gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 14 Apr 2015.

Nuclear receptor coactivator 3

AIB1, SRC-3, RAC3, ACTR, amplified in breast cancer 1
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Src, SRC-1, CAN, MSH6, SFRP1
Papers using AIB1 antibodies
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism
Supplier
Vadlamudi Ratna K et al., In Breast Cancer Research : BCR, 2007
... Antibodies for phospho-Rb, phospho-CDK2, and AIB1 were purchased from Cell Signaling (Beverly, MA, USA) ...
Papers on AIB1
Structure of a biologically active estrogen receptor-coactivator complex on DNA.
New
O'Malley et al., Houston, United States. In Mol Cell, 19 Apr 2015
Here, we use cryoelectron microscopy (cryo-EM) to determine the quaternary structure of an active complex of DNA-bound ERα, steroid receptor coactivator 3 (SRC-3/NCOA3), and a secondary coactivator (p300/EP300).
Reprogramming of the ERRα and ERα target gene landscape triggers tamoxifen resistance in breast cancer.
New
Lichter et al., Heidelberg, Germany. In Cancer Res, 15 Mar 2015
This analysis uncovered a global redirection in the target genes controlled by ERα, ERRα, and their coactivator AIB1, defining a novel set of target genes in tamoxifen-resistant cells.
The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells.
New
Lien et al., Bergen, Norway. In Plos One, Dec 2014
E2 deprivation and knockdown of Steroid Receptor Coactivator-3 (SRC-3)/Amplified in Breast Cancer 1 (AIB1) mRNA in MCF-7 cells were performed to further characterize specific effects on gene expression.
Silencing of rac3 inhibits proliferation and induces apoptosis of human lung cancer cells.
New
Liu et al., Shenyang, China. In Asian Pac J Cancer Prev, Dec 2014
BACKGROUND: Rac3, a member of the Rac family of small guanosine triphosphatases (GTPases), regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion.
Steroid receptor coactivators: servants and masters for control of systems metabolism.
Review
New
O'Malley et al., Houston, United States. In Trends Endocrinol Metab, Jul 2014
The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions.
Genetically engineered ERα-positive breast cancer mouse models.
Review
New
Furth et al., Washington, D.C., United States. In Endocr Relat Cancer, Jun 2014
ESR1, CCDN1, prolactin, TGFα, AIB1, ESPL1, and WNT1 overexpression, PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer.
Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.
Review
Acharya et al., Wellesley, United States. In J Neuroendocrinol, 2013
The present review focuses on the function of the p160 family of coactivators, which includes steroid receptor coactivator-1 (SRC-1), SRC-2 and SRC-3, in steroid receptor action in the brain.
New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Review
Chen et al., Wuhan, China. In Acta Pharmacol Sin, 2013
These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.
Steroid receptor coactivator-3 as a potential molecular target for cancer therapy.
Review
Xu et al., Houston, United States. In Expert Opin Ther Targets, 2012
INTRODUCTION: Steroid receptor coactivator-3 (SRC-3), also called amplified-in-breast cancer-1 (AIB1), is an oncogenic coactivator in endocrine and non-endocrine cancers.
The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
GeneRIF
He et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2012
The HBx-AIB1 interaction was important for the activation of NFkappaB signal transduction, the HBx mutant that did not interact with AIB1showed dramatically lower NFkappaB activation activity than the WT HBx.
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
GeneRIF
Wu et al., Washington, D.C., United States. In Cell Res, 2012
The steroid receptor coactivator 3 regulates expression of macrophage migration inhibitory factor at the transcriptional level as demonstrated by reduced Mif mRNA in cells derived from SRC-3-null mutant mice.
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell Metab, 2012
Results show Steroid Receptor Coactivator-3 (SRC-3) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
GeneRIF
O'Malley et al., Houston, United States. In J Clin Invest, 2012
A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
GeneRIF
Zhang et al., Zhengzhou, China. In World J Gastroenterol, 2012
Data show that sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Impact
Yanagisawa et al., Tsukuba, Japan. In Nat Cell Biol, 2009
Proteomic analysis identified the transcriptional co-activator SRC-3 (refs 13, 14, 15, 16, 17, 18, 19) as a direct target for ubiquitylation and degradation by CHIP.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Impact
Carroll et al., Cambridge, United Kingdom. In Nature, 2009
We show that PAX2 and the ER co-activator AIB-1/SRC-3 compete for binding and regulation of ERBB2 transcription, the outcome of which determines tamoxifen response in breast cancer cells.
Staying the distance: avoiding the proteasomal trap.
Impact
Evans et al., Los Angeles, United States. In Cancer Cell, 2008
However, SRC-3 has distinguished itself by persistent association with cell growth.
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.
Impact
GeneRIF
O'Malley et al., Houston, United States. In Cell, 2007
ubiquitination of SRC-3 is a phospho-mediated biphasic event and a transition from multi-(mono)ubiquitination (SRC-3 activation) to long-chain polyubiquitination (SRC-3 degradation) is processive during the coactivation of select transcription factors
share on facebooktweetadd +1mail to friends