Genetically engineered ERα positive breast cancer mouse models.
Washington, D.C., United States. In Endocr Relat Cancer, 02 Mar 2014
Esr1, Ccdn1, prolactin, TGFα, AIB1, Espl1, and Wnt1 over-expression, Pik3ca gain of function, as well as loss of p53 or loss of Stat1 are associated with ER+ mammary cancer.
New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Wuhan, China. In Acta Pharmacol Sin, Feb 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.