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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic, alpha-2A-, receptor

ADRA2A, alpha2A-adrenoceptor, alpha2A-adrenergic receptor
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on ADRA2A
The rs553668 polymorphism of the ADRA2A gene predicts the worsening of fasting glucose values in a cohort of subjects without diabetes. A population-based study.
Gambino et al., Torino, Italy. In Diabet Med, 2012
the rs553668 polymorphism is associated with glucose worsening in subjects without diabetes at baseline
Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.
Quasney et al., Memphis, United States. In Psychophysiology, 2012
In young African Americans, the -1291C/G promoter polymorphism in the alpha(2A) -AR gene was associated with vascular reactivity to stress; vasoconstriction increased as a linear function of the number of copies of the variant G allele.
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.
Humphries et al., London, United Kingdom. In Diabetologia, 2011
Multiple ADRA2A SNPs are associated with metabolic traits, blood pressure and type 2 diabetes risk.
The effect of maternal and fetal β2-adrenoceptor and nitric oxide synthase genotype on vasopressor requirement and fetal acid-base status during spinal anesthesia for cesarean delivery.
Ngan Kee et al., Seattle, United States. In Anesth Analg, 2011
neonatal ADRB2 p.Arg16 homozygosity, but not nitric oxide synthase genotype, confers a protective effect against developing ephedrine-induced fetal acidemia
Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.
Stein et al., Nashville, United States. In Circ Cardiovasc Genet, 2011
The genetic variants in ADRA2A are associated with different blood pressure responses to the selective alpha 2-selective agonist dexmedetomidine.
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