Translational control by oncogenic signaling pathways.
Montréal, Canada. In Biochim Biophys Acta, 01 Jan 2015
The phosphoinositide 3-kinase (PI3K)/Akt and Ras/mitogen-activated protein kinase (MAPK) pathways are strongly implicated in cancer etiology, and they exert their biological effects by modulating both global and specific mRNA translation.
Biomarker Analyses in CLEOPATRA: A Phase III, Placebo-Controlled Study of Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive, First-Line Metastatic Breast Cancer.
Barcelona, Spain. In J Clin Oncol, 20 Dec 2014
PATIENTS AND METHODS: Mandatory tumor and serum samples were collected (N = 808; 58% to 99.8% were assessable), and amphiregulin, betacellulin, epidermal growth factor (EGF), transforming growth factor alpha, EGF receptor, HER2, HER3, insulin-like growth factor 1 receptor, PTEN, phosphorylated AKT, PIK3CA, CMYC, serum HER2 extracellular domain (sHER2), and FCγR were assessed using appropriate assays.
PINK1 signaling in cancer biology.
Cork, Ireland. In Biochim Biophys Acta, 23 Nov 2014
Mechanistically, PINK1 has been shown to interact on a number of levels with the pivotal oncogenic PI3-kinase/Akt/mTOR signalling axis and to control critical mitochondrial and metabolic functions that regulate cancer survival, growth, stress resistance and the cell cycle.
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
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Nijmegen, Netherlands. In Science, Oct 2014
Trained monocytes display high glucose consumption, high lactate production, and a high ratio of nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH), reflecting a shift in metabolism with an increase in glycolysis dependent on the activation of mammalian target of rapamycin (mTOR) through a dectin-1-Akt-HIF-1α (hypoxia-inducible factor-1α) pathway.
The PKB/AKT pathway in cancer.
In PLoS ONE, 2009
... NCL-c-erbB-3); HER4 (clone sc-283), 1∶500 (Santa Cruz, ErbB-4); Akt1 (clone 2H10), 1∶500 (Cell Signaling, 2967); phospho-Akt (pAkt, Ser473), 1∶75 (Cell Signaling, 4051); PTEN (clone 28H6), ... EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
In Blood Cancer Journal, 2009
... NY, USA), phospho-ALK-Y1604 (recognizes Y664 on NPM–ALK), phospho-p38-T180/Y182, p38, phospho-Erk1/2- T202/Y204, Erk1/2, phospho-STAT3-Y705, STAT3, phospho-Akt-S473, Akt were all from Cell Signaling Technologies (Beverly, MA, USA) ... FRET and mechanobiology.
In PLoS ONE, 2008
... A specific inhibitor of Rac GTPase, N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride (NSC23766), from Tocris Bioscience (Ellisville, Missouri), was ... A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
In PLoS ONE, 2008
... CA), anti-Ras (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Rab5 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-AKT (Cell Signaling Technology, Danvers, MA), anti-AKT-p473 ... A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
In PLoS ONE, 2008
... monoclonal c-myc (9E10; WB 1∶1,000; IF 1∶500; immunoprecipitation [IP] 1∶200; Abcam, Cambridge, UK), rabbit polyclonal phospho-Akt (serine 473; #9271; WB 1∶1,000; Cell Signaling Technology, Danvers, MA, USA), ... Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
In PLoS ONE, 2008
... AMPKα, phospho-AMPKα, acetyl CoA carboxylase, phospho-acetyl CoA carboxylase, raptor, phospho-eIF2α, acetylated lysine, acetylated-p53, AKT, and phospho-AKT were purchased from Cell Signaling Technology (Danvers, MA, USA.) ... Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
In Carcinogenesis, 2007
... p-IκBα, IKKα/β, p65, p50, p-ERK, p-p38, p-JNK, p-Akt, ERK, p38, c-Jun N-terminal kinase (JNK) and Akt were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ... Necrotic death as a cell fate.
In PLoS ONE, 2005
... Antibodies against p-ERK, FOXO3a, p-FOXO3a (Thr32), p-FOXO3a (Ser253), Bad, PARP, NOXA and PUMA, and the AKT kinase assay kit were purchased from Cell Signaling Technology (Danvers, MA) ... Tumor necrosis factor inhibitors for rheumatoid arthritis
In Journal of Bone and Mineral Research, 2005
... Antibodies to phosphorylated and total Pyk2, Src, paxillin, Cbl, Erk1/2, JNK, p38 MAPK, Akt, and IκBα were from Cell Signaling Technology (Danvers, MA, USA), ... Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.
