gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Jagged 1

Ags, Jagged1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CD4, ACID
Papers using Ags antibodies
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
Xu Dawei et al., In Molecular Cancer, 2007
... Human gastric cancer cell lines AGS, BGC-823 and HGC-27, and cervical cancer cell lines HeLa and SiHa used in the present study were cultured at 37°C/95%air/5%CO2 in RPMI 1640 medium (Life Technologies, Paisley, Scotland, UK) containing ...
Recent insights into the role of Notch signaling in tumorigenesis
Kawakami T et al., In European Journal of Medical Research, 2005
... following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; 4°C, overnight) and Jagged1 rabbit polyclonal antibody (ab7771, Abcam plc, Cambridge; dilution: 1/500; ...
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Yim JH et al., In Cell death and differentiation, 2002
... Tetracycline inducible IRF-1 stably-transfected AGS cells (AGSI) were propagated with 10% Tet System Approved FBS from Clontech (Mountain View, CA, USA), ...
Papers on Ags
CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology.
Clark et al., Barcelona, Spain. In J Immunol, 15 Dec 2015
CD (cluster of differentiation) Ags are cell surface molecules expressed on leukocytes and other cells relevant for the immune system.
Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole.
Amini et al., Tehrān, Iran. In Med Chem, 12 Dec 2015
The antiproliferative activity of the final compounds were examined in MCF-7, AGS, HT-29 and NIH3T3 cell lines by MTT assay, using different concentration of each compounds to determine their IC50 .
Carbonic anhydrase 9 mRNA/microRNA34a interplay in hypoxic human mammospheres.
Bonafé et al., Bologna, Italy. In J Cell Physiol, 10 Dec 2015
We also convey that the over-expression of cloned CA9-mRNA-3'UTR increases the mRNA half-life and protein levels of two miR34a targets JAGGED1 and NOTCH3.
Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.
Haddad et al., Québec, Canada. In J Immunol, 06 Dec 2015
Altered microenvironmental conditions in lymphoid tissues leading to altered Tfh cell differentiation could provide one explanation for the poor responsiveness of HIV-infected individuals to new Ags.
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Tang et al., Shanghai, China. In Mol Med Report, 06 Dec 2015
The expression levels of CDC42 in the AGS and SGC7901 human GC cell lines were reduced by RNA interference.
RIG-I-like receptors and autoimmune diseases.
Fujita et al., Kyoto, Japan. In Curr Opin Immunol, 27 Nov 2015
Recently an increased expression of type I IFN, also termed IFN signature, has been reported in patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi-Goutières syndrome (AGS).
Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives.
Mutis et al., Utrecht, Netherlands. In Bone Marrow Transplant, 26 Nov 2015
Their therapeutic effect, the graft-versus-tumor (GvT) effect, is based mainly on an alloimmune response of donor T cells directed at tumor cells, in which differences in the expression of minor histocompatibility Ags (mHags) on the cells of the patient and donor have a crucial role.
Donor Unrestricted T Cells: A Shared Human T Cell Response.
Moody et al., Utrecht, Netherlands. In J Immunol, Oct 2015
The now-famous term "restriction" derived from experiments in which T cells from Donor A failed to recognize Ags presented by cells from Donor B. Restriction results from interdonor variation in MHC genes.
Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma.
Oudard et al., Paris, France. In Oncoimmunology, May 2015
Phase III trials are focusing on the possible synergy between therapeutic vaccines (e.g., IMA-901 and AGS-003) and anti-angiogenic agents.
T cell antigen receptor recognition of antigen-presenting molecules.
McCluskey et al., Australia. In Annu Rev Immunol, Dec 2014
The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags).
Maintenance of Immune Homeostasis through ILC/T Cell Interactions.
Finke et al., Basel, Switzerland. In Front Immunol, Dec 2014
Both ILC2s and ILC3s are able to process and present foreign antigens (Ags) via major histocompatibility complex class II, and to induce cognate CD4(+) T cell responses.
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Ahn et al., Seoul, South Korea. In Nat Med, Aug 2014
By enzymatically characterizing Aicardi-Goutières syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.
Crow et al., Manchester, United Kingdom. In Lancet Neurol, 2013
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.
Pavlidis et al., Thessaloníki, Greece. In Clin Exp Metastasis, 2012
immunohistochemical analysis of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells.
Spillane et al., Galway, Ireland. In Biochem Biophys Res Commun, 2012
these results reveal a regulatory interplay between miR-21, JAG1 and E2 that is important for advancing understanding of how the oncogenic potential of miR-21 and JAG1 manifests in different sub-types of breast cancer.
Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
Asahara et al., Japan. In J Neurotrauma, 2012
transplanted endothelial progenitor cells promote astrogliosis, vascular regulation, and spinal cord regeneration through activation of Jagged1-Notch signaling
Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.
Kawasaki et al., Tokyo, Japan. In Febs J, 2012
Study suggest the requirement for cell-surface localization of Jagged1 for cis-inhibition activities.
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
Lo et al., Riverside, United States. In Dev Comp Immunol, 2012
Studies provide evidence that Jagged1 and Notch influence Peyer's patch follicle associated epithelium M cell numbers and distribution by regulating M cell development at an early stage within the crypts adjacent to the Peyer's patch follicle.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Butcher et al., Stanford, United States. In Immunity, 2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remained poorly defined.
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Stetson et al., Seattle, United States. In Immunity, 2012
Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease.
share on facebooktweetadd +1mail to friends