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Akap7 A kinase (PRKA) anchor protein 7

AKAP15, AKAP18, A-kinase anchoring protein 18
member of the A-kinase anchoring protein (AKAP) family; binds to the regulatory subunit (RII) of cAMP-dependent protein kinase A [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, Cav1.2, ACID, CAN, CD36
Papers on AKAP15
Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
New
Manganiello et al., Lund, Sweden. In J Biol Chem, Apr 2015
Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for these inotropic effects and that murine PDE3A1 associates with sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2), phospholamban (PLB), and AKAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).
Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150.
Catterall et al., Seattle, United States. In J Gen Physiol, 2014
PKA up-regulation of CaV1.2 activity can be reconstituted in a transfected cell system expressing CaV1.2Δ1800 truncated at the in vivo proteolytic processing site, the distal C-terminal domain (DCT; CaV1.2[1801-2122]), the auxiliary α2δ and β subunits of CaV1.2 channels, and A-kinase anchoring protein-15 (AKAP15), which binds to a site in the DCT.
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection.
Scott et al., Seattle, United States. In J Biol Chem, 2013
Biochemical and cell-based experiments validated the efficacy of RSelect proteins for AKAP2 and AKAP18.
Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Pohl et al., Linz, Austria. In J Biol Chem, 2013
The AKAP18 family comprises AKAP18α, AKAP18β, AKAP18γ, and AKAP18δ.
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
McKnight et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2012
It has been suggested that the short and long isoforms of AKAP7 (also called AKAP15/18) localize PKA in complexes with Ca(V)1.2 and PLN, respectively.
Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms.
GeneRIF
Dodge-Kafka et al., Farmington, United States. In Biochem J, 2012
Data from studies using recombinant proteins suggest that both AKAP7-gamma and AKAP7-alpha exhibit high-affinity interactions with isoenzymes of PKC (protein kinase C); AKAP7 could dictate PKC localization/function.
Molecular evolution of A-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization.
Danziger et al., Chicago, United States. In Bmc Evol Biol, 2011
Splice variants from the AKAP7 gene (AKAP15/18) are vital components of neuronal and cardiac phosphatase complexes, ion channels, cardiac Ca2+ handling and renal water transport.
AKAP phosphatase complexes in the heart.
Review
Dodge-Kafka et al., Farmington, United States. In J Cardiovasc Pharmacol, 2011
The focus of this review is on the emerging role of AKAPs in regulating the 3 main cardiac phosphatases: Protein Phosphatase 1 by AKAP18 and Yotiao, and Protein Phosphatases 2A and 2B by muscle specific A-kinase anchoring protein.
AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
Shapiro et al., San Antonio, United States. In J Neurosci, 2011
Transfection of AKAP79, but not ΔA-AKAP79 or AKAP15, rescued suppression of I(M) by muscarinic receptors in AKAP150(-/-) neurons.
Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.
GeneRIF
Catterall et al., Seattle, United States. In J Biol Chem, 2011
CaV1.2 channels in DCT-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced
Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.
GeneRIF
Catterall et al., Seattle, United States. In J Biol Chem, 2011
AKAP15 co-immunoprecipitates with CaV1.2 and CaV1.3 channels. AKAP15 has overlapping localization with CaV1.2 and CaV1.3 channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 channels in punctate clusters.
The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.
Dodge-Kafka et al., Farmington, United States. In Mol Pharmacol, 2011
We now report that the formation of a signaling complex containing PKA and I-1 by the A-kinase anchoring protein 18 (AKAP18) facilitates this regulation in cells.
AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells.
GeneRIF
Nielsen et al., Copenhagen, Denmark. In Febs Lett, 2010
The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.
Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
GeneRIF
Abel et al., Chicago, United States. In Sleep, 2010
Alterations in cortical synaptic receptors, impairments in sleep continuity, and alterations in sleep oscillations in R(AB) mice imply that PKA is involved not only in synaptic plasticity and memory storage but also in the regulation of sleep/wake states.
Molecular mechanism of calcium channel regulation in the fight-or-flight response.
Catterall et al., Seattle, United States. In Sci Signal, 2009
(a form of the channel truncated at the in vivo site of proteolytic processing), its noncovalently associated distal carboxyl-terminal domain, the auxiliary α₂δ₁ and β(2b) subunits, and A-kinase anchoring protein 15 (AKAP15).
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Bond et al., Baltimore, United States. In J Biol Chem, 2008
Coimmunoprecipitation showed that more AKAP15/18 was pulled down by the phosphomimic, RIIS96D, than RIIS96A.
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
Review
Klussmann et al., Berlin, Germany. In Eur J Cell Biol, 2006
Here, AKAP18 isoforms and members of the PDE4 family of PDEs are shown to be differentially localised in renal principal cells.
Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Review
Rosenthal et al., Berlin, Germany. In Kidney Int, 2001
One potential candidate is a new splice variant of AKAP18, namely AKAP18 delta.
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