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Adducin 2

ADD2, beta-Add, AddB
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Sterol Regulatory Element Binding Protein 1, CAN, HAD, AGE, V1a
Papers on ADD2
Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination.
Dillingham et al., Madrid, Spain. In Nucleic Acids Res, Feb 2016
Chi recognition elicits a structural change in AddAB that maps to a region of AddB which resembles a helicase domain, and which harbours both the Chi recognition locus and the latch.
ADDing a piece to the puzzle of cognition in schizophrenia.
Cavallaro et al., Milano, Italy. In Eur J Med Genet, Jan 2016
ADD2 is more prominently expressed in brain tissues and influences memory and learning, commonly impaired in schizophrenia.
Beta-adducin and sodium-calcium exchanger 1 gene variants are associated with systemic lupus erythematosus and lupus nephritis.
Manfredi et al., Milano, Italy. In Rheumatol Int, Dec 2015
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
High-throughput sequencing reveals adaptation-induced mutations in pentose-fermenting strains of Zymomonas mobilis.
Rao et al., Urbana, United States. In Biotechnol Bioeng, Nov 2015
We also found that mutations in the AddB protein increase plasmid stability and can reduce cellular aggregation in these strains.
Kinetic and mechanistic study of the reaction of OH radicals with methylated benzenes: 1,4-dimethyl-, 1,3,5-trimethyl-, 1,2,4,5-, 1,2,3,5- and 1,2,3,4-tetramethyl-, pentamethyl-, and hexamethylbenzene.
Zetzsch et al., Bayreuth, Germany. In Phys Chem Chem Phys, Jun 2015
The other (add2) is more elusive and only detectable at elevated temperatures, similar to the single OH adduct of hexamethylbenzene.
Common variant rs7597774 in ADD2 is associated with dilated cardiomyopathy in Chinese Han population.
Yang et al., Dalian, China. In Int J Clin Exp Med, 2014
Two polymorphisms, rs7597774 and rs1739843 in ADD2 and HSPB7 respectively, were found to be associated with dilated cardiomyopathy (DCM) in European cohorts but the results were not validated in the Chinese Han population.
[Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population].
Bedoya et al., Medellín, Colombia. In Biomedica, 2013
OBJECTIVES: To evaluate the effect of both variants in genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R PTGS2, and the result of the individual ancestry component on hypertension and blood pressure levels among population in Antioquia.
Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
Wigley et al., London, United Kingdom. In Embo J, 2012
The structure allows identification of a putative Chi-recognition site in an inactivated helicase domain of the AddB subunit.
Identification of 3' gene ends using transcriptional and genomic conservation across vertebrates.
Muro et al., Trieste, Italy. In Bmc Genomics, 2011
For example, we have previously reported two different genes, ADD2 and CPEB3, with conserved 3'UTR alternative isoforms not annotated in the current versions of Ensembl and RefSeq human databases.
Multilocus family-based association analysis of seven candidate polymorphisms with essential hypertension in an african-derived semi-isolated brazilian population.
Mingroni-Netto et al., São Paulo, Brazil. In Int J Hypertens, 2011
Seven variants were investigated: ACE (rs1799752), AGT (rs669), ADD2 (rs3755351), NOS3 (rs1799983), GNB3 (rs5441 and rs5443), and GRK4 (rs1801058).
The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster.
White et al., Saint Andrews, United Kingdom. In Plos One, 2011
We show here that Cas4 family proteins from the archaeon Sulfolobus solfataricus utilise four conserved cysteine residues to bind an iron-sulfur cluster in an arrangement reminiscent of the AddB nuclease of Bacillus subtilis.
Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.
Cole et al., Sydney, Australia. In J Biol Chem, 2011
phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons.
β-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment.
Caroni et al., Basel, Switzerland. In Neuron, 2011
mice lacking beta-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment.
Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone.
Heagerty et al., Japan. In J Hypertens, 2011
Mutations in the beta subunit of the adducin protein result in damage to renal artery myogenic tone and this is associated with renal damage as manifest by proteinuria.
The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain.
Dillingham et al., Bristol, United Kingdom. In Nucleic Acids Res, 2011
We show that the enzyme is functional as a heterodimer of the AddA and AddB subunits, that it is a rapid and processive DNA helicase, and that it catalyses DNA unwinding using one single-stranded DNA motor of 3' → 5' polarity located in the AddA subunit.
Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells.
Peters et al., Bar Harbor, United States. In Blood, 2010
Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC) spectrin deficiency, resulting in markedly reduced RBC membrane spectrin content, decreased band 3, and absent beta-adducin.
beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.
Muro et al., Trieste, Italy. In Genes Brain Behav, 2010
These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
Adducin polymorphisms and the treatment of hypertension.
Ferrandi et al., Milano, Italy. In Pharmacogenomics, 2007
Adducin is a heterodimeric cytoskeleton protein, the three subunits of which are encoded by genes (ADD1, ADD2 and ADD3) that map to three different chromosomes.
Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm.
Bianchi et al., Milano, Italy. In J Am Soc Nephrol, 2006
Adducin is a heterodimeric cytoskeleton protein, the three subunits of which are encoded by genes (ADD1, ADD2, and ADD3) that map to three different chromosomes.
Adducin polymorphism: detection and impact on hypertension and related disorders.
Staessen et al., Milano, Italy. In Hypertension, 2005
Adducin is a heterodymeric cytoskeleton protein, the 3 subunits of which are encoded by genes (ADD1, ADD2, ADD3) mapping to 3 different chromosomes.
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