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Acylglycerol kinase

AGK, acetylglutamate kinase, ARG5,6, acylglycerol kinase
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, N-acetylglucosamine kinase, CAN, HAD, STEP
Papers on AGK
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
New
Herson et al., Aurora, United States. In Exp Neurol, Jan 2016
The Sirt2 inhibitor AGK-2 was administered intravenously 30min after resuscitation.
Controlling the transcription levels of argGH redistributed L-arginine metabolic flux in N-acetylglutamate kinase and ArgR-deregulated Corynebacterium crenatum.
New
Xu et al., Wuxi, China. In J Ind Microbiol Biotechnol, Jan 2016
Further study indicated that feedback inhibition of SYPA5-5 N-acetylglutamate kinase (CcNAGK) by L-arginine, as another rate-limiting step, could be deregulated by introducing point mutations.
Acylglycerol kinase is over-expressed in early-stage cervical squamous cell cancer and predicts poor prognosis.
New
Yu et al., Guangzhou, China. In Tumour Biol, Jan 2016
UNASSIGNED: Acylglycerol kinase (AGK) had been shown to contribute to cancer progression and unfavorable clinical outcomes of patients.
Modular pathway engineering of Corynebacterium glutamicum for production of the glutamate-derived compounds ornithine, proline, putrescine, citrulline, and arginine.
New
Wendisch et al., Bielefeld, Germany. In J Biotechnol, Dec 2015
Feedback alleviation of N-acetylglutamate kinase, tuning of the promoter of glutamate dehydrogenase gene gdh, lowering expression of phosphoglucoisomerase gene pgi, along with the introduction of a second copy of the arginine biosynthesis operon argCJB(A49V,M54V)D into the chromosome resulted in a C. glutamicum strain producing ornithine with a yield of 0.52g ornithine per g glucose, an increase of 71% as compared to the parental ΔargFRG strain.
Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma.
New
Guo et al., Guangzhou, China. In Tumour Biol, Nov 2015
UNASSIGNED: Acylglycerol kinase (AGK) has been reported to promote a malignant phenotype and enhance the development of cancer stem cells.
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
New
Alkuraya et al., Riyadh, Saudi Arabia. In Trans Am Ophthalmol Soc, Sep 2015
The remaining 12 families each had mutations in 12 different genes (CRYAA, CRYBA1, AKR1E2, AGK, BFSP2, CYP27A1, CYP51A1, EPHA2, GCNT2, LONP1, RNLS, WDR87) with unique phenotypes noted for CYP27A1 (bilateral juvenile fleck with anterior and/or posterior capsular cataract and later cerebrotendinous xanthomatosis), EPHA2 (bilateral anterior persistent fetal vasculature), and BFSP2 (bilateral flecklike with cloudy cortex).
miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling.
New
Chi, Daqing, China. In Biomed Pharmacother, Apr 2015
Furthermore, we demonstrated that miR-194 could reduce the phosphoinositide 3-kinase (PI3K)/AKT/FoxO3a signaling pathway by suppressing acylglycerol kinase (AGK) directly, resulting in decreasing cyclin D1 expression and increasing expression of p21 in OSCC.
Lipid metabolism in mitochondrial membranes.
Review
Mayr, Salzburg, Austria. In J Inherit Metab Dis, 2015
Mutations in TAZ, SERAC1 and AGK affect mitochondrial phospholipid metabolism and cause Barth syndrome, MEGDEL and Sengers syndrome, respectively.
Fermentative production of the diamine putrescine: system metabolic engineering of corynebacterium glutamicum.
Wendisch et al., Bielefeld, Germany. In Metabolites, 2014
Additional engineering steps improved further putrescine production with the largest contributions from preventing the formation of the by-product N-acetylputrescine by deletion of spermi(di)ne N-acetyltransferase gene snaA and from overexpression of the gene for a feedback-resistant N-acetylglutamate kinase variant.
Metabolic pathway engineering using the central signal processor PII.
Forchhammer et al., Tübingen, Germany. In Microb Cell Fact, 2014
PCC6803 strain with a PII-I86N mutation over-accumulated arginine through constitutive activation of the key enzyme N-acetylglutamate kinase (NAGK).
The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms.
Review
Tuchman et al., Washington, D.C., United States. In Int J Mol Sci, 2014
A bifunctional enzyme was identified in certain bacteria, which catalyzes both NAGS and N-acetylglutamate kinase (NAGK) activities, the first two steps of the arginine biosynthetic pathway.
The genetics of feed conversion efficiency traits in a commercial broiler line.
Wimmers et al., Germany. In Sci Rep, 2014
The analyses pointed to acylglycerol kinase (AGK) and general transcription factor 2-I (GTF2I) as positional and functional candidate genes.
Sengers syndrome: six novel AGK mutations in seven new families and review of the phenotypic and mutational spectrum of 29 patients.
Review
Prokisch et al., Boston, United States. In Orphanet J Rare Dis, 2013
Mutations in the acylglycerol kinase (AGK) gene have been recently described as the cause of Sengers syndrome in nine families.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Review
Saudubray et al., Paris, France. In J Inherit Metab Dis, 2013
(3) Muscular/cardiac presentations include recurrent myoglobinuria in phosphatidate phosphatase 1 (Lipin1) deficiency; cardiomyopathy and multivisceral involvement in Barth syndrome secondary to tafazzin mutations; congenital muscular dystrophy due to choline kinase deficiency, Sengers syndrome due to acylglycerol kinase deficiency and Chanarin Dorfman syndrome due to α/β- hydrolase 5 deficiency.
Identification of a truncation mutation of acylglycerol kinase (AGK) gene in a novel autosomal recessive cataract locus.
GeneRIF
Alkuraya et al., Riyadh, Saudi Arabia. In Hum Mutat, 2012
This is the first mutation in AGK gene to be implicated in the development of isolated cataract.
Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome.
GeneRIF
Prokisch et al., Salzburg, Austria. In Am J Hum Genet, 2012
The loss of AGK led to a decrease of the adenine nucleotide translocator in the inner mitochondrial membrane in muscle.
Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
GeneRIF
Mootha et al., Boston, United States. In Sci Transl Med, 2012
Recessive mutations in AGK cause mitochondrial DNA depletion
Small-molecule chromatin-modifying agents: therapeutic applications.
Review
Mai, Roma, Italy. In Epigenomics, 2010
Furthermore, the SIRT2-selective AGK-2 has been reported to have protective effects against Parkinson's disease, and resveratrol and other sirtuin activators can be useful for the treatment of Alzheimer's disease.
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
GeneRIF
Kakehi et al., Japan. In Cancer Sci, 2009
High Expression of acylglycerol kinase is associated with development and progression of prostate cancer.
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
GeneRIF
Topham et al., Hamilton, Canada. In Biochemistry, 2008
The chiral specificity of diacylglycerol kinase alpha, zeta & epsilon mimics the substrate specificity, with MuLK being the least selective and the epsilon isoform of diacylglycerol kinase exhibiting the greatest selectivity.
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