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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Jagged 1

Ags, Jagged1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, MHC, CD4
Papers using Ags antibodies
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
Supplier
Xu Dawei et al., In Molecular Cancer, 2007
... Human gastric cancer cell lines AGS, BGC-823 and HGC-27, and cervical cancer cell lines HeLa and SiHa used in the present study were cultured at 37°C/95%air/5%CO2 in RPMI 1640 medium (Life Technologies, Paisley, Scotland, UK) containing ...
Recent insights into the role of Notch signaling in tumorigenesis
Supplier
Kawakami T et al., In European Journal of Medical Research, 2005
... following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; 4°C, overnight) and Jagged1 rabbit polyclonal antibody (ab7771, Abcam plc, Cambridge; dilution: 1/500; ...
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Supplier
Yim JH et al., In Cell death and differentiation, 2002
... Tetracycline inducible IRF-1 stably-transfected AGS cells (AGSI) were propagated with 10% Tet System Approved FBS from Clontech (Mountain View, CA, USA), ...
Papers on Ags
Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
New
Riley et al., London, United Kingdom. In J Immunol, 08 May 2015
We hypothesized, therefore, that HCMV seropositivity would be associated with altered NK cell responses to vaccine Ags.
Association of MMP7-181A/G promoter polymorphism with gastric cancer risk: Influence of nicotine in differential allele-specific transcription via increased phosphorylation of CREB.
New
Swarnakar et al., India. In J Biol Chem, 06 May 2015
In support, MMP7 promoter-reporter assays showed greater transcriptional activity towards A to G transition under basal/nicotine-induced/CREB-over-expressed conditions in gastric adenocarcinoma cells (AGS).
TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling.
New
Wang et al., Guangzhou, China. In Oncotarget, 23 Apr 2015
TMEM16A silencing significantly decreased calcium activated chloride currents, impaired TGF-β secretion, reduced E-cadherin expression, and inhibited the migration and invasion without affecting proliferation of GC cells (AGS and BGC-823).
T cell antigen receptor recognition of antigen-presenting molecules.
New
Impact
McCluskey et al., Australia. In Annu Rev Immunol, 21 Apr 2015
The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags).
Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma.
Review
New
Cho et al., New York City, United States. In Bone Marrow Transplant, 09 Apr 2015
Preclinical and clinical data indicate that myeloma-associated Ags elicit humoral and cellular immune responses (IRs) in myeloma patients.
Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics.
Review
New
Zanetti, San Diego, United States. In J Immunol, 01 Apr 2015
In this article, I discuss the role and regulation of CD4 T cells in response to tumor Ags.
The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression.
New
Shan et al., In Bmc Cancer, Dec 2014
A co-culture system of OPN+-AGS and U937 cells was designed to study the effect of OPN on the skewing of macrophages toward M2-TAMs for gastric cancer progression in vitro and in vivo.
Telomerase Activity Impacts on Epstein-Barr Virus Infection of AGS Cells.
New
Nadal et al., Zürich, Switzerland. In Plos One, Dec 2014
Using HONE-1, AGS and HEK293 cells we generated epithelial model cell lines with increased or suppressed telomerase activity by stable ectopic expression of hTERT or of a catalytically inactive, dominant negative hTERT mutant.
Role and regulation of CD1d in normal and pathological B cells.
Review
New
Karadimitris et al., London, United Kingdom. In J Immunol, Dec 2014
CD1d is a nonpolymorphic, MHC class I-like molecule that presents phospholipid and glycosphingolipid Ags to a subset of CD1d-restricted T cells called invariant NKT (iNKT) cells.
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
New
Impact
Ahn et al., Seoul, South Korea. In Nat Med, Aug 2014
By enzymatically characterizing Aicardi-Goutières syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.
Impact
Crow et al., Manchester, United Kingdom. In Lancet Neurol, 2013
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer.
Review
Chatterjee et al., Providence, United States. In Crit Rev Oncog, 2013
Infection with H. pylori increases levels of phosphorylation of Raf kinase inhibitor protein (pRKIP) in gastric adenocarcinoma (AGS) cells in vitro and in vivo.
The notch ligand JAGGED1 as a target for anti-tumor therapy.
Review
Harris et al., Oxford, United Kingdom. In Front Oncol, 2013
One of the Notch ligands, Jagged1 (JAG1), is overexpressed in many cancer types, and plays an important role in several aspects of tumor biology.
Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.
GeneRIF
Pavlidis et al., Thessaloníki, Greece. In Clin Exp Metastasis, 2012
immunohistochemical analysis of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells.
GeneRIF
Spillane et al., Galway, Ireland. In Biochem Biophys Res Commun, 2012
these results reveal a regulatory interplay between miR-21, JAG1 and E2 that is important for advancing understanding of how the oncogenic potential of miR-21 and JAG1 manifests in different sub-types of breast cancer.
Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
GeneRIF
Asahara et al., Japan. In J Neurotrauma, 2012
transplanted endothelial progenitor cells promote astrogliosis, vascular regulation, and spinal cord regeneration through activation of Jagged1-Notch signaling
Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.
GeneRIF
Kawasaki et al., Tokyo, Japan. In Febs J, 2012
Study suggest the requirement for cell-surface localization of Jagged1 for cis-inhibition activities.
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
GeneRIF
Lo et al., Riverside, United States. In Dev Comp Immunol, 2012
Studies provide evidence that Jagged1 and Notch influence Peyer's patch follicle associated epithelium M cell numbers and distribution by regulating M cell development at an early stage within the crypts adjacent to the Peyer's patch follicle.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Impact
Butcher et al., Stanford, United States. In Immunity, 2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remained poorly defined.
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Impact
Stetson et al., Seattle, United States. In Immunity, 2012
Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease.
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