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Perilipin 2

ADRP, adipophilin, ADFP
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: ACID, Perilipin, HAD, CAN, Rhodopsin
Papers using ADRP antibodies
Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets
Brown Deborah A. et al., In The Journal of Cell Biology, 1999
... Primary antibodies used were as follows: rabbit anti–caveolin-1 and mouse anti-GM130 (Transduction Laboratories); mouse antiadipophilin/ADRP (Research Diagnostics); rabbit anti-PLAP (DakoCytomation); mouse ...
A third-generation lentivirus vector with a conditional packaging system.
Lindenbach Brett D., In PLoS Pathogens, 1997
... ); ADRP (Probiogen); Golgi Matrix Protein (Epitomics ...
Papers on ADRP
Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival.
Liu et al., Guangzhou, China. In Oncotarget, Jan 2016
UNASSIGNED: Clear cell renal cell carcinoma (ccRCC) is composed of cells whose cytoplasm filled with lipid droplets, subcellular organelles coated with adipocyte differentiation-related protein (ADFP) for the storage of triacylglycerol converted from excess free fatty acids.
Expression of hepatic lipid droplets is decreased in the nitrofen model of congenital diaphragmatic hernia.
Puri et al., Dublin, Ireland. In Pediatr Surg Int, Jan 2016
Hepatic lipid droplet expressions were evaluated by hepatic adipose differentiation-related protein (ARDP) expression.
Histologic differentiation and mucin phenotype in white opaque substance-positive gastric neoplasias.
Murakami et al., Ōita, Japan. In Endosc Int Open, Dec 2015
BACKGROUND AND STUDY AIMS: The authors previously reported that the white opaque substance (WOS) in gastric epithelial neoplasia was caused by accumulation of lipid droplets by immunohistochemical and immunoelectron microscopic studies of adipophilin, which was recently identified and validated as a marker of lipid droplets.
Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein.
Negro et al., Genève, Switzerland. In Plos One, Dec 2015
To further understand the role of lipid droplets in HCV life cycle, we assessed the relationship between HCV and the adipose differentiation-related protein (ADRP), a lipid droplet-associated protein.
Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma.
Sasaki et al., Tokyo, Japan. In Virchows Arch, Dec 2015
UNASSIGNED: Adipophilin, a lipid droplet-associated protein that regulates lipid droplet structure and formation, is expressed in a wide variety of tumors.
Metastasis of myxoid liposarcoma to fat-bearing areas: A case report of unusual metastatic sites and a hypothesis.
Min et al., Shanghai, China. In Oncol Lett, Oct 2015
Recent studies have suggested that MLPS expresses high levels of adipophilin and chemokine (C-X-C motif) receptor 4 (CXCR4), which are correlated with adipogenesis and metastasis.
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.
Takehara et al., Suita, Japan. In Dig Endosc, Mar 2015
Immunohistochemical examination with adipophilin reveals WOS in gastric neoplasms as lipid droplets, and WOS is specific for neoplasm with intestinal or gastrointestinal phenotype.
Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma.
Horvai et al., San Francisco, United States. In Case Report Pathol, 2014
Adipocyte-like differentiation was confirmed by a combination of positive Oil Red O and adipophilin immunohistochemical staining.
Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
Tarnopolsky et al., Canada. In Appl Physiol Nutr Metab, 2012
PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle.
[The progress of adipose differentiation-related protein].
Liu, Rizhao, China. In Sheng Li Ke Xue Jin Zhan, 2012
ADRP is the major lipid-droplet associated protein presents in almost all cells that accumulate lipids.
Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
Chanat et al., Jouy-le-Moutier, France. In Biochim Biophys Acta, 2012
Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
Ryoo et al., New York City, United States. In Nat Cell Biol, 2012
A well-established example is autosomal dominant retinitis pigmentosa (ADRP), an age-related retinal degenerative disease caused by mutant rhodopsins.
Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.
Paul et al., Albany, United States. In Plos One, 2011
Data indicate that perilipin 2 deficiency does not increase cholesterol-induced toxicity in macrophages, and thus supports the safety of targeting PLIN2 to prevent foam cell formation and atherosclerosis.
Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands.
McManaman et al., Aurora, United States. In J Cell Sci, 2011
Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands
Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray.
Yamada et al., Tokyo, Japan. In Cancer Epidemiol Biomarkers Prev, 2011
High PLIN2 protein level is associated with colorectal cancer.
Molecular genetics of retinal degeneration: A Drosophila perspective.
Shieh, Nashville, United States. In Fly (austin), 2011
Some mutations in Rh1 (NinaE) are dominant due to constitutive activity or folding defects, like autosomal dominant retinitis pigmentosa (ADRP) in humans.
Determinants of adipophilin function in milk lipid formation and secretion.
McManaman et al., Aurora, United States. In Trends Endocrinol Metab, 2011
Adipophilin (ADRP/ADPH/PLIN2), a member of the perilipin (PAT) family of lipid droplet proteins, is hypothesized to play a pivotal role in both formation and secretion of milk lipids.
Computational Screening of Rhodopsin Mutations Associated with Retinitis Pigmentosa.
Fanelli et al., Strasbourg, France. In J Chem Theory Comput, 2009
Rhodopsin mutations account for >25% of the autosomal dominant form of the disease (ADRP).
Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.
LaVail et al., Gainesville, United States. In Nat Med, 1998
Twelve percent of American patients with the blinding disease autosomal dominant retinitis pigmentosa (ADRP) carry a substitution of histidine for proline at codon 23 (P23H) in their rhodopsin gene, resulting in photoreceptor cell death from the synthesis of the abnormal gene product.
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