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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Activity-dependent neuroprotective protein

ADNP, Activity-dependent neuroprotective protein
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NaP, ACID, Vasoactive Intestinal Peptide, HAD, POLYMERASE
Papers on ADNP
Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory.
New
Gozes et al., Tel Aviv-Yafo, Israel. In Mol Psychiatry, Feb 2016
UNASSIGNED: Activity-dependent neuroprotective protein (ADNP), essential for brain formation, is a frequent autism spectrum disorder (ASD)-mutated gene.
Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.
New
Gozes et al., Tel Aviv-Yafo, Israel. In J Alzheimers Dis, Dec 2015
Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions.
ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain.
New
Gozes et al., Tel Aviv-Yafo, Israel. In Peptides, Oct 2015
ADNP is a protein necessary for brain development, important for brain plasticity, cognitive and social functioning, characteristics that are all impaired in autism and in the Adnp(+/-) mouse model, in a sex-dependent manner.
ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment.
New
Gozes et al., Tel Aviv-Yafo, Israel. In J Mol Neurosci, Oct 2015
Activity-dependent neuroprotective protein (ADNP), an early marker essential for brain formation, interacts with microtubule end-binding proteins (EB1, EB2, and EB3).
Novel hexapeptide interacts with tubulin and microtubules, inhibits Aβ fibrillation, and shows significant neuroprotection.
New
Ghosh et al., Calcutta, India. In Acs Chem Neurosci, Sep 2015
Herein, we report a novel hexapeptide, derived from activity dependent neuroprotective protein (ADNP), that spontaneously self-assembles to form antiparallel β-sheet structure and produces nanovesicles under physiological conditions.
The cytoskeleton as a drug target for neuroprotection: the case of the autism- mutated ADNP.
New
Gozes, In Biol Chem, Jul 2015
UNASSIGNED: Fifteen years ago we discovered activity-dependent neuroprotective protein (ADNP), and showed that it is essential for brain formation/function.
Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies.
Gozes et al., Tel Aviv-Yafo, Israel. In Transl Psychiatry, 2014
Activity-dependent neuroprotective protein (ADNP) is a most frequent autism spectrum disorder (ASD)-associated gene and the only protein significantly decreasing in the serum of Alzheimer's disease (AD) patients.
ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration.
Review
Ivashko-Pachima et al., Tel Aviv-Yafo, Israel. In Front Aging Neurosci, 2014
Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism.
Assessment of plasma brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) concentrations in treatment-naïve humans with multiple sclerosis.
Bik et al., Warsaw, Poland. In Neuro Endocrinol Lett, 2014
Aim of the study was to assess plasma levels of brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) in treatment-naïve humans with newly diagnosed multiple sclerosis.
Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.
Gozes et al., Tel Aviv-Yafo, Israel. In Sci Rep, 2014
The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule dynamics leading to synaptic plasticity and neuroprotection.
Coffin-Siris syndrome and related disorders involving components of the BAF (mSWI/SNF) complex: historical review and recent advances using next generation sequencing.
Review
Carey et al., In Am J Med Genet C Semin Med Genet, 2014
Also, ADNP was found to be mutated in an autism/ID syndrome.
A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP.
Impact
Van der Aa et al., Antwerp, Belgium. In Nat Genet, 2014
Here, we report ten patients with ASD and other shared clinical characteristics, including intellectual disability and facial dysmorphisms caused by a mutation in ADNP, a transcription factor involved in the SWI/SNF remodeling complex.
Davunetide: Peptide therapeutic in neurological disorders.
Review
Gozes et al., Tel Aviv-Yafo, Israel. In Curr Med Chem, 2013
This review focuses on the therapeutic effects and mechanisms of action of NAP (davunetide), an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP) which was discovered in the laboratory of Prof. Illana Gozes.
Microtubule-stabilizing peptides and small molecules protecting axonal transport and brain function: focus on davunetide (NAP).
Review
Gozes et al., Tel Aviv-Yafo, Israel. In Neuropeptides, 2013
This review focuses on the therapeutic effects and mechanisms of action of NAP (davunetide), an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP) which was discovered in our laboratory.
D-NAP prophylactic treatment in the SOD mutant mouse model of amyotrophic lateral sclerosis: review of discovery and treatment of tauopathy.
Review
Gozes et al., Tel Aviv-Yafo, Israel. In J Mol Neurosci, 2012
Davunetide is an eight-amino-acid peptide fragment derived by structure-activity studies from activity-dependent neuroprotective protein, activity-dependent neuroprotective protein (ADNP).
Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease.
GeneRIF
Tyan et al., Taiwan. In J Proteomics, 2012
Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD.
Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: deregulation in schizophrenia.
GeneRIF
Gozes et al., Tel Aviv-Yafo, Israel. In Eur Neuropsychopharmacol, 2011
In the prefrontal cortex of schizophrenia patients the correlation between ADNP and ADNP2 mRNA levels was apparently higher than in the hippocampus (r=0.854, p<0.001), but did not reach a significant difference (p=0.25).
Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.
GeneRIF
Pozo et al., Sevilla, Spain. In J Mol Neurosci, 2010
Results support the hypothesis that ADNP expression is related to early or mild Alzheimer's disease progression by a VIP-independent mechanism.
Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis.
GeneRIF
Constantinescu et al., Nottingham, United Kingdom. In Neuroimmunomodulation, 2009
ADNP is expressed in many immune system cells. ADNP mRNA is reduced in PBMCs in MS. The peptide NAP, which plays an important role in neuroprotection, has potential immunomodulatory properties.
Nitric oxide regulates activity-dependent neuroprotective protein (ADNP) in the dentate gyrus of the rodent model of kainic acid-induced seizure.
GeneRIF
Thippeswamy et al., Liverpool, United Kingdom. In J Mol Neurosci, 2009
Results suggest that nitric oxide regulates activity-dependent neuroprotective protein in the dentate gyrus under both basal and pathophysiological conditions.
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