GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
AHA1, activator of heat shock 90kDa protein ATPase homolog 1
AHA1
Encodes a plasma membrane proton ATPase. Mutants have a reduced ability to close their stomata in response to drought and are affected in stomatal but not seed responsiveness to ABA. (from
NCBI)
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Papers on
AHA1
Haem oxygenase modifies salinity tolerance in Arabidopsis by controlling K⁺ retention via regulation of the plasma membrane H⁺-ATPase and by altering SOS1 transcript levels in roots.
New
Hobart, Australia. In J Exp Bot, Jan 2013
The gene expression analysis after 12h and 24h of salt stress revealed high expression levels of H(+)-ATPases (AHA1/2/3) and Na(+)/H(+) antiporter [salt overly sensitive1 (SOS1)] transcripts in the plasma membrane of HO overexpressors.
Stabilization of polyplexes via polymer crosslinking for efficient siRNA delivery.
New
München, Germany. In Eur J Pharm Sci, Jan 2013
Downregulation of endogenous AHA1 mRNA (85% knockdown compared to control) by crosslinked HD-O/AHA1-siRNA particles was detected by quantitative real-time PCR.
Modulation of the cochaperone AHA1 regulates heat-shock protein 90 and endothelial NO synthase activation by vascular endothelial growth factor.
New
Montréal, Canada. In Arterioscler Thromb Vasc Biol, Oct 2012
Our study is designed to determine whether modulation of the activator of Hsp90 ATPase 1 (AHA1) regulates the function of Hsp90 in ECs.
Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
New
Bethesda, United States. In Mol Cell, Sep 2012
Progression through the chaperone cycle requires release of p50(Cdc37) and recruitment of the ATPase activating cochaperone AHA1, but the molecular regulation of this complex process at the cellular level is poorly understood.
The effect of a genetically reduced plasma membrane protonmotive force on vegetative growth of Arabidopsis.
New
Madison, United States. In Plant Physiol, Mar 2012
In Arabidopsis (Arabidopsis thaliana), this gradient is generated by the plasma membrane proton pump encoded by a family of 11 genes (abbreviated as AHA, for Arabidopsis H(+)-ATPase), of which AHA1 and AHA2 are the two most predominantly expressed in seedlings and adult plants.
Phosphosite mapping of P-type plasma membrane H+-ATPase in homologous and heterologous environments.
New
Frederiksberg, Denmark. In J Biol Chem, Mar 2012
After a mass spectrometric analysis of the resulting peptides we could identify 10 different phosphorylation sites in plasma membrane H(+)-ATPases AHA1, AHA2, AHA3, and AHA4/11, five of which have not been reported before, bringing the total number of phosphosites up to 11, which is substantially higher than reported so far for any other P-type ATPase.
The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922.
Edmonton, Canada. In Plos One, 2011
Deletion of HCH1, but not AHA1, mitigates the temperature sensitive phenotype and high sensitivity to Hsp90 inhibitor drugs observed in Saccharomyces cerevisiae that express either of these two Hsp90 variants.
Δ9-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use.
New Orleans, United States. In J Neurochem, 2011
Six proteins were found to significantly differ among the four treatment groups, with Δ9-THC and ovariectomy (OVX) decreasing the mitochondrial proteins, pyruvate carboxylase and NADH dehydrogenase, whereas the levels of putative cytosolic molecular chaperones NM23B, translationally controlled tumor protein, DJ-1 and activator of heat-shock 90kDa protein ATPase homolog 1 (AHA1) were increased.
The activation of the Arabidopsis P-ATPase 1 by the brassinosteroid receptor BRI1 is independent of threonine 948 phosphorylation.
Tübingen, Germany. In Plant Signal Behav, 2011
Here, we show that BRI1 also associates with a mutant version of the Arabidopsis P-ATPase 1 (AHA1) characterized by an exchange of a well-known regulatory threonine for a non-phosphorylatable residue in the auto-inhibitory C-terminal domain.
Characterization of StPPI1, a proton pump interactor from Solanum tuberosum L. that is up-regulated during tuber development and by abiotic stress.
Buenos Aires, Argentina. In Planta, 2011
In addition, a novel interaction partner of the AHA1 PM H(+)-ATPase, named PPI1 (proton pump interactor, isoform 1), was identified in Arabidopsis thaliana.
Regulatory posttranslational modifications in hsp90 can be compensated by cochaperone aha1.
Garching bei München, Germany. In Mol Cell, 2011
Several impacts can be compensated by overexpression of the cochaperone Aha1.
PAMP (pathogen-associated molecular pattern)-induced changes in plasma membrane compartmentalization reveal novel components of plant immunity.
Köln, Germany. In J Biol Chem, 2011
Mutants of three candidates (DET3, AHA1, FER) exhibited a conspicuous defect in the PAMP-triggered accumulation of reactive oxygen species.
Hsp90 cochaperone Aha1 is a negative regulator of the Saccharomyces MAL activator and acts early in the chaperone activation pathway.
GeneRIF
New York City, United States. In J Biol Chem, 2010
an interaction between Aha1 and residues near the C terminus of Mal63
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.
GeneRIF
Los Angeles, United States. In Mol Biol Cell, 2010
Data propose a model for Aha1 in the Hsp90 ATPase cycle where Aha1 regulates dwell time of Hsp90, and suggest Aha1 activity integrates chaperone function with client folding energetics by modulating ATPase sensitive dimer structural transitions.
Asymmetric activation of the hsp90 dimer by its cochaperone aha1.
GeneRIF
Garching bei München, Germany. In Mol Cell, 2010
For maximum activation of Hsp90, the two domains of Aha1 bind to sites in the middle and N-terminal domains of Hsp90 in a sequential manner.
Genes associated with long-chain omega-3 fatty acids in bovine skeletal muscle.
Madrid, Spain. In J Appl Genet, 2009
Through the analysis of extreme O3I phenotypes, 3 genes of interest (AANAT, UCP2 and AHA1) were identified.
Investigating the functions of the RIN4 protein complex during plant innate immune responses.
Review
Davis, United States. In Plant Signal Behav, 2009
However, the molecular mechanisms by which RIN4 controls multiple immune responses have remained elusive. in our recently published study, we purified components of the RIN4 protein complex from A. thaliana and identified several novel RIN4-associated proteins.1 we found that one class of RIN4-associated proteins, the plasma membrane H(+)-ATPases AHA1 and AHA2, play a crucial role in resisting pathogen invasion.
RIN4 functions with plasma membrane H+-ATPases to regulate stomatal apertures during pathogen attack.
GeneRIF
Davis, United States. In Plos Biol, 2009
Results indicate that protein RIN4 functions with the PM H(+)-ATPase to regulate stomatal apertures, inhibiting the entry of bacterial pathogens into the plant leaf during infection.
Dissecting iron deficiency-induced proton extrusion in Arabidopsis roots.
GeneRIF
Udine, Italy. In New Phytol, 2008
the rhizosphere acidification in response to Fe deficiency is chiefly mediated by AHA2, while AHA1 functions as a housekeeping isoform.
Genes and proteins governing the cellular sensitivity to HSP90 inhibitors: a mechanistic perspective.
Review
United Kingdom. In Curr Cancer Drug Targets, 2003
Important determinants of response include: 1) Dependence upon key HSP90 client proteins such as ERBB2, steroid hormone receptors and AKT/PKB; 2) Levels of HSP90 family members and co-chaperones, such as HSP70 and AHA1; and 3) expression of various cell cycle and apoptotic regulators.
