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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Jagged 1

Ags, Jagged1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CD4, ACID
Papers using Ags antibodies
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
Supplier
Xu Dawei et al., In Molecular Cancer, 2007
... Human gastric cancer cell lines AGS, BGC-823 and HGC-27, and cervical cancer cell lines HeLa and SiHa used in the present study were cultured at 37°C/95%air/5%CO2 in RPMI 1640 medium (Life Technologies, Paisley, Scotland, UK) containing ...
Recent insights into the role of Notch signaling in tumorigenesis
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Kawakami T et al., In European Journal of Medical Research, 2005
... following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; 4°C, overnight) and Jagged1 rabbit polyclonal antibody (ab7771, Abcam plc, Cambridge; dilution: 1/500; ...
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Supplier
Yim JH et al., In Cell death and differentiation, 2002
... Tetracycline inducible IRF-1 stably-transfected AGS cells (AGSI) were propagated with 10% Tet System Approved FBS from Clontech (Mountain View, CA, USA), ...
Papers on Ags
JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.
New
Persani et al., Milano, Italy. In J Clin Endocrinol Metab, Feb 2016
We previously reported that perturbations of the Notch pathway and knockdown of the ligand jagged1 cause a hypothyroid phenotype in the zebrafish.
Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.
New
Joo et al., Kwangju, South Korea. In Gastric Cancer, Feb 2016
METHODS: A small interfering RNA against PROX1 was used to silence PROX1 expression in gastric cancer cell lines AGS and SNU638.
Downregulation of microRNA-193-3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene.
New
Yang et al., Chongqing, China. In Tumour Biol, Feb 2016
Gastric cancer cell line AGS and MKN-45 cells were stably transduced with lentivirus to downregulate endogenous miR-193-3p.
Landscape of Tumor Antigens in T Cell Immunotherapy.
Review
New
Yang et al., Bethesda, United States. In J Immunol, Jan 2016
Cancer immunotherapy is a rapidly evolving field that exploits T cell responses to tumor-associated Ags to induce tumor rejection.
TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-β signaling.
New
Yan et al., Shanghai, China. In Sci Rep, Dec 2015
Small interfering RNA (siRNA)-mediated knockdown of TRIM25 expression in MGC-803 and AGS cells had no effects on cell proliferation, whereas reduced cell migration and invasion.
RIG-I-like receptors and autoimmune diseases.
Review
New
Fujita et al., Kyoto, Japan. In Curr Opin Immunol, Dec 2015
Recently an increased expression of type I IFN, also termed IFN signature, has been reported in patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières syndrome (AGS).
Helicobacter pylori strains harboring babA2 from Indian sub population are associated with increased virulence in ex vivo study.
New
Mukhopadhyay et al., Calcutta, India. In Gut Pathog, Dec 2015
The comparative study of IL-8 production and apoptosis were done by co-culturing the AGS cell line with H. pylori strains with different genotypes.
Is the role of human RNase H2 restricted to its enzyme activity?
Review
New
Cao et al., Hengyang, China. In Prog Biophys Mol Biol, Dec 2015
Dysfunction mutations in any of the three subunits of human RNase H2 complex can result in embryonic/perinatal lethality or cause Aicardi-Goutières syndrome (AGS).
Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives.
Review
New
Mutis et al., Utrecht, Netherlands. In Bone Marrow Transplant, Nov 2015
Their therapeutic effect, the graft-versus-tumor (GvT) effect, is based mainly on an alloimmune response of donor T cells directed at tumor cells, in which differences in the expression of minor histocompatibility Ags (mHags) on the cells of the patient and donor have a crucial role.
T cell antigen receptor recognition of antigen-presenting molecules.
Review
Impact
McCluskey et al., Australia. In Annu Rev Immunol, 2014
The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags).
Maintenance of Immune Homeostasis through ILC/T Cell Interactions.
Review
Finke et al., Basel, Switzerland. In Front Immunol, 2014
Both ILC2s and ILC3s are able to process and present foreign antigens (Ags) via major histocompatibility complex class II, and to induce cognate CD4(+) T cell responses.
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Impact
Ahn et al., Seoul, South Korea. In Nat Med, 2014
By enzymatically characterizing Aicardi-Goutières syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.
Impact
Crow et al., Manchester, United Kingdom. In Lancet Neurol, 2013
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.
GeneRIF
Pavlidis et al., Thessaloníki, Greece. In Clin Exp Metastasis, 2012
immunohistochemical analysis of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells.
GeneRIF
Spillane et al., Galway, Ireland. In Biochem Biophys Res Commun, 2012
these results reveal a regulatory interplay between miR-21, JAG1 and E2 that is important for advancing understanding of how the oncogenic potential of miR-21 and JAG1 manifests in different sub-types of breast cancer.
Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
GeneRIF
Asahara et al., Japan. In J Neurotrauma, 2012
transplanted endothelial progenitor cells promote astrogliosis, vascular regulation, and spinal cord regeneration through activation of Jagged1-Notch signaling
Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.
GeneRIF
Kawasaki et al., Tokyo, Japan. In Febs J, 2012
Study suggest the requirement for cell-surface localization of Jagged1 for cis-inhibition activities.
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
GeneRIF
Lo et al., Riverside, United States. In Dev Comp Immunol, 2012
Studies provide evidence that Jagged1 and Notch influence Peyer's patch follicle associated epithelium M cell numbers and distribution by regulating M cell development at an early stage within the crypts adjacent to the Peyer's patch follicle.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Impact
Butcher et al., Stanford, United States. In Immunity, 2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remained poorly defined.
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Impact
Stetson et al., Seattle, United States. In Immunity, 2012
Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease.
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