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Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on adrenomedullin
Contribution of maternal-fetal adrenomedullin polymorphism to gestational hypertension and preedlampsia--gene-gene interaction pilot study.
Drews et al., Poznań, Poland. In Ginekol Pol, 2012
The observed tendency for overrepresentation of minor -1984G ADM allele in the GH and PE women and their newborns, despite lack of statistical significance, suggests participation of this genetic variant in the pathogenesis of the mentioned conditions.
Adrenomedullin promotes human endothelial cell proliferation via HIF-1α.
Luo et al., Chongqing, China. In Mol Cell Biochem, 2012
ADM up-regulated the protein expressions of HIF-1alpha through down-regulation of proline hydroxylase (PHD) mRNA expression and PHD activity.
Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy.
O et al., Hong Kong, Hong Kong. In J Clin Endocrinol Metab, 2012
Lower ADM level in the oviducts of tubal pregnancy may lead to the decrease in ciliary beating and muscle contraction, with the result that the embryo is retained and implanted in the oviduct.
The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
Wang et al., North Bay Shore, United States. In Biol Chem, 2012
role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection
Evidence for a functional adrenomedullin signaling pathway in the mouse retina.
Eldred et al., Boston, United States. In Mol Vis, 2011
A functional adrenomedullin signaling pathway is operating in the mouse retina.
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