The origins, function, and regulation of T follicular helper cells.
Australia. In J Exp Med, Aug 2012
Ab responses against most antigens (Ags) require interactions between B cells and CD4(+) T helper cells, and it is now well recognized that T follicular helper cells (Tfh) specialize in providing cognate help to B cells and are fundamentally required for the generation of T cell-dependent B cell responses.
[Research progress of the anti-HIV activity of SAMHD1].
Shanghai, China. In Bing Du Xue Bao, Jun 2012
The early studies have focused on its gene mutations associated with Aicardi-Goutières syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis.
Helicobacter Pylori CagA and Gastric Carcinogenesis.
Beijing, China. In Asian Pac J Cancer Prev, 2011
Objectives: This study aimed to demonstrate the tyrosine phosphorylation motif (TPM) and 3' region structure of the Helicobacter pylori CagA gene as well as its SHP-2 binding activity in AGS cells and relation to gastric carcinogenesis.