Biological diversity of cytochrome P450 redox partner systems.
Manchester, United Kingdom. In Adv Exp Med Biol, 2014
Early studies suggested that P450 redox partner machinery fell into only two major classes: either the eukaryotic diflavin enzyme NADPH-cytochrome P450 oxidoreductase, or bacterial/mitochondrial NAD(P)H-ferredoxin reductase and ferredoxin partners.
Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast.
Gif-sur-Yvette, France. In Nat Biotechnol, 1998
Engineering of sterol biosynthesis by disruption of the delta 22-desaturase gene and introduction of the Arabidopsis thaliana delta 7-reductase activity and coexpression of bovine side chain cleavage cytochrome P450, adrenodoxin, and adrenodoxin reductase, lead to pregnenolone biosynthesis from a simple carbon source.