GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGAP1, KIAA1099, A GAP, centaurin gamma-2, CENTG2
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from
MacLennan et al., Adelaide, Australia. In Mol Psychiatry, Feb 2015
Ten de novo mutations in three previously identified disease genes (TUBA1A (n=2), SCN8A (n=1) and KDM5C (n=1)) and in six novel candidate CP genes (AGAP1, JHDM1D, MAST1, NAA35, RFX2 and WIPI2) were predicted to be potentially pathogenic for CP.
Cunningham et al., Vancouver, Canada. In Healthc Policy, 2011
THERE IS A GAP BETWEEN RHETORIC AND REALITY CONCERNING HEALTHCARE EXPENDITURES AND POPULATION AGING: although decades-old research suggests otherwise, there is widespread belief that the sustainability of the healthcare system is under serious threat owing to population aging.
Willman et al., Albuquerque, United States. In Blood, 2011
One unique cluster was characterized by high expression of distinct outlier genes AGAP1, CCNJ, CHST2/7, CLEC12A/B, and PTPRM; ERG DNA deletions; and 4-year relapse-free survival of 94.7% ± 5.1%, compared with 63.5% ± 3.7% for the cohort (P = .01).
Greengard et al., New York City, United States. In Embo J, 2010
The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.