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Adrenomedullin

adrenomedullin
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Calcitonin, HAD, CAN, AGE, V1a
Papers on adrenomedullin
Biomarkers for predicting short-term mortality in community-acquired pneumonia: A systematic review and meta-analysis.
Review
New
Carratalà et al., Colombia. In J Infect, Feb 2016
The highest AUC values for predicting mortality were associated with pro-adrenomedullin (0.80) and prohormone forms of atrial natriuretic peptide (0.79), followed by cortisol (0.78), procalcitonin (0.75), copeptin (0.71), and C-reactive protein (0.62).
Contribution of adrenomedullin to the switch of G protein coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats.
New
Hong et al., Fuzhou, China. In Br J Pharmacol, Feb 2016
BACKGROUND AND PURPOSE: Chronic exposure to morphine increases spinal adrenomedullin (AM) bioactivity resulting in the development and maintenance of morphine tolerance.
Predictive Value of Depressive Symptoms for All-Cause Mortality: Findings From the PRIME Belfast Study Examining the Role of Inflammation and Cardiovascular Risk Markers.
New
Kee et al., Belfast, United Kingdom. In Psychosom Med, Feb 2016
Inflammation markers (C-reactive protein [CRP], neopterin, interleukin [IL]-1 receptor antagonist [IL-1Ra], and IL-18) and cardiovascular-specific risk factors (N-terminal pro-b-type natriuretic peptide, midregion pro-atrial natriuretic peptide, midregion pro-adrenomedullin, C-terminal pro-endothelin-1 [CT-proET]) were obtained at baseline.
Plasma levels of intermedin (adrenomedullin-2) in healthy human volunteers and patients with heart failure.
New
Harbinson et al., Belfast, United Kingdom. In Peptides, Feb 2016
IMD and its precursor fragments, preproIMD25-56 and preproIMD57-92, were measured by radioimmunoassay in 75 healthy subjects and levels of IMD were also compared to those of adrenomedullin (AM) and mid-region proadrenomedullin45-92 (MRproAM45-92) in 19 patients with systolic heart failure (LVEF<45%).
Endothelium-derived Intermedin/Adrenomedullin-2 protects human ventricular cardiomyocytes from ischaemia-reoxygenation injury predominantly via the AM1 receptor.
New
Harbinson et al., Belfast, United Kingdom. In Peptides, Jan 2016
UNASSIGNED: Application of intermedin/adrenomedullin-2 (IMD/AM-2) protects cultured human cardiac vascular cells and fibroblasts from oxidative stress and simulated ischaemia-reoxygenation injury (I-R), predominantly via adrenomedullin AM1 receptor involvement; similar protection had not been investigated previously in human cardiomyocytes (HCM).
Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.
New
Beck-Sickinger et al., Leipzig, Germany. In J Pept Sci, Dec 2015
The human adrenomedullin (ADM) is a 52 amino acid peptide hormone belonging to the calcitonin family of peptides, which plays a major role in the development and regulation of cardiovascular and lymphatic systems.
Complement factor H in its alternative identity as adrenomedullin-binding protein 1.
Review
New
Kishore et al., Oxford, United Kingdom. In Mol Immunol, Nov 2015
It has another role, however, as a binding protein for the regulatory peptide adrenomedullin.
Bench-to-bedside pharmacology of adrenomedullin.
Review
New
Kitamura et al., Miyazaki, Japan. In Eur J Pharmacol, Nov 2015
The bioactive peptide adrenomedullin (AM) exerts pleiotropic actions in various organs and tissues.
[Involvement of adrenomedullin in the pathogenesis of inflammatory pain and morphine tolerance].
Review
New
Hong et al., Fuzhou, China. In Sheng Li Xue Bao, Sep 2015
Adrenomedullin (AM) belongs to calcitonin gene-related peptide (CGRP) family and has been recently demonstrated to be a pain-related peptide.
Adrenomedullin in lymphangiogenesis: from development to disease.
Review
New
Caron et al., Chapel Hill, United States. In Cell Mol Life Sci, Aug 2015
In the following review, we focus on a potent lymphangiogenic factor, adrenomedullin, and its known roles in lymphangiogenesis, lymphatic function, and human lymphatic disease.
Contribution of maternal-fetal adrenomedullin polymorphism to gestational hypertension and preedlampsia--gene-gene interaction pilot study.
GeneRIF
Drews et al., Poznań, Poland. In Ginekol Pol, 2012
The observed tendency for overrepresentation of minor -1984G ADM allele in the GH and PE women and their newborns, despite lack of statistical significance, suggests participation of this genetic variant in the pathogenesis of the mentioned conditions.
Adrenomedullin promotes human endothelial cell proliferation via HIF-1α.
GeneRIF
Luo et al., Chongqing, China. In Mol Cell Biochem, 2012
ADM up-regulated the protein expressions of HIF-1alpha through down-regulation of proline hydroxylase (PHD) mRNA expression and PHD activity.
Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy.
GeneRIF
O et al., Hong Kong, Hong Kong. In J Clin Endocrinol Metab, 2012
Lower ADM level in the oviducts of tubal pregnancy may lead to the decrease in ciliary beating and muscle contraction, with the result that the embryo is retained and implanted in the oviduct.
The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
Review
GeneRIF
Wang et al., North Bay Shore, United States. In Biol Chem, 2012
role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection
Evidence for a functional adrenomedullin signaling pathway in the mouse retina.
GeneRIF
Eldred et al., Boston, United States. In Mol Vis, 2011
A functional adrenomedullin signaling pathway is operating in the mouse retina.
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.
Impact
International Union of Pharmacology et al., Birmingham, United Kingdom. In Pharmacol Rev, 2008
It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin.
Nonclassic endogenous novel [corrected] regulators of angiogenesis.
Review
Impact
Nussdorfer et al., Bari, Italy. In Pharmacol Rev, 2007
An in vivo and in vitro proangiogenic effect has been demonstrated for erythropoietin, angiotensin II (ANG-II), endothelins (ETs), adrenomedullin (AM), proadrenomedullin N-terminal 20 peptide (PAMP), urotensin-II, leptin, adiponectin, resistin, neuropeptide-Y, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and substance P.
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
Review
Impact
Grant et al., London, United Kingdom. In Physiol Rev, 2004
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin (AM).
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
Review
Impact
Foord et al., Birmingham, United Kingdom. In Pharmacol Rev, 2002
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin.
Adrenomedullin, a multifunctional regulatory peptide.
Review
Impact
Smith et al., London, United Kingdom. In Endocr Rev, 2000
Since the discovery of adrenomedullin in 1993 several hundred papers have been published regarding the regulation of its secretion and the multiplicity of its actions.
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