The role of SRC-1 and SRC-2 in steroid-induced SDF-1 expression in normal and ectopic endometrium.
Nanjing, China. In Reproduction, 28 Mar 2014
UNLABELLED: Objective: To compare the expression patterns of steroid receptor coactivator (SRC) and steroid-induced stromal cell-derived factor-1 (SDF-1) in normal and ectopic endometrium and to explore the roles of SRC-1 and SRC-2 in the steroid-induced SDF-1 expression in normal and ectopic endometrial stromal cell (ESC).Study Design: The SRC-1, SRC-2, SRC-3 and SDF-1α mRNA levels in normal and ectopic endometrium were analyzed by quantitative real-time polymerase chain reaction.
New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Wuhan, China. In Acta Pharmacol Sin, Feb 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.