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Adenylate cyclase 10

Adenylate Cyclase, Sac
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: PACAP, V1a, CAN, HAD, ACID
Papers using Adenylate Cyclase antibodies
Gaussian 09, RevisionA.
Supplier
Song Haiwei, In PLoS ONE, 2008
... SacII, was cloned into the pUC57 vector (GenScript).
Comparison of ethylene- and wound-induced responses in fruit of wild-type, rin and nor tomatoes
Supplier
Kubo Yasutaka et al., In Journal of Experimental Botany, 2003
... SacI-digested pBI121 (Clontech) to place it under ...
A novel connexin 26 gene mutation associated with features of the keratitisichthyosis-deafness syndrome and the follicular occlusion triad.
Supplier
Lightowlers Bob, In PLoS ONE, 2003
... SacII restriction sites in vectors pEGFPN1 and pDsRedN1 (Clontech, Palo Alto, CA, USA) ...
Loss of actin cytoskeletal function and EDS1 activity, in combination, severely compromises non-host resistance in Arabidopsis against wheat powdery mildew
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Takken Frank L. W. et al., In Journal of Experimental Botany, 2002
... SacI fragment of I-2 FL in the yeast two-hybrid (Y2H) bait vector pAS2-1 (Clontech Laboratories, Palo Alto, CA, ...
The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.
Supplier
van Veen Hendrik W., In PLoS ONE, 1998
... SacI and ApaI) (Clontech), to give the plasmid ...
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Papers on Adenylate Cyclase
Localized signals that regulate transendothelial migration.
Review
New
Muller, United States. In Curr Opin Immunol, Feb 2016
CD99 signals through soluble adenylate cyclase to activate protein kinase A to recruit a second wave of LBRC trafficking.
Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein (TgARO).
New
Soldati-Favre et al., Genève, Switzerland. In J Cell Sci, Feb 2016
Here, we show that two TgARO partners, ARO interacting protein (TgAIP) and adenylate cyclase β (TgACβ) localize to a rhoptry subcompartment.
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
New
Farnham et al., Sydney, Australia. In J Neurosci, Feb 2016
Pituitary adenylate cyclase activating polypeptide (PACAP) is an excitatory neuropeptide with neuroprotective properties, whereas microglia are key players in inflammatory responses in CNS.
cAMP regulates the functional activity, coupling efficiency and structural organization of mammalian FOF1 ATP synthase.
New
Papa et al., Bari, Italy. In Biochim Biophys Acta, Feb 2016
UNASSIGNED: The present study shows that in isolated mitochondria and myoblast cultures depletion of cAMP, induced by sAC inhibition, depresses both ATP synthesis and hydrolysis by the FOF1 ATP synthase (complex V) of the oxidative phosphorylation system (OXPHOS).
Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase a signaling pathway in primary human macrophages.
New
Paul et al., Châtenay-Malabry, France. In Biochim Biophys Acta, Feb 2016
Moreover, the activation of adenylate cyclase by forskolin and the inhibition of cAMP phosphodiesterase by isobutylmethylxanthine restored ABCA1 cholesterol efflux in EPA-treated human macrophages.
Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease.
New
Fournier et al., Mont-Saint-Aignan, France. In Biochim Biophys Acta, Feb 2016
This phenomenon is related to apoptosis and its activation can be blocked by the pituitary adenylate cyclase-activating polypeptide (PACAP).
Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function".
Review
New
Nestler, New York City, United States. In Brain Res, Jan 2016
Previous studies have shown that chronic morphine increases levels of the G-protein subunits Giα and Goα, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Giα and increases levels of adenylate cyclase in dorsal root ganglion/spinal cord (DRG-SC) co-cultures.
Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides.
Review
New
Raisman-Vozari et al., Pécs, Hungary. In Prog Neurobiol, Dec 2015
Among them, pituitary adenylate cyclase-activating polypeptide, a member of the secretin/glucagon superfamily, has several advantageous effects in models of neurodegeneration, namely anti-apoptotic, anti-inflammatory and antioxidant actions, the combination of which offers a potent protective effect in dopaminergic neurons.
