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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Alpha-fetoprotein

AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, PrP
Papers using AFP antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... The reagent for assaying AFP consists of magnetic nanoparticles (MF-DEX-0060, MagQu, New Taipei, Taiwan, Republic of China) functionalized with antibodies (ab40942; Abcam, Cambridge, MA), against AFP ...
27 kDa extracellular matrix protein revealed by a monoclonal antibody raised against rat testis.
Supplier
Uversky Vladimir N., In PLoS ONE, 1999
... Human AFP (#105-10, Lee Biosolutions, Inc., USA) was purified ...
The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions
Supplier
Hemmilä Ilkka A. et al., In Analytical and Bioanalytical Chemistry, 1988
... and hCGβ and AFP-coated cups and calibrators were from the DELFIA Xpress Free hCGβ and AFP Immunoassay Kits (PerkinElmer).
Papers on AFP
Detection of multiple cocirculating wild poliovirus type 1 lineages through environmental surveillance: impact and progress during 2011-2013 in pakistan.
New
Zaidi et al., Islamabad, Pakistan. In J Infect Dis, 01 Dec 2014
BACKGROUND: The environmental surveillance has proven to be a useful tool to identify poliovirus circulation in different countries and was started in Pakistan during July 2009 to support the acute flaccid paralysis (AFP) surveillance system.
Combined aberrant expression of N-Myc downstream-regulated gene 2 and CD24 is associated with disease-free survival and overall survival in patients with hepatocellular carcinoma.
New
Chen et al., In Diagn Pathol, 23 Nov 2014
Moreover, combined NDRG2 downregulation and CD24 upregulation (NDRG2-low/CD24-high) more frequently occurred in HCC tissues with high serum AFP (P¿=¿0.03),
The use of α-fetoprotein for the delivery of cytotoxic payloads to cancer cells.
New
Pak, In Ther Deliv, Aug 2014
On the other hand, AFP-drug non-covalent complexes can exploit the natural role of the AFP as a nutrition delivery "shuttle".
Diagnostic accuracy of Golgi protein 73 in primary hepatic carcinoma using ELISA: a systematic review and meta-analysis.
Review
New
Bao et al., In Clin Lab, Dec 2013
CONCLUSIONS: Serum GP73 has a relatively high diagnostic accuracy in primary hepatic carcinoma with better sensitivity and high specificity than AFP.
Overexpression of HOXA13 as a Potential Marker for Diagnosis and Poor Prognosis of Hepatocellular Carcinoma.
New
Xu et al., Tianjin, China. In Tohoku J Exp Med, Dec 2013
Receiver operating characteristics was analyzed to calculate diagnostic accuracy of serum HOXA13, alpha-fetoprotein (AFP) and their combination.
Clinical applicability of multi-tumor marker protein chips for diagnosing ovarian cancer.
New
Ming et al., Zhengzhou, China. In Asian Pac J Cancer Prev, Dec 2013
MATERIALS AND METHODS: Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, β-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects.
Alpha-fetoprotein: a renaissance.
Review
New
Moldogazieva et al., Moscow, Russia. In Tumour Biol, Aug 2013
Alpha-fetoprotein (AFP) is a major mammalian embryo-specific and tumor-associated protein that is also present in small quantities in adults at normal conditions.
Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.
Review
New
Mizejewski, Albany, United States. In Tumour Biol, Jun 2013
The identification of a tumor cell receptor for alpha-fetoprotein (AFP) has long been sought in the field of medicine.
HSP72 and gp96 in gastroenterological cancers.
Review
New
Yang et al., Xianyang, China. In Clin Chim Acta, Mar 2013
Interestingly, studies have found that HSP72 chaperoned alpha-fetoprotein (AFP), HBx in hepatocellular carcinoma, and CD44 in colonic carcinomas.
Expression and role of icam-1 in the occurrence and development of hepatocellular carcinoma.
Review
Gong et al., Chongqing, China. In Asian Pac J Cancer Prev, 2012
ICAM-1 has diagnostic significance for AFP-negative or suspected HCC, and may be a prognositic significance.
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
GeneRIF
Kishimoto et al., Chiba, Japan. In Exp Mol Pathol, 2012
The results indicated that histone deacetylation is a silencing mechanism for GATA4 expression in AFP-producing gastric cancer cells.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Impact
Qin et al., Shanghai, China. In Lancet Oncol, 2012
Furthermore, DKK1 maintained diagnostic accuracy for patients with HCC who were α-fetoprotein (AFP) negative (0·841 [0·801-0·882], 70·4%, and 90·0% in the test cohort; 0·869 [0·815-0·923], 66·7%, and 87·2% in the validation cohort), including for patients with early-stage HCC (0·870 [0·829-0·911], 73·1%, and 90·0% in the test cohort; 0·893 [0·804-0·983], 72·2%, and 87·2% in the validation cohort), compared with all controls.
AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma.
GeneRIF
Tokat et al., İstanbul, Turkey. In Hepatobiliary Pancreat Dis Int, 2012
Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation for hepatocellular carcinoma.
The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
GeneRIF
Qu et al., Beijing, China. In Hepatogastroenterology, 2012
The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with hepatocellular carcinoma after curative resection.
Distinctions between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients.
GeneRIF
Zhang et al., Xi'an, China. In Asian Pac J Cancer Prev, 2011
High alpha-fetoprotein is associated with hepatocelluar carcinoma.
Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary tract - a comparative study from the western region of Nepal.
GeneRIF
Hussain et al., Pokhara, Nepal. In Asian Pac J Cancer Prev, 2010
High alpha fetoprotein is associated with hepatocellular carcinoma.
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Impact
Keller et al., New York City, United States. In Nat Biotechnol, 2006
Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45-70%) for cells that express the alpha-fetoprotein and albumin proteins.
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions.
Impact
McConkey et al., Waterloo, Canada. In Nat Biotechnol, 2006
However, the underlying molecular basis of their ice-binding activity is unclear because of the difficulty of studying the AFP-ice interaction directly and the lack of a common motif, domain or fold among different AFPs.
The initiation of liver development is dependent on Foxa transcription factors.
Impact
Kaestner et al., Philadelphia, United States. In Nature, 2005
In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression of the hepatoblast marker alpha-fetoprotein (Afp) is lost.
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Impact
Dong et al., Atlanta, United States. In Nat Genet, 2005
Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good candidate for the 16q22 tumor-suppressor gene.
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