The roles of purinergic signaling in psychiatric disorders.
Toruń, Poland. In Acta Biochim Pol, Nov 2015
It is believed that any action leading to the effective increase of adenosine concentration: activation of nucleotide metabolizing ecto-enzymes (mainly NTPDases - nucleoside triphosphate diphosphohydrolases), inhibition of adenosine deaminase and/or adenosine kinase activity as well as therapies using P1 receptor agonists (adenosine or its analogues) might be beneficial in therapy of psychiatric disorders.
Adenosine receptor targets for pain.
Halifax, Canada. In Neuroscience, Nov 2015
Endogenous adenosine levels can be augmented by inhibition of metabolism (via adenosine kinase) or increased generation (via nucleotidases), and these approaches have implications for pain.
Comorbidities in Neurology: Is adenosine the common link?
Portland, United States. In Neuropharmacology, Oct 2015
Here we will specifically focus on the 'adenosine hypothesis of comorbidities' implying that astrocyte activation, via overexpression of adenosine kinase (ADK), induces a deficiency in the homeostatic tone of adenosine.
Crucial role of astrocytes in temporal lobe epilepsy.
Bonn, Germany. In Neuroscience, Feb 2015
In addition, disturbed gliotransmission as well as malfunction of glutamate transporters and of the astrocytic glutamate- and adenosine-converting enzymes - glutamine synthetase and adenosine kinase, respectively - have been observed in epileptic tissues.