gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Alpha-fetoprotein

AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, POLYMERASE, Serum albumin
Papers using AFP antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... The reagent for assaying AFP consists of magnetic nanoparticles (MF-DEX-0060, MagQu, New Taipei, Taiwan, Republic of China) functionalized with antibodies (ab40942; Abcam, Cambridge, MA), against AFP ...
27 kDa extracellular matrix protein revealed by a monoclonal antibody raised against rat testis.
Supplier
Uversky Vladimir N., In PLoS ONE, 1999
... Human AFP (#105-10, Lee Biosolutions, Inc., USA) was purified ...
The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions
Supplier
Hemmilä Ilkka A. et al., In Analytical and Bioanalytical Chemistry, 1988
... and hCGβ and AFP-coated cups and calibrators were from the DELFIA Xpress Free hCGβ and AFP Immunoassay Kits (PerkinElmer).
Papers on AFP
JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis.
New
Hu et al., Shanghai, China. In J Cancer Res Clin Oncol, 27 Apr 2014
High JAB1 and p27S10 expression correlated with histological grade, vascular invasion, and serum α-fetoprotein (AFP) level (all P < 0.01).
Nanocomposites: Graphene-Ruthenium(II) Complex Composites for Sensitive ECL Immunosensors (Small 4/2014).
New
Xia et al., Nanjing, China. In Small, 28 Feb 2014
A solidstate electrochemiluminescent (ECL) immunosensor is developed based on the Ru-PTCA/G nanocomposites for sensitive detection of α-fetoprotein (AFP).
Aberrant p16INK4A methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma.
New
Elghobary et al., Cairo, Egypt. In South Asian J Cancer, Jan 2014
All HCC cases with aberrant p16INK4A methylation show very high serum alpha fetoprotein (AFP) level (9,080; 30,000 μg/mL).
Albumin suppresses human hepatocellular carcinoma proliferation and the cell cycle.
New
Joh et al., Nagoya, Japan. In Int J Mol Sci, Dec 2013
After 24-h incubation, the expressions of α-fetoprotein (AFP), p53, p21, and p57 were evaluated with real-time PCR using total RNA extracted from the liver.
Alpha-fetoprotein: a renaissance.
Review
New
Moldogazieva et al., Moscow, Russia. In Tumour Biol, Aug 2013
Alpha-fetoprotein (AFP) is a major mammalian embryo-specific and tumor-associated protein that is also present in small quantities in adults at normal conditions.
Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.
Review
New
Mizejewski, Albany, United States. In Tumour Biol, Jun 2013
The identification of a tumor cell receptor for alpha-fetoprotein (AFP) has long been sought in the field of medicine.
HSP72 and gp96 in gastroenterological cancers.
Review
New
Yang et al., Xianyang, China. In Clin Chim Acta, Mar 2013
Interestingly, studies have found that HSP72 chaperoned alpha-fetoprotein (AFP), HBx in hepatocellular carcinoma, and CD44 in colonic carcinomas.
Expression and role of icam-1 in the occurrence and development of hepatocellular carcinoma.
Review
Gong et al., Chongqing, China. In Asian Pac J Cancer Prev, 2012
ICAM-1 has diagnostic significance for AFP-negative or suspected HCC, and may be a prognositic significance.
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
GeneRIF
Kishimoto et al., Chiba, Japan. In Exp Mol Pathol, 2012
The results indicated that histone deacetylation is a silencing mechanism for GATA4 expression in AFP-producing gastric cancer cells.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Impact
Qin et al., Shanghai, China. In Lancet Oncol, 2012
Furthermore, DKK1 maintained diagnostic accuracy for patients with HCC who were α-fetoprotein (AFP) negative (0·841 [0·801-0·882], 70·4%, and 90·0% in the test cohort; 0·869 [0·815-0·923], 66·7%, and 87·2% in the validation cohort), including for patients with early-stage HCC (0·870 [0·829-0·911], 73·1%, and 90·0% in the test cohort; 0·893 [0·804-0·983], 72·2%, and 87·2% in the validation cohort), compared with all controls.
AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma.
GeneRIF
Tokat et al., İstanbul, Turkey. In Hepatobiliary Pancreat Dis Int, 2012
Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation for hepatocellular carcinoma.
The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
GeneRIF
Qu et al., Beijing, China. In Hepatogastroenterology, 2012
The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with hepatocellular carcinoma after curative resection.
Distinctions between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients.
GeneRIF
Zhang et al., Xi'an, China. In Asian Pac J Cancer Prev, 2011
High alpha-fetoprotein is associated with hepatocelluar carcinoma.
GP73 expression and its significance in the diagnosis of hepatocellular carcinoma: a review.
Review
Cui et al., Guangzhou, China. In Int J Clin Exp Pathol, 2011
Serum alpha-fetoprotein (AFP) levels and abdominal ultrasound have been widely used for diagnosis as well as surveillance of HCC.
Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary tract - a comparative study from the western region of Nepal.
GeneRIF
Hussain et al., Pokhara, Nepal. In Asian Pac J Cancer Prev, 2010
High alpha fetoprotein is associated with hepatocellular carcinoma.
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Impact
Keller et al., New York City, United States. In Nat Biotechnol, 2006
Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45-70%) for cells that express the alpha-fetoprotein and albumin proteins.
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions.
Impact
McConkey et al., Waterloo, Canada. In Nat Biotechnol, 2006
However, the underlying molecular basis of their ice-binding activity is unclear because of the difficulty of studying the AFP-ice interaction directly and the lack of a common motif, domain or fold among different AFPs.
Carcinoma with shared pathologic characteristics of both hepatocellular carcinoma and cholangiocarcinoma.
Onji et al., Japan. In Curr Ther Res Clin Exp, 2005
BACKGROUND: α-Fetoprotein (AFP) is a useful marker of hepatocellular carcinoma (HCC), and protein induced by vitamin K absence or antagonist II (PIVKA-II) and fucosylated AFP (AFP-L3) are specific tumor markers.
The initiation of liver development is dependent on Foxa transcription factors.
Impact
Kaestner et al., Philadelphia, United States. In Nature, 2005
In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression of the hepatoblast marker alpha-fetoprotein (Afp) is lost.
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Impact
Dong et al., Atlanta, United States. In Nat Genet, 2005
Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good candidate for the 16q22 tumor-suppressor gene.
share on facebooktweetadd +1mail to friends