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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Alpha-fetoprotein

AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, PrP
Papers using AFP antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... The reagent for assaying AFP consists of magnetic nanoparticles (MF-DEX-0060, MagQu, New Taipei, Taiwan, Republic of China) functionalized with antibodies (ab40942; Abcam, Cambridge, MA), against AFP ...
27 kDa extracellular matrix protein revealed by a monoclonal antibody raised against rat testis.
Supplier
Uversky Vladimir N., In PLoS ONE, 1999
... Human AFP (#105-10, Lee Biosolutions, Inc., USA) was purified ...
The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions
Supplier
Hemmilä Ilkka A. et al., In Analytical and Bioanalytical Chemistry, 1988
... and hCGβ and AFP-coated cups and calibrators were from the DELFIA Xpress Free hCGβ and AFP Immunoassay Kits (PerkinElmer).
Papers on AFP
Structure and Dynamics of Antifreeze Protein - Model Membrane Interactions: A Combined Spectroscopic and Molecular Dynamics Study.
New
Bhunia et al., In J Phys Chem B, 19 Feb 2016
Micelle model systems of zwitterionic DPC and negatively charged SDS were utilized in this study, against which a significant interaction is experienced by two AFP molecules, namely Peptide 1m and wfAFP (the popular AFP sourced from winter flounder).
Transcription Factors and Medium Suitable for Initiating the Differentiation of Human Induced Pluripotent Stem Cells to the Hepatocyte Lineage.
New
Ishige et al., Yotsukaidō, Japan. In J Cell Biochem, 15 Feb 2016
RNA was isolated and subjected to real-time quantitative PCR to analyze the expression of alpha-feto protein (AFP) and albumin.
Expression profile and prognostic value of glypican-3 in post-operative South Korean hepatocellular carcinoma patients.
New
Jeong et al., Seoul, South Korea. In Apmis, 13 Feb 2016
GPC3-positive patients were younger with higher frequencies of microvascular invasion and higher AFP levels than GPC3-negative patients.
Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells.
New
Li et al., Haikou, China. In J Cell Mol Med, 12 Feb 2016
UNASSIGNED: A high level of serum alpha fetoprotein (AFP) is positively associated with human hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of AFP in HCC metastasis is unknown.
SSRP1 contributes to the malignancy of hepatocellular carcinoma and is negatively regulated by miR-497.
New
Guoan et al., Guangzhou, China. In Mol Ther, 12 Feb 2016
We also demonstrated its up-regulation was associated with several clinicopathologic features such as higher serum AFP level, larger tumor size and higher T stage of HCC patients; and its high expression indicated shorter overall survival and faster recurrence.
Hepatic miR-126 is a Potential Plasma Biomarker for Detection of Hepatitis B Virus Infected Hepatocellular Carcinoma.
New
Banerjee et al., Calcutta, India. In Int J Cancer, 12 Feb 2016
Subsequently, ROC curve analysis revealed that neither miR-126 nor miR-142-3p performed better than AFP in discriminating HCC from non-HCC while combination of each with AFP showed significantly higher efficiency rather than AFP alone (AUC: 0.922, 0.908 vs. 0.88; sensitivity: 0.84, 0.86 vs. 0.82 and specificity: 0.92, 0.94 vs. 0.86 respectively).
A new paradigm about HERV-K102 particle production and blocked release to explain cortisol mediated immunosenescence and age-associated risk of chronic disease.
New
Laderoute, Ottawa, Canada. In Discov Med, 31 Dec 2015
New evidence presented here suggests DHEA but not DHEA-S may specifically bind and inactivate alpha-fetoprotein (AFP).
Alpha-fetoprotein-L3 and Golgi protein 73 may serve as candidate biomarkers for diagnosing alpha-fetoprotein-negative hepatocellular carcinoma.
New
Xu et al., Mingshui, China. In Onco Targets Ther, 31 Dec 2015
Currently, there is no reliable biomarker for use in diagnosing alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC).
[Yeast expression and application of an antifreeze protein from the desert beetle Microdera punctipennis].
New
Ma et al., In Sheng Wu Gong Cheng Xue Bao, Aug 2015
Insect antifreeze protein (AFP) has high antifreeze activity.
Influence of vascular endothelial growth factor and alpha-fetoprotein on hepatocellular carcinoma.
Silva et al., Ribeirão Preto, Brazil. In Genet Mol Res, 2014
Serum VEGF and alpha-fetoprotein (AFP) levels were determined and used to characterize sensitivity and specificity.
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
GeneRIF
Kishimoto et al., Chiba, Japan. In Exp Mol Pathol, 2012
The results indicated that histone deacetylation is a silencing mechanism for GATA4 expression in AFP-producing gastric cancer cells.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Impact
Qin et al., Shanghai, China. In Lancet Oncol, 2012
Furthermore, DKK1 maintained diagnostic accuracy for patients with HCC who were α-fetoprotein (AFP) negative (0·841 [0·801-0·882], 70·4%, and 90·0% in the test cohort; 0·869 [0·815-0·923], 66·7%, and 87·2% in the validation cohort), including for patients with early-stage HCC (0·870 [0·829-0·911], 73·1%, and 90·0% in the test cohort; 0·893 [0·804-0·983], 72·2%, and 87·2% in the validation cohort), compared with all controls.
AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma.
GeneRIF
Tokat et al., İstanbul, Turkey. In Hepatobiliary Pancreat Dis Int, 2012
Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation for hepatocellular carcinoma.
The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
GeneRIF
Qu et al., Beijing, China. In Hepatogastroenterology, 2012
The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with hepatocellular carcinoma after curative resection.
Distinctions between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients.
GeneRIF
Zhang et al., Xi'an, China. In Asian Pac J Cancer Prev, 2011
High alpha-fetoprotein is associated with hepatocelluar carcinoma.
Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary tract - a comparative study from the western region of Nepal.
GeneRIF
Hussain et al., Pokhara, Nepal. In Asian Pac J Cancer Prev, 2010
High alpha fetoprotein is associated with hepatocellular carcinoma.
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Impact
Keller et al., New York City, United States. In Nat Biotechnol, 2006
Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45-70%) for cells that express the alpha-fetoprotein and albumin proteins.
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions.
Impact
McConkey et al., Waterloo, Canada. In Nat Biotechnol, 2006
However, the underlying molecular basis of their ice-binding activity is unclear because of the difficulty of studying the AFP-ice interaction directly and the lack of a common motif, domain or fold among different AFPs.
The initiation of liver development is dependent on Foxa transcription factors.
Impact
Kaestner et al., Philadelphia, United States. In Nature, 2005
In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression of the hepatoblast marker alpha-fetoprotein (Afp) is lost.
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Impact
Dong et al., Atlanta, United States. In Nat Genet, 2005
Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good candidate for the 16q22 tumor-suppressor gene.
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