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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hm:gc12

Agrin
Top mentioned proteins: MuSK, CAN, ACID, STEP, V1a
Papers on Agrin
Effects of a One-Year Physical Activity Program on Serum C-Terminal Agrin Fragment (CAF) Concentrations among Mobility-Limited Older Adults.
New
Life Study Investigators et al., Gainesville, United States. In J Nutr Health Aging, Nov 2015
OBJECTIVES: C-terminal Agrin Fragment (CAF) has been proposed as a potential circulating biomarker for predicting changes in physical function among older adults.
Myasthenia gravis: subgroup classification and therapeutic strategies.
Review
New
Impact
Verschuuren et al., Bergen, Norway. In Lancet Neurol, Oct 2015
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and fatigue, is B-cell mediated, and is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction.
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo.
New
Dell'Accio et al., Hamburg, Germany. In Ann Rheum Dis, Sep 2015
Agrin is a heparan sulfate proteoglycan which, through binding to low-density lipoprotein receptor-related protein 4 (LRP4), is required for neuromuscular synapse formation.
Combination of agrin and laminin increase acetylcholine receptor clustering and enhance functional neuromuscular junction formation In vitro.
New
Kapsa et al., Melbourne, Australia. In Dev Neurobiol, Sep 2015
The aim of this study is to investigate the effect of agrin and laminin-1; agents with known AChR clustering activity; on NMJ formation and muscle maturation.
Effects of electroacupuncture on recovery of the electrophysiological properties of the rabbit gastrocnemius after contusion: an in vivo animal study.
Wang et al., Beijing, China. In Bmc Complement Altern Med, 2014
We also examined acetylcholinesterase (AchE) and Agrin expression in the neuromuscular junction (NMJ) via immunohistochemistry. RESULTS: Compared with the contusion group, the EMG amplitude and NCV in rabbits in the EA group were significantly higher at all time points after contusion.
C-Terminal Fragment of Agrin (CAF): A Novel Marker for Progression of Kidney Disease in Type 2 Diabetics.
Arampatzis et al., Bern, Switzerland. In Plos One, 2014
C-terminal fragment of agrin (CAF) is a novel kidney function and injury biomarker.
The Basement Membrane Proteoglycans Perlecan and Agrin: Something Old, Something New.
McCarthy, Shreveport, United States. In Curr Top Membr, 2014
Several members of the proteoglycan family are integral components of basement membranes; other proteoglycan family members interact with or bind to molecular residents of the basement membrane.
Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction.
Review
Mei et al., Augusta, United States. In Dev Neurobiol, 2014
Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation.
The role of MuSK in synapse formation and neuromuscular disease.
Review
Zhang et al., New York City, United States. In Cold Spring Harb Perspect Biol, 2013
Developing synapses are stabilized by neuronal Agrin, which is released by motor nerve terminals and binds to Lrp4, a member of the low-density lipoprotein receptor family, stimulating further association between Lrp4 and MuSK and increasing MuSK kinase activity.
The disturbed blood-brain barrier in human glioblastoma.
Review
Wolburg-Buchholz et al., Tübingen, Germany. In Mol Aspects Med, 2012
Probably, this dislocation might be due to the degradation of the proteoglycan agrin by the matrix metalloproteinase 3 (MMP3).
Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction.
Review
Salinas et al., Concepción, Chile. In Acta Physiol (oxf), 2012
Here, we focus our attention on recent studies at the vertebrate NMJ that demonstrate that some Wnt proteins collaborate with the Agrin-MuSK signalling to induce post-synaptic differentiation.
Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish.
GeneRIF
Cole et al., Durham, United States. In Birth Defects Res A Clin Mol Teratol, 2011
Agrin expression and function may be a target of ethanol exposure during embryogenesis.
Lrp4 is a receptor for Agrin and forms a complex with MuSK.
Impact
Burden et al., New York City, United States. In Cell, 2008
MuSK, a receptor tyrosine kinase that is expressed in skeletal muscle, and Agrin, a motor neuron-derived ligand that stimulates MuSK phosphorylation, play critical roles in synaptic differentiation, as synapses do not form in their absence, and mutations in MuSK or downstream effectors are a major cause of a group of neuromuscular disorders, termed congenital myasthenic syndromes (CMS).
Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.
GeneRIF
Cole et al., Bethesda, United States. In Glycobiology, 2007
Agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish.
Alpha3Na+/K+-ATPase is a neuronal receptor for agrin.
Impact
Smith et al., Irvine, United States. In Cell, 2006
Agrin, through its interaction with the receptor tyrosine kinase MuSK, mediates accumulation of acetylcholine receptors (AChR) at the developing neuromuscular junction.
Synapses form in skeletal muscles lacking neuregulin receptors.
Impact
Brenner et al., Basel, Switzerland. In Science, 2005
Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated.
New insights into the roles of agrin.
Review
Impact
Ruegg et al., Basel, Switzerland. In Nat Rev Mol Cell Biol, 2003
The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues.
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