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proteins. Page last changed on 14 Mar 2013.
Nuclear receptor coactivator 3
AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from
This cooperative activation of gene expression was enhanced by SRC-3 coactivator and required each ligand-bound subunit of the dimer to bind to DNA, as well as both activation function-1 domains for maximal transcriptional activity.
Riegel et al., Washington, D.C., United States. In J Biol Chem, 2011
a model whereby the transcriptional activity of AIB1 is squelched by a repressive mechanism utilizing the N-terminal domain and that the increased coactivator function of AIB1-Delta4 is due to the loss of this inhibitory domain
O'Malley et al., Houston, United States. In J Biol Chem, 2011
The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes.
O'Malley et al., Houston, United States. In Cell, 2007
ubiquitination of SRC-3 is a phospho-mediated biphasic event and a transition from multi-(mono)ubiquitination (SRC-3 activation) to long-chain polyubiquitination (SRC-3 degradation) is processive during the coactivation of select transcription factors