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Adenosine deaminase, tRNA-specific 1

ADAT1, tRNA-specific adenosine deaminase, hADAT1, tRNA-specific adenosine deaminase ADAT1, mADAT1
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: RED1, PKI, CAN, V1a, Orf
Papers on ADAT1
Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores.
Moroz et al., United States. In Integr Comp Biol, Dec 2015
However, the overall molecular diversity of RNA-editing enzymes in ctenophores is lower, suggesting a possible "compensation" by an expansion of the ADAT1-like subfamily in this lineage.
Identification of Reproduction-Related Gene Polymorphisms Using Whole Transcriptome Sequencing in the Large White Pig Population.
Sironen et al., Green, United States. In G3 (bethesda), Jul 2015
Seven genes (PGR, FRAS1, TCF4, ADAT1, SPAG6, PIWIL2, and DNAH8) with polymorphisms were highlighted as reproduction-related based on their biological function.
Identification of enzymes for adenosine-to-inosine editing and discovery of cytidine-to-uridine editing in nucleus-encoded transfer RNAs of Arabidopsis.
Bock et al., Potsdam, Germany. In Plant Physiol, 2014
The encoded proteins (AtTAD2 and AtTAD3, for tRNA-specific adenosine deaminase) localize to the nucleus and interact with each other in planta in bimolecular fluorescence complementation and coimmunoprecipitation assays.
Escherichia coli ASKA Clone Library Harboring tRNA-Specific Adenosine Deaminase (tadA) Reveals Resistance towards Xanthorrhizol.
Pan et al., Seoul, South Korea. In Molecules, 2014
tadA encodes a tRNA-specific adenosine deaminase.
Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis.
Witte et al., Berlin, Germany. In Plant Cell, 2013
GSDA belongs to the cytidine/deoxycytidylate deaminase family of proteins together with a deaminase involved in riboflavin biosynthesis, the chloroplastic tRNA adenosine deaminase Arg and a predicted tRNA-specific adenosine deaminase 2 in A. thaliana.
Importance of adenosine-to-inosine editing adjacent to the anticodon in an Arabidopsis alanine tRNA under environmental stress.
Bock et al., Potsdam, Germany. In Nucleic Acids Res, 2013
The enzyme is homologous to Tad1p, a yeast tRNA-specific adenosine deaminase, and it selectively deaminates the adenosine in the position 3'-adjacent to the anticodon (A37) to inosine.
Transition state structure of E. coli tRNA-specific adenosine deaminase.
Schramm et al., New York City, United States. In J Am Chem Soc, 2008
Bacterial tRNA-specific adenosine deaminase (TadA) catalyzes the essential deamination of adenosine to inosine at the wobble position of tRNAs and is necessary to permit a single tRNA species to recognize multiple codons.
Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.
Almo et al., New York City, United States. In Biochemistry, 2006
The essential tRNA-specific adenosine deaminase catalyzes the deamination of adenosine to inosine at the wobble position of tRNAs.
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
Bass et al., Salt Lake City, United States. In Science, 2005
Indeed, IP6 is also essential for in vivo and in vitro deamination of adenosine 37 of tRNAala by ADAT1.
Crystallization and preliminary X-ray crystallographic analysis of the tRNA-specific adenosine deaminase from Streptococcus pyogenes.
Hwang et al., Seoul, South Korea. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005
The tRNA-specific adenosine deaminase from the pathogenic bacteria Streptococcus pyogenes (spTAD) has been overexpressed in Escherichia coli and crystallized in the presence of Zn2+ ion at 295 K using ammonium sulfate as a precipitant.
RNA editing by adenosine deaminases generates RNA and protein diversity.
Keller et al., Basel, Switzerland. In Biochimie, 2002
ADAT1 generates I at position 37 (3' of the anticodon) in eukaryotic tRNA(Ala).
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli.
Keller et al., Basel, Switzerland. In Embo J, 2002
We report the characterization of tadA, the first prokaryotic RNA editing enzyme to be identified.
Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases.
Rich et al., Cambridge, United States. In Mamm Genome, 2001
Human tRNA-specific adenosine deaminase (hADAT1) specifically converts A37 in the anticodon loop of human tRNA(Ala) to inosine via a hydrolytic deamination mechanism.
Identification and molecular characterization of two novel Trypanosoma cruzi genes encoding polypeptides sharing sequence motifs found in proteins involved in RNA editing reactions.
Guilvard et al., Montpellier, France. In Gene, 2000
The aa sequence from the ORF-C localized downstream of the Tc52 gene showed significant homology to human adenosine deaminase acting on RNA (hADAT1) that specifically deaminates adenosine 37 to inosine in eukaryotic tRNA(Ala) and to its homologue yeast protein (Tad1p) (22-25% identity and an additional 38-40% similarity over 177aa).
An adenosine deaminase that generates inosine at the wobble position of tRNAs.
Keller et al., Basel, Switzerland. In Science, 1999
The tRNA-specific adenosine deaminase of Saccharomyces cerevisiae that forms I(34) in tRNAs is described.
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