GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Nuclear receptor coactivator 3
AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from
NCBI)
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Papers using
AIB1
antibodies
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism
Supplier
In Breast Cancer Research : BCR, 2007
Papers on
AIB1
Cooperative Activation of Gene Expression by Agonists and Antagonists Mediated by Estrogen Receptor Heteroligand Dimer Complexes.
New
In Mol Pharmacol, 05 Apr 2013
This cooperative activation of gene expression was enhanced by SRC-3 coactivator and required each ligand-bound subunit of the dimer to bind to DNA, as well as both activation function-1 domains for maximal transcriptional activity.
AIB1 and its significant role in tumor pathogenesis in systemic malignancies: beyond breast carcinomas.
New
Chicago, United States. In Ann Oncol, 27 Mar 2013
Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses.
New
Novato, United States. In Nucleic Acids Res, 26 Mar 2013
We focused on ERα/glucocorticoid receptor interplay and demonstrated that it requires steroid receptor coactivators (SRC-2, SRC-3) and the mediator component MED14.
Estrogen receptor beta expression induces changes in the microRNA pool in human colon cancer cells.
New
Houston, United States. In Carcinogenesis, 22 Mar 2013
The repression of miR-17 also influences cell death upon DNA damage, and mediates regulation of NCOA3 (SRC-3) and CLU in colon cancer cells.
β-estradiol-dependent activation of the Jak/Stat pathway requires p/CIP and CARM1.
New
London, Canada. In Biochim Biophys Acta, 19 Mar 2013
The steroid receptor coactivator p/CIP, also known as SRC-3, is an oncogene commonly amplified in breast and ovarian cancers.
Androgen receptor co-activators in the regulation of cellular events in prostate cancer.
Review
New
Innsbruck, Austria. In World J Urol, Jun 2012
In addition to stimulating AR, some co-activators suppress apoptosis in prostate cancer cells that do not express the AR (p300 and SRC-3).
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
New
Impact
Houston, United States. In Cell Metab, Jun 2012
Here we show Steroid Receptor Coactivator-3 (SRC-3) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
A role for Rac3 GTPase in the regulation of autophagy.
GeneRIF
Singapore, Singapore. In J Biol Chem, 2011
Rac3 GTPase has a role in the regulation of autophagy
Transcriptional repression of the tumor suppressor DRO1 by AIB1.
GeneRIF
Valencia, Spain. In Febs Lett, 2011
Results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis.
Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.
GeneRIF
Washington, D.C., United States. In J Biol Chem, 2011
a model whereby the transcriptional activity of AIB1 is squelched by a repressive mechanism utilizing the N-terminal domain and that the increased coactivator function of AIB1-Delta4 is due to the loss of this inhibitory domain
Assessing estrogen signaling aberrations in breast cancer risk using genetically engineered mouse models.
Review
Washington, D.C., United States. In Ann N Y Acad Sci, 2011
Initiation and promotion can be increased by p53 haploinsufficiency and by coexpressing the nuclear coactivators amplified in breast cancer 1 (AIB1) or the splice variant AIB1Δ3.
Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis.
Review
Houston, United States. In Endocrinology, 2011
A member of the steroid receptor coactivator (SRC)/p160 family, SRC-3 acts as a coregulator for nuclear receptor (NR) and non-NR transcription factors.
Steroid receptor coactivator (SRC) family: masters of systems biology.
Review
Houston, United States. In J Biol Chem, 2011
The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes.
Regulation of the BRCA1 gene by an SRC3/53BP1 complex.
GeneRIF
London, Canada. In Bmc Biochem, 2010
both 53BP1 and SRC3 have a common function that converge at the BRCA1 promoter and possibly other genes important for DNA repair and genomic stability
Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.
GeneRIF
Milano, Italy. In Plos One, 2010
Rac1 and Rac3 GTPases participate in the normal development of hilar mossy cells.
SRC-3 has a role in cancer other than as a nuclear receptor coactivator.
Review
Xi'an, China. In Int J Biol Sci, 2010
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Impact
Tsukuba, Japan. In Nat Cell Biol, 2009
Proteomic analysis identified the transcriptional co-activator SRC-3 (refs 13, 14, 15, 16, 17, 18, 19) as a direct target for ubiquitylation and degradation by CHIP.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Impact
Cambridge, United Kingdom. In Nature, 2009
We show that PAX2 and the ER co-activator AIB-1/SRC-3 compete for binding and regulation of ERBB2 transcription, the outcome of which determines tamoxifen response in breast cancer cells.
Staying the distance: avoiding the proteasomal trap.
Impact
Los Angeles, United States. In Cancer Cell, 2008
However, SRC-3 has distinguished itself by persistent association with cell growth.
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.
Impact
GeneRIF
Houston, United States. In Cell, 2007
ubiquitination of SRC-3 is a phospho-mediated biphasic event and a transition from multi-(mono)ubiquitination (SRC-3 activation) to long-chain polyubiquitination (SRC-3 degradation) is processive during the coactivation of select transcription factors
