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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

Alpha-fetoprotein

AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, PrP, ACID
Papers using AFP antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... The reagent for assaying AFP consists of magnetic nanoparticles (MF-DEX-0060, MagQu, New Taipei, Taiwan, Republic of China) functionalized with antibodies (ab40942; Abcam, Cambridge, MA), against AFP ...
27 kDa extracellular matrix protein revealed by a monoclonal antibody raised against rat testis.
Supplier
Uversky Vladimir N., In PLoS ONE, 1999
... Human AFP (#105-10, Lee Biosolutions, Inc., USA) was purified ...
The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions
Supplier
Hemmilä Ilkka A. et al., In Analytical and Bioanalytical Chemistry, 1988
... and hCGβ and AFP-coated cups and calibrators were from the DELFIA Xpress Free hCGβ and AFP Immunoassay Kits (PerkinElmer).
Papers on AFP
Targeting Gene-Virus-Mediated Manganese Superoxide Dismutase Effectively Suppresses Tumor Growth in Hepatocellular Carcinoma In Vitro and In Vivo.
New
Xia et al., Hangzhou, China. In Cancer Biother Radiopharm, 21 Dec 2014
In this article, the dual-regulated oncolytic adenovirus Ad-AFP-E1A-E1B(Δ55kDa)-Mn-SOD (briefly named AD55-Mn-SOD) was constructed using a liver cancer-specific α-fetoprotein (AFP) promoter to control replication-essential E1A gene and deliver the novel tumor suppression gene Manganese superoxide dismutase (Mn-SOD).
Multiplication of alpha-fetoprotein and protein induced by vitamin K absence-II is a powerful predictor of prognosis and recurrence in hepatocellular carcinoma patients after a hepatectomy.
New
Taketomi et al., Laizhou, China. In Hepatol Res, 10 Dec 2014
AIM: To evaluate the oncological implications of multiplication of alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonists-II (PIVKA-II) in patients with hepatocellular carcinoma (HCC).
Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis.
New
Su et al., United States. In Hepatol Res, 10 Dec 2014
It had a sensitivity of 81.8% (36/44) for AFP-negative HCC.
Diagnostic Value of Serum Level of Soluble Tumor Necrosis Factor Receptor IIα in Egyptian Patients With Chronic Hepatitis C Virus Infection and Hepatocellular Carcinoma.
New
Abutaleb et al., Cairo, Egypt. In Hepat Mon, Sep 2014
in addition, the following laboratory tests were requested: liver function tests, complete blood count, HBsAg, anti-HCVAb, HCV-RNA by qualitative PCR, and serum levels of α-fetoprotein (AFP) and sTNFR-IIα.
Diagnostic accuracy of Golgi protein 73 in primary hepatic carcinoma using ELISA: a systematic review and meta-analysis.
Review
New
Bao et al., In Clin Lab, Dec 2013
CONCLUSIONS: Serum GP73 has a relatively high diagnostic accuracy in primary hepatic carcinoma with better sensitivity and high specificity than AFP.
Cytoplasmic and/or Nuclear Expression of β-Catenin Correlate with Poor Prognosis and Unfavorable Clinicopathological Factors in Hepatocellular Carcinoma: A Meta-Analysis.
New
Cai et al., Hangzhou, China. In Plos One, Dec 2013
Besides, no significant association was observed between cytoplasmic and/or nuclear β-catenin expression and poor differentiation grade, advanced TNM stage, liver cirrhosis, tumor size, tumor encapsulation, AFP and etiologies.
Alpha-fetoprotein: a renaissance.
Review
New
Moldogazieva et al., Moscow, Russia. In Tumour Biol, Aug 2013
Alpha-fetoprotein (AFP) is a major mammalian embryo-specific and tumor-associated protein that is also present in small quantities in adults at normal conditions.
Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.
Review
New
Mizejewski, Albany, United States. In Tumour Biol, Jun 2013
The identification of a tumor cell receptor for alpha-fetoprotein (AFP) has long been sought in the field of medicine.
HSP72 and gp96 in gastroenterological cancers.
Review
New
Yang et al., Xianyang, China. In Clin Chim Acta, Mar 2013
Interestingly, studies have found that HSP72 chaperoned alpha-fetoprotein (AFP), HBx in hepatocellular carcinoma, and CD44 in colonic carcinomas.
Expression and role of icam-1 in the occurrence and development of hepatocellular carcinoma.
Review
Gong et al., Chongqing, China. In Asian Pac J Cancer Prev, 2012
ICAM-1 has diagnostic significance for AFP-negative or suspected HCC, and may be a prognositic significance.
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
GeneRIF
Kishimoto et al., Chiba, Japan. In Exp Mol Pathol, 2012
The results indicated that histone deacetylation is a silencing mechanism for GATA4 expression in AFP-producing gastric cancer cells.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Impact
Qin et al., Shanghai, China. In Lancet Oncol, 2012
Furthermore, DKK1 maintained diagnostic accuracy for patients with HCC who were α-fetoprotein (AFP) negative (0·841 [0·801-0·882], 70·4%, and 90·0% in the test cohort; 0·869 [0·815-0·923], 66·7%, and 87·2% in the validation cohort), including for patients with early-stage HCC (0·870 [0·829-0·911], 73·1%, and 90·0% in the test cohort; 0·893 [0·804-0·983], 72·2%, and 87·2% in the validation cohort), compared with all controls.
AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma.
GeneRIF
Tokat et al., İstanbul, Turkey. In Hepatobiliary Pancreat Dis Int, 2012
Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation for hepatocellular carcinoma.
The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.
GeneRIF
Qu et al., Beijing, China. In Hepatogastroenterology, 2012
The two cut-off values of preoperative AFP levels might be of different implications in cirrhotic patients with hepatocellular carcinoma after curative resection.
Distinctions between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive hepatocelluar carcinoma patients.
GeneRIF
Zhang et al., Xi'an, China. In Asian Pac J Cancer Prev, 2011
High alpha-fetoprotein is associated with hepatocelluar carcinoma.
Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary tract - a comparative study from the western region of Nepal.
GeneRIF
Hussain et al., Pokhara, Nepal. In Asian Pac J Cancer Prev, 2010
High alpha fetoprotein is associated with hepatocellular carcinoma.
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Impact
Keller et al., New York City, United States. In Nat Biotechnol, 2006
Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45-70%) for cells that express the alpha-fetoprotein and albumin proteins.
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions.
Impact
McConkey et al., Waterloo, Canada. In Nat Biotechnol, 2006
However, the underlying molecular basis of their ice-binding activity is unclear because of the difficulty of studying the AFP-ice interaction directly and the lack of a common motif, domain or fold among different AFPs.
The initiation of liver development is dependent on Foxa transcription factors.
Impact
Kaestner et al., Philadelphia, United States. In Nature, 2005
In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression of the hepatoblast marker alpha-fetoprotein (Afp) is lost.
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
Impact
Dong et al., Atlanta, United States. In Nat Genet, 2005
Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good candidate for the 16q22 tumor-suppressor gene.
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