In PLoS ONE, 2004
... PEBP2aA) antibody, anti-extracellular signal-regulated kinase (ERK), p-ERK, p-p38, p38, c-jun N-terminal kinase (JNK), p-JNK, Akt, p-Akt antibody, anti-mouse, and rabbit IgG peroxidase conjugate antibodies were purchased from Santa Cruz Biotechnology Inc (Waltham, MA, USA) ... Cellular targets of gefitinib.
In PLoS ONE, 2004
... Signaling Technology, #2971), total mTOR (Cell Signaling Technology, #2983), phospho-P70S6K (T389) (Cell Signaling Technology, #9234), phospho-AKT (S473) (Cell Signaling Technology, #4051), total AKT ... Persistent activation of the Akt pathwayin head and neck squamous cell carcinoma: a potential target for UCN-01
In Medicina Oral, Patología Oral y Cirugía Bucal, 2003
... (H-81 – Sc:15396; Santa Cruz Biotechnology, CA, USA), dilution 1:100, incubated at 4°C overnight, and anti-p-Akt 1 ⁄ 2 ⁄ 3 (Thr 308 – Sc:16646-R; Santa Cruz Biotechnology, Santa Cruz, CA, USA), ... In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells.
In PLoS ONE, 2003
... p38, JNK, Akt, Src, PLCγ1, phospho-Src (Tyr416 and 527), phospho-Paxillin (Tyr118), phospho-Erk1/2, phospho-JNK, phospho-p38 and phospho-Akt (Ser473) were from Cell Signaling Technology (Danvers, MA, USA) ... Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines.
In PLoS ONE, 2002
... Germany), anti-caspase-3 cleaved, anti-caspase-3, anti-caspase-9 cleaved, anti-caspase-9, anti-caspase-8 cleaved, anti-caspase-8, anti-PARP cleaved, anti-PARP, anti-FADD, anti-Akt-S473, anti-Akt (Cell Signaling, Frankfurt a.M., Germany), anti-β-actin ... Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
In Breast Cancer Research : BCR, 2001
... A/C (1:1,000), pEGFR (phosphorylated EGFR) (1:1,000), extracellular signal-regulated kinase (ERK) (1:1,000), phosphorylated ERK (pERK) (1:1,000), AKT (1:2,000), and pAKT (1:1,000) (Cell Signaling Technology, Inc., Danvers, MA, ... VEGF receptor signal transduction.
In PLoS ONE, 2000
... Tyr 1175, Cell Signaling #2478S; Tyr 1214, Upstate 07-374); rabbit anti-VEGFR2 (Cell Signaling #2479); rabbit anti-phospho-Akt (Ser 473, Cell Signaling #9271S); rabbit anti-Akt (Cell ... Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells
In BMC Neuroscience, 1999
... Louis, MO, USA), rabbit anti-phospho-Akt (Ser473), rabbit anti-phospho-Akt (Thr308), rabbit anti-phospho-GSK-3β (Ser9), rabbit anti-Akt and rabbit anti-GSK-3β (Cell Signaling Technology, MA, USA), mouse ... Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.
In PLoS ONE, 1999
... For Western blotting experiments, anti-GAPDH, anti-PI3K, anti-HSC70 were obtained from Santa Cruz Biotechnology (CA, USA), anti-phospho-Akt from Upstate (Milipore, Molsheim, France), anti-Akt, and ... Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding.
In Environmental Health Perspectives, 1998
... (EGFR), erbB2, phosphorylatederbB3, phosphorylatederbB3, insulin-like growth factor 1 receptor (IGF-1R), phosphorylated-IGF-1R, phosphorylated-Bad, PI3K, PTEN, Akt 1, Akt 3, phosphorylatedAkt, glycogen synthase kinase-3-beta (GSK-3β), and phosphorylatedGSK-3β were purchased from Cell Signaling Technologies (Danvers, MA) ... Thyroid tumorigenesis
In British Journal of Cancer, 1993
... Fremont, CA, USA); anti-Phospho-p44/42 MAPK Thr202/Tyr204 monoclonal rabbit antibody (20G11, Cell Signalling, Danvers, MA, USA), anti-Phospho-Akt Ser473 monoclonal rabbit monoclonal antibody (736E11, Cell Signaling). The identification and characterization of an actin-binding site in α-actinin by mutagenesis.
In PLoS ONE, 1991
... Immunoblots for ICAM-2, α-actinin, ezrin, actin, AKT, and phospho-AKT were done with AF244 (R&D Systems, Minneapolis, MN) and C-20 (Santa Cruz Biotechnologies, Beverly, MA), CBL231 (Research Diagnostics, Inc., Flanders, NJ), C-20 ...