In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Guangzhou, China. In Chem Biol Interact, Nov 2015
Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases.
Steroidogenesis of the testis -- new genes and pathways.
Bern, Switzerland. In Ann Endocrinol (paris), 2014
However, recently found mutations in AKR1C2/4 genes in undervirilized 46,XY individuals have established a role for a novel, alternative, backdoor pathway for fetal testicular DHT synthesis.
AKR1C3 as a target in castrate resistant prostate cancer.
Philadelphia, United States. In J Steroid Biochem Mol Biol, 2013
Selective inhibition of AKR1C3 will be important, however, due to the presence of closely related isoforms, AKR1C1 and AKR1C2 that are also involved in androgen inactivation.