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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Autoimmune regulator

AIRE, PGA1, APECED, APS I
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Aps, ACID, AGE
Papers using AIRE antibodies
AIRE Functions As an E3 Ubiquitin Ligase
Supplier
Matsumoto Mitsuru et al., In The Journal of Experimental Medicine, 2002
... Human AIRE cDNA was amplified by PCR from Marathon-Ready human thymus cDNA (CLONTECH Laboratories, Inc.) ...
Papers on AIRE
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
New
Kassie et al., Richmond, United States. In Mol Carcinog, Feb 2016
The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6).
Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.
New
Babich et al., New York City, United States. In Ann N Y Acad Sci, Feb 2016
We focus on prostaglandin J2 (PGJ2) because it is highly neurotoxic compared to PGA1, D2, and E2.
Sonic Hedgehog regulates thymic epithelial cell differentiation.
New
Crompton et al., London, United Kingdom. In J Autoimmun, Feb 2016
Neutralisation of endogenous Hh proteins in WT FTOC led to a reduction in TEC numbers, and in the proportion of mature Aire-expressing medullary TEC, but an increase in cell surface expression of MHC Class II molecules on medullary TEC.
AIRE: From promiscuous molecular partnerships to promiscuous gene expression.
Review
New
Goldfarb et al., Israel. In Eur J Immunol, Jan 2016
Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immunological self-tolerance.
Aire-Overexpressing Dendritic Cells Induce Peripheral CD4⁺ T Cell Tolerance.
New
Yang et al., Changchun, China. In Int J Mol Sci, Dec 2015
Autoimmune regulator (Aire) can promote the ectopic expression of peripheral tissue-restricted antigens (TRAs) in thymic medullary epithelial cells (mTECs), which leads to the deletion of autoreactive T cells and consequently prevents autoimmune diseases.
A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice.
Review
New
Peterson et al., Tartu, Estonia. In Eur J Immunol, Dec 2015
Autoimmune regulator (Aire) has a unique expression pattern in thymic medullary epithelial cells (mTECs), in which it plays a critical role in the activation of tissue-specific antigens.
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
New
Impact
Takayanagi et al., Tokyo, Japan. In Cell, Dec 2015
The transcriptional regulator Aire has been thought to be sufficient for the induction of TRAs, despite some indications that other factors may promote TRA expression in the thymus.
Central tolerance to self revealed by the autoimmune regulator.
Review
New
Anderson et al., San Francisco, United States. In Ann N Y Acad Sci, Nov 2015
The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity.
Aire controls gene expression in the thymic epithelium with ordered stochasticity.
New
Impact
Benoist et al., Boston, United States. In Nat Immunol, Sep 2015
The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery.
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
New
Impact
Coulombe et al., Baltimore, United States. In Nat Genet, Aug 2015
We report that autoimmune regulator (Aire), a transcriptional regulator, is inducibly expressed in human and mouse tumor keratinocytes in a K17-dependent manner and is required for timely onset of Gli2-induced skin tumorigenesis in mice.
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.
New
Impact
Klein et al., München, Germany. In Immunity, Jul 2015
Here, we found that Aire is expressed in thymic but not peripheral B cells.
Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.
New
Impact
Husebye et al., Bergen, Norway. In Immunity, Jul 2015
The autoimmune regulator (AIRE) gene is crucial for establishing central immunological tolerance and preventing autoimmunity.
[Autoimmune polyglandular syndrome type 1-like clinical picture of hereditary hemochromatosis].
Okopień et al., In Przegl Lek, 2014
Our report shows that the presence of hemochromatosis should always be taken into consideration in the differential diagnosis of autoimmune polyglandular syndrome type 1, a rare autosomal recessive disorder characterized by autoimmune multiorgan disease secondary to mutations in the autoimmune regulator gene (AIRE), and leading to hypofunction of the adrenal cortex and parathyroid glands.
Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis.
Review
Caspi et al., Guangzhou, China. In Curr Mol Med, 2014
Several spontaneous models of uveitis induced by autoreactive T cells targeting on IRBP have been recently developed in IRBP specific TCR transgenic mice (R161H) and in AIRE(-/-) mice.
The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance.
Review
Oliveira et al., Ribeirão Preto, Brazil. In Front Immunol, 2014
The Aire gene is an important factor that controls the expression of a large set of PTAs.
Autoimmune regulator is acetylated by transcription coactivator CBP/p300.
GeneRIF
Peterson et al., Tartu, Estonia. In Exp Cell Res, 2012
The results suggest that the AIRE acetylation can influence the selection of AIRE activated genes.
AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH.
GeneRIF
Peterson et al., Tartu, Estonia. In Biochem Biophys Res Commun, 2012
AIRE-induced apoptosis pathway is associated with GAPDH nuclear translocation and induction of NO-induced cellular stress in AIRE-expressing cells.
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.
GeneRIF
Pietropaolo et al., Ann Arbor, United States. In J Biol Chem, 2012
polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells.
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.
GeneRIF
Anderson et al., Chapel Hill, United States. In J Immunol, 2012
Mutant Aire-mediated central tolerance to myelin protein zero initiates an autoimmune T helper cell type (Th)1 effector response toward peripheral nerves.
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.
Impact
GeneRIF
Anderson et al., Birmingham, United Kingdom. In Immunity, 2012
demonstrated a Rank-mediated reciprocal link between dendritic epidermal T cell progenitors and Aire(+) medullary thymic epithelial cell maturation
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