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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Jagged 1

Ags, Jagged1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CD4, MHC
Papers using Ags antibodies
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
Supplier
Xu Dawei et al., In Molecular Cancer, 2007
... Human gastric cancer cell lines AGS, BGC-823 and HGC-27, and cervical cancer cell lines HeLa and SiHa used in the present study were cultured at 37°C/95%air/5%CO2 in RPMI 1640 medium (Life Technologies, Paisley, Scotland, UK) containing ...
Recent insights into the role of Notch signaling in tumorigenesis
Supplier
Kawakami T et al., In European Journal of Medical Research, 2005
... following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; 4°C, overnight) and Jagged1 rabbit polyclonal antibody (ab7771, Abcam plc, Cambridge; dilution: 1/500; ...
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Supplier
Yim JH et al., In Cell death and differentiation, 2002
... Tetracycline inducible IRF-1 stably-transfected AGS cells (AGSI) were propagated with 10% Tet System Approved FBS from Clontech (Mountain View, CA, USA), ...
Papers on Ags
The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance.
New
Dai et al., Shenyang, China. In Int J Oncol, 30 Nov 2014
Enhanced gene expression was detected when the HGC27, AGS and BGC823 GC cell lines were treated with the DNA-demethylating agent 5-aza-2'-deoxycytidine.
FcRγ-Chain ITAM Signaling Is Critically Required for Cross-Presentation of Soluble Antibody-Antigen Complexes by Dendritic Cells.
New
Leusen et al., Utrecht, Netherlands. In J Immunol, 29 Nov 2014
UNLABELLED: The uptake of Ag-Ab immune complexes (IC) after the ligation of activating FcγR on dendritic cells (DC) leads to 100 times more efficient Ag presentation than the uptake of free Ags.
CD28-CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation.
New
Parker et al., Oxford, United Kingdom. In J Immunol, 29 Nov 2014
UNLABELLED: Regulatory T cells (Tregs) are essential for tolerance to self and environmental Ags, acting in part by downmodulating costimulatory molecules on the surface of dendritic cells (DCs) and altering naive CD4 T cell-DC interactions.
Polyreactivity and Autoreactivity among HIV-1 Antibodies.
New
Kelsoe et al., Durham, United States. In J Virol, 29 Nov 2014
Our observations are consistent with a role of heteroligation for HIV-1 neutralization and/or structural mimicry of host Ags by conserved HIV-1 neutralization sites.
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
New
Impact
Ahn et al., Seoul, South Korea. In Nat Med, Aug 2014
By enzymatically characterizing Aicardi-Goutières syndrome (AGS)-associated SAMHD1 mutations and mutations in the allosteric dGTP-binding site of SAMHD1 for defects in RNase or dNTPase activity, we identify SAMHD1 point mutants that cause loss of one or both functions.
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad.
Review
New
Lanier et al., Charleston, United States. In Mol Pharmacol, Mar 2014
Activators of G protein signaling (AGS), initially discovered in the search for receptor-independent activators of G protein signaling, define a broad panel of biologic regulators that influence signal transfer from receptor to G-protein, guanine nucleotide binding and hydrolysis, G protein subunit interactions, and/or serve as alternative binding partners for Gα and Gβγ independently of the classic heterotrimeric Gαβγ.
13-Acetoxysarcocrassolide Induces Apoptosis on Human Gastric Carcinoma Cells Through Mitochondria-Related Apoptotic Pathways: p38/JNK Activation and PI3K/AKT Suppression.
New
Wu et al., Taiwan. In Mar Drugs, Dec 2013
13-acetoxysarcocrassolide (13-AC), an active compound isolated from cultured Formosa soft coral Sarcophyton crassocaule, was found to possess anti-proliferative and apoptosis-inducing activities against AGS (human gastric adenocarcinoma cells) gastric carcinoma cells.
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.
New
Impact
Crow et al., Manchester, United Kingdom. In Lancet Neurol, Dec 2013
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.
Review
New
Tangye et al., Australia. In Front Immunol, Dec 2013
Two broad categories of Ags exist that cause B-cell activation and differentiation: T cell dependent (TD) or T cell independent (TI).
Immunotherapeutic strategies for the treatment of renal cell carcinoma: where are we now?
Review
New
Stenzl et al., Tübingen, Germany. In Expert Rev Anticancer Ther, Dec 2013
Autologous or dendritic cell (DC) based tumor vaccination with vitespen or AGS-003, adoptive T-cell transfer and synthetic peptide vaccination with IMA901 are new and promising approaches.
The notch ligand JAGGED1 as a target for anti-tumor therapy.
Review
New
Harris et al., Oxford, United Kingdom. In Front Oncol, Dec 2013
One of the Notch ligands, Jagged1 (JAG1), is overexpressed in many cancer types, and plays an important role in several aspects of tumor biology.
The structural basis of antibody-antigen recognition.
Review
Ofran et al., Ramat Gan, Israel. In Front Immunol, 2012
The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of other components of the immune system to fight pathogens.
Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.
GeneRIF
Pavlidis et al., Thessaloníki, Greece. In Clin Exp Metastasis, 2012
immunohistochemical analysis of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells.
GeneRIF
Spillane et al., Galway, Ireland. In Biochem Biophys Res Commun, 2012
these results reveal a regulatory interplay between miR-21, JAG1 and E2 that is important for advancing understanding of how the oncogenic potential of miR-21 and JAG1 manifests in different sub-types of breast cancer.
Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
GeneRIF
Asahara et al., Japan. In J Neurotrauma, 2012
transplanted endothelial progenitor cells promote astrogliosis, vascular regulation, and spinal cord regeneration through activation of Jagged1-Notch signaling
Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.
GeneRIF
Kawasaki et al., Tokyo, Japan. In Febs J, 2012
Study suggest the requirement for cell-surface localization of Jagged1 for cis-inhibition activities.
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
GeneRIF
Lo et al., Riverside, United States. In Dev Comp Immunol, 2012
Studies provide evidence that Jagged1 and Notch influence Peyer's patch follicle associated epithelium M cell numbers and distribution by regulating M cell development at an early stage within the crypts adjacent to the Peyer's patch follicle.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Impact
Butcher et al., Stanford, United States. In Immunity, 2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remained poorly defined.
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Impact
Stetson et al., Seattle, United States. In Immunity, 2012
Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease.
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
Impact
Savina et al., Paris, France. In Cell, 2012
Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated immunity in response to certain pathogens and tumor cells.
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