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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic, alpha-2C-, receptor

ADRA2C, alpha2C-adrenoceptor, alpha2C-adrenergic receptor
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: alpha2C, alpha2A, HAD, ADRA2A, alpha2B
Papers on ADRA2C
Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [(11) C]ORM-13070.
Scheinin et al., Turku, Finland. In Synapse, Feb 2016
PET imaging can for some neurotransmitters be used to measure synaptic neurotransmitter concentrations.
Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations.
Manzanares et al., Barcelona, Spain. In Neuropsychopharmacology, Oct 2015
Real-time PCR and immunohistochemical studies were carried out to analyze dopamine transporter (DAT) and α-2C adrenergic receptor (ADRA2C) gene expressions and the distribution of parvalbumin (PV) and cholecystokinin-8 (CCK) immunoreactive (ir) cortical neurons, respectively.
Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Kurnik et al., Haifa, Israel. In Physiol Genomics, Sep 2015
We used multiple linear regressions to determine the effect of functional candidate genetic variants in autonomic pathways (6 ADRA2A, 1 ADRA2B, 4 ADRA2C, 2 ADRB1, 3 ADRB2, 2 NET, 2 CHT, and 1 GRK5) on the outcomes before and after adjustment for potential confounders.
Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.
Hui et al., In Clin Lab, 2014
METHODS: The polymorphisms ADRA2A C-1291G (rs1800544), ADRA2B 301-303 I/D (rs28365031), and ADRA2C 322-325 I/D (rs61767072) were genotyped in 317 patients with orthostatic hypotension and 664 age- and gender-matched controls.
Anti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model.
Drinkenburg et al., Rijswijk, Netherlands. In Behav Brain Res, 2014
Here the putative anti-Parkinson effects of the oral selective alpha2C-adrenoceptor antagonist (JNJ27063699 0.1-10mg/kg p.o.) and of vehicle (fruit syrup) were evaluated in the MPTP-marmoset model.
Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction.
Kim et al., South Korea. In Mol Med Report, 2014
The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms.
Cardiovascular pharmacogenomics: expectations and practical benefits.
Pirmohamed et al., Liverpool, United Kingdom. In Clin Pharmacol Ther, 2014
There is an increased risk of simvastatin-induced muscle toxicity in SLCO1B1*5 carriers, ADRB1 and ADRA2C polymorphisms are associated with differential response to bucindolol, and rare congenital arrhythmia gene variants have been identified in drug-induced torsade de pointes.
Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
Palczewski et al., In J Clin Invest, 2013
Focusing on adrenergic (AR) and serotonin (5-HT) receptors, we found that adrenoceptor α 2C (Adra2c) and serotonin receptor 2a (Htr2a) were the most highly expressed.
The strong selective sweep candidate gene ADRA2C does not explain domestication related changes in the stress response of chickens.
Altimiras et al., Linköping, Sweden. In Plos One, 2013
The autoregulatory α-adrenergic receptor 2C (ADRA2C) gene is the closest to the selective sweep and was proposed as an important gene in the domestication of layer chickens.
Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis.
Ji et al., Stanford, United States. In Bmc Med Genomics, 2012
RESULTS: A fit of the elastic-net regularized regression to 197 samples and integrated analysis of four genomic platforms identified the set of top gene predictors of advanced clinical stage, including: WRN, SYK, DDX5 and ADRA2C.
The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide.
Uhlén et al., Bergen, Norway. In Eur J Pharmacol, 2012
the predicted signal peptide in the N-terminal tail of the alpha(2C)-adrenoceptor does not act as a cleavable signal peptide
The α(2C)-Del322-325 adrenoceptor polymorphism and the occurrence of left ventricular hypertrophy in hypertensives.
Maqbool et al., Leeds, United Kingdom. In Blood Press, 2012
there is little evidence for an association between alpha(2C)Del322-325 polymorphism and an increased prevalence of left ventricular hypertrophy in patients with systemic hypertension.
Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study.
Entschladen et al., Nottingham, United Kingdom. In Breast Cancer Res Treat, 2011
alpha1b and alpha2c AR is over-expressed in basal-like breast tumours of poor prognosis
α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension.
Vieira-Coelho et al., Porto, Portugal. In Basic Clin Pharmacol Toxicol, 2011
During the development of hypertension, adrenal alpha(2) -adrenoceptor inhibitory function is conserved, accompanied by reduced noradrenaline release and unchanged adrenaline release in spontaneously hypertensive rats.
Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats.
Bruijnzeel et al., Gainesville, United States. In Neuropharmacology, 2011
Stimulation of adrenergic alpha 2 receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking behavior.
Molecular genetics of attention-deficit/hyperactivity disorder: an overview.
Coghill et al., Mannheim, Germany. In Eur Child Adolesc Psychiatry, 2010
Genes associated with the noradrenergic (such as NET1/SLC6A2, ADRA2A, ADRA2C) and serotonergic systems (such as 5-HTT/SLC6A4, HTR1B, HTR2A, TPH2) have also received considerable interest.
Genetic variation associated with ischemic heart failure: a HuGE review and meta-analysis.
Zintzaras et al., Lárisa, Greece. In Am J Epidemiol, 2007
Seven polymorphisms (ACE I/D, AGT M235T, ADRA2C Del322-325, ADRB2 Arg16Gly, ADRB2 Gln27Glu, EDN1 Lys198Asn, VEGF G-405C) showed a significant association in individual studies.
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
Liggett et al., Cincinnati, United States. In N Engl J Med, 2002
In transfected cells, a polymorphic alpha2C-adrenergic receptor (alpha2CDel322-325) has decreased function, and a variant of the beta1-adrenergic receptor (beta1Arg389) has increased function.
Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders.
Comings, Duarte, United States. In Ann N Y Acad Sci, 2001
Some of the specific loci involved are dopamine genes--DRD2, DRD4, DRD5, and the dopamine transporter; norepinephrine (NE) and epinephrine (EPI) genes--dopamine beta-hydroxylase, ADRA2A, ADRA2C, PNMT, norepinephrine transporter, MAOA, COMT; serotonin genes--TDO2, HTR1A, HTR1DA, serotonin transporter; GABA genes--GABRB3; androgen receptor and other genes.
Molecular heterosis: a review.
MacMurray et al., Duarte, United States. In Mol Genet Metab, 2000
A number of examples are reviewed, including those for the following genes: ADRA2C, C3 complement, DRD1, DRD2, DRD3, DRD4, ESR1, HP, HBB, HLA-DR DQ, HTR2A, properdin B, SLC6A4, PNMT, and secretor.
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