AFAP120 regulates actin organization during neuronal differentiation.
Minneapolis, United States. In Differentiation, 2009
These results indicate that AFAP120 plays a role in organizing dynamic actin structures during neuronal differentiation and suggest that AFAP120 may help regulate the transition from motile precursor to morphologically differentiated neurons.
Familial adenomatous polyposis.
Kefar Sava, Israel. In Orphanet J Rare Dis, 2008
A less aggressive variant of FAP, attenuated FAP (AFAP), is characterized by fewer colorectal adenomatous polyps (usually 10 to 100), later age of adenoma appearance and a lower cancer risk.
Colonic polyps in children and adolescents.
Toronto, Canada. In Can J Gastroenterol, 2007
Attenuated familial adenamatous polyposis (AFAP) can occur either by a mutation at the extreme ends of the adenomatous polyposis coli gene or by biallelic mutations in the mutY homologue (MYH) gene.
Matrix-degrading podosomes in smooth muscle cells.
Salzburg, Austria. In Eur J Cell Biol, 2006
The molecular basis for this local inhibition of contractility includes the clustering of cortactin during podosome formation (which precedes the rapid, local dispersion of myosin, tropomyosin and h1 calponin), and the specific recruitment of 110-kDa actin filament-associated protein (AFAP-110) and 190-kDa Rho-specific GTPase-activating protein (p190RhoGAP) to the microdomains.