anti-Akt1/2 ...
Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells
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In BMC Neuroscience, 1999
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
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In The Journal of Cell Biology, 1999
Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.
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In PLoS ONE, 1999
... For Western blotting experiments, anti-GAPDH, anti-PI3K, anti-HSC70 were obtained from Santa Cruz Biotechnology (CA, USA), anti-phospho-Akt from Upstate (Milipore, Molsheim, France), anti-Akt, and ...
Role of the pleckstrin homology domain of PLCγ1 in its interaction with the insulin receptor
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In The Journal of Cell Biology, 1999
The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells
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In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
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In Nutrition Research and Practice, 1998
Cytolytic T lymphocyte-associated antigen-4 and the TcRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
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In PLoS ONE, 1998
... and anti-phospho-BAD (Ser-136) mAbs from Biosource (Nivelles, Belgium), anti-AKT1/2 from Autogen Bioclear (Wiltshire, UK), anti-phospho AKT (Thr-308) from New England Biolabs (Hertfordshire, UK), anti-BcL-XL from ...
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding.
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In Environmental Health Perspectives, 1998
... (EGFR), erbB2, phosphorylatederbB3, phosphorylatederbB3, insulin-like growth factor 1 receptor (IGF-1R), phosphorylated-IGF-1R, phosphorylated-Bad, PI3K, PTEN, Akt 1, Akt 3, phosphorylatedAkt, glycogen synthase kinase-3-beta (GSK-3β), and phosphorylatedGSK-3β were purchased from Cell Signaling Technologies (Danvers, MA) ...
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression
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In British Journal of Cancer, 1998
... Anti-phosphospecific-PKB Ser473 and GSK3β Ser-9 were obtained from New England Biolabs Inc ...
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
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In The Journal of Cell Biology, 1998
... Antibodies against ERK1/2, phosphorylated JNK1/2 (Thr183/Tyr185), JNK1/2, and Ser473 phospho-Akt were purchased from Cell Signaling Technology (New England Biolabs, ...
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
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In Journal of Cell Science, 1998
... Tokyo, Japan), Ki-67 (Novocastra Laboratories, Newcastle upon Tyne, UK), JAM-A (R&D Systems), Akt, and phosphorylated Akt (Cell Signaling Technology) ...
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
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In The Journal of Cell Biology, 1998
Analysis of gene expression in single oocytes and embryos by real-time rapid cycle fluorescence monitored RT-PCR.
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In PLoS ONE, 1998
An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
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In The Journal of Cell Biology, 1998
... Rabbit polyclonal antibody to Akt and phosphospecific antibody for Akt Serine-473 were from New England Biolabs, Inc., and a rabbit polyclonal ...
Regulation of Ras–MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells
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In The Journal of Cell Biology, 1998
Bcl-2 inhibits early apoptotic events and reveals post-mitotic multinucleation without affecting cell cycle arrest in human epithelial tumor cells exposed to etoposide
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In Journal of Biomedical Science, 1998
... The antibodies for Western blotting, p-PI3K, PI3K, p-Akt, and Akt were purchased from Cell Signaling (Beverly, MA) ...
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
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In Oncogene, 1997
Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
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In Diabetes, 1997
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
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In The Journal of Cell Biology, 1997
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
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In The Journal of Cell Biology, 1997
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation
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In The Journal of Cell Biology, 1997
... The transferrin receptor, phospho-PKB (Ser473), and HA epitope tag antibodies were obtained from Leinco Technologies, Cell Signaling Technology, and ...
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
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In The Journal of Biological Chemistry, 1997
An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients
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In The Journal of Cell Biology, 1997
Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IkappaB-beta, and sequestration of protein phosphatase 2A by the viral phosphoprotein
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In BMC Microbiology, 1997
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
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In The Journal of Cell Biology, 1997
... L-α-LPA, oleoyl (C18:1,[cis]-9), anti-myc, anti–β-actin, and anti-Flag were purchased from Sigma-Aldrich; anti-Akt, anti-pSer473Akt, and anti-pThr308 from Santa Cruz Biotechnology, Inc.; anti-HA from Boehringer; ...
Protein kinase B (c-Akt)a multifunctional mediator of phosphatidylinositol 3-kinase activation
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In The Journal of Experimental Medicine, 1997
... Biotechnology, Inc.); rabbit anti–Grb2-associated binder 1 (Gab1; Upstate Biotechnology); rabbit anti–stromal cell–derived factor (SDF)-1α (PeproTech); rabbit anti-Akt (H-136; Santa Cruz Biotechnology, Inc.); phospho-specific rabbit anti-Akt ...
Effects of transforming growth factor-beta and platelet-derived growth factor on oligodendrocyte precursors: insights gained from a neuronal cell line.
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In PLoS ONE, 1996
... Rabbit polyclonal antibodies against pERK, ERK, pAkt and Akt were from Cell Signaling.
Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
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In The Journal of Experimental Medicine, 1996
... Rabbit anti–phospho-Akt (Ser472/473/474) was from BD Biosciences.
Misexpression of chick Vg1 in the marginal zone induces primitive streak formation
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In Neural Development, 1996
Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway
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In The Journal of Cell Biology, 1996
... Antibodies against c-Src and pTyr418-Src were obtained from Cell Signaling Technology and Millipore, anti-Rac was obtained from BD Biosciences, and anti–lysobisphosphatidic acid antibody ...
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
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In Journal of Experimental & Clinical Cancer Research : CR, 1995
Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices
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In Molecular Pain, 1995
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
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In The Journal of Cell Biology, 1995
... The serine 473 phosphospecific PKB antibody was purchased from New England Biolabs ...
Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways
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In The Journal of Cell Biology, 1995
The stress activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
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In British Journal of Cancer, 1995
... and anti-AKT antibodies were from New England Biolabs (Schwalbach/Taunus, Germany) ...
VMD: visual molecular dynamics
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In PLoS Biology, 1995
... Okadaic acid sodium salt and AKT inhibitor VIII were from Calbiochem (Merck KGaA) ...
Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons
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In The Journal of Cell Biology, 1994
... Akt/PKBα cDNA was cloned from the human kidney cDNA library (CLONTECH Laboratories, Inc.), and NH ...
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
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In PLoS ONE, 1994
... Rabbit anti-human Phospho-AktCell Signaling Technology ...
Integrin transmembrane signaling and cytoskeletal control
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In The Journal of Cell Biology, 1994
... kinase antibody and p44/42 MAP kinase assay kits, as well as polyclonal anti-phospho-MEK1, anti-phospho-Akt, and anti-Akt were purchased from New England BioLabs, Inc ...
Integrin-dependent activation of MAP kinasea link to shape-dependent cell proliferation
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In The Journal of Cell Biology, 1994
... Anti-Akt/PKB and anti–phospho-Akt/PKB antibodies were from New England Biolabs, Inc ...
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
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In PLoS ONE, 1993
... Mouse monoclonal antibody against GAPDH and rabbit polyclonal anti-human Akt were purchased from Santa Cruz Biotechnology Inc ...
Safety of esmolol in patients with acute myocardial infarction treated with thrombolytic therapy who had relative contraindications to beta-blocker therapy
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In Cardiovascular Drugs and Therapy, 1993
... Dilution for anti-pAkt and anti-Akt (Santa Cruz Biotechnology, Santa Cruz, CA) was ...
Requirement of dendritic Akt degradation by the ubiquitin–proteasome system for neuronal polarity
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In The Journal of Cell Biology, 1993
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402
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In The EMBO Journal, 1992
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
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In PLoS ONE, 1992
The identification and characterization of an actin-binding site in α-actinin by mutagenesis.
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In PLoS ONE, 1991
... Immunoblots for ICAM-2, α-actinin, ezrin, actin, AKT, and phospho-AKT were done with AF244 (R&D Systems, Minneapolis, MN) and C-20 (Santa Cruz Biotechnologies, Beverly, MA), CBL231 (Research Diagnostics, Inc., Flanders, NJ), C-20 ...
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
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In The Journal of Cell Biology, 1989
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
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In PLoS ONE, 1987
... (pY397) (BD Biosciences), rabbit anti-human p-GSK3β (Ser9), anti-human total GSK3β, anti-human p-Akt (Ser473), anti-human total Akt (Cell Signaling), and anti-human actin serum ...
Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer
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In BMC Molecular Biology, 1984
... Antibodies to Akt and phosphor-Akt were purchased from Cell Signaling Technology, Inc ...
Temperature-dependent physiological stability of rat skeletal muscle in vitro.
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In PLoS ONE, 1984
Developments of a water-maze procedure for studying spatial learning in the rat.
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In PLoS ONE, 1983
Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
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In PLoS ONE, 1982
... rabbit polyclonal IgG antibodies against phospho-p44/42 mitogen-activated protein kinase (MAPK), p44/42 MAPK, phospho-Akt HM(S473), and Akt HM(S473) were purchased from Cell Signaling Technology (Beverly, MA, US) ...
Insulin resistance in adipocytes from fed and fasted obese rats: Dissociation of two insulin actions.
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In PLoS ONE, 1980
Evidence that vascular endothelial cells can induce the retraction of fibrin clots.
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In PLoS ONE, 1980
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
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In The Journal of Cell Biology, 1979
... Phosphorylated Akt (ser473) antibody was from Cell Signaling and antibody against total ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
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In PLoS ONE, 1975
... beads from BioRad; Wortmannin, LY294002 and zymosan from ICN Biomedical Inc.; anti-phospho Akt and total Akt from New England Biolabs; genistein, protease inhibitor cocktail ...
