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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aldo-keto reductase family 7, member A3

Afar, AKR7A2, aflatoxin B1 aldehyde reductase, AKR7A1
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, fibrillin-1
Papers on Afar
Far-ultraviolet absorbance detection of sugars and peptides by high-performance liquid chromatography.
Koda et al., Kokubunji, Japan. In J Chromatogr A, Jan 2016
A far-ultraviolet (FUV)-absorbance detector with a transmission flow cell was developed and applied to detect absorbance of sugars and peptides by HPLC.
Enhancing Tissue Engineering and Regenerative Medicine Product Commercialization: The Role of Science in Regulatory Decision-Making for the TE/RM Product Development.
Hellman et al., Blacksburg, United States. In Tissue Eng Part A, Oct 2015
A far-ranging discussion with FDA representatives, industrialists, physicians, regenerative medicine biologists, and tissue engineers considered the gaps in today's scientific and regulatory understanding of TE/RM technologies.
Spinal neurenteric cysts: Associated developmental anomalies and rationale of surgical approaches.
Jain et al., Lucknow, India. In Acta Neurochir (wien), Sep 2015
A far lateral approach was adopted for anteriorly placed FM lesions and posterior laminectomy for subaxial lesions.
Dual Origin of Extradural Posterior Inferior Cerebellar Artery From Vertebral and Occipital Arteries: Anatomic Case Report.
Benet et al., San Francisco, United States. In Neurosurgery, Aug 2015
METHODS: A far lateral exposure was completed on a cadaveric head prepared for surgical simulation.
A far-field radio-frequency experimental exposure system with unrestrained mice.
Ewert et al., Fargo, United States. In Springerplus, 2014
Many studies have been performed on exploring the effects of radio-frequency (RF) energy on biological function in vivo.
Exploring causal networks underlying fat deposition and muscularity in pigs through the integration of phenotypic, genotypic and transcriptomic data.
Rosa et al., Madison, United States. In Bmc Syst Biol, 2014
One genomic region on SSC6 showed significant associations with three relevant phenotypes, off-midline10th-rib backfat thickness, loin muscle weight, and average intramuscular fat percentage, and also with the expression of seven genes, including ZNF24, SSX2IP, and AKR7A2.
How the brainstem controls orofacial behaviors comprised of rhythmic actions.
Wang et al., San Diego, United States. In Trends Neurosci, 2014
A far greater challenge is to understand the coordination of multiple actions.
Pathogenic mechanisms of bradykinin mediated diseases: dysregulation of an innate inflammatory pathway.
Joseph et al., Charleston, United States. In Adv Immunol, 2013
A far more rapid activation of the remaining unactivated factor XII occurs by enzymatic cleavage by kallikrein (kallikrein-feedback) and sequential cleavage yields two forms of activated factor XII; namely, factor XIIa followed by factor XII fragment (factor XIIf).
"Common synthetic scaffolds" in the synthesis of structurally diverse natural products.
Zografos et al., Thessaloníki, Greece. In Chem Soc Rev, 2012
A far more economical approach using common synthetic scaffolds that can be readily transformed through biomimetic-like pathways to a range of structurally diverse natural products has been evolved in the last decade, leading synthesis to new directions.
Corpora cavernosa lesion by gunshot. Case study and literature review.
de la Peña Barthel et al., Madrid, Spain. In Actas Urol Esp, 2009
A far more exceptional cause is a gunshot wound; in this case, there are frequently concomitant lesions to other structures.
Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency.
Gibson et al., Roma, Italy. In Hum Genomics, 2009
SSADH, in conjunction with aldo-keto reductase 7A2 (AKR7A2), represent two neural enzymes responsible for further catabolism of succinic semialdehyde, producing either succinate (SSADH) or gamma-hydroxybutyrate (GHB; AKR7A2).
Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.
Henrich et al., Heidelberg, Germany. In Cancer Lett, 2009
The human AFAR gene family maps to a genomic region in 1p36 of frequent hemizygous deletions in various human cancers.
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.
Han et al., Jinan, China. In Pancreatology, 2008
Aflatoxin B(1) aldehyde reductase (AKR7A2) was confirmed to be only highly expressed in pancreatic cancer, not in normal adjacent pancreas and benign tumors.
Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.
Ellis et al., Glasgow, United Kingdom. In J Biol Chem, 2007
The human aldo-keto reductase AKR7A2 has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to gamma-Hydroxybutyrate in human brain
Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.
Ellis et al., Glasgow, United Kingdom. In Toxicology, 2006
AKR7A isozymes may be important in protecting against toxic aldehydes derived from lipid peroxidation in vivo
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Schwab et al., Heidelberg, Germany. In Oncogene, 2003
structure and tissue-related expression of AFAR genes
A Far-Field Hydrothermal Plume from Loihi Seamount
Lupton, United States. In Science, 1996
An extensive helium plume in the north central Pacific emanates from Loihi Seamount on the flanks of Hawaii.
A Western apache writing system: the symbols of silas john.
Anderson et al., In Science, 1973
A far more useful contrast, and one we have already employed, is presented in most etic typologies as an opposition between compound (composite) and noncompound (noncomposite) symbols.
Apollo 16 far-ultraviolet camera/spectrograph: Earth observations.
Page et al., In Science, 1972
A far-ultraviolet camera/spectograph experiment was operated on the lunar surface during the Apollo 16 mission.
Exposed guyot from the afar rift, ethiopia.
Tazieff et al., In Science, 1970
A series of originally submarine volcanoes has been found in the Afar Depression.
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