gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

C-type lectin domain family 2, member B

AICL, activation-induced C-type lectin, CLECSF2
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NKp80, NKG2D, osteoclast inhibitory lectin, CD94, CD69
Papers on AICL
HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity.
New
Kellner et al., Kiel, Germany. In Oncotarget, Nov 2015
B7-H6, AICL and PVR, respectively) were fused to a single-chain fragment variable (scFv) targeting the human epidermal growth factor receptor 2 (HER2), which is displayed by various solid tumors.
Generation and preclinical characterization of an NKp80-Fc fusion protein for redirected cytolysis of natural killer (NK) cells against leukemia.
New
Sun et al., Hefei, China. In J Biol Chem, Oct 2015
Given that activation-induced C-type lectin (AICL), an identified ligand for the NK-activating receptor NKp80, is frequently highly expressed on leukemia cells, the lack of therapeutic AICL-specific antibodies limits clinical application.
Structural basis for recognition of cellular and viral ligands by NK cell receptors.
Review
Mariuzza et al., Rockville, United States. In Front Immunol, 2013
A growing number of NK receptor-ligand interaction pairs involving non-MHC molecules have also been identified, including NKp30-B7-H6, killer cell lectin-like receptor G1-cadherin, and NKp80-AICL.
Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.
Steinle et al., Frankfurt am Main, Germany. In Blood, 2013
As with other lectin-like NK receptors, NKp80 is encoded in the natural killer gene complex, but unlike most of these, adjacent to its ligand, ie, activation-induced C-type lectin (AICL).
Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.
Mariuzza et al., Rockville, United States. In Proc Natl Acad Sci U S A, 2013
This previously unreported structure of an NKC-encoded receptor-ligand complex, coupled with mutational analysis of the interface, establishes a docking template that is directly applicable to other genetically linked pairs in the NKC, including Nkrp1-Clr, NKRP1A-LLT1, and NKp80-AICL.
Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity.
Steinle et al., Frankfurt am Main, Germany. In J Biol Chem, 2013
Among these is the C-type lectin-like receptor NKp80 which is encoded in the human Natural Killer Gene Complex (NKC) adjacent to its ligand, activation-induced C-type lectin (AICL).
Transcriptome analysis of duck liver and identification of differentially expressed transcripts in response to duck hepatitis A virus genotype C infection.
Yue et al., Chengdu, China. In Plos One, 2012
Of the 20 unigenes, nine matched the known genes in the database, including three up-regulated genes (virus replicase polyprotein, LRRC3B, and PCK1) and six down-regulated genes (CRP, AICL-like 2, L1CAM, CYB26A1, CHAC1, and ADAM32).
Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
Review
Steinle et al., Frankfurt am Main, Germany. In Front Immunol, 2012
Ligands of the human NKPR1 receptors are likewise C-type lectin-like glycoproteins belonging to the CLEC2 subfamily (i.e., LLT1, AICL, and KACL), and are encoded in the NKC in tight genetic linkage to their respective receptors.
Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity.
Steinle et al., Tübingen, Germany. In J Immunol, 2011
The human NK cell receptor NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand AICL.
Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.
Steinle et al., Tübingen, Germany. In Proc Natl Acad Sci U S A, 2010
In contrast to the other CLEC2 family members AICL, CD69, and LLT1, KACL expression is mostly restricted to skin.
Peptide mimicry of AICL inhibits cytolysis of NK cells by blocking NKp80-AICL recognition.
Sun et al., Hefei, China. In Immunol Invest, 2009
AICL has been identified as a ligand of the activating NK cell receptor NKp80, but the interaction sites of NKp80-AICL were unknown.
NKp80 defines and stimulates a reactive subset of CD8 T cells.
GeneRIF
Steinle et al., Tübingen, Germany. In Blood, 2009
NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells.
Natural killer cell evasion by an E3 ubiquitin ligase from Kaposi's sarcoma-associated herpesvirus.
Review
Lehner et al., Cambridge, United Kingdom. In Biochem Soc Trans, 2008
Furthermore, K5 down-regulates cell-surface expression of another NK cell activatory receptor ligand, AICL (activation-induced C-type lectin).
Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction.
Impact
Steinle et al., Tübingen, Germany. In Nat Immunol, 2006
Here we demonstrate that NKp80 binds to the genetically linked 'orphan' receptor AICL, which, like NKp80, is absent from rodents.
share on facebooktweetadd +1mail to friends