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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Absent in melanoma 2

AIM2, absent in melanoma 2
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, ASC, IL-18, Ipaf, CAN
Papers on AIM2
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
New
Yang et al., Taiwan. In Dna Cell Biol, Feb 2016
We evaluated NLRP3, NLRC4, AIM2, and ASC inflammasome complex gene expression on real-time polymerase chain reaction (PCR).
ASC provides a potential link between depression and inflammatory disorders: A clinical study of depressed Iranian medical students.
New
Kennedy et al., Rafsanjān, Iran. In Nord J Psychiatry, Feb 2016
UNASSIGNED: Background and aims AIM2 is a component of inflammasomes which can activate caspase-1 via an adaptor protein (ASC) after pathogen-associated molecular pattern (PAMP) or danger-associated molecular pattern (DAMP) recognition.
Microbial Nucleic Acid Sensing in Oral and Systemic Diseases.
Review
New
Sahingur et al., Richmond, United States. In J Dent Res, Jan 2016
The discovery of innate immune activation through nucleic acid recognition by intracellular PRRs such as endosomal TLRs (TLR3, TLR7, TLR8, and TLR9) and cytoplasmic proteins (absent in melanoma 2 and DNA-dependent activator of interferon regulatory factor) opened a new paradigm: Nucleic acid sensing is now implicated in multiple immune and inflammatory conditions (e.g., atherosclerosis, cancer), viral (e.g., human papillomavirus, herpes virus) and bacterial (e.g., Helicobacter pylori, pneumonia) diseases, and autoimmune disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis).
IFN-γ primes keratinocytes for HSV-1-induced inflammasome activation.
New
Beer et al., Zürich, Switzerland. In J Invest Dermatol, Jan 2016
This secretion was dependent on several inflammasome complexes, however, the AIM2 inflammasome, which is activated by binding of dsDNA, played the most important role.
AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity.
Review
New
Kanneganti et al., Memphis, United States. In Eur J Immunol, Jan 2016
AIM2 is a cytoplasmic sensor that recognizes dsDNA of microbial or host origin.
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
New
Zaki et al., Dallas, United States. In Cell Rep, Jan 2016
However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown.
Inflammasomes in non-alcoholic fatty liver disease.
New
Tipoe et al., In Front Biosci, Dec 2015
Currently, there are several identified inflammasomes, including nod-like receptor protein (NLRP)-1, 2, 3, 6, 10, 12, NLRC4 and absent in melanoma 2 (AIM2) inflammasomes.
Regulation and Function of the NLRP3 Inflammasome in Lung Disease.
Review
New
Choi et al., New York City, United States. In Am J Respir Cell Mol Biol, Oct 2015
Several NOD-like receptor (NLR) family members (i.e., NLRP1, NLRP3, and NLRC4) as well as the PYHIN family member AIM2 can form inflammasome complexes in human cells.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
New
Impact
Ting et al., Chapel Hill, United States. In Nat Med, Aug 2015
The absent in melanoma 2 (AIM2) inflammasome is activated by double-stranded DNA, and AIM2 expression is reduced in several types of cancer, but the mechanism by which AIM2 restricts tumor growth remains unclear.
AIMing 2 Curtail Cancer.
New
Impact
Subramanian et al., Seattle, United States. In Cell, Aug 2015
In this issue, Man et al. reveal that the intracellular innate sensor AIM2 regulates microbial and stem cell homeostasis in the gut to protect against colorectal cancer.
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.
New
Impact
Kanneganti et al., Memphis, United States. In Cell, Aug 2015
Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown.
The pathogenic role of the inflammasome in neurodegenerative diseases.
Review
New
Ting et al., Chapel Hill, United States. In J Neurochem, Jul 2015
These events can potentially trigger the activation of NLRP3, NLRP1, and AIM2 during TBI but have yet to be confirmed (dashed lines).
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
New
Impact
Kanneganti et al., Memphis, United States. In Nat Immunol, May 2015
The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear.
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
New
Impact
Broz et al., Basel, Switzerland. In Nat Immunol, May 2015
The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL-1β) and IL-18.
An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp.
Review
Park et al., Seoul, South Korea. In Mediators Inflamm, 2014
Currently identified PRR families are the Toll-like receptors (TLRs), the C-type lectin receptors (CLRs), the nucleotide-binding oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR).
Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA.
GeneRIF
Li et al., College Station, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
AIM2 HIN-200 domain in complex with the 15 bp DNA crystallized in the cubic space group I23 or I2(1)3, with unit-cell parameter a = 235.60 A
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Impact
GeneRIF
Xiao et al., Bethesda, United States. In Immunity, 2012
crystal structures of their HIN domains in complex with double-stranded (ds) DNA.
Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
GeneRIF
Shao et al., Beijing, China. In Proc Natl Acad Sci U S A, 2012
Data show that SdhA is required for preventing AIM2 inflammasome activation.
Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation.
GeneRIF
Morishita et al., Miyazaki, Japan. In Cancer Sci, 2012
expression of AIM2 and IFI16 may have oncogenic activities in the OSCC cells that have inactivated the p53 system.
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
GeneRIF
Rothenfusser et al., München, Germany. In J Immunol, 2012
a pathway activating DNA damage signaling plays an important independent role in detecting intracellular foreign DNA, thereby complementing the induction of IFN and activation of the AIM2 inflammasome
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