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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear receptor coactivator 3

AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Src, SRC-1, CAN, MSH6, SFRP1
Papers using AIB1 antibodies
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism
Vadlamudi Ratna K et al., In Breast Cancer Research : BCR, 2007
... Antibodies for phospho-Rb, phospho-CDK2, and AIB1 were purchased from Cell Signaling (Beverly, MA, USA) ...
Papers on AIB1
Adaptation to AI therapy in breast cancer can induce dynamic alterations in ER activity resulting in estrogen independent metastatic tumours.
Young et al., Ireland. In Clin Cancer Res, Feb 2016
The adaptive ER response to AI treatment was highlighted by the ER/AIB1 target gene, early growth response 3 (EGR3).
The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study.
Levinger et al., Melbourne, Australia. In Osteoporos Int, Feb 2016
Australian Clinical Trials Registry (ACTR) number: ACTRN12613000467730 ( ).
Interaction of steroid receptor coactivators and estrogen receptors in the human placenta.
An et al., Miryang, South Korea. In J Mol Endocrinol, Feb 2016
In addition, SRC family including SRC-1, SRC-2, and SRC-3 was expressed in the human placenta, and the levels of SRC-1, SRC-2, and SRC-3 were increased in the placenta at the late stage of gestation.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Mitsiades et al., Houston, United States. In Horm Cancer, Feb 2016
In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs).
The effects of bufadienolides on HER2 overexpressing breast cancer cells.
Yuan et al., Dalian, China. In Tumour Biol, Jan 2016
Our results showed that arenobufagin and bufalin could significantly inhibit the proliferation and survival of HER2 overexpressing breast cancer cells, along with the declination of SRC-1, SRC-3, nuclear transcription factor E2F1, phosphorylated AKT, and ERK.
Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.
O'Malley et al., Houston, United States. In Cancer Cell, Sep 2015
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics.
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction.
Lydon et al., Houston, United States. In Biol Reprod, 2014
The p160/steroid receptor coactivator (SRC) family comprises three pleiotropic coregulators (SRC-1, SRC-2, and SRC-3; otherwise known as NCOA1, NCOA2, and NCOA3, respectively), which modulate a wide spectrum of physiological responses and clinicopathologies.
Steroid receptor coactivators: servants and masters for control of systems metabolism.
O'Malley et al., Houston, United States. In Trends Endocrinol Metab, 2014
The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions.
Genetically engineered ERα-positive breast cancer mouse models.
Furth et al., Washington, D.C., United States. In Endocr Relat Cancer, 2014
ESR1, CCDN1, prolactin, TGFα, AIB1, ESPL1, and WNT1 overexpression, PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer.
Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.
Acharya et al., Wellesley, United States. In J Neuroendocrinol, 2013
The present review focuses on the function of the p160 family of coactivators, which includes steroid receptor coactivator-1 (SRC-1), SRC-2 and SRC-3, in steroid receptor action in the brain.
The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
He et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2012
The HBx-AIB1 interaction was important for the activation of NFkappaB signal transduction, the HBx mutant that did not interact with AIB1showed dramatically lower NFkappaB activation activity than the WT HBx.
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
Wu et al., Washington, D.C., United States. In Cell Res, 2012
The steroid receptor coactivator 3 regulates expression of macrophage migration inhibitory factor at the transcriptional level as demonstrated by reduced Mif mRNA in cells derived from SRC-3-null mutant mice.
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
O'Malley et al., Houston, United States. In Cell Metab, 2012
Results show Steroid Receptor Coactivator-3 (SRC-3) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
O'Malley et al., Houston, United States. In J Clin Invest, 2012
A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
Zhang et al., Zhengzhou, China. In World J Gastroenterol, 2012
Data show that sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Yanagisawa et al., Tsukuba, Japan. In Nat Cell Biol, 2009
Proteomic analysis identified the transcriptional co-activator SRC-3 (refs 13, 14, 15, 16, 17, 18, 19) as a direct target for ubiquitylation and degradation by CHIP.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Carroll et al., Cambridge, United Kingdom. In Nature, 2009
We show that PAX2 and the ER co-activator AIB-1/SRC-3 compete for binding and regulation of ERBB2 transcription, the outcome of which determines tamoxifen response in breast cancer cells.
Staying the distance: avoiding the proteasomal trap.
Evans et al., Los Angeles, United States. In Cancer Cell, 2008
However, SRC-3 has distinguished itself by persistent association with cell growth.
Genetic Alterations in Gastric Carcinomas and Adjacent Mucosa Detected by Comparative Genomic Hybridization (CGH).
Koo et al., In Cancer Res Treat, 2001
While CGH may be useful in predicting the prognosis or therapeutic decision of gastric carcinomas, further study of several candidate genes, such as DP1, FLT1, c-myb, AIB1, BTAK, is needed to clarify gastric carcinogenesis and its progression.
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