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1-acylglycerol-3-phosphate O-acyltransferase 6

AGPAT6, GPAT4
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: ACID, Diacylglycerol O-Acyltransferase, Calnexin, STEP, HAD
Papers on AGPAT6
Application of human haploid cell genetic screening model in identifying the genes required for resistance to environmental toxicants: Chlorpyrifos as a case study.
New
Ren et al., Buffalo, United States. In J Pharmacol Toxicol Methods, Nov 2015
RESULTS: We identified total 9 human genes in which the cells carrying these genes conferred the resistance to CPF, including AGPAT6, AIG1, ATP8B2, BIK, DCAF12, FNBP4, LAT2, MZF1-AS1 and PPTC7.
Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression.
New
de Lima et al., São Paulo, Brazil. In Biochim Biophys Acta, Oct 2015
Gene expression of TAG synthesis enzymes (ApoB100, MTTP, GPAT1 and GPAT4) was not differentially altered in TLR4/LDLr KO and LDLrKO mice.
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Review
New
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes.
New
Coleman et al., Chapel Hill, United States. In J Biol Chem, Jul 2015
Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups grew poorly during the suckling period and, as adults, were protected from high fat diet-induced obesity.
Short communication: Effect of inhibition of fatty acid synthase on triglyceride accumulation and effect on lipid metabolism genes in goat mammary epithelial cells.
New
Loor et al., Urbana, United States. In J Dairy Sci, May 2015
Inhibition of FASN in mammary cells by C75-mediated interference, a synthetic inhibitor of FASN activity, and short hairpin RNA-mediated interference markedly reduced cellular triglyceride content at least in part by decreasing the expression of genes related to triglyceride synthesis (GPAT, AGPAT6, and DGAT2) and enhancing the expression of lipolysis-related genes (ATGL and HSL).
Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.
New
Lezmi et al., Champaign, United States. In Toxicol Appl Pharmacol, May 2015
In PND1 males, BPA increased hepatic expression of FFA uptake gene Fat/Cd36, and decreased the expression of TG synthesis- and β-oxidation-related genes (Dgat, Agpat6, Cebpα, Cebpβ, Pck1, Acox1, Cpt1a, Cybb).
Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.
Nielsen et al., Göteborg, Sweden. In Sci Rep, 2014
Five of the identified metabolic genes, AGPAT6, GALT, GCLC, GSS, and RRM2B, were predicted to be dispensable in normal cell metabolism.
Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells.
Ajuwon et al., West Lafayette, United States. In Plos One, 2014
Results show that butyrate treatment enhanced adipogenesis and lipid accumulation, perhaps through upregulation of glucose uptake and de novo lipogenesis and other mechanisms that include induction of SREBP-1c, C/EBPα/β, GLUT4, LPL, PPARγ, GPAT4, DGAT1 and DGAT2 expression.
Functional roles of three cutin biosynthetic acyltransferases in cytokinin responses and skotomorphogenesis.
Guo et al., Lanzhou, China. In Plos One, 2014
The gfc1-associated phenotypes were also observed in the cutin-deficient glycerol-3-phosphate acyltransferase 4/8 (gpat4/8) double mutant [defective in glycerol-3-phosphate (G3P) acyltransferase enzymes GPAT4 and GPAT8, which redundantly catalyze the acylation of G3P by hydroxyl fatty acid (OH-FA)], but not in the cutin-deficient mutant cytochrome p450, family 86, subfamily A, polypeptide 2/aberrant induction of type three 1 (cyp86A2/att1), which affects the biosynthesis of some OH-FAs.
Peroxisome proliferator-activated receptor γ1 and γ2 isoforms alter lipogenic gene networks in goat mammary epithelial cells to different extents.
Loor et al., China. In J Dairy Sci, 2014
Along with a tendency for greater expression of AGPAT6, DGAT1, and PLIN2, these data suggest that PPARG1 is the isoform controlling lipogenesis in mammary cells.
Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
Coleman et al., Chapel Hill, United States. In Am J Physiol Endocrinol Metab, 2014
We asked whether microsomal GPAT4, an isoform regulated by insulin, might contribute to the development of hepatic insulin resistance.
Glycerol-3-phosphate acyltransferase 4 is essential for the normal development of reproductive organs and the embryo in Brassica napus.
Weselake et al., Edmonton, Canada. In J Exp Bot, 2014
The enzyme sn-glycerol-3-phosphate acyltransferase 4 (GPAT4) is involved in the biosynthesis of plant lipid poly-esters.
Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Gimeno et al., Cambridge, United States. In Am J Physiol Endocrinol Metab, 2014
Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two closely related genes, GPAT3 and GPAT4.
Glycerolipid acyltransferases in triglyceride metabolism and energy homeostasis-potential as drug targets.
Review
Hammond et al., Indianapolis, United States. In Endocr Metab Immune Disord Drug Targets, 2012
The potential function of one of the GPATs, GPAT4, was studied in GPAT4 deficient mice that suggested its role in TAG synthesis in multiple tissues.
GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
GeneRIF
Cao et al., Cambridge, United States. In J Lipid Res, 2010
Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.
GeneRIF
Lu et al., Changsha, China. In Acta Biochim Biophys Sin (shanghai), 2009
Glycerol-3-phosphate acyltransferase 4 might play an important role in spermatogenesis, especially in mid-meiosis.[Glycerol-3-phosphate acyltransferase 4]
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity.
Review
Cao et al., Cambridge, United States. In J Lipid Res, 2008
The activity referred to as microsomal GPAT is encoded by two closely related genes, GPAT3 and GPAT4.
ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation.
GeneRIF
Loor et al., Urbana, United States. In J Nutr, 2008
The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
GeneRIF
Cao et al., Indianapolis, United States. In J Biol Chem, 2008
AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4.
Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.
GeneRIF
Coleman et al., Chapel Hill, United States. In J Lipid Res, 2008
"Agpat6(-/-) mice" are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4
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