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Adenylate kinase 5
AK5, adenylate kinase 5, adenylate kinase isoenzyme 5
This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
ACID, HAD, Adenylate Kinase, Sox, Homer
Papers on
AK5
Purine metabolism gene deregulation in Parkinson's disease.
New
Barcelona, Spain. In Neuropathol Appl Neurobiol, Dec 2015
METHODS: Analysis of mRNA using real-time quantitative PCR of 22 genes involved in purine metabolism in the substantia nigra, putamen and cerebral cortex area 8 in PD at different stages of disease progression, and localization of selected purine metabolism-related enzymes with immunohistochemistry. RESULTS: Reduced expression of adenylate kinase 2 (AKA2), AK3, AK4, adenine phosphoribosyltransferase, ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), ENTPD3, nonmetastatic cells 3, nucleoside-diphosphatese kinase 3 (NME1), NME7 and purine nucleoside phosphorylase 1 (PNP1) mRNA in the substantia nigra at stages 3-6; up-regulation of ADA mRNA in the frontal cortex area 8 at stages 3-4 and of AK1, AK5, NME4, NME5, NME6, 5'-nucleotidase (NT5E), PNP1 and prune homolog Drosophila at stages 5-6.
Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis.
New
San Francisco, United States. In J Neuroimmunol, Nov 2015
Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain.
Deregulation of purine metabolism in Alzheimer's disease.
l'Hospitalet de Llobregat, Spain. In Neurobiol Aging, 2015
APRT, DGUOK, POLR3B, ENTPD3, AK5, NME1, NME3, NME5, NME7, and ENTPD2 messenger RNAs were deregulated, with regional variations, in AD cases when compared with controls.
Next-generation sequencing, FISH mapping and synteny-based modeling reveal mechanisms of decreasing dysploidy in Cucumis.
Madison, United States. In Plant J, 2014
The 12 inferred chromosomes (AK1-AK12) of an ancestor similar to melon and C. hystrix had strikingly different evolutionary fates, with cucumber chromosome C1 apparently resulting from insertion of chromosome AK12 into the centromeric region of translocated AK2/AK8, cucumber chromosome C3 originating from a Robertsonian-like translocation between AK4 and AK6, and cucumber chromosome C5 originating from fusion of AK9 and AK10.
The organization of naphthalene degradation genes in Pseudomonas putida strain AK5.
Moscow, Russia. In Res Microbiol, 2013
The Pseudomonas putida АК5 that was isolated from the slime pit of a Nizhnekamsk oil chemical factory can metabolize naphthalene via salicylate and gentisate.
Aliidiomarina haloalkalitolerans sp. nov., a marine bacterium isolated from coastal surface seawater.
Cochin, India. In Antonie Van Leeuwenhoek, 2012
A novel Gram-negative, rod shaped, motile, non-sporing strictly aerobic bacterium, designated strain AK5(T), was isolated from a sea water sample collected near Visakhapatnam coast, Bay of Bengal, India.
Antineuronal autoantibodies in neurological disorders.
In Biomol Concepts, 2011
Autoantibodies (abs) related to neurological disease are currently classified into two large groups depending on the site of the respective target antigen: Group I encompasses abs that recognise intracellular antigens (Hu, Yo, Ri, CV2/CRMP5, amphiphysin, Ma2, SOX, ZIC, GAD, adenylate kinase 5, homer 3), whereas group II abs are targeted against neuronal cell membrane antigens (VGKC, AMPA-R, GABAB-R, NMDA-R, Glycine-R, VGCC, metabotropic GluR1).
The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes.
Huddinge, Sweden. In Biochem J, 2011
AK8 is the second known human AK with two complete and active AK domains within its polypeptide chain, a feature that has previously been shown for AK5.
Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation.
Rochester, United States. In Plos One, 2010
The cardiogenic growth factor TGF-β promoted AK1 expression, while knockdown of AK1, AK2 and AK5 activities with siRNA or suppression by hyperglycemia disrupted cardiogenesis compromising mitochondrial and myofibrillar network formation and contractile performance.
Antibodies and neuronal autoimmune disorders of the CNS.
Review
Barcelona, Spain. In J Neurol, 2010
Antibodies in group Ic (glutamic acid decarboxylase (GAD), adenylate kinase 5 and Homer 3) identify non-PNS: stiff-person syndrome (SPS), cerebellar ataxia, and limbic encephalitis (LE).
Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration.
Winston-Salem, United States. In Mol Psychiatry, 2010
Increased levels of proteins in the cocaine-exposed monkeys include glial fibrillary acidic protein, syntaxin-binding protein 3, protein kinase C isoform, adenylate kinase isoenzyme 5 and mitochondrial-related proteins, whereas decreased levels of proteins included beta-soluble N-ethylmaleimide-sensitive factor attachment protein and neural and non-neural enolase.
Identification of two active functional domains of human adenylate kinase 5.
GeneRIF
Huddinge, Sweden. In Febs Lett, 2009
Data demonstrate that human adenylate kinase 5 has two separate functional domains and that both have enzymatic activity.
Protein profiling of human endometrial tissues in the midsecretory and proliferative phases of the menstrual cycle.
Mumbai, India. In Fertil Steril, 2009
RESULT(S): Densitometry analysis and subsequent MALDI-TOF-TOF analysis revealed up-regulation of calreticulin, the beta chain of fibrinogen, adenylate kinase isoenzyme 5, and transferrin in the PROE and of annexin V, alpha1-antitrypsin, creatine kinase, and peroxidoxin 6 in MSE compared with the other phase.
2-D PAGE-based comparison of proteasome inhibitor bortezomib in sensitive and resistant mantle cell lymphoma.
München, Germany. In Electrophoresis, 2009
All cell lines exhibited alterations of the cellular protein levels of heat shock-induced protein species (HSPA9, HSP7C, HSPA5, HSPD1), whereas sensitive cell lines also displayed altered cellular protein levels of energy metabolism (ATP5B, AK5, TPI1, ENO-1, ALDOC, GAPDH), RNA and transcriptional regulation (HNRPL, SFRS12) and cell division (NEBL, ACTB, SMC1A, C20orf23) as well as tumor suppressor genes (ENO-1, FH).
Dynamics of nucleotide metabolism as a supporter of life phenomena.
Review
Tokushima, Japan. In J Med Invest, 2005
So far, six AK isozymes, AK1, AK2, AK3, AK4, AK5, and AK6, were identified.
