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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenosine A1 receptor

adenosine A1 receptor, adenosine A1 receptor in
inhibits adenylyl cyclase activity; plays a role in regulation of arterial pressure, heart rate, and sodium excretion [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, HAD, A2A, ACID
Papers on adenosine A1 receptor
Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems.
New
Souza et al., Porto Alegre, Brazil. In Mol Neurobiol, Feb 2016
Although the hippocampal glutamate uptake was not modulated by guanosine (both ex vivo and in vitro protocols), the synaptosomal K(+)-stimulated glutamate release in vitro was decreased by guanosine (100 μM) and by the specific adenosine A1 receptor agonist, 2-chloro-N (6)-cyclopentyladenosine (CCPA, 100 nM).
AMP-guided tumour-specific nanoparticle delivery via adenosine A1 receptor.
New
Liu et al., Shanghai, China. In Biomaterials, Feb 2016
RNA interference and inhibitor assays reveal that the targeting effects mainly rely on the specific binding of AMP to adenosine A1 receptor (A1R), which is greatly up-regulated in cancer cells than in matched normal cells.
Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors.
New
Papatheodoropoulos et al., Pátrai, Greece. In Neuroscience, Feb 2016
Here, using CA1 field recordings from hippocampal slices, we show that activation of NMDA receptors (NMDARs) reduced excitatory transmission more in VH than in DH, with an adenosine A1 receptor-independent mechanism, and reduced inhibition and enhanced postsynaptic excitability only in DH.
Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure.
New
Gheorghiade et al., Durham, United States. In Heart Fail Rev, Jan 2016
In this context, a partial adenosine A1 receptor (A1R) agonist holds promise as a potentially hemodynamically neutral therapy for HF that could simultaneous improve cardiomyocyte energetics, calcium homeostasis, cardiac structure and function, and long-term clinical outcomes when added to background therapies.
Adenosine A1 Receptors Selectively Modulate Oxygen-Induced Retinopathy at the Hyperoxic and Hypoxic Phases by Distinct Cellular Mechanisms.
New
Chen et al., Wenzhou, China. In Invest Ophthalmol Vis Sci, Jan 2016
PURPOSE: We critically evaluated the role of the adenosine A1 receptor (A1R) in normal development of retinal vasculature and pathogenesis of retinopathy of prematurity (ROP) by using the A1R knockout (KO) mice and oxygen-induced retinopathy (OIR) model.
Chronic caffeine exposure attenuates blast-induced memory deficit in mice.
New
Zhou et al., Chongqing, China. In Chin J Traumatol, Sep 2015
Adenosine A1 receptor expression was detected using qPCR.
Regulatory role of adenosine in insulin secretion from pancreatic β-cells--action via adenosine A₁ receptor and beyond.
Review
New
Szkudelska et al., Poznań, Poland. In J Physiol Biochem, Mar 2015
In rat islets, low adenosine was demonstrated to decrease glucose-induced insulin secretion and this effect is mediated via adenosine A1 receptor.
Alpha2-adrenoceptor and adenosine A1 receptor within the nucleus tractus solitarii in hypertension development.
Review
Carrettiero et al., Santo André, Brazil. In Auton Neurosci, 2015
Alpha2-adrenoceptor and A1 adenosine receptor systems within the nucleus tractus solitarii (NTS) play an important role in cardiovascular control.
Pharmacotherapy of dilated cardiomyopathy.
Review
Spinar et al., Brno, Czech Republic. In Curr Pharm Des, 2014
Of the recent treatment options, the vasopressin blocker and adenosine A1 receptor antagonist (rolofylline) were disappointing.
Roles of adenosine and its receptors in sleep-wake regulation.
Review
Qu et al., Shanghai, China. In Int Rev Neurobiol, 2013
There are four adenosine receptor subtypes: adenosine A1 receptor (R, A1R), A2AR, A2BR, and A3R.
Adenosine receptors and epilepsy: current evidence and future potential.
Review
Ruskin et al., Hartford, United States. In Int Rev Neurobiol, 2013
There is evidence for the involvement of multiple adenosine receptor subtypes in epilepsy, but in particular the adenosine A1 receptor subtype can powerfully and bidirectionally regulate seizure activity.
Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes.
GeneRIF
Dhalla et al., Fremont, United States. In Eur J Pharmacol, 2012
Data suggest that expression of Adora1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; studies include investigation of gene expression under influence of Adora1 agonists.
Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.
GeneRIF
Marek, United States. In J Pharmacol Exp Ther, 2012
Activation of adenosine A receptors could contribute to antidepressant effects.
Molecular mechanism underlying adenosine receptor-mediated mitochondrial targeting of protein kinase C.
GeneRIF
Hu et al., Columbus, United States. In Biochim Biophys Acta, 2012
The present study was designed to determine whether and how adenosine receptor activation induces translocation of PKCepsilon to mitochondria.
Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation.
GeneRIF
Patel et al., Charlottesville, United States. In Epilepsia, 2012
Our data indicate that the actions of adenosine on mEC layer II stellate neurons is accentuated in temporal lobe epilepsy due to an upregulation of adenosine A(1)-receptors.
Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.
GeneRIF
Walker et al., London, United Kingdom. In Epilepsia, 2012
Data show that A(1)R activation can prevent the progression to SE and suggest that reduced A(1)R signaling promotes the transition of seizures to SSSE.
Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor.
Impact
Nedergaard et al., Rochester, United States. In Nat Med, 2008
Adenosine A1 receptor activation depresses excitatory transmission in the thalamus and reduces both tremor- and DBS-induced side effects.
DNA antisense therapy for asthma in an animal model.
Impact
Metzger et al., Greenville, United States. In Nature, 1997
Administration of an aerosolized phosphorothioate antisense oligodeoxynucleotide targeting the adenosine A1 receptor desensitized the animals to subsequent challenge with either adenosine or dust-mite allergen.
Release of adenosine by activation of NMDA receptors in the hippocampus.
Impact
Nicoll et al., San Francisco, United States. In Science, 1994
This depression was blocked by an adenosine A1 receptor antagonist, which suggests that activation of the NMDA subtype of glutamate receptor raises the concentration of extracellular adenosine, which acts on presynaptic inhibitory A1 receptors.
Preferential inhibition of omega-conotoxin-sensitive presynaptic Ca2+ channels by adenosine autoreceptors.
Impact
Chuhma et al., Kyoto, Japan. In Nature, 1993
The adenosine A1 receptor is assumed to reside in presynaptic terminals and to function as a negative autoreceptor.
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