Impaired structural and functional regeneration of skeletal muscles from β2-adrenoceptor knockout mice.
São Paulo, Brazil. In Acta Physiol (oxf), 2014
Furthermore, there was an increase in inflammation and in the number of macrophages in regenerating muscles lacking the β2-adrenoceptor at 3 and 10 days, a predominance of M1 macrophage phenotype, a decrease in TβR-I/Smad2/3 activation, and in the Smad4 expression at 3 days, while akirin1 expression increased at 10 days in muscles from β2 KO mice when compared to those from wild type.
Evolution of the multifaceted eukaryotic akirin gene family.
Saint Andrews, United Kingdom. In Bmc Evol Biol, 2008
Using comprehensive phylogenetic analysis, coupled with comparisons of conserved synteny and genomic organisation, we show that the intron-exon structure of metazoan akirin genes was established prior to the bilateria and that a single proto-orthologue duplicated in the vertebrates, before the gnathostome-agnathan separation, producing akirin1 and akirin2.