Familial pituitary tumors.
London, United Kingdom. In Handb Clin Neurol, 2013
The genetic alterations responsible for the formation of familial pituitary syndromes include the MEN1 gene, responsible for about 80% of MEN1 cases, the regulatory subunit of the protein kinase A, PRKAR1A, responsible for about 70% of Carney complex cases, and AIP, the gene coding the aryl hydrocarbon receptor interacting protein, responsible for about 20% of FIPA cases.
Familial Isolated Pituitary Adenoma
Madagascar. In Unknown Journal, 2012
Of these FIPA families, around 15-20% (3,4) have been identified to have mutations within the aryl hydrocarbon receptor interacting protein (AIP) gene, a tumour suppressor gene located at 11q13.
WWP2 is an E3 ubiquitin ligase for PTEN.
Hyderābād, India. In Nat Cell Biol, 2011
In this study, by using a tandem affinity-purification approach, we have identified WWP2 (also known as atrophin-1-interacting protein 2, AIP-2) as a PTEN-interacting protein.