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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Nuclear receptor coactivator 3

AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Src, SRC-1, CAN, MSH6, SFRP1
Papers using AIB1 antibodies
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism
Supplier
Vadlamudi Ratna K et al., In Breast Cancer Research : BCR, 2007
... Antibodies for phospho-Rb, phospho-CDK2, and AIB1 were purchased from Cell Signaling (Beverly, MA, USA) ...
Papers on AIB1
The p160/Steroid Receptor Coactivator Family: Potent Arbiters of Uterine Physiology and Dysfunction.
New
Lydon et al., In Biol Reprod, 08 Nov 2014
UNLABELLED: The p160/steroid receptor coactivator (SRC) family comprises three pleiotropic coregulators (SRC-1, -2, and -3; otherwise known as NCOA1, NCOA2, NCOA3), which modulate a wide spectrum of physiological responses and clinicopathologies.
Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer.
New
Mitsiades et al., Houston, United States. In Cancer Res, 01 Nov 2014
SPOP promotes ubiquitination and degradation of several protein substrates, including the androgen receptor (AR) coactivator SRC-3.
The AIB1 gene polyglutamine repeat length polymorphism contributes to risk of epithelial ovarian cancer risk: a case-control study.
New
Qin et al., Hangzhou, China. In Tumour Biol, 30 Oct 2014
AIB1 gene (amplified in breast cancer-1), an androgen receptor (AR) coactivator, expresses a polyglutamine (poly-Q) sequence within the carboxyl-terminal coding region.
Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling.
New
Yu et al., Xiamen, China. In Oncogene, 29 Oct 2014
Amplified in breast cancer 1 (AIB1), also known as steroid receptor coactivator 3 or NCOA3, is a transcriptional coactivator that promotes cancer cell proliferation and invasiveness.
The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate.
New
Xu et al., Houston, United States. In Int J Biol Sci, Dec 2013
Here, we demonstrate prostate tumors in TRAMP mice with a mixed genetic background are characterized mostly by atypical hyperplasia (AH) containing steroid receptor coactiator-3-positive, androgen receptor-positive and synaptophysin-negative (SRC-3+/AR+/Syp-) cells.
New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Review
New
Chen et al., Wuhan, China. In Acta Pharmacol Sin, Feb 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.
Steroid receptor coactivator-3 as a potential molecular target for cancer therapy.
Review
Xu et al., Houston, United States. In Expert Opin Ther Targets, 2012
INTRODUCTION: Steroid receptor coactivator-3 (SRC-3), also called amplified-in-breast cancer-1 (AIB1), is an oncogenic coactivator in endocrine and non-endocrine cancers.
The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
GeneRIF
He et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2012
The HBx-AIB1 interaction was important for the activation of NFkappaB signal transduction, the HBx mutant that did not interact with AIB1showed dramatically lower NFkappaB activation activity than the WT HBx.
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
GeneRIF
Wu et al., Washington, D.C., United States. In Cell Res, 2012
The steroid receptor coactivator 3 regulates expression of macrophage migration inhibitory factor at the transcriptional level as demonstrated by reduced Mif mRNA in cells derived from SRC-3-null mutant mice.
Androgen receptor co-activators in the regulation of cellular events in prostate cancer.
Review
Santer et al., Innsbruck, Austria. In World J Urol, 2012
In addition to stimulating AR, some co-activators suppress apoptosis in prostate cancer cells that do not express the AR (p300 and SRC-3).
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell Metab, 2012
Results show Steroid Receptor Coactivator-3 (SRC-3) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
GeneRIF
O'Malley et al., Houston, United States. In J Clin Invest, 2012
A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
GeneRIF
Zhang et al., Zhengzhou, China. In World J Gastroenterol, 2012
Data show that sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
Assessing estrogen signaling aberrations in breast cancer risk using genetically engineered mouse models.
Review
Nakles et al., Washington, D.C., United States. In Ann N Y Acad Sci, 2011
Initiation and promotion can be increased by p53 haploinsufficiency and by coexpressing the nuclear coactivators amplified in breast cancer 1 (AIB1) or the splice variant AIB1Δ3.
SRC-3 has a role in cancer other than as a nuclear receptor coactivator.
Review
He et al., Xi'an, China. In Int J Biol Sci, 2010
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Impact
Yanagisawa et al., Tsukuba, Japan. In Nat Cell Biol, 2009
Proteomic analysis identified the transcriptional co-activator SRC-3 (refs 13, 14, 15, 16, 17, 18, 19) as a direct target for ubiquitylation and degradation by CHIP.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Impact
Carroll et al., Cambridge, United Kingdom. In Nature, 2009
We show that PAX2 and the ER co-activator AIB-1/SRC-3 compete for binding and regulation of ERBB2 transcription, the outcome of which determines tamoxifen response in breast cancer cells.
Staying the distance: avoiding the proteasomal trap.
Impact
Evans et al., Los Angeles, United States. In Cancer Cell, 2008
However, SRC-3 has distinguished itself by persistent association with cell growth.
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell, 2007
ubiquitination of SRC-3 is a phospho-mediated biphasic event and a transition from multi-(mono)ubiquitination (SRC-3 activation) to long-chain polyubiquitination (SRC-3 degradation) is processive during the coactivation of select transcription factors
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