[CHANGES IN LIFESTYLE FACTORS AFFECT THE LEVELS OF NEUROPEPTIDES, INVOLVED IN THE CONTROL OF EATING BEHAVIOR, INSULIN RESISTANCE AND LEVEL OF CHRONIC SYSTEMIC INFLAMMATION IN YOUNG OVERWEIGHT PERSONS].
Poltava, Ukraine. In Georgian Med News, Nov 2015
The second, control, group consisted of 16 males and 11 females with BMI - 18.5 - 24.9 kg/m 2. Lipid profile, fasting glucose and insulin levels, HOMA-IR, TNF-α, ceruloplasmin, neuropeptides Agouti-related protein - AgRP and kokain- and amphetamine-mediated transcript - CART were examined at the beginning of the study (Day 1) and after 10 week treatment period (Day 70).
Regulation of the avian central melanocortin system and the role of leptin.
Newcastle upon Tyne, United Kingdom. In Gen Comp Endocrinol, Oct 2015
The avian central melanocortin system is well conserved between birds and mammals in terms of the component genes, the localisation of their expression in the hypothalamic arcuate nucleus, the effects on feeding behaviour of their encoded peptides and the sensitivity of agouti-related protein (AGRP) and pro-opiomelanocortin (POMC) gene expression to changes in energy status.
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Nashville, United States. In Nature, May 2015
The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role in the regulation of energy homeostasis.
Genetic association studies of obesity in Africa: a systematic review.
Cape Town, South Africa. In Obes Rev, Mar 2015
Polymorphisms in genes such as ACE, ADIPOQ, ADRB2, AGRP, AR, CAPN10, CD36, C7orf31, DRD4, FTO, MC3R, MC4R, SGIP1 and LEP were found to be associated with various measures of obesity.
Evolution of the melanocortin system.
Castelló de la Plana, Spain. In Gen Comp Endocrinol, 2015
It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs).
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.
New York City, United States. In Cell, 2012
Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17.