adenylyl cyclase type V
Ciliary adenylyl cyclases control the Hedgehog pathway.
Barcelona, Spain. In J Cell Sci, Sep 2015
Here, we show that adenylyl cyclase 5 and adenylyl cyclase 6 (AC5 and AC6, also known as ADCY5 and ADCY6, respectively) are the two isoforms most strongly expressed in cerebellar granular neuron precursors (CGNPs).
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Seattle, United States. In Ann Neurol, 2014
OBJECTIVE: To identify the cause of childhood onset involuntary paroxysmal choreiform and dystonic movements in 2 unrelated sporadic cases and to investigate the functional effect of missense mutations in adenylyl cyclase 5 (ADCY5) in sporadic and inherited cases of autosomal dominant familial dyskinesia with facial myokymia (FDFM).
Vidarabine is neither a potent nor a selective AC5 inhibitor.
Hannover, Germany. In Biochem Pharmacol, 2014
Scientific interest in vidarabine has been recently renewed due to the fact that the compound exhibits beneficial effects in animal models of heart failure and cancer, replicating effects of the knockout of adenylyl cyclase 5 (AC5).