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G protein-coupled receptor 182

adrenomedullin receptor, ADMR, AM-R
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: adrenomedullin, Calcitonin, calcitonin receptor-like receptor, CAN, HAD
Papers on adrenomedullin receptor
Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.
New
Beck-Sickinger et al., Leipzig, Germany. In J Pept Sci, Dec 2015
For potential use in clinical applications, we aimed to investigate the fate of the peptide ligand after binding and activation of the adrenomedullin receptor (AM1 ), a heterodimer consisting of the calcitonin receptor-like receptor (CLR), a G protein-coupled receptor, associated with the receptor activity-modifying protein 2 (RAMP2).
Source, profile, and carcinogenic risk assessment for cohorts occupationally exposed to dust-bound PAHs in Lahore and Rawalpindi cities (Punjab province, Pakistan).
New
Cincinelli et al., Islamabad, Pakistan. In Environ Sci Pollut Res Int, Jul 2015
In this study, the occurrence and concentrations of PAHs in dust samples, which were collected from the traffic police cabins/working spots, located on the main busy roads of Lahore (TP-L) and Rawalpindi (TP-R) cities (Punjab province, Pakistan) and from the public transport vehicles in the same cities (named as AM-L and AM-R, respectively) were determined.
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
New
Mukhopadhyay et al., Rochester, United States. In Gut, May 2015
Duolink Assay was used to study AM and adrenomedullin receptor (ADMR) interaction in adipocytes treated with exosomes.
Nuclear receptors in pancreatic tumor cells.
Review
Kouraklis et al., Athens, Greece. In Anticancer Res, 2014
RESULTS: Receptors of growth factors, such as the epithelial growth factor receptor, insulin-like growth factor-1 receptor, vascular endothelial growth factor receptor and others, such as integrin α5β1, somatostatin receptors, the death receptor 5, claudin, notch receptors, mesothelin receptors, follicle-stimulating hormone receptors, the MUC1 receptor, the adrenomedullin receptor, the farnesoid X receptor, the transferrin receptor, sigma-2 receptors, the chemokine receptor CXCR4, the urokinase plasminogen activator receptor, the ephrine A2 receptor, the GRIA3 receptor, the RON receptor and the angiotensin II receptor AT-1 are expressed in pancreatic tumor cells.
Molecular imaging of the human pulmonary vascular endothelium using an adrenomedullin receptor ligand.
Dupuis et al., In Mol Imaging, 2014
PulmoBind is a ligand of the adrenomedullin receptor abundantly distributed in lung capillaries.
Adrenomedullin mediates early phase angiogenesis induced diabetic nephropathy in STZ diabetic rats.
Al-Masri et al., Saudi Arabia. In Eur Rev Med Pharmacol Sci, 2014
The present study investigated the effects of adrenomedullin receptor antagonist (ADM-52-22) on the early phase angiogenesis-induced diabetic nephropathy.
Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.
Zhu et al., Nanjing, China. In Hypertension, 2014
Bilateral PVN microinjection of IMD caused greater decreases in renal sympathetic nerve activity and mean arterial pressure in 2K1C rats than in sham-operated rats, which were prevented by pretreatment with adrenomedullin receptor antagonist AM22-52 or nonselective nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester, and attenuated by selective neuronal NO synthase inhibitor N(ω)-propyl-l-arginine hydrochloride or endothelial NO synthase inhibitor N(5)-(1-iminoethyl)-l-ornithine dihydrochloride.
Adrenomedullin22-52 suppresses high-glucose-induced migration, proliferation, and tube formation of human retinal endothelial cells.
Lu et al., Suzhou, China. In Mol Vis, 2013
PURPOSE: To investigate the roles of an adrenomedullin receptor antagonist (adrenomedullin(22-52)) on high-glucose-induced human retinal endothelial cell (HREC) in vitro cell biology.
G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases.
Review
Caron et al., Chapel Hill, United States. In Arterioscler Thromb Vasc Biol, 2009
The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice.
The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.
GeneRIF
Logsdon et al., Houston, United States. In Plos One, 2008
ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age.
GeneRIF
Di Iorio et al., Roma, Italy. In J Reprod Med, 2007
distribution of adrenomedullin receptor (AM-R )in the villous and extravillous trophoblast cells of the placenta and in chorion and decidua cells of the fetal membranes changed with gestational age but not with labor
New methods for researching accessory proteins.
Review
Holbrook et al., Stevenage, United Kingdom. In J Mol Neurosci, 2004
There are five of these peptides: calcitonin, calcitonix/calcitixin gene-related peptide (CGRP), adrenomedullin, amylin, and now adrenomedullin 2. The calcitonin receptor is specific for calcitonin when expressed alone but it can function as an amylin or CGRP receptor when co-expressed with a RAMP.
[RAMPs and G protein coupled receptors].
Review
Garel et al., Paris, France. In Med Sci (paris), 2004
CGRP receptors are observed in presence of the RAMP1/calcitonin receptor-like receptor (CRLR), but the association of RAMP2 or RAMP3 with CRLR generates an adrenomedullin receptor.
[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease].
GeneRIF
Song et al., Shenzhen, China. In Zhonghua Jie He He Hu Xi Za Zhi, 2003
Hybridization in situ showed that ADMR mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease.
Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.
GeneRIF
Tajima et al., Miyazaki, Japan. In Biochem Biophys Res Commun, 2003
Chondrocyte phenotype cells expressed adrenomedullin and the adrenomedullin receptor, and secreted high concentration of adrenomedullin into the culture medium
Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.
GeneRIF
Born et al., Zürich, Switzerland. In Brain Res, 2002
The co-expression of Adm and its receptor in perineural fibroblasts and the expression of an Adm receptor in Schwann cells suggest autocrine and/or paracrine modes of action of Adm in peripheral nerves.
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
Review
Impact
Foord et al., Birmingham, United Kingdom. In Pharmacol Rev, 2002
RAMP2 and -3 enable the same CL receptor to behave as an adrenomedullin receptor.
Adrenomedullin, a multifunctional regulatory peptide.
Review
Impact
Smith et al., London, United Kingdom. In Endocr Rev, 2000
In particular, the putative adrenomedullin receptor clones and signal transduction pathways are described.
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Impact
Foord et al., Stevenage, United Kingdom. In Nature, 1998
Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed.
Fluorescence detected magnetic resonance of the primary donor and inner core antenna chlorophyll in Photosystem I reaction centre protein: Sign inversion and energy transfer.
Schaafsma et al., Wageningen, Netherlands. In Photosynth Res, 1992
cm(-1) and E=38.5×10(-4) cm(-1), were independent of the detection wavelength, and agreed with ADMR (Absorption Detected Magnetic Resonance) and EPR values.
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