Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity.
Beersheba, Israel. In Int J Obes (lond), Feb 2016
Bafilomycin-A1 pre-treatment of AT explants from high fat fed (HFF) mice had no effect on the secretion of some adipose tissue-derived endocrine factors, but partially or fully reversed obesity-related changes in secretion of a sub-set of adipo-cytokines by >35%, including the obesity-associate up-regulation of IL-6, VEGF, TNFα and certain IGFBP's, and down-regulated secretion of IL-10 and adiponectin.
Improvement of plasma adiponectin, leptin and c-reactive protein concentrations by orlistat: A systematic review and meta-analysis.
Pavia, Italy. In Br J Clin Pharmacol, Jan 2016
FINDINGS: Meta-analysis suggested a significant increase in plasma levels of adiponectin [weighted mean difference (WMD): 19·18%, 95% confidence interval (CI): 5·80, 32·57, p=0·005] and significant reductions in plasma levels of leptin (WMD: -13·24%, 95% CI: -20·69, -5·78, p=0·001) and CRP (WMD: -11·52%, 95% CI: -16·55, -6·49, p<0·001) following treatment with orlistat.
Osteocalcin as a hormone regulating glucose metabolism.
Japan. In World J Diabetes, Jan 2016
Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance.
Adipokines in nonalcoholic fatty liver disease.
Thessaloníki, Greece. In Metabolism, Dec 2015
Data regarding the association between NAFLD and circulating leptin and adiponectin levels are generally well documented: leptin levels increase, whereas adiponectin levels decrease, by increasing the severity of NAFLD.
The UK10K project identifies rare variants in health and disease.
More papers using
In Nature, Nov 2015
In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests.