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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic, alpha-2A-, receptor

ADRA2A, alpha2A-adrenoceptor, alpha2A-adrenergic receptor
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: alpha2A, HAD, CAN, AGE, Insulin
Papers on ADRA2A
Next-generation re-sequencing of genes involved in increased platelet reactivity in diabetic patients on acetylsalicylic acid.
New
Mirowska-Guzel et al., Warsaw, Poland. In Platelets, Dec 2015
Fifty eight exons and corresponding introns of eight selected genes, including PTGS1, PTGS2, TXBAS1, PTGIS, ADRA2A, ADRA2B, TXBA2R, and P2RY1 were re-sequenced in 230 DNA samples from T2D patients by using a pooled PCR amplification and next-generation sequencing by Illumina HiSeq2000.
ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer.
New
Bounecer et al., Batna, Algeria. In Pathol Oncol Res, Dec 2015
Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders.
α2A -Adrenergic receptor polymorphisms and mRNA expression levels are associated with delay discounting in cocaine users.
New
Quednow et al., Zürich, Switzerland. In Addict Biol, Dec 2015
Recent evidence suggests that the norepinephrine system and more specifically the α2A -adrenergic receptor (ADRA2A) are impacted by chronic cocaine use while also being potentially involved in the neural mechanisms underlying DD.
Genes associated with diabetes: potential for novel therapeutic targets?
New
Odawara et al., Tokyo, Japan. In Expert Opin Ther Targets, Nov 2015
This paper also reviews the current status of the compounds targeting the T2D-associated genes GCK, GKRP, ADIPOQ, and ADRA2A in clinical and preclinical phases.
Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.
Hui et al., In Clin Lab, 2014
METHODS: The polymorphisms ADRA2A C-1291G (rs1800544), ADRA2B 301-303 I/D (rs28365031), and ADRA2C 322-325 I/D (rs61767072) were genotyped in 317 patients with orthostatic hypotension and 664 age- and gender-matched controls.
A Multiple Interaction Analysis Reveals ADRB3 as a Potential Candidate for Gallbladder Cancer Predisposition via a Complex Interaction with Other Candidate Gene Variations.
Mittal et al., Kyŏngsan, South Korea. In Int J Mol Sci, 2014
Here, we performed Multifactor-Dimensionality Reduction (MDR) and Classification and Regression Tree Analysis (CRT) to investigate the gene-gene interactions and the combined effect of 14 SNPs in nine genes (DR4 (rs20576, rs6557634); FAS (rs2234767); FASL (rs763110); DCC (rs2229080, rs4078288, rs7504990, rs714); PSCA (rs2294008, rs2978974); ADRA2A (rs1801253); ADRB1 (rs1800544); ADRB3 (rs4994); CYP17 (rs2486758)) involved in various signaling pathways.
[Genetic bases of attention deficit hyperactivity disorder].
Review
Ramos-Quiroga et al., Barcelona, Spain. In Rev Neurol, 2012
The work carried out to date point to genes in the dopaminergic system, such as the gene that codes for the dopamine transporter (DAT1 or SLC6A3) and for the dopamine receptor D4 (DRD4); in the noradrenergic system, like the gene coding for the adrenergic alpha-2A receptor (ADRA2A), the COMT gene, which codes for the enzyme catechol-O-methyltransferase and the gene that codes for latrophilin 3 (LPHN3), as genes that are candidates for playing a part in the susceptibility to ADHD, and being involved in the pharmacological response as well as in the risk of presenting associated behavioural disorders.
Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder.
Review
Caylak, Çankırı, Turkey. In Am J Med Genet B Neuropsychiatr Genet, 2012
To date, these studies have reported substantial evidence implicating several genes (dopaminergic: DRD4, DAT1, DRD5, COMT; noradrenergic: DBH, ADRA2A; serotonergic: 5-HTT, HTR1B, HTR2A; cholinergic: CHRNA4, and central nervous system development pathway: SNAP25, BDNF) in the etiology of ADHD.
Guanfacine extended release as adjunctive therapy to psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder.
Review
Childress, Las Vegas, United States. In Adv Ther, 2012
In these patients, clinicians frequently use a combination of psychostimulants and nonscheduled medications to manage ADHD, although published evidence supporting this practice was relatively scarce until recently.Guanfacine extended release (GXR), a selective alpha2A-adrenoceptor agonist, is approved as a monotherapy and adjunctive therapy to psychostimulant medications for ADHD in patients 6-17 years of age.
The rs553668 polymorphism of the ADRA2A gene predicts the worsening of fasting glucose values in a cohort of subjects without diabetes. A population-based study.
GeneRIF
Gambino et al., Torino, Italy. In Diabet Med, 2012
the rs553668 polymorphism is associated with glucose worsening in subjects without diabetes at baseline
Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.
GeneRIF
Quasney et al., Memphis, United States. In Psychophysiology, 2012
In young African Americans, the -1291C/G promoter polymorphism in the alpha(2A) -AR gene was associated with vascular reactivity to stress; vasoconstriction increased as a linear function of the number of copies of the variant G allele.
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.
GeneRIF
Humphries et al., London, United Kingdom. In Diabetologia, 2011
Multiple ADRA2A SNPs are associated with metabolic traits, blood pressure and type 2 diabetes risk.
The genetics of common variation affecting platelet development, function and pharmaceutical targeting.
Review
Johnson, Framingham, United States. In J Thromb Haemost, 2011
These studies demonstrate synergy with some prior candidate gene findings (e.g., GP6, ADRA2A) but also uncover novel loci involved in platelet function.
Suicidal ideation during antidepressant treatment: do genetic predictors exist?
Review
Perroud, Genève, Switzerland. In Cns Drugs, 2011
In this perspective, several genetic predictors have been highlighted, the majority of which relate to common mechanisms of antidepressant action: genes involved in the neurotrophic and synaptic plasticity systems (CREB1, and BDNF and its receptor NTRK2), noradrenergic system (ADRA2A), glutamatergic system (GRIA3, GRIK2 and GDA), inflammatory and hypothalamic-pituitary-adrenal (HPA) axis systems (IL28RA and FKBP5) and in other brain functions (PAPLN, APOO, KCNIP4 and ELP3).
The effect of maternal and fetal β2-adrenoceptor and nitric oxide synthase genotype on vasopressor requirement and fetal acid-base status during spinal anesthesia for cesarean delivery.
GeneRIF
Ngan Kee et al., Seattle, United States. In Anesth Analg, 2011
neonatal ADRB2 p.Arg16 homozygosity, but not nitric oxide synthase genotype, confers a protective effect against developing ephedrine-induced fetal acidemia
Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.
GeneRIF
Stein et al., Nashville, United States. In Circ Cardiovasc Genet, 2011
The genetic variants in ADRA2A are associated with different blood pressure responses to the selective alpha 2-selective agonist dexmedetomidine.
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Impact
Becker et al., Framingham, United States. In Nat Genet, 2010
ADRA2A (P=3.3x10(-11)),
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Impact
Barroso et al., Boston, United States. In Nat Genet, 2010
These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1).
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.
Impact
GeneRIF
Renström et al., Malmö, Sweden. In Science, 2010
study identified a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk
Central hypotensive effects of the alpha2a-adrenergic receptor subtype.
Impact
Limbird et al., Nashville, United States. In Science, 1996
Gene targeting was used to introduce a point mutation into the alpha2aAR subtype in the mouse genome.
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