[Octarphin--Nonopioid Peptide of the Opioid Origin].
Review
New
Navolotskaya, In Bioorg Khim, Sep 2015
Binding to the receptor octarphin increases increases the mitogen-induced pro- liferation of human and mouse T and B lymphocytes in vitro, activates murine peritoneal macrophages in vitro and in vivo, stimulates growth of human T-lymphoblast cell lines Jurkat and MT-4, inhibits adenylate cyclase activity of rat adrenal cortex membranes and suppresses the secretion of glucocorticoids from the adrenal gland into the blood.
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.
New
Impact
Bishai et al., Baltimore, United States. In Nat Med, Apr 2015
We found that a di-adenylate cyclase (disA or dacA)-overexpressing M. tuberculosis strain that secretes excess c-di-AMP activates the interferon regulatory factor (IRF) pathway with enhanced levels of IFN-β, elicits increased macrophage autophagy, and exhibits substantial virulence attenuation in mice.
Neurofibromin - protein structure and cellular functions in the context of neurofibromatosis type I pathogenesis.
Review
Gos et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2014
In addition, neurofibromin is a regulator of adenylate cyclase activity and therefore may interfere with signaling by the cAMP/protein kinase A pathway that regulates cell cycle progression or learning and memory formation processes.
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
Impact
Lowell et al., Boston, United States. In Nature, 2014
Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1).
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Impact
Birnbaum et al., Philadelphia, United States. In Nature, 2013
In mouse hepatocytes, metformin leads to the accumulation of AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and protein kinase A (PKA) activity, abrogate phosphorylation of critical protein targets of PKA, and block glucagon-dependent glucose output from hepatocytes.
Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.
Impact
Nedergaard et al., Rochester, United States. In Science, 2013
In contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages.
Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery.
GeneRIF
Munger et al., Baltimore, United States. In Am J Physiol Endocrinol Metab, 2012
It was concluded that there are T1R3-dependent and -independent pathways in the gastrointestinal tract to regulate GLP-1 secretion. Enteroendocrine cells of the large, but not small intestine, use a potassium channel to facilitate GLP-1 secretion.
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Impact
Pays et al., Brussels, Belgium. In Science, 2012
Using a dominant-negative strategy, we found that reducing adenylate cyclase activity by about 50% allowed trypanosome growth but reduced the parasite's ability to control the early innate immune defense of the host.
Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal.
GeneRIF
Spector et al., Tallahassee, United States. In Am J Physiol Regul Integr Comp Physiol, 2012
T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli.
Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells.
GeneRIF
Ishii et al., Obihiro, Japan. In J Cell Biochem, 2012
examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as an amino acid sensor
Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptor.
GeneRIF
Briand et al., Dijon, France. In Protein Expr Purif, 2012
Overexpressed the human N-terminal domain of T1R3 in E. coli and found that the refolded protein behaves as a dimer; showed that hT1R3-NTD is functional and capable of binding sucralose with an affinity in the millimolar range.
Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
GeneRIF
Boekhoff et al., München, Germany. In Plos One, 2011
Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa.
More papers using Adenylate Cyclase antibodies
N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.
Supplier
Dryer Stuart E., In PLoS ONE, 1998
... Sac II digestion site at the C-terminus, and then sub-cloned into the mammalian expression vector pEYFP-N1 (Clontech, Mountain View, CA) to ...
Cluster analysis and display of genome-wide expression patterns.
Supplier
Devaux Frédéric et al., In Genome Biology, 1997
... SacII digestion, the two PCR fragments were ligated using the Quick Ligation kit (New England Biolabs, Ipswich, MA, USA) ...
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)
Supplier
Thwaites David T. et al., In Biochimica et Biophysica Acta, 1997
... PACAP (pituitary adenylate cyclase-activating polypeptide) was from Bachem (St ...
Effective transgenic resistance to Globodera pallida in potato field trials.
Supplier
Smagghe Guy, In PLoS ONE, 1985
... Sac I fragment into the binary vector pBI121 (Clontech, California, USA) from which ...
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