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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Nov 2014.

Jagged 1

Ags, Jagged1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CD4, MHC
Papers using Ags antibodies
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
Xu Dawei et al., In Molecular Cancer, 2007
... Human gastric cancer cell lines AGS, BGC-823 and HGC-27, and cervical cancer cell lines HeLa and SiHa used in the present study were cultured at 37°C/95%air/5%CO2 in RPMI 1640 medium (Life Technologies, Paisley, Scotland, UK) containing ...
Recent insights into the role of Notch signaling in tumorigenesis
Kawakami T et al., In European Journal of Medical Research, 2005
... following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; 4°C, overnight) and Jagged1 rabbit polyclonal antibody (ab7771, Abcam plc, Cambridge; dilution: 1/500; ...
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Yim JH et al., In Cell death and differentiation, 2002
... Tetracycline inducible IRF-1 stably-transfected AGS cells (AGSI) were propagated with 10% Tet System Approved FBS from Clontech (Mountain View, CA, USA), ...
Papers on Ags
Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase Blocks Intracellular TLR Signaling in Chronic Lymphocytic Leukemia and Normal Hematopoietic Cells.
Lerner et al., Boston, United States. In J Immunol, 21 Dec 2014
UNLABELLED: A subset of chronic lymphocytic leukemia (CLL) BCRs interacts with Ags expressed on apoptotic cells, suggesting that CLL BCRs have the potential to internalize apoptotic cell RNA- or DNA-containing fragments with resultant activation of TLR7 or TLR9, respectively.
Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells.
Bhattacharyya et al., Bhubaneshwar, India. In Faseb J, 17 Dec 2014
For this, various GECs such as AGS, MKN45, and KATO III were either infected with H. pylori or left uninfected.
Epidermal growth factor receptor-coamplified and overexpressed protein (VOPP1) is a putative oncogene in gastric cancer.
Li et al., Chengdu, China. In Clin Exp Med, 15 Dec 2014
Subsequently, ectopic overexpression and RNAi-mediated silencing of VOPP1 was effected in the human gastric cancer cell line, AGS.
Role and Regulation of CD1d in Normal and Pathological B Cells.
Karadimitris et al., London, United Kingdom. In J Immunol, 15 Dec 2014
UNLABELLED: CD1d is a nonpolymorphic, MHC class I-like molecule that presents phospholipid and glycosphingolipid Ags to a subset of CD1d-restricted T cells called invariant NKT (iNKT) cells.
Helicobacter pylori γ-glutamyl transpeptidase-induced Ca(2+) release via PLC-IP3 receptors in AGS cells.
Baik et al., Chinju, South Korea. In Can J Microbiol, 28 Nov 2014
UNLABELLED: In our previous study, γ-glutamyl transpeptidase (GGT) isolated from Helicobacter pylori induced apoptosis of AGS cells.
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Ahn et al., Seoul, South Korea. In Nat Med, Aug 2014
By enzymatically characterizing Aicardi-Goutières syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.
iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses.
Casorati et al., Milano, Italy. In Eur J Immunol, Aug 2014
CD1d-restricted invariant natural killer T (iNKT) cells are a subset of innate-like T lymphocytes that rapidly respond to stimulation with specific lipid antigens (Ags) that are derived from infectious pathogens or stressed host cells.
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad.
Lanier et al., Charleston, United States. In Mol Pharmacol, Mar 2014
Activators of G protein signaling (AGS), initially discovered in the search for receptor-independent activators of G protein signaling, define a broad panel of biologic regulators that influence signal transfer from receptor to G-protein, guanine nucleotide binding and hydrolysis, G protein subunit interactions, and/or serve as alternative binding partners for Gα and Gβγ independently of the classic heterotrimeric Gαβγ.
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.
Crow et al., Manchester, United Kingdom. In Lancet Neurol, Dec 2013
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
The notch ligand JAGGED1 as a target for anti-tumor therapy.
Harris et al., Oxford, United Kingdom. In Front Oncol, Dec 2013
One of the Notch ligands, Jagged1 (JAG1), is overexpressed in many cancer types, and plays an important role in several aspects of tumor biology.
Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.
Tangye et al., Australia. In Front Immunol, Dec 2013
Two broad categories of Ags exist that cause B-cell activation and differentiation: T cell dependent (TD) or T cell independent (TI).
Impact of NPR-A expression in gastric cancer cells.
Wang et al., Xi'an, China. In Int J Clin Exp Med, Dec 2013
RESULTS: Down-regulation of NPR-A expression by shNPR-A induced apoptosis, inhibited proliferation and invasion in AGS cells.
Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.
Pavlidis et al., Thessaloníki, Greece. In Clin Exp Metastasis, 2012
immunohistochemical analysis of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells.
Spillane et al., Galway, Ireland. In Biochem Biophys Res Commun, 2012
these results reveal a regulatory interplay between miR-21, JAG1 and E2 that is important for advancing understanding of how the oncogenic potential of miR-21 and JAG1 manifests in different sub-types of breast cancer.
Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
Asahara et al., Japan. In J Neurotrauma, 2012
transplanted endothelial progenitor cells promote astrogliosis, vascular regulation, and spinal cord regeneration through activation of Jagged1-Notch signaling
Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.
Kawasaki et al., Tokyo, Japan. In Febs J, 2012
Study suggest the requirement for cell-surface localization of Jagged1 for cis-inhibition activities.
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
Lo et al., Riverside, United States. In Dev Comp Immunol, 2012
Studies provide evidence that Jagged1 and Notch influence Peyer's patch follicle associated epithelium M cell numbers and distribution by regulating M cell development at an early stage within the crypts adjacent to the Peyer's patch follicle.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Butcher et al., Stanford, United States. In Immunity, 2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remained poorly defined.
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Stetson et al., Seattle, United States. In Immunity, 2012
Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease.
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
Savina et al., Paris, France. In Cell, 2012
Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated immunity in response to certain pathogens and tumor cells.
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