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Solute carrier family 4, anion exchanger, member 1

AE1, Anion Exchange Protein 1, HA1
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, HAD, vimentin, S-100, CAN
Papers using AE1 antibodies
Probing the unknown in cancer of unknown primary: which way is the right way?
Supplier
Stojadinovic Alexander et al., In Journal of Cancer, 2009
... for LCA (which reacts with all hematopoietic cells, including lymphocytes) and cytokeratin (CK) AE1/AE3 (clone; AE1/AE3, Dako, Carpinteria, CA,USA) (which react ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
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Adam Patrick et al., In Diagnostic Pathology, 2006
... AE1/3DAKO ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.
Supplier
Dent Paul, In PLoS ONE, 2006
... Monoclonal antibodies against cytokeratin (AE1/AE3) was purchased from DAKO (Glostrup, Denmark) ...
A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancer
Supplier
Balslev Eva et al., In Pathology Research International, 2005
... were done at two levels 200 microns apart with 2 HE and one section with anticytokeratin AE1/AE3 IHC (DAKO, ready to use) ...
Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases
Supplier
Ghorab Zeina et al., In Diagnostic Pathology, 2003
... AE1/AE3Dako (Carpinteria, CA) ...
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Papers on AE1
Influence of magnesium sulfate on HCO3/Cl transmembrane exchange rate in human erythrocytes.
New
Chernyshev et al., Novosibirsk, Russia. In J Theor Biol, Feb 2016
For a quantitative analysis of the obtained experimental data, we introduced and verified a molecular kinetic model, which describes activation of major anion exchanger Band 3 (or AE1) by its complexation with free intracellular Mg(2+) (taking into account Mg(2+) membrane transport and intracellular buffering).
Paracoccidioides brasiliensis interacts with dermal dendritic cells and keratinocytes in human skin and oral mucosa lesions.
New
Sotto et al., São Paulo, Brazil. In Med Mycol, Feb 2016
The biopsies were subjected to immunohistochemical and/or immunofluorescence staining with anti-factor XIIIa (marker of dermal dendrocytes), anti-CD207 (marker of mature Langerhans cells), anti-pan cytokeratins (AE1-AE3) and anti-P.
Clinicopathological features of five unusual cases of intraosseous myoepithelial carcinomas, mimicking conventional primary bone tumours, including EWSR1 rearrangement in one case.
New
Puri et al., Mumbai, India. In Apmis, Feb 2016
By immunohistochemistry, tumour cells were positive for EMA (5/5), pan CK (AE1/AE3) (3/3), CK5/6 (4/4), CK MNF116 (1/1), S100 protein (5/5) and GFAP (3/5).
Adenocarcinoma arising in urinary bladder endocervicosis.
New
Ono et al., Seto, Japan. In Pathol Int, Feb 2016
Immunohistochemically, the endocervicosis was positive for cytokeratin (CK) 7, AE1/AE3, CAM5.2, HBME1, CA19-9, and estrogen receptor (ER), and negative for CK20, CDX2, progesterone receptor (PR), MUC5AC, and β-catenin.
Oral vaccine of Lactococcus lactis harbouring pandemic H1N1 2009 haemagglutinin1 and nisP anchor fusion protein elevates anti-HA1 sIgA levels in mice.
New
Rahim et al., Kuala Selangor, Malaysia. In Biotechnol Lett, Feb 2016
OBJECTIVE: An oral lactococcal-based vaccine which haboured the haemagglutinin1 (HA1) antigen fused to nisP anchor protein for the purpose of surface displaying the HA1 antigen was developed against H1N1 virus.
Crystal structure of the anion exchanger domain of human erythrocyte band 3.
New
Impact
Iwata et al., Kyoto, Japan. In Science, Dec 2015
Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes.
Primary, large extra-axial chordoma in proximal tibia: a rare case report with literature review and diagnostic implications.
Review
New
Rekhi, Mumbai, India. In Apmis, Dec 2015
By immunohistochemistry, tumour cells were diffusely positive for pan cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), CK19, S100P, meso (HBME1) and Brachyury/T.
Case of plasmablastic lymphoma of the sigmoid colon and literature review.
Review
New
Eguchi et al., Nagasaki, Japan. In World J Gastroenterol, Jul 2015
The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79a, UCHL1 (CD45RO) and cytokeratin (AE1/AE3).
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Review
New
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
[A CASE OF PRIMITIVE NEUROECTODERMAL TUMOR OF THE TESTIS].
Review
Soma et al., In Nihon Hinyokika Gakkai Zasshi, 2015
Immunohistochemical staining was positive for CD56, synaptophysin, vimentin, GFAP, and CD99 (MIC2), but negative for AE1/AE3, OCT-4, chromogranin, INI-1, and desmin.
Regulators of Slc4 bicarbonate transporter activity.
Review
Bevensee et al., Birmingham, United States. In Front Physiol, 2014
The Slc4 family of transporters is comprised of anion exchangers (AE1-4), Na(+)-coupled bicarbonate transporters (NCBTs) including electrogenic Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate cotransporters (NBCn1 and NBCn2), and the electroneutral Na-driven Cl-bicarbonate exchanger (NDCBE), as well as a borate transporter (BTR1).
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
Impact
Oh et al., Dallas, United States. In Immunity, 2014
Finally, we found that targeting influenza hemagglutinin 1 (HA1) subunit to LOX-1 elicited HA1-specific protective antibody responses in rhesus macaques.
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.
Review
Impact
Boron et al., Cleveland, United States. In Physiol Rev, 2013
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1).
From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion.
GeneRIF
Venkatraman et al., Mumbai, India. In Biochem J, 2012
Dsg-2 with a mutation at the predicted cleavage site is resistant to cleavage by matriptase. Thus Dsg-2 seems to be a functionally relevant physiological substrate of matriptase.
Mutation conferring apical-targeting motif on AE1 exchanger causes autosomal dominant distal RTA.
GeneRIF
Karet Frankl et al., Cambridge, United Kingdom. In J Am Soc Nephrol, 2012
Mutation conferring apical-targeting motif on AE1 exchanger causes autosomal dominant distal renal tubular acidosis.
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
GeneRIF
Caughey et al., San Francisco, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
there is much more active prostasin than active matriptase on the apical and basolateral surfaces of airway epithelial cells
A thiol-mediated active membrane transport of selenium by erythroid anion exchanger 1 protein.
GeneRIF
Nakayama et al., Nagasaki, Japan. In Dalton Trans, 2012
a thiol-mediated and energy-dependent membrane transport of selenium by erythroid anion exchanger 1
Diversity of matriptase expression level and function in breast cancer.
GeneRIF
Frame et al., Edinburgh, United Kingdom. In Plos One, 2011
Overexpression of matriptase in 4T1 mouse breast carcinoma cells resulted in visible changes in morphology, actin staining and cell to cell contacts
Tissue-engineered autologous urethras for patients who need reconstruction: an observational study.
Impact
Atala et al., Winston-Salem, United States. In Lancet, 2011
AE1/AE3, α actin, desmin, and myosin antibodies confirmed the presence of cells of epithelial and muscle lineages on all cultures.
A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.
Impact
Sadegh-Nasseri et al., Baltimore, United States. In Nat Med, 2010
Our reductionist system successfully identified the physiologically selected immunodominant epitopes of two model antigens: hemagglutinin-1 (HA1) from influenza virus (A/Texas/1/77) and type II collagen (CII).
More papers using AE1 antibodies
Co-stimulation of human breast cancer cells with transforming growth factor-beta and tenasicin-c enhances matrix metalloproteinase-9 expression and cancer cell invasion
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Stojadinovic Alexander et al., In Journal of Cancer, 2003
... cells within leukocyte aggregates, sections were double immunostained for LCA and cytokeratin (CK) AE1/3 (clone; AE1/AE3, Dako, Carpinteria, CA), which are ...
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Supplier
Moschetta Antonio, In PLoS ONE, 2001
... used include mouse antibodies against human gelsolin (Abcam), β-actin (Sigma-Aldrich), GAPDH (Santa Cruz Biotechnology), pan-cytokeratin (AE1/3) (Dako), uPA (America Diagnostica), uPAR, ...
One step screening of retroviral producer clones by real time quantitative PCR.
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Jung Jae U., In PLoS Pathogens, 1998
... Anti-HA monoclonal antibody HA1.11 was obtained from Covance, rabbit anti-HA polyclonal was obtained from Rockland and anti-BST2 monoclonal antibody ...
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrsarcoma
Supplier
Mentzel Thomas et al., In Virchows Archiv, 1987
... AE1/31:50DAKO, Glostrup, Denmark ...
Changes in the cell kinetics of pig epidermis after single doses of X rays.
Supplier
Borgmann Kerstin, In PLoS ONE, 1987
... Monoclonal mouse anti AE1/AE3cytokeratin1/200Dako ...
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