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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aggrecan

Aggrecan, A GC, AGC1
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, ACID, HAD, CD45
Papers on Aggrecan
High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF.
New
Chai et al., Shanghai, China. In Biomaterials, Mar 2016
In the present work, biodegradable high-purity magnesium (HP Mg) showed good cytocompatibility and promoted the expression of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), fibrocartilage markers (Aggrecan, COL2A1 and SOX-9), and glycosaminoglycan (GAG) production in vitro.
Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1.
New
Zhou et al., Beijing, China. In Tissue Eng Part A, Jan 2016
A putative pro-chondrogenic growth factor, NEL-like molecule-1 (NELL-1), was added to the hPSC pellets to upregulate gene expression of chondrogenic markers including AGGRECAN, COLLAGEN II, and COMP.
A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole.
New
Mangion et al., Rahway, United States. In J Pharm Biomed Anal, Jan 2016
UNASSIGNED: N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture.
A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan.
New
Du et al., Taiyuan, China. In J Chromatogr B Analyt Technol Biomed Life Sci, Jan 2016
A GC-MS based metabolomics approach and the multivariate statistical methods were used for analyzing the urine metabolites of depressed patients before and after treatment compared with healthy controls.
Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays.
New
Pierri et al., Bari, Italy. In Biochem Pharmacol, Dec 2015
We also demonstrated that chebulinic acid and suramin are "highly selective" AAC2 inhibitors, since they poorly inhibit other human mitochondrial carriers (namely ORC1, APC1 and AGC1).
Alendronate Prevents Intervertebral Disc Degeneration Adjacent to a Lumbar Fusion in Ovariectomized Rats.
New
Zhang et al., Tangshan, China. In Spine (phila Pa 1976), Nov 2015
ALN also significantly decreased Col-I, MMP-13, and ADAMTS-4 expression and increased Col-II and Aggrecan expression in the disc matrix (P < 0.05).
Role of AGC1/aralar in the metabolic synergies between neuron and glia.
Review
New
Contreras, Madrid, Spain. In Neurochem Int, Sep 2015
This review will consider the cellular distribution of the mitochondrial aspartate-glutamate carrier, aralar/AGC1/SLC25A12, and its role in the synergic metabolism between neurons and astrocytes.
The regulation of neuronal mitochondrial metabolism by calcium.
Review
New
Satrustegui et al., Madrid, Spain. In J Physiol, Sep 2015
The aspartate-glutamate exchanger Aralar/AGC1 (Slc25a12), a component of the malate-aspartate shuttle (MAS), is stimulated by modest increases in cytosolic Ca(2+) and upregulates respiration in cortical neurons by enhancing pyruvate supply into mitochondria.
A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats.
Li et al., Tianjin, China. In Molecules, 2014
Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA).
MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
GeneRIF
Hansson et al., Lund, Sweden. In Biochem J, 2012
Data suggest that matrix metalloproteinases are mainly involved in normal aggrecan turnover in extracellular matrix and may have less-active roles in aggrecan degradation during knee injury or osteoarthritis (where aggrecanase-1 has central role).
Aggrecan: Beyond cartilage and into the brain.
GeneRIF
Matthews et al., Leipzig, Germany. In Int J Biochem Cell Biol, 2012
In the CNS, aggrecan is expressed in a precise and tightly regulated manner both temporally and spatially. (Review)
Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains.
GeneRIF
Yin et al., Chongqing, China. In Exp Neurol, 2012
We suggest that the role of aggrecan is to maintain retinal ganglion cell dendritic structure in the inner plexiform layer and to provide adequate support and flexibility for the photoreceptor outer segments, which is necessary to maintain their function.
Perinatal exposure to vitamin A differentially regulates chondrocyte growth and the expression of aggrecan and matrix metalloprotein genes in the femur of neonatal rats.
GeneRIF
Ross et al., United States. In J Nutr, 2012
Data suggest that expression of aggrecan and matrix metallopeptidase 13 in femur of female neonatal rats is altered by maternal vitamin A status and neonatal diet (i.e., supplementation with vitamin A and retinoic acid).
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
GeneRIF
Singh et al., Shanghai, China. In Eur Cell Mater, 2011
Increased expression of collagen II, aggrecan, and cartilage oligomeric matrix protein (COMP), were observed during differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes.
The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autism.
Review
Palmieri et al., Roma, Italy. In Mol Neurobiol, 2011
SLC25A12, an ASD susceptibility gene, encodes the Ca(2+)-regulated mitochondrial aspartate-glutamate carrier, isoform 1 (AGC1).
Genetics of digital osteoarthritis.
Review
Michou, Canada. In Joint Bone Spine, 2011
Many candidate-gene studies found associations with AGC1, ASPN, ENPP1, HFE, KL, VDR, IL-1 cluster, and IL-6, although the results were not consistently reproducible.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Impact
Pap et al., Hannover, Germany. In Nat Med, 2009
Aggrecan cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 5 (ADAMTS-5) is crucial for the breakdown of cartilage matrix during osteoarthritis, a degenerative joint disease that leads to the progressive destruction of articular structures.
AGC1 deficiency associated with global cerebral hypomyelination.
Impact
Wedell et al., Stockholm, Sweden. In N Engl J Med, 2009
The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), specific to neurons and muscle, supplies aspartate to the cytosol and, as a component of the malate-aspartate shuttle, enables mitochondrial oxidation of cytosolic NADH, thought to be important in providing energy for neurons in the central nervous system.
Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review.
Review
MacGregor et al., Norwich, United Kingdom. In Ann Rheum Dis, 2008
We found relatively few instances in which a specific gene-disease association had been analysed by more than one study, and there were 14 cases in which significant associations were replicated in independent studies (at joints associated with the AGC1, ASPN, COL9A2, COL9A3, COL11A2, ESR1, FZRB, HFE, IL1A, IL1RN, PTGS2 and VDR genes).
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.
Impact
Ikegawa et al., Tokyo, Japan. In Nat Genet, 2005
Asporin suppresses TGF-beta-mediated expression of the genes aggrecan (AGC1) and type II collagen (COL2A1) and reduced proteoglycan accumulation in an in vitro model of chondrogenesis.
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