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Nuclear receptor coactivator 3

AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Src, SRC-1, CAN, MSH6, SFRP1
Papers using AIB1 antibodies
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism
Supplier
Vadlamudi Ratna K et al., In Breast Cancer Research : BCR, 2007
... Antibodies for phospho-Rb, phospho-CDK2, and AIB1 were purchased from Cell Signaling (Beverly, MA, USA) ...
Papers on AIB1
Binding rate constants reveal distinct features of disordered protein domains.
New
Jemth et al., In Biochemistry, 08 Aug 2015
We have performed an extensive characterization of the ionic strength dependence of the interaction between the molten globular nuclear co-activator binding domain (NCBD) of CREB binding protein and five different protein ligands, including the intrinsically disordered activation domain of p160 transcriptional co-activators (SRC1, TIF2, ACTR), the p53 transactivation domain and the folded pointed domain (PNT) of the transcription factor ETS-2. Direct comparisons of the binding rate constants under identical conditions show that the association rate constant, kon, for interactions between NCBD and disordered protein domains is high at low salt concentrations (90-350×106 M-1s-1 at 4°C) but is reduced significantly (10- to 30-fold) with increasing ionic strength and reaching a plateau around physiological ionic strength.
Apelin-13 induces MCF-7 cell proliferation and invasion via phosphorylation of ERK1/2.
New
Huo et al., Changchun, China. In Int J Mol Med, 30 Jul 2015
Apelin‑13 also markedly increased the expression of cyclin D1, extracellular matrix metalloproteinase‑1 and amplified in breast cancer 1 (AIB1) in a dose‑dependent manner by polymerase chain reaction assays.
Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/beta-Catenin Signaling.
New
Yu et al., Xiamen, China. In J Biol Chem, 16 Jul 2015
In addition, SRC-1 and SRC-3 were co-overexpressed in 47.5% of HCC specimens, and they cooperated to promote HCC cell proliferation.
Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer.
New
Hou et al., Xi'an, China. In Oncotarget, 10 Jul 2015
Amplified in breast cancer 1 (AIB1) is a member of p160 steroid receptor coactivator (SRC) family that mediates the transcriptional activities of nuclear receptors and other transcription factors.
Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force - implications for studies on extracellular vesicles.
New
Rak et al., In Cell Mol Biol Lett, Apr 2015
Here we report that ultracentrifugationonly EV preparations from highly transformed cancer cells, driven by the overexpression of oncogenic H-ras (RAS-3) and v-src (SRC-3), may contain clonogenic cancer cells, while preparations of normal or less aggressive human cell lines are generally free from such contamination.
Steroid receptor coactivators: servants and masters for control of systems metabolism.
Review
New
O'Malley et al., Houston, United States. In Trends Endocrinol Metab, Jul 2014
The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions.
Genetically engineered ERα-positive breast cancer mouse models.
Review
New
Furth et al., Washington, D.C., United States. In Endocr Relat Cancer, Jun 2014
ESR1, CCDN1, prolactin, TGFα, AIB1, ESPL1, and WNT1 overexpression, PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer.
Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.
Review
Acharya et al., Wellesley, United States. In J Neuroendocrinol, 2013
The present review focuses on the function of the p160 family of coactivators, which includes steroid receptor coactivator-1 (SRC-1), SRC-2 and SRC-3, in steroid receptor action in the brain.
New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Review
Chen et al., Wuhan, China. In Acta Pharmacol Sin, 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.
Steroid receptor coactivator-3 as a potential molecular target for cancer therapy.
Review
Xu et al., Houston, United States. In Expert Opin Ther Targets, 2012
INTRODUCTION: Steroid receptor coactivator-3 (SRC-3), also called amplified-in-breast cancer-1 (AIB1), is an oncogenic coactivator in endocrine and non-endocrine cancers.
The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
GeneRIF
He et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2012
The HBx-AIB1 interaction was important for the activation of NFkappaB signal transduction, the HBx mutant that did not interact with AIB1showed dramatically lower NFkappaB activation activity than the WT HBx.
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
GeneRIF
Wu et al., Washington, D.C., United States. In Cell Res, 2012
The steroid receptor coactivator 3 regulates expression of macrophage migration inhibitory factor at the transcriptional level as demonstrated by reduced Mif mRNA in cells derived from SRC-3-null mutant mice.
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell Metab, 2012
Results show Steroid Receptor Coactivator-3 (SRC-3) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
GeneRIF
O'Malley et al., Houston, United States. In J Clin Invest, 2012
A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
GeneRIF
Zhang et al., Zhengzhou, China. In World J Gastroenterol, 2012
Data show that sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Impact
Yanagisawa et al., Tsukuba, Japan. In Nat Cell Biol, 2009
Proteomic analysis identified the transcriptional co-activator SRC-3 (refs 13, 14, 15, 16, 17, 18, 19) as a direct target for ubiquitylation and degradation by CHIP.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Impact
Carroll et al., Cambridge, United Kingdom. In Nature, 2009
We show that PAX2 and the ER co-activator AIB-1/SRC-3 compete for binding and regulation of ERBB2 transcription, the outcome of which determines tamoxifen response in breast cancer cells.
Staying the distance: avoiding the proteasomal trap.
Impact
Evans et al., Los Angeles, United States. In Cancer Cell, 2008
However, SRC-3 has distinguished itself by persistent association with cell growth.
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell, 2007
ubiquitination of SRC-3 is a phospho-mediated biphasic event and a transition from multi-(mono)ubiquitination (SRC-3 activation) to long-chain polyubiquitination (SRC-3 degradation) is processive during the coactivation of select transcription factors
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