gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

2-aminoethanethiol

Ado
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, OUT
Papers using Ado antibodies
Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
Supplier
Keating Damien, In PLoS ONE, 2005
... (8CPT-2′-OMe-cAMP -Biolog #C041), hydrolysis-resistant 8-(4-chlorophenylthio)-2′-O-methyl-cAMPs, Sp-isomer (Sp-8CPT-2′-OMe-cAMP - Biolog # C052), 8-(4-chlorophenylthio)-2′-O-methyladenosine-5′-O-monophosphate (8CPT-2-OMe-5′AMP – Biolog # C078), 8-(4-chlorophenylthio)-2′-O-methyladenosine (8CPT-2′OMe-Ado – Biolog #C070), and 8-(4-chlorophenylthio) adenine (8CPT-Ade – Biolog #C069) were purchased from Axxora,LLC (San Diego, CA) ...
Papers on Ado
Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
New
Jain et al., Boston, United States. In J Natl Cancer Inst, Feb 2016
The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) has shown efficacy in trastuzumab-resistant systemic breast cancer.
Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats.
New
Pelligrino et al., Chicago, United States. In Brain Res, Feb 2016
After 48h of continuous icv infusion, a cranial window/intravital microscopy was applied to animals for evaluation of pial arteriolar dilating responses to sciatic nerve stimulation (SNS), hypercapnia, and topical suffusion of vasodilators including acetylcholine (ACh), s-nitroso-N-acetyl penicillamine (SNAP), or adenosine (ADO).
Purinergic signaling in scarring.
Review
New
Cronstein et al., Ferrara, Italy. In Faseb J, Jan 2016
Adenosine (ADO) and nucleotides such as ATP, ADP, and uridine 5'-triphosphate (UTP), among others, may serve as extracellular signaling molecules.
Ado-trastuzumab emtansine targets hepatocytes via human epidermal growth factor receptor 2 to induce hepatotoxicity.
New
Wu et al., United States. In Mol Cancer Ther, Jan 2016
UNASSIGNED: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2-positive metastatic breast cancer.
An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
New
Jaskolski et al., Poznań, Poland. In Acta Crystallogr D Biol Crystallogr, Jan 2016
After methyl-group transfer from SAM, S-adenosyl-L-homocysteine (SAH) is formed as a byproduct, which in turn is hydrolyzed to adenosine (Ado) and homocysteine (Hcy) by SAHase.
Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression.
New
Mayer et al., Mainz, Germany. In Adv Exp Med Biol, Dec 2015
As a result of this characteristic property, adenosine (ADO) accumulation (range: 50-100 μM) occurs caused by intra- and extracellular generation of ADO.
Much Ado about Zero.
New
Impact
Fenyo et al., New York City, United States. In Cell, Nov 2015
LINE retrotransposons actively shape mammalian genomes.
Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
New
Treff et al., United States. In Fertil Steril, Nov 2015
MAIN OUTCOME MEASURE(S): Allele dropout (ADO) and failed amplification rate, genotyping consistency, chromosome screening success rate, and clinical outcomes of qPCR-based screening.
Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer.
Review
New
Dirix et al., Antwerp, Belgium. In Expert Opin Biol Ther, May 2015
INTRODUCTION: Ado- trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine; mertansine).
Solution Structural Studies of GTP:Adenosylcobinamide-Phosphateguanylyl Transferase (CobY) from Methanocaldococcus jannaschii.
Markley et al., Madison, United States. In Plos One, 2014
GTP:adenosylcobinamide-phosphate (AdoCbi-P) guanylyl transferase (CobY) is an enzyme that transfers the GMP moiety of GTP to AdoCbi yielding AdoCbi-GDP in the late steps of the assembly of Ado-cobamides in archaea.
Effects of nucleosides on glia - neuron interactions open up new vistas in the development of more effective antiepileptic drugs.
Review
Heja et al., Szombathely, Hungary. In Curr Med Chem, 2014
A great deal of results suggests that adenosine (Ado), guanosine (Guo), inosine (Ino) or uridine (Urd) are endogenous antiepileptogenic modulators.
Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature.
Review
Dobolyi et al., Szombathely, Hungary. In Mini Rev Med Chem, 2014
Adenosine (Ado) and some non-adenosine (non-Ado) nucleosides including inosine (Ino), guanosine (Guo) and uridine (Urd) are modulatory molecules in the central nervous system (CNS), regulating different physiological and pathophysiological processes in the brain such as sleep and epilepsy.
NAD⁺-Metabolizing Ectoenzymes in Remodeling Tumor-Host Interactions: The Human Myeloma Model.
Review
Malavasi et al., Torino, Italy. In Cells, 2014
As a substrate, it is converted to adenosine (ADO) and then taken up by the cells, where it is transformed and reincorporated into the intracellular nucleotide pool.
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.
Impact
Yang et al., Chongqing, China. In Nat Genet, 2014
ADO-ZNF365-EGR2, rs442309, P(combined) = 2.97 × 10(-11), OR = 1.37; and HLA-DRB1/DQA1, rs3021304, P(combined) = 1.26 × 10(-118), OR = 2.97).
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Impact
Delattre et al., Paris, France. In Nat Genet, 2012
Variants at these loci were associated with expression levels of TARDBP, ADO (encoding cysteamine dioxygenase) and EGR2.
Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.
GeneRIF
Stipanuk et al., Ithaca, United States. In J Biol Chem, 2007
cysteamine (2-aminoethanethiol) dioxygenase (ADO)is encoded by the gene Gm237 and belongs to the DUF1637 protein family.
share on facebooktweetadd +1mail to friends