Inexpensive Method for Selecting Receptor Structures for Virtual Screening.
Saint Louis, United States. In J Chem Inf Model, Jan 2016
We evaluated the performance of the SPI by applying it to study eight protein systems: fatty acid binding protein adipocyte FABP4, serine/threonine-protein kinase BRAF, beta-1 adrenergic receptor ADRB1, TGF-beta receptor type I TGFR1, adenosylhomocysteinase SAHH, thyroid hormone receptor beta-1 THB, phospholipase A2 group IIA PA2GA, and cytochrome P450 3a4 CP3A4.
Curious discoveries in antiviral drug development: the role of serendipity.
Leuven, Belgium. In Med Res Rev, Jul 2015
The S-adenosylhomocysteine hydrolase inhibitors (ix), while active against a broad range of (-)RNA viruses and poxviruses may be particularly effective against Ebola virus, and for (x) the O-ANP derivatives, the potential application range encompasses virtually all DNA viruses.
[Structural biology for developing antimalarial compounds].
In Yakugaku Zasshi, 2012
One example is the structural studies for S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum (PfSAHH) and the other example is those for 1-deoxy-D-xylulose reductoisomerase from Plasmodium falciparum (PfDXR).
Crystallization of mouse S-adenosyl-L-homocysteine hydrolase.
Tokyo, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.
Cladribine: not just another purine analogue?
Portland, United States. In Expert Opin Investig Drugs, 2009
Emerging data show that in addition to its known purine nucleoside analogue activity, cladribine possesses epigenetic properties, inhibiting S-adenosylhomocysteine hydrolase and DNA methylation.