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Adenosine kinase

adenosine kinase
catalyzes the phosphorylation of purine nucleosides; plays a role in adenosine metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, Ado
Papers on adenosine kinase
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.
Gemma et al., Pavia, Italy. In Chem Biol Drug Des, Jan 2016
We recently developed a series of non-nucleoside non-competitive inhibitors of human adenosine kinase (hAK), based on a pyrrolobenzoxa(thia)zepinone scaffold.
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
Blom et al., Heidelberg, Germany. In J Inherit Metab Dis, Jan 2016
BACKGROUND: Adenosine kinase deficiency is a recently described defect affecting methionine metabolism with a severe clinical phenotype comprising mainly neurological and hepatic impairment and dysmorphism.
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma‑associated epilepsy.
Long et al., Changsha, China. In Mol Med Report, Nov 2015
The aim of the present study was to investigate adenosine deaminase (ADA) and adenosine kinase (ADK) expression in human glioma and to explore its correlation with glioma‑associated epilepsy.
The roles of purinergic signaling in psychiatric disorders.
Roszek et al., Toruń, Poland. In Acta Biochim Pol, Nov 2015
It is believed that any action leading to the effective increase of adenosine concentration: activation of nucleotide metabolizing ecto-enzymes (mainly NTPDases - nucleoside triphosphate diphosphohydrolases), inhibition of adenosine deaminase and/or adenosine kinase activity as well as therapies using P1 receptor agonists (adenosine or its analogues) might be beneficial in therapy of psychiatric disorders.
Anticancer effect of adenosine on gastric cancer via diverse signaling pathways.
Nishizaki et al., Nishinomiya, Japan. In World J Gastroenterol, Nov 2015
Extracellular adenosine is transported into cells through an adenosine transporter and converted to AMP by adenosine kinase.
Adenosine receptor targets for pain.
Sawynok, Halifax, Canada. In Neuroscience, Nov 2015
Endogenous adenosine levels can be augmented by inhibition of metabolism (via adenosine kinase) or increased generation (via nucleotidases), and these approaches have implications for pain.
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.
Rosenberger et al., Tübingen, Germany. In Crit Care Med, Nov 2015
Adenosine levels are regulated by a close interplay between nucleoside transporters and adenosine kinase.
Differences in properties and proteomes of the midribs contribute to the size of the leaf angle in two near-isogenic maize lines.
Wang et al., Zhengzhou, China. In J Proteomics, Nov 2015
Quantitative analysis of 24 identified midrib proteins indicated that the maximum changes in abundance of 22 proteins between Shen137 and NIL appeared at the 10th leaf stage, of which phosphoglycerate kinase, adenosine kinase, fructose-bisphosphate aldolase and adenylate kinase were implicated in glycometabolism.
Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine.
el Kouni et al., Birmingham, United States. In Comp Biochem Physiol B Biochem Mol Biol, Oct 2015
Initial velocity and product inhibition studies of Toxoplasma gondii adenosine kinase (TgAK, EC
Comorbidities in Neurology: Is adenosine the common link?
Aronica et al., Portland, United States. In Neuropharmacology, Oct 2015
Here we will specifically focus on the 'adenosine hypothesis of comorbidities' implying that astrocyte activation, via overexpression of adenosine kinase (ADK), induces a deficiency in the homeostatic tone of adenosine.
The adenosine neuromodulation system in schizophrenia.
Cunha et al., Coimbra, Portugal. In Int Rev Neurobiol, 2013
This proposal should also provide a rationale to assist the design of future therapeutic intervention targeting the adenosine modulation system to manage schizophrenia endophenotypes: these should not be based only on an attempt to target adenosine kinase-A1 receptors or only A2A receptors, but should instead simultaneously target these two arms of the adenosine modulation system.
Role of adenosine in status epilepticus: a potential new target?
Boison, Portland, United States. In Epilepsia, 2013
Adenosine homeostasis in the adult brain is largely under the control of metabolic clearance through adenosine kinase (ADK), expressed predominantly in astrocytes.
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication.
Melton et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2012
Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
Adenosine kinase regulation of cardiomyocyte hypertrophy.
Bache et al., Minneapolis, United States. In Am J Physiol Heart Circ Physiol, 2011
Adenosine kinase is an important mediator of adenosine attenuation of cardiomyocyte hypertrophy.
Role of adenosine kinase in cochlear development and response to noise.
Thorne et al., Auckland, New Zealand. In J Neurosci Res, 2010
In the developing cochlea, ADK is strongly expressed in multiple cell types at birth and reaches its peak level of expression at postnatal day 21; it is involved in purine salvage pathways for nucleotide synthesis in the adult cochlea.
A kinetic study of the rat liver adenosine kinase reverse reaction.
Leoncini et al., Siena, Italy. In Nucleosides Nucleotides Nucleic Acids, 2008
The reaction catalyzed by adenosine kinase (adenosine + ATP --> AMP + ADP) can be easily reversed when coupled with adenosine deaminase, which transforms adenosine into inosine and ammonia.
Adenosine kinase from rat liver: new biochemical properties.
Marinello et al., Siena, Italy. In Nucleosides Nucleotides Nucleic Acids, 2005
biochemical analysis of adenosine kinase from rat liver
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection.
Linden, Charlottesville, United States. In Annu Rev Pharmacol Toxicol, 2000
In ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in inflamed tissues adenosine is formed from adenine nucleotides that are released from many cells including platelets, mast cells, nerves, and endothelium.
Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.
Seegmiller et al., In Science, 1977
Mutants deficient in adenosine kinase or adenine phosphoribosyltransferase activities were selected from the WI-L2 line of human lymphoblasts.
Hereditary hemolytic anemia with increased red cell adenosine deaminase (45- to 70-fold) and decreased adenosine triphosphate.
Gilsanz et al., In Science, 1977
Since adenosine deaminase and adenosine kinase compete for a common substrate, the greatly increased activity of the former may interfere with nucleotide salvage via the latter.
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