gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenylate cyclase 6

adenylyl cyclase VI, ACVI, Ca(2+)-inhibitable adenylyl cyclase
may play a role in intracellular signaling [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, HAD, Aquaporin 1, CAN, CD36
Papers on adenylyl cyclase VI
Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.
Chiamvimonvat et al., Davis, United States. In Circ Res, 2013
AC types 5 (ACV) and 6 (ACVI) are the 2 main isoforms in the heart.
Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.
Kohan et al., Salt Lake City, United States. In J Am Soc Nephrol, 2013
In summary, these data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity in the kidney.
Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.
Kohan et al., Salt Lake City, United States. In Am J Physiol Renal Physiol, 2012
Collecting duct (CD) adenylyl cyclase VI (AC6) has been implicated in arginine vasopressin (AVP)-stimulated renal water reabsorption.
Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
GeneRIF
Chern et al., Taipei, Taiwan. In Mol Cell Biol, 2011
In primary hippocampal neurons and Neuro2A cells, elevated AC6 expression suppressed neurite outgrowth, whereas the downregulation or genetic removal of AC6 promoted neurite extension.
Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.
GeneRIF
Challiss et al., Leicester, United Kingdom. In Cardiovasc Res, 2011
AC6, but not the closely related AC5, plays a principal role in vasodilator signalling and regulation of the membrane potential in Vascular smooth muscle cells (VSMCs).
Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.
GeneRIF
Stevens et al., Mobile, United States. In Am J Physiol Lung Cell Mol Physiol, 2011
Isoproterenol activation of ACs promoted filamin phosphorylation, whereas thrombin inhibition of AC6 reduced filamin phosphorylation within the membrane fraction
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
GeneRIF
Hammond et al., San Diego, United States. In Mol Pharmacol, 2011
catalytically inactive mutant has same biological effects of intact enzyme, indicating that these effects do not require increased cAMP generation
L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
GeneRIF
Florán et al., Mexico. In Neurobiol Dis, 2011
Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.
Xiang et al., Urbana, United States. In Mol Pharmacol, 2010
At higher concentrations, isoproterenol promotes a dose-dependent selective dissociation of PDE4D but not ACVI from the receptor complex, which shifts the equilibrium between AC and PDE.
alpha-Lipoic acid prevents cisplatin-induced acute kidney injury in rats.
Kim et al., Kwangju, South Korea. In Nephrol Dial Transplant, 2009
The expression of adenylyl cyclase VI and vasopressin-stimulated cAMP generation was decreased.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
GeneRIF
Hammond et al., San Diego, United States. In J Biol Chem, 2008
increased expression of adenylyl cyclase VI activates Akt by phosphorylation at serine 473 and threonine 308 and is associated with increased nuclear phospho-Akt. Activated Akt phosphorylates phospholamban
Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.
Hamakubo et al., Tokyo, Japan. In J Biotechnol, 2008
We infected Sf9 cells with a combination of four recombinant baculoviruses individually encoding the dopamine D1 receptor (DR-D1), G-protein alpha-subunit (Galpha(s)), G-protein beta(1)gamma(2) subunit dimer (Gbeta(1)gamma(2)), and adenylyl cyclase type VI (ACVI).
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.
Hammond et al., San Diego, United States. In J Am Coll Cardiol, 2008
OBJECTIVES: This study sought to evaluate whether increased left ventricular (LV) adenylyl cyclase VI (AC(VI)) expression, at a time when severe congestive heart failure (CHF) was present, would increase function of the actively failing heart.
MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.
Valle et al., Chicago, United States. In J Biol Chem, 2007
Our results suggest that miR-96 and miR-182 are involved in circadian rhythm regulation, perhaps by modulating the expression of adenylyl cyclase VI (ADCY6).
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
Patel et al., Maywood, United States. In J Biol Chem, 2007
Likewise, activities of the recombinant, engineered, soluble forms of ACV and ACVI, which lack the N termini, were not enhanced by Gbetagamma subunits.
Adenylylcyclase gene transfer increases function of the failing heart.
Hammond et al., San Diego, United States. In Hum Gene Ther, 2006
Here we test the hypothesis that intracoronary delivery of adenovirus encoding adenylylcyclase type VI (Ad.ACVI) in the setting of active heart failure will increase function of the failing heart.
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
Scott et al., Portland, United States. In Mol Cell, 2006
Here, we provide evidence for interactions between AKAP79/150 and ACV and ACVI.
Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction.
Narayan et al., San Diego, United States. In J Am Coll Cardiol, 2006
OBJECTIVES: The purpose of this study was to test the hypothesis that cardiac-directed expression of adenylyl cyclase VI (AC(VI)) facilitates atrioventricular (AV) nodal conduction.
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy.
Chiamvimonvat et al., Davis, United States. In J Mol Cell Cardiol, 2006
Recently, Roth et al. have shown that long-term cardiac-directed expression of ACVI, a dominant AC isoform in mammalian cardiac myocytes, increases survival and abrogates myocardial hypertrophy in transgenic (TG) mice with Galphaq-associated cardiomyopathy.
Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment.
Review
Roeske et al., Tucson, United States. In Life Sci, 2004
Raf-1 in turn phosphorylates and sensitizes the native adenylyl cyclase VI isoenzyme in hDOR/CHO cells, causing a rebound increase in forskolin-stimulated cAMP formation upon agonist withdrawal.
share on facebooktweetadd +1mail to friends