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Ferredoxin reductase

adrenodoxin reductase, ferredoxin reductase, FDXR
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: P450scc, CAN, ACID, Presenilin-1, HAD
Papers on adrenodoxin reductase
Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol.
New
Bernhardt et al., Saarbrücken, Germany. In J Biotechnol, Feb 2016
The human mitochondrial cytochrome P450CYP27A1 was co-expressed with its redox partners adrenodoxin reductase (Adr) and adrenodoxin (Adx).
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
New
Zhang et al., Chapel Hill, United States. In Embo J, Jan 2016
Mechanistically, by forming an activator complex with PGC1α and NRF1 on chromatin, EglN2 promotes the transcription of ferridoxin reductase (FDXR) and maintains mitochondrial function.
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma.
New
Natsugoe et al., Kagoshima, Japan. In Anticancer Res, Dec 2015
BACKGROUND: Ferredoxin reductase (Fdxr) is the mitochondrial cytochrome P-450 NADPH reductase.
Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR.
New
Khavari et al., Stanford, United States. In Dev Cell, Dec 2015
MPZL3 protein localized to mitochondria, where it interacted with FDXR, which was itself also found to be essential for differentiation.
Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex.
Review
New
Miyamoto et al., Fukui, Japan. In Mol Cell Endocrinol, Jul 2015
Genome-wide analyses with promoter tiling array and DNA microarray identified 10 genes as novel SF-1-target genes including glutathione S-transferase A family, 5-aminolevulinic acid synthase 1 and ferredoxin reductase.
Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium.
Hannemann et al., Saarbrücken, Germany. In Microb Cell Fact, 2014
Fluorescence-microscopic analysis revealed that cholesterol accumulates in the carbon and energy storage-serving poly(3-hydroxybutyrate) (PHB) bodies and that the membrane proteins CYP11A1 and its redox partner adrenodoxin reductase (AdR) are likewise localized to their surrounding phospholipid/protein monolayer.
Biological diversity of cytochrome P450 redox partner systems.
Review
Munro et al., Manchester, United Kingdom. In Adv Exp Med Biol, 2014
Early studies suggested that P450 redox partner machinery fell into only two major classes: either the eukaryotic diflavin enzyme NADPH-cytochrome P450 oxidoreductase, or bacterial/mitochondrial NAD(P)H-ferredoxin reductase and ferredoxin partners.
Gene Expression Biodosimetry: Quantitative Assessment of Radiation Dose with Total Body Exposure of Rats.
Makvandi et al., Ahvāz, Iran. In Asian Pac J Cancer Prev, 2014
OBJECTIVES: Changes in the FDXR and the RAD51 gene expression (GE) levels were here analyzed in response to total body exposure (TBE) to a 6 MV x-ray beam in rats.
From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.
Review
Cooper et al., Valhalla, United States. In Adv Nutr, 2014
In the type I mitochondrial system, FAD-adrenodoxin reductase interfaces with adrenodoxin before electron transfer to CYP heme proteins.
The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism.
Review
Mühlenhoff et al., Marburg an der Lahn, Germany. In Biochim Biophys Acta, 2012
First, the cysteine desulfurase complex Nfs1-Isd11 as the sulfur donor cooperates with ferredoxin-ferredoxin reductase acting as an electron transfer chain, and frataxin to synthesize an [2Fe-2S] cluster on the scaffold protein Isu1.
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
GeneRIF
Rouault et al., Bethesda, United States. In Biochim Biophys Acta, 2012
results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis
Structural and molecular genetic analyses of the bacterial carbazole degradation system.
Review
Nojiri, Tokyo, Japan. In Biosci Biotechnol Biochem, 2011
This type of dioxygenation is termed "angular dioxygenation," and is catalyzed by carbazole 1,9a-dioxygenase (CARDO), consisting of terminal oxygenase, ferredoxin, and ferredoxin reductase components.
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
GeneRIF
Croce et al., Columbus, United States. In J Biol Chem, 2008
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells
Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1.
GeneRIF
Wikvall et al., Uppsala, Sweden. In Biochim Biophys Acta, 2003
ADXR rate of hydroxylation was linear with incubation time.
Total biosynthesis of hydrocortisone from a simple carbon source in yeast.
Impact
Dumas et al., Gif-sur-Yvette, France. In Nat Biotechnol, 2003
Biosynthesis involves eight mammalian proteins (mature forms of CYP11A1, adrenodoxin (ADX), and adrenodoxin reductase (ADR); mitochondrial forms of ADX and CYP11B1; 3beta-HSD, CYP17A1, and CYP21A1).
The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.
GeneRIF
Chen et al., Birmingham, United States. In Oncogene, 2002
The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase.
GeneRIF
Headlam et al., Australia. In J Steroid Biochem Mol Biol, 2002
comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc]
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
Impact
Vogelstein et al., Baltimore, United States. In Nat Med, 2001
The gene encoding mitochondrial ferredoxin reductase (protein, FR; gene, FDXR) was one of the few genes significantly induced by p53 after 5-FU treatment.
Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast.
Impact
Pompon et al., Gif-sur-Yvette, France. In Nat Biotechnol, 1998
Engineering of sterol biosynthesis by disruption of the delta 22-desaturase gene and introduction of the Arabidopsis thaliana delta 7-reductase activity and coexpression of bovine side chain cleavage cytochrome P450, adrenodoxin, and adrenodoxin reductase, lead to pregnenolone biosynthesis from a simple carbon source.
Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family.
Impact
Herriott et al., Ithaca, United States. In Science, 1991
With these key residues as a guide, conclusive evidence is presented that the ferredoxin reductase structure is a prototype for the nicotinamide dinucleotide and FAD binding domains of the enzymes NADPH-cytochrome P450 reductase, NADPH-sulfite reductase, NADH-cytochrome b5 reductase, and NADH-nitrate reductase.
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