Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Richmond, United States. In Mol Carcinog, Feb 2016
The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6).
Sonic Hedgehog regulates thymic epithelial cell differentiation.
London, United Kingdom. In J Autoimmun, Feb 2016
Neutralisation of endogenous Hh proteins in WT FTOC led to a reduction in TEC numbers, and in the proportion of mature Aire-expressing medullary TEC, but an increase in cell surface expression of MHC Class II molecules on medullary TEC.
Central tolerance to self revealed by the autoimmune regulator.
San Francisco, United States. In Ann N Y Acad Sci, Nov 2015
The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity.
[Autoimmune polyglandular syndrome type 1-like clinical picture of hereditary hemochromatosis].
In Przegl Lek, 2014
Our report shows that the presence of hemochromatosis should always be taken into consideration in the differential diagnosis of autoimmune polyglandular syndrome type 1, a rare autosomal recessive disorder characterized by autoimmune multiorgan disease secondary to mutations in the autoimmune regulator gene (AIRE), and leading to hypofunction of the adrenal cortex and parathyroid glands.