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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic, alpha-2B-, receptor

ADRA2B, alpha2B-adrenoceptor, alpha2B-adrenergic receptor, alpha2B-adrenergic receptor gene
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: alpha2B, HAD, AGE, alpha2A, ADRA2A
Papers on ADRA2B
Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances.
Luo et al., Hangzhou, China. In Seizure, Jan 2016
(FCMTE4), only one probably causative mutation was found co-segregated in two FCMTE2 pedigrees in the α2-adrenergic receptor subtype B (ADRA2B) gene.
Next-generation re-sequencing of genes involved in increased platelet reactivity in diabetic patients on acetylsalicylic acid.
Mirowska-Guzel et al., Warsaw, Poland. In Platelets, Dec 2015
Fifty eight exons and corresponding introns of eight selected genes, including PTGS1, PTGS2, TXBAS1, PTGIS, ADRA2A, ADRA2B, TXBA2R, and P2RY1 were re-sequenced in 230 DNA samples from T2D patients by using a pooled PCR amplification and next-generation sequencing by Illumina HiSeq2000.
Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes.
Liang et al., Milwaukee, United States. In Hypertension, Oct 2015
The result indicated significant suppression of the abundance of mRNA encoded by ADM by endogenous miR-181a-5p, ATP2B1 by the miR-27 family, FURIN by miR-125a-5p, FGF5 by the let-7 family, GOSR2 by miR-27a-3p, JAG1 by miR-21-5p, SH2B3 by miR-30a-5p, miR-98, miR-181a-5p, and the miR-125 family, TBX3 by the miR-92 family, ADRA1B by miR-22-3p, ADRA2A by miR-30a-5p and miR-30e-5p, ADRA2B by miR-30e-5p, ADRB1 by the let-7 family and miR-98, EDNRB by the miR-92 family, and NOX4 by the miR-92 family, miR-100-5p, and miR-99b-5p (n=3-9; P<0.05 versus scrambled anti-miR).
Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Kurnik et al., Haifa, Israel. In Physiol Genomics, Sep 2015
We used multiple linear regressions to determine the effect of functional candidate genetic variants in autonomic pathways (6 ADRA2A, 1 ADRA2B, 4 ADRA2C, 2 ADRB1, 3 ADRB2, 2 NET, 2 CHT, and 1 GRK5) on the outcomes before and after adjustment for potential confounders.
Maternal fructose-intake-induced renal programming in adult male offspring.
Chan et al., Kao-hsiung, Taiwan. In J Nutr Biochem, Jun 2015
Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).
ADRA2B genotype differentially modulates stress-induced neural activity in the amygdala and hippocampus during emotional memory retrieval.
Thiel et al., Oldenburg, Germany. In Psychopharmacology (berl), Feb 2015
Twenty-two healthy male volunteers were genotyped for the ADRA2B gene encoding the α2B-adrenergic receptor.
Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.
Hui et al., In Clin Lab, 2014
METHODS: The polymorphisms ADRA2A C-1291G (rs1800544), ADRA2B 301-303 I/D (rs28365031), and ADRA2C 322-325 I/D (rs61767072) were genotyped in 317 patients with orthostatic hypotension and 664 age- and gender-matched controls.
A 9-nucleotide Ins/Del in ADRA2B modulates orientation of attention to facial expressions and emotional words.
Fuchang et al., Luoyang, China. In Behav Pharmacol, 2014
Here, we investigated to what extent the expression of ADRA2B, an adrenergic receptor, modulated attention regulation and emotional processes.
ADRA2B deletion variant selectively predicts stress-induced enhancement of long-term memory in females.
Rorabaugh et al., United States. In Psychoneuroendocrinology, 2014
Previous work has shown that carriers of the ADRA2B Glu(301)-Glu(303) deletion variant exhibit enhanced emotional memory, greater amygdala responses to emotional stimuli and greater intrusiveness of traumatic memories.
The downside of strong emotional memories: how human memory-related genes influence the risk for posttraumatic stress disorder--a selective review.
Kolassa et al., Ulm, Germany. In Neurobiol Learn Mem, 2014
Here, we focus on genes involved in noradrenergic (ADRA2B), serotonergic (SLC6A4), and dopaminergic signaling (COMT) as well as in the molecular cascades of memory formation (PRKCA and WWC1).
Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction.
Kim et al., South Korea. In Mol Med Report, 2014
The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms.
Modulation of a number of genes on personality traits in a sample of healthy subjects.
Serretti et al., Brescia, Italy. In Neurosci Lett, 2014
Examination of previously studied gene variants showed an effect of adrenergic alpha 2B receptor (ADRA2B) on Cooperativeness and of serotonin receptor HTR2A on Self Directedness.
[The role of alfa-2-beta-adrenoreceptor in development of ventricular conduction disturbance].
Chernov et al., In Vestn Ross Akad Med Nauk, 2013
BACKGROUND: The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β-adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction.
Expression of energy metabolism related genes in the gastric tissue of obese individuals with non-alcoholic fatty liver disease.
Younossi et al., United States. In Bmc Gastroenterol, 2013
The levels expression of 21 genes, including ADRA2B, CNR1 and LEP were significantly altered in the gastric tissue of NAFLD patients with hepatic inflammation.
Gender-related associations of genetic polymorphisms of α-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses.
Mansur et al., São Paulo, Brazil. In Open Heart, 2013
Genotypes for the α-adrenergic receptors ADRA1A Arg347Cys (rs1048101), ADRA2A 1780 C>T (rs553668), ADRA2B Del 301-303 (rs28365031), endothelial nitric synthase (eNOS) 786 T>C (rs2070744), eNOS Glu298Asp (rs1799983) and BK2R (rs5810761) polymorphisms were assessed by PCR and high-resolution melting analysis.
Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.
Ijzerman et al., Leiden, Netherlands. In Arterioscler Thromb Vasc Biol, 2012
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.
Wu et al., New Orleans, United States. In Traffic, 2012
A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export
Haplotype polymorphism in the alpha-2B-adrenergic receptor gene influences response inhibition in a large Chinese sample.
Dong et al., Beijing, China. In Neuropsychopharmacology, 2012
this study found significant effects of ADRA2B haplotype polymorphisms on response inhibition in a large Chinese sample, with the minor AAGG haplotype associated with shorter SSR.
Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.
Yang et al., London, Canada. In Plos One, 2011
Adenosine A(2B) receptor signaling plays a role in regulating placental 11beta-hydroxysteroid dehydrogenase type 2 expression, and consequently fetal development.
[Association of 2B-adrenergic receptor gene polymorphism with disturbances of cardiac conduction].
Chernov et al., In Kardiologiia, 2011
For the first time, we revealed on clinical - genetic material association between hereditary disturbances of cardiac conduction and polymorphism of 2-adrenergic receptor gene.
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