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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adiponectin receptor 1

AdipoR1, adiponectin receptor 1, adiponectin receptor
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: adiponectin, AdipoR2, Insulin, V1a, AMPK
Papers on AdipoR1
Analysis of the Relationship Between ADIPOR1 Variants and the Susceptibility of Chronic Metabolic Diseases in a Northeast Han Chinese Population.
Yang et al., Beijing, China. In Genet Test Mol Biomarkers, Feb 2016
OBJECTIVE: Shared genetic variants in ADIPOR1 have been identified as closely related to coronary artery disease (CAD), type 2 diabetes (T2D), and T2D with CAD susceptibility, suggesting that these variants are strong candidates for the common soil hypothesis.
Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action.
Hill et al., Columbia, United States. In Microcirculation, Feb 2016
OBJECTIVE: AdipoRon, an adiponectin receptor agonist, was recently proposed for treating insulin resistance and hyperglycemia.
Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats.
Xia et al., Hong Kong, Hong Kong. In Diabetes, Jan 2016
Hypoxic postconditioning(HPo)-induced protection against hypoxia/reoxygnation injury was lost in Adipo(-/-) cardiomyocytes but restored by recombinant adiponectin, while this adiponectin beneficial effect was abolished by either specific STAT3 or adiponectin receptor-1(AdipoR1) gene knockdown, or caveolin-3(Cav3) disruption.
Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio.
Karmazyn et al., Edmonton, Canada. In Plos One, Dec 2015
ATCM supressed the hypertrophic response to ET-1 in a concentration-dependent manner, an effect enhanced by the leptin receptor antagonist and attenuated by an antibody against the adiponectin AdipoR1 receptor.
Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity.
Kadowaki et al., Tokyo, Japan. In Diabetes Metab J, Oct 2015
To this end, we have identified "AdipoRon" as an adiponectin receptor agonist.
The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin.
Kamarul et al., Kuala Lumpur, Malaysia. In Life Sci, Sep 2015
Likewise, the up-regulation of the expression and stimulation of adiponectin receptors by using adiponectin receptor agonists would be an effective method to treat obesity-related conditions.
Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies.
Christodoulatos et al., In Horm Mol Biol Clin Investig, Jul 2015
Enhancement of endogenous adiponectin, adiponectin replacement, or manipulation of adiponectin receptor sensitivity may be an attractive goal for prevention and an effective therapeutic strategy against hematopoietic cancer, specifically in overweight/obese individuals.
Molecular targeting of obesity pathways in cancer.
Otvos et al., In Horm Mol Biol Clin Investig, May 2015
This review focuses on our novel leptin receptor antagonists and adiponectin receptor agonists designed for therapeutic modulation of obesity-associated pathways in cancer.
Crystal structures of the human adiponectin receptors.
Yokoyama et al., Yokohama, Japan. In Nature, May 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Cross-Talk between Adiponectin and IGF-IR in Breast Cancer.
Andò et al., Cosenza, Italy. In Front Oncol, 2014
In this review, we discuss the cross-talk between adiponectin/AdipoR1 and IGF-I/IGF-IR in breast cancer.
Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.
Ji et al., Shanghai, China. In Int J Clin Exp Med, 2014
In addition, HLF intervention dramatically increased circulating adiponectin levels and up-regulated the expression of adiponectin receptors, particularly adiponectin receptor 2 (AdipoR2) in the liver.
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Kadowaki et al., Tokyo, Japan. In Nature, 2013
One of these compounds, AdipoR agonist (AdipoRon), bound to both AdipoR1 and AdipoR2 in vitro.
Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.
Kadowaki et al., Tokyo, Japan. In Cell Metab, 2013
The cloning of Adiponectin receptors AdipoR1 and AdipoR2 has stimulated adiponectin research, revealing pivotal roles for AdipoRs in pleiotropic adiponectin actions, as well as some postreceptor signaling mechanisms.
Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction.
Park et al., South Korea. In Biochem Pharmacol, 2012
These data demonstrated that globular adiponectin prevents ethanol-induced apoptosis in HepG2 cells via HO-1 induction and revealed a novel biological response of globular adiponectin in the protection of liver injury from alcohol consumption.
Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human.
Shimada et al., Houston, United States. In Fertil Steril, 2012
Adiponectin differentially alters the expression of Adipor1/Adipor2 as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells versus granulosa cells.
The role of adiponectin in cancer: a review of current evidence.
Mantzoros et al., Athens, Greece. In Endocr Rev, 2012
Studies in both animals and humans have investigated adiponectin and adiponectin receptor regulation and expression in several cancers.
Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease.
Raptis et al., Athens, Greece. In Am J Hypertens, 2012
Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with coronary artery disease.
Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.
Uusitupa et al., Kuopio, Finland. In Neurosci Lett, 2012
Our findings reveal that rs10753929 ADIPOR1 variant is a novel candidate for age-related macular degeneration genetic risk factor in Finnish population.
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Qiu et al., Beijing, China. In Chin Med J (engl), 2011
Findings suggest that AdipoR1 may mediate the difference in adiponectin-induced PGE2 production in rheumatoid arthritis and osteoarthritis.
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.
Kadowaki et al., Tokyo, Japan. In Cell Metab, 2011
Many actions of adiponectin, a well-recognized antidiabetic adipokine, are currently attributed to the activation of two critical molecules downstream of AdipoR1 and R2: AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα).
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