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Agouti related protein homolog

AGRP, Agouti-related protein
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: Neuropeptide, neuropeptide Y, leptin, proopiomelanocortin, MC4R
Papers on AGRP
α-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?
Terzioğlu et al., In J Clin Res Pediatr Endocrinol, Jan 2016
The anorexigenic neuropeptide α-melanocyte-stimulating hormone (α-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among major peptides produced by hypothalamus.
Decreased hypothalamic glucagon-like peptide-1 receptor expression in type 2 diabetes patients.
Alkemade et al., Amsterdam, Netherlands. In J Clin Endocrinol Metab, Jan 2016
We observed sporadic co-localization of the GLP-1R in the IFN with the orgexigenic neuropeptide Y (NPY), agouti related peptide (AGRP), or pro-opiomelanocortin (POMC) transcripts.
Blunted hypothalamic ghrelin signaling reduces diet intake in rats fed a low-protein diet in late pregnancy.
Yallampalli et al., Houston, United States. In Physiol Rep, Dec 2015
Hypothalami were dissected and analyzed for expression of genes related to appetite regulation (Npy, Agrp, Pomc and Cart) and phosphorylation of AMPK and ACC proteins (downstream proteins of ghrelin receptor activation).
Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol.
Roepke et al., New Brunswick, United States. In Mol Cell Endocrinol, Dec 2015
Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons.
Kaidashev et al., Poltava, Ukraine. In Georgian Med News, Nov 2015
The second, control, group consisted of 16 males and 11 females with BMI - 18.5 - 24.9 kg/m 2. Lipid profile, fasting glucose and insulin levels, HOMA-IR, TNF-α, ceruloplasmin, neuropeptides Agouti-related protein - AgRP and kokain- and amphetamine-mediated transcript - CART were examined at the beginning of the study (Day 1) and after 10 week treatment period (Day 70).
Regulation of the avian central melanocortin system and the role of leptin.
Dunn et al., Newcastle upon Tyne, United Kingdom. In Gen Comp Endocrinol, Oct 2015
The avian central melanocortin system is well conserved between birds and mammals in terms of the component genes, the localisation of their expression in the hypothalamic arcuate nucleus, the effects on feeding behaviour of their encoded peptides and the sensitivity of agouti-related protein (AGRP) and pro-opiomelanocortin (POMC) gene expression to changes in energy status.
Neurons for hunger and thirst transmit a negative-valence teaching signal.
Sternson et al., United States. In Nature, Jun 2015
We found that starvation-sensitive AGRP neurons exhibit properties consistent with a negative-valence teaching signal.
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Cone et al., Nashville, United States. In Nature, May 2015
The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role in the regulation of energy homeostasis.
Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding.
Horvath et al., New Haven, United States. In Cell, Apr 2015
Hypothalamic Agrp neurons are known to be crucial for feeding behavior.
Genetic association studies of obesity in Africa: a systematic review.
Kengne et al., Cape Town, South Africa. In Obes Rev, Mar 2015
Polymorphisms in genes such as ACE, ADIPOQ, ADRB2, AGRP, AR, CAPN10, CD36, C7orf31, DRD4, FTO, MC3R, MC4R, SGIP1 and LEP were found to be associated with various measures of obesity.
Evolution of the melanocortin system.
Cerdá-Reverter et al., Castelló de la Plana, Spain. In Gen Comp Endocrinol, 2015
It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs).
Parallel, redundant circuit organization for homeostatic control of feeding behavior.
Sternson et al., United States. In Cell, 2014
This is exemplified by AGRP neurons, which are a molecularly defined population that is sufficient to rapidly coordinate voracious food seeking and consumption behaviors.
Agouti-related protein neuron circuits that regulate appetite.
Atasoy et al., United States. In Neuroendocrinology, 2013
Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior.
Targeting central melanocortin receptors: a promising novel approach for treating alcohol abuse disorders.
Thiele et al., Chapel Hill, United States. In Front Neurosci, 2013
Agouti-related protein (AgRP), also produced in the arcuate nucleus, is secreted in terminals expressing MCRs and functions as an endogenous MCR antagonist.
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.
Horvath et al., New Haven, United States. In Cell, 2013
Here, we show that mitochondria number decrease but their size increase in orexigenic agouti-related protein (Agrp) neurons during the transition from fasted to fed to overfed state.
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors.
Horvath et al., New Haven, United States. In Nat Neurosci, 2012
A previously unsuspected role is revealed for hypothalamic hunger-promoting Agrp neurons in setting midbrain dopamine neuronal activity and nonfood-related behaviors.
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.
Accili et al., New York City, United States. In Cell, 2012
Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17.
AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in αMSH are related to type 2 diabetes.
Kalsbeek et al., Almere Stad, Netherlands. In J Clin Endocrinol Metab, 2012
AgRP and NPY are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms.
Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.
Palmiter et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2012
AgRP-expressing neurons play a critical role in mediating the metabolic syndrome and infertility of Lep(ob/ob) mice, whereas MCH-expressing neurons have only a minor role
Heparanase affects food intake and regulates energy balance in mice.
Dickson et al., Göteborg, Sweden. In Plos One, 2011
heparanase acts as a negative modulator of AgRP signaling at MC4R, through cleavage of heparan sulfate chains presumably linked to syndecan-3
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