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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Alpha-fetoprotein

AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, PrP, ACID
Papers using AFP antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... The reagent for assaying AFP consists of magnetic nanoparticles (MF-DEX-0060, MagQu, New Taipei, Taiwan, Republic of China) functionalized with antibodies (ab40942; Abcam, Cambridge, MA), against AFP ...
27 kDa extracellular matrix protein revealed by a monoclonal antibody raised against rat testis.
Supplier
Uversky Vladimir N., In PLoS ONE, 1999
... Human AFP (#105-10, Lee Biosolutions, Inc., USA) was purified ...
The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions
Supplier
Hemmilä Ilkka A. et al., In Analytical and Bioanalytical Chemistry, 1988
... and hCGβ and AFP-coated cups and calibrators were from the DELFIA Xpress Free hCGβ and AFP Immunoassay Kits (PerkinElmer).
Papers on AFP
Serum fucosylated paraoxonase 1 as a potential glycobiomarker for clinical diagnosis of early hepatocellular carcinoma using ELISA Index.
New
Liu et al., Shanghai, China. In Glycoconj J, 22 Mar 2015
ELISA Index in training group (90 LC and 90 HCC) was measured and area under the ROC curve (AUROC) was 0.803 with 80 % of sensitivity and 64.4 % of specificity in distinguishing early HCC from LC. Within training group, AFP(-) HCC (20/90) exhibited better AUROC (0.850), higher sensitivity (90 %) and specificity (75 %) than AFP(+) HCC (70/90).
Afp14 is involved in regulating the length of Anti-feeding prophage (Afp).
New
Hurst et al., Christchurch, New Zealand. In Mol Microbiol, 17 Mar 2015
UNASSIGNED: The anti-feeding prophage (Afp), a phage-tail-like particle that causes cessation of feeding in the New Zealand grass grub, Costelytra zealandica, is encoded by 18 open reading frames (afp1-18).
miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells.
New
Tang et al., Tianjin, China. In Oncotarget, 21 Feb 2015
UNASSIGNED: Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC).
Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells.
New
Cao et al., Hangzhou, China. In Oncotarget, 21 Feb 2015
UNASSIGNED: To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-phosphate dehydrogenase, eukaryotic translation initiation factor 4E and DNA polymerase α respectively under the control of a recombinant promoter comprised of human α-fetoprotein enhancer and basal promoter.
Serum miR-224 Reflects Stage of Hepatocellular Carcinoma and Predicts Survival.
New
Meng et al., Shanghai, China. In Biomed Res Int, Dec 2014
Serum levels of miR-224 showed significant relation with parameters of liver damage and serum AFP.
The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein: is the same receptor present on circulating monocytes and macrophages? A commentary.
Review
New
Mizejewski, Albany, United States. In Tumour Biol, Aug 2014
Recently, it was proposed that the alpha-fetoprotein (AFP) receptor, known to be present on solid epithelial-derived malignant tumor cells, can be identified as a mucin glycoprotein.
Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.
Review
New
Lee et al., Hong Kong, Hong Kong. In Expert Rev Mol Diagn, Jun 2014
In comparison to serum α-fetoprotein (AFP) level, which remains the gold standard for HCC diagnosis, high serum DKK1 levels have higher diagnostic value for HCC, especially for AFP-negative HCC, and can distinguish HCC from non-malignant chronic liver diseases.
Alpha-fetoprotein, a fascinating protein and biomarker in neurology.
Review
New
Willemsen et al., Nijmegen, Netherlands. In Eur J Paediatr Neurol, May 2014
Alpha-fetoprotein (AFP) is present in fetal serum in concentrations up to 5,000,000 μg/l.
Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature.
Review
New
Slone et al., Louisville, United States. In Mod Pathol, Apr 2014
The current diagnostic criteria for hepatoid adenocarcinoma of lung include typical acinar or papillary adenocarcinoma and a component resembling hepatocellular carcinoma and expressing α-fetoprotein (AFP).
Diagnostic accuracy of Golgi protein 73 in primary hepatic carcinoma using ELISA: a systematic review and meta-analysis.
Review
Bao et al., In Clin Lab, 2013
CONCLUSIONS: Serum GP73 has a relatively high diagnostic accuracy in primary hepatic carcinoma with better sensitivity and high specificity than AFP.
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
GeneRIF
Kishimoto et al., Chiba, Japan. In Exp Mol Pathol, 2012
The results indicated that histone deacetylation is a silencing mechanism for GATA4 expression in AFP-producing gastric cancer cells.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Impact
Qin et al., Shanghai, China. In Lancet Oncol, 2012
Furthermore, DKK1 maintained diagnostic accuracy for patients with HCC who were α-fetoprotein (AFP) negative (0·841 [0·801-0·882], 70·4%, and 90·0% in the test cohort; 0·869 [0·815-0·923], 66·7%, and 87·2% in the validation cohort), including for patients with early-stage HCC (0·870 [0·829-0·911], 73·1%, and 90·0% in the test cohort; 0·893 [0·804-0·983], 72·2%, and 87·2% in the validation cohort), compared with all controls.
AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma.
GeneRIF
Tokat et al., İstanbul, Turkey. In Hepatobiliary Pancreat Dis Int, 2012
Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation for hepatocellular carcinoma.
The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
GeneRIF
Qu et al., Beijing, China. In Hepatogastroenterology, 2012
The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with hepatocellular carcinoma after curative resection.
Distinctions between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients.
GeneRIF
Zhang et al., Xi'an, China. In Asian Pac J Cancer Prev, 2011
High alpha-fetoprotein is associated with hepatocelluar carcinoma.
Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary tract - a comparative study from the western region of Nepal.
GeneRIF
Hussain et al., Pokhara, Nepal. In Asian Pac J Cancer Prev, 2010
High alpha fetoprotein is associated with hepatocellular carcinoma.
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Impact
Keller et al., New York City, United States. In Nat Biotechnol, 2006
Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45-70%) for cells that express the alpha-fetoprotein and albumin proteins.
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions.
Impact
McConkey et al., Waterloo, Canada. In Nat Biotechnol, 2006
However, the underlying molecular basis of their ice-binding activity is unclear because of the difficulty of studying the AFP-ice interaction directly and the lack of a common motif, domain or fold among different AFPs.
The initiation of liver development is dependent on Foxa transcription factors.
Impact
Kaestner et al., Philadelphia, United States. In Nature, 2005
In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression of the hepatoblast marker alpha-fetoprotein (Afp) is lost.
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Impact
Dong et al., Atlanta, United States. In Nat Genet, 2005
Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good candidate for the 16q22 tumor-suppressor gene.
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