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ATPase, Na+/K+ transporting, beta 1 polypeptide

adenosinetriphosphatase, ATP1B1
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ATPase, ACID, HAD, CAN, V1a
Papers on adenosinetriphosphatase
Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.
Wong-Riley et al., Milwaukee, United States. In Biochim Biophys Acta, Jan 2016
It also regulates Atp1a1 and Atp1b1 subunit genes of Na(+)/K(+)-ATPase, a major energy-consuming enzyme, as well as all 13 subunits of cytochrome c oxidase (COX), an important energy-generating enzyme.
PUGNAc induces protein ubiquitination in C2C12 myotube cells.
Baek et al., Taegu, South Korea. In Cell Biochem Funct, Dec 2015
Among 205 selected genes, we identified 68 nucleotide-binding proteins, 14 proteins that have adenosinetriphosphatase activity, and 10 proteins with ligase activity.
Interactions between Microcystis aeruginosa and coexisting amoxicillin contaminant at different phosphorus levels.
Gao et al., Jinan, China. In J Hazard Mater, Nov 2015
Phosphorus and amoxicillin affected the contents of chlorophyll-a, adenosine triphosphate (ATP) and malondialdehyde, the expression of psbA and rbcL, as well as the activities of adenosinetriphosphatase and glutathione S-transferase in similar manners, but regulated the production and release of microcystins and the activities of superoxide dismutase and peroxidase in different ways.
Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia.
Wang et al., Beijing, China. In Oncotarget, Nov 2015
UNASSIGNED: ATP1B1 encodes the Na,K-ATPase β subunit, a key regulator of the Na+ and K+ electrochemical gradients across the plasma membrane and an essential regulator of cellular activity.
Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring.
Pang et al., Kingston, Canada. In Mol Cell Biochem, Oct 2015
Gene expression of Na(+)/K(+) ATPase channel isoforms, Atp1a1, Atp1a3, and Atp1b1, displayed no significant differences.
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
Srivastava et al., Greenwood, United States. In Plos One, 2014
Using a yeast two-hybrid screen, we found that the KIRREL3 extracellular domain interacts with brain expressed proteins MAP1B and MYO16 and its intracellular domain can potentially interact with ATP1B1, UFC1, and SHMT2.
Protein kinase A (PKA) phosphorylation of Na+/K+-ATPase opens intracellular C-terminal water pathway leading to third Na+-binding site in molecular dynamics simulations.
Khandelia et al., Århus, Denmark. In J Biol Chem, 2012
Data show that protein kinase A (PKA) phosphorylation has a drastic impact on Na(+)/K(+)-ATPase (NKA) structure and dynamics
Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.
Adeyemo et al., Washington, D.C., United States. In J Hypertens, 2011
examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans
Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits.
Vagin et al., Los Angeles, United States. In J Biol Chem, 2011
interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions
Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions.
Apell et al., Konstanz, Germany. In Biochemistry, 2011
FXYD1 raises the affinity of the human alpha1beta1 isoform of Na,K-ATPase for Na ions
Na(+)/K (+)-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication.
Gao et al., Beijing, China. In Sci China Life Sci, 2010
Results identified that the beta1 subunit of the host Na(+)/K(+)-ATPase beta1 subunit (ATP1B1) interacts with the cytoplasmic domain of both the influenza A and B virus M2 and BM2 proteins.
Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase.
Cutuli et al., Buffalo, United States. In Biochem Biophys Res Commun, 2010
Once phosphorylated, TORCs enter the nucleus, and activate transcription of the ATP1B1 gene encoding for the Na,K-ATPase beta subunit.
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Chakravarti et al., München, Germany. In Nat Genet, 2009
Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology.
Familial hemiplegic migraine.
Pietrobon, Padova, Italy. In Neurotherapeutics, 2007
Mutations in the genes CACNA1A and SCNA1A, encoding the pore-forming alpha(1) subunits of the neuronal voltage-gated Ca2+ channels Ca(V)2.1 and Na+ channels Na(V)1.1, are responsible for FHM1 and FHM3, respectively, whereas mutations in ATP1A2, encoding the alpha2 subunit of the Na+, K+ adenosinetriphosphatase (ATPase), are responsible for FHM2.
Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control.
Doucet et al., Genève, Switzerland. In Physiol Rev, 2001
Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis.
Inotropic and energetic effects of altering the force-calcium relationship: mechanisms, experimental results, and potential molecular targets.
Koretsky et al., Pittsburgh, United States. In J Card Fail, 2000
Potential molecular targets include the protein kinase A and C phosphorylation sites on troponin I, which, when phosphorylated, mediate a reduction in calcium sensitivity and a reduction in maximal actomyosin adenosinetriphosphatase activity, respectively.
Ion pumps in epithelial cells: sorting, stabilization, and polarity.
Caplan, New Haven, United States. In Am J Physiol, 1997
The P-type family of ion-transporting ATPases includes all of the isoforms of Na(+)-K(+)-adenosinetriphosphatase (ATPase), the plasma membrane and organellar Ca(2+)-ATPases, gastric H(+)-K(+)-ATPase, and the recently characterized nongastric H(+)-K(+)-ATPases, among others.
Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads.
Hartshorne et al., In Science, 1981
The relationship between the actin-activated adenosinetriphosphatase activity of smooth muscle myosin and the extent of myosin light chain phosphorylation is nonlinear.
Neurotrophic influence on lobster skeletal muscle.
Sellers et al., In Science, 1980
In both claws, myofibrillar adenosinetriphosphatase activity was independent of the pattern of innervation.
Fischer et al., In Science, 1945
A method has been described for the histochemical localization of acid and alkaline ATPase in plant and animal tissues respectively.